{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:36:19Z","timestamp":1790278579879,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100014232","name":"Norwegian Directorate of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100014232","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fysiofondet","award":["7\/370-00\/05"],"award-info":[{"award-number":["7\/370-00\/05"]}]},{"name":"Samarbeidsorganet","award":["2006\/9264-95"],"award-info":[{"award-number":["2006\/9264-95"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Paediatr Dent"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The study aimed to investigate associations between maternal vitamin D status during pregnancy and molar\u00a0incisor hypomineralisation (MIH) and hypomineralised second primary molars (HSPM) among children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study had a longitudinal design using prospectively collected data from 176 mother and child pairs. Mothers were initially recruited in a randomised controlled trial to assess a pregnancy exercise programme. Along with the 7-year follow-up, we invited the children to a dental examination. The exposure variable was maternal serum 25-hydroxyvitamin D in gestational weeks 18\u201322 and 32\u201336, categorised as insufficient (&lt;\u200950\u00a0nmol\/l) and sufficient (\u2265\u200950\u00a0nmol\/l). Negative binomial hurdle models were used to analyse potential associations between the exposure variables and MIH or HSPM. The models were adjusted for potential confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the children (7\u20139\u00a0years old), 32% and 22% had at least one tooth with MIH or HSPM, respectively. A significant association was found between insufficient maternal vitamin D measured in gestational weeks 18\u201322 and the number of affected teeth among those with MIH at 7\u20139\u00a0years (adjusted\u00a0RR\u2009=\u20091.82, 95% CI 1.13\u20132.93).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Considering any limitations of the present study, it has been shown that insufficient maternal serum vitamin D at mid-pregnancy was associated with a higher number of affected teeth among the offspring with MIH at 7\u20139\u00a0years of age. Further prospective studies are needed to investigate whether this finding is replicable and to clarify the role of maternal vitamin D status during pregnancy and MIH, as well as HSPM, in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40368-022-00712-y","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T13:04:39Z","timestamp":1652360679000},"page":"557-566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Maternal vitamin D status in pregnancy and molar\u00a0incisor hypomineralisation and hypomineralised second primary molars in the offspring at 7\u20139\u00a0years of age: a longitudinal study"],"prefix":"10.1007","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-3807","authenticated-orcid":false,"given":"T.","family":"B\u00f8rsting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7759-2946","authenticated-orcid":false,"given":"A.","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"van Dommelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-477X","authenticated-orcid":false,"given":"S. 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J Stat Softw. 2008. https:\/\/doi.org\/10.18637\/jss.v027.i08.","journal-title":"J Stat Softw"}],"container-title":["European Archives of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-022-00712-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40368-022-00712-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-022-00712-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T16:23:56Z","timestamp":1659111836000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40368-022-00712-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,12]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["712"],"URL":"https:\/\/doi.org\/10.1007\/s40368-022-00712-y","relation":{},"ISSN":["1818-6300","1996-9805"],"issn-type":[{"value":"1818-6300","type":"print"},{"value":"1996-9805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,12]]},"assertion":[{"value":"21 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Ethical approval from the Norwegian Regional Committees for Medical and Health Research (REK) was acquired before the initiation of the current study (2015\/639\/REK s\u00f8r-\u00f8st), the original TRIP-study (4.2007.81), and the 7-year follow-up (2014\/618\/REK midt).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The parents and their child were given information about the current study, including a child-friendly information sheet about the dental examination. The mothers gave written informed consent to participate in the TRIP-study, and both the parents gave written informed consent for their child to participate in the current study, including the dental examination.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}