{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:49:55Z","timestamp":1782863395830,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T00:00:00Z","timestamp":1433894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Paediatr Dent"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1007\/s40368-015-0192-x","type":"journal-article","created":{"date-parts":[[2015,6,10]],"date-time":"2015-06-10T20:39:46Z","timestamp":1433968786000},"page":"449-454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of a chlorhexidine\/thymol and a fluoride varnish on caries development in erupting permanent molars: a comparative study"],"prefix":"10.1007","volume":"16","author":[{"given":"S.","family":"Flamee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gizani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Caroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Papagiannoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Twetman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,10]]},"reference":[{"key":"192_CR1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000065961","volume":"36","author":"AMPG Araujo","year":"2002","unstructured":"Araujo AMPG, Naspitz GMCC, Chelotti A, Cai S. Effect of Cervitec\u00ae on Mutans Streptococci in plaque and on caries formation on occlusal fissures of erupting permanent molars. Caries Res. 2002;36:373\u20136.","journal-title":"Caries Res"},{"key":"192_CR2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.14219\/jada.archive.2008.0155","volume":"139","author":"J Beauchamp","year":"2008","unstructured":"Beauchamp J, Caufield PW, Crall JJ, et al. Evidence-based clinical recommendations for the use of pit-and-fissure sealants: a report of the American Dental Association Council on Scientific Affairs. J Am Dent Assoc. 2008;139:257\u201368.","journal-title":"J Am Dent Assoc"},{"key":"192_CR3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-0528.1991.tb00099.x","volume":"19","author":"JC Carvalho","year":"1991","unstructured":"Carvalho JC, Ekstrand KR, Thylstrup A. Results after 1\u00a0year of non-operative occlusal caries treatment of erupting permanent first molars. Community Dent Oral Epidemiol. 1991;19:23\u20138.","journal-title":"Community Dent Oral Epidemiol"},{"key":"192_CR4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000260872","volume":"19","author":"FC Driessens","year":"1985","unstructured":"Driessens FC, Heijligers HJ, Borggreven JM, Woltgens JH. Posteruptive maturation of tooth enamel studied with the electron microprobe. Caries Res. 1985;19:390\u20135.","journal-title":"Caries Res"},{"issue":"3","key":"192_CR5","first-page":"CD003067","volume":"17","author":"A Hiiri","year":"2010","unstructured":"Hiiri A, Ahovuo-Saloranta A, Nordblad A, M\u00e4kel\u00e4 M. Pit and fissure sealants versus fluoride varnishes for preventing dental decay in children and adolescents. Cochrane Database Syst Rev. 2010;17(3):CD003067.","journal-title":"Cochrane Database Syst Rev"},{"key":"192_CR6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000315346","volume":"44","author":"P James","year":"2010","unstructured":"James P, Parnell C, Whelton H. The caries-preventive effect of chlorhexidine varnish in children and adolescents: a systematic review. Caries Res. 2010;44:333\u201340.","journal-title":"Caries Res"},{"key":"192_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00016350310001460","volume":"61","author":"M Korhonen","year":"2003","unstructured":"Korhonen M, K\u00e4kilehto T, Larmas M. Tooth-by-tooth survival analysis of the first caries attack in different age cohorts and health centers in Finland. Acta Odontol Scand. 2003;61:1\u20135.","journal-title":"Acta Odontol Scand"},{"key":"192_CR8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/0022034512453049","volume":"24","author":"M Maltz","year":"2012","unstructured":"Maltz M, Beighton D. Multidisciplinary research agenda for novel antimicrobial agents for caries prevention and treatment. Adv Dent Res. 2012;24:133\u20136.","journal-title":"Adv Dent Res"},{"issue":"7","key":"192_CR9","first-page":"CD002279","volume":"11","author":"VC Marinho","year":"2013","unstructured":"Marinho VC, Worthington HV, Walsh T, Clarkson JE. Fluoride varnishes for preventing dental caries in children and adolescents. Cochrane Database Syst Rev. 2013;11(7):CD002279.","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"192_CR10","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/00016357.2013.822548","volume":"72","author":"I Mej\u00e0re","year":"2014","unstructured":"Mej\u00e0re I, Axelsson S, Dahl\u00e9n G, et al. Caries risk assessment. A systematic review. Acta Odontol Scand. 2014;72(2):81\u201391.","journal-title":"Acta Odontol Scand"},{"issue":"6","key":"192_CR11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/ipd.12085","volume":"24","author":"S Paul","year":"2014","unstructured":"Paul S, Baranya Shrikrishna S, Suman E, Shenoy R, Rao A. Effect of fluoride varnish and chlorhexidine-thymol varnish on mutans streptococci levels in human dental plaque: a double-blinded randomized controlled trial. Int J Paediatr Dent. 2014;24(6):399\u2013408.","journal-title":"Int J Paediatr Dent"},{"key":"192_CR12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000016581","volume":"34","author":"LG Petersson","year":"2000","unstructured":"Petersson LG, Magnusson K, Andersson H, Almquist B, Twetman S. Effect of quarterly treatments with a chlorhexidine and a fluoride varnish on approximal caries in caries-susceptible teenagers: a 3-year clinical study. Caries Res. 2000;34:140\u20133.","journal-title":"Caries Res"},{"key":"192_CR13","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2012.87802","volume":"308","author":"G Piaggio","year":"2012","unstructured":"Piaggio G, Elbourne DR, Pocock SJ, Evans SJ, Altman DG, CONSORT Group. Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA. 2012;308:2594\u2013604.","journal-title":"JAMA"},{"key":"192_CR14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jdent.2007.01.007","volume":"35","author":"LG Ribeiro","year":"2007","unstructured":"Ribeiro LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature. J Dent. 2007;35:359\u201370.","journal-title":"J Dent"},{"key":"192_CR15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/idh.12028","volume":"11","author":"PG Sajjan","year":"2013","unstructured":"Sajjan PG, Nagesh L, Sajjanar M, Reddy SK, Venktesh UG. Comparative evaluation of chlorhexidine varnish and fluoride varnish on plaque Streptococcus mutans count\u2014an in vivo study. Int J Dent Hyg. 2013;11:191\u20137.","journal-title":"Int J Dent Hyg"},{"issue":"4","key":"192_CR16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/0022034515571184","volume":"94","author":"F Schwendicke","year":"2015","unstructured":"Schwendicke F, J\u00e4ger AM, Paris S, Hsu LY, Tu YK. Treating pit-and-fissure caries: a systematic review and network meta-analysis. J Dent Res. 2015;94(4):522\u201333.","journal-title":"J Dent Res"},{"key":"192_CR17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/0022034512450028","volume":"24","author":"JM Cate ten","year":"2012","unstructured":"ten Cate JM, Zaura E. The numerous microbial species in oral biofilms: how could antibacterial therapy be effective? Adv Dent Res. 2012;24:108\u201311.","journal-title":"Adv Dent Res"},{"key":"192_CR18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1752-7325.2010.00163.x","volume":"70","author":"OK Tut","year":"2010","unstructured":"Tut OK, Milgrom PM. Topical iodine and fluoride varnish combined is more effective than fluoride varnish alone for protecting erupting first permanent molars: a retrospective cohort study. J Public Health Dent. 2010;70:249\u201352.","journal-title":"J Public Health Dent"},{"key":"192_CR19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000077758","volume":"38","author":"S Twetman","year":"2004","unstructured":"Twetman S. Antimicrobials in future caries control? A review with special reference to chlorhexidine treatment. Caries Res. 2004;38:223\u20139.","journal-title":"Caries Res"},{"key":"192_CR20","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3109\/00016357.2012.690448","volume":"71","author":"S Twetman","year":"2013","unstructured":"Twetman S, Axelsson S, Dahl\u00e9n G, et al. Adjunct methods for caries detection: a systematic review of literature. Acta Odontol Scand. 2013;71:388\u201397.","journal-title":"Acta Odontol Scand"},{"key":"192_CR21","first-page":"346","volume":"62","author":"JH Unkel","year":"1995","unstructured":"Unkel JH, Fenton SJ, Hobbs G Jr, Frere CL. Toothbrushing ability is related to age in children. ASDC J Dent Child. 1995;62:346\u20138.","journal-title":"ASDC J Dent Child"},{"key":"192_CR22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.phrs.2012.11.006","volume":"69","author":"WG Wade","year":"2013","unstructured":"Wade WG. The oral microbiome in health and disease. Pharmacol Res. 2013;69:137\u201343.","journal-title":"Pharmacol Res"},{"key":"192_CR23","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.14219\/jada.archive.2013.0057","volume":"144","author":"RJ Weyant","year":"2013","unstructured":"Weyant RJ, Tracy SL, Anselmo TT, et al. Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc. 2013;144:1279\u201391.","journal-title":"J Am Dent Assoc"},{"key":"192_CR24","unstructured":"World Health Organisation. Oral health surveys. Basic methods. 3rd ed. World Health Organisation: Geneva, 1997."},{"key":"192_CR25","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.jdent.2007.04.002","volume":"35","author":"Q Zhang","year":"2007","unstructured":"Zhang Q, Mulder J, Truin GJ, van Palestein Helderman WH. Effect of 40\u00a0% chlorhexidine varnish on mutans streptococci in pits and fissures of permanent first molars. J Dent. 2007;35:588\u201392.","journal-title":"J Dent"}],"container-title":["European Archives of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-015-0192-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40368-015-0192-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-015-0192-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T22:41:51Z","timestamp":1559515311000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40368-015-0192-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,10]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["192"],"URL":"https:\/\/doi.org\/10.1007\/s40368-015-0192-x","relation":{},"ISSN":["1818-6300","1996-9805"],"issn-type":[{"value":"1818-6300","type":"print"},{"value":"1996-9805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,10]]}}}