{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T19:07:44Z","timestamp":1793214464207,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Paediatr Dent"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s40368-022-00720-y","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T16:02:32Z","timestamp":1656777752000},"page":"803-811","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Direct pulp capping in asymptomatic carious primary molars using three different pulp capping materials: a prospective clinical trial"],"prefix":"10.1007","volume":"23","author":[{"given":"K.","family":"Chatzidimitriou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vadiakas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Koletsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"720_CR1","unstructured":"American Academy of Pediatric Dentistry. Guideline on pulp therapy for primary and immature permanent teeth. Revised 2014 Pediatric Dentistry Reference Manual 2014\u20132015; 2014. p. 242\u201350. http:\/\/www.aapd.org\/media\/policies_guidelines \/g_pulp.pdf"},{"key":"720_CR2","first-page":"384","volume-title":"Pulp therapy for primary and immature permanent teeth. The Reference Manual of Pediatric Dentistry","author":"American Academy of Pediatric Dentistry","year":"2020","unstructured":"American Academy of Pediatric Dentistry. Pulp therapy for primary and immature permanent teeth. The Reference Manual of Pediatric Dentistry. Chicago: American Academy of Pediatric Dentistry; 2020. p. 384\u201392."},{"issue":"1","key":"720_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.5681\/joddd.2013.002","volume":"7","author":"N Asl Aminabadi","year":"2013","unstructured":"Asl Aminabadi N, Maljaei E, Erfanparast L, Ala Aghbali A, Hamishehkar H, Najafpour E. Simvastatin versus calcium hydroxide direct pulp capping of human primary molars: a randomized clinical trial. J Dent Res Dent Clin Dent Prospects. 2013;7(1):8\u201314. https:\/\/doi.org\/10.5681\/joddd.2013.002.","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"issue":"5","key":"720_CR4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s40368-018-0360-x","volume":"19","author":"C Boutsiouki","year":"2018","unstructured":"Boutsiouki C, Frankenberger R, Kr\u00e4mer N. Relative effectiveness of direct and indirect pulp capping in the primary dentition. Eur Arch Paediatr Dent. 2018;19(5):297\u2013309. https:\/\/doi.org\/10.1007\/s40368-018-0360-x.","journal-title":"Eur Arch Paediatr Dent"},{"issue":"1","key":"720_CR5","first-page":"16","volume":"39","author":"JA Coll","year":"2017","unstructured":"Coll JA, Seale NS, Vargas K, Marghalani AA, Al Shamali S, Graham L. Primary tooth vital pulp therapy: a systematic review and meta-analysis. Pediatr Dent. 2017;39(1):16\u2013123.","journal-title":"Pediatr Dent"},{"issue":"5","key":"720_CR6","first-page":"146","volume":"39","author":"V Dhar","year":"2017","unstructured":"Dhar V, Marghalani AA, Crystal YO, Kumar A, Ritwik P, Tulunoglu O, Graham L. Use of vital pulp therapies in primary teeth with deep caries lesions. Pediatr Dent. 2017;39(5):146\u201359.","journal-title":"Pediatr Dent"},{"issue":"5","key":"720_CR7","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s40368-019-00419-7","volume":"20","author":"D Dimitraki","year":"2019","unstructured":"Dimitraki D, Papageorgiou SN, Kotsanos N. Direct pulp capping versus pulpotomy with MTA for carious primary molars: a randomised clinical trial. Eur Arch Paediatr Dent. 2019;20(5):431\u201340. https:\/\/doi.org\/10.1007\/s40368-019-00419-7.","journal-title":"Eur Arch Paediatr Dent"},{"issue":"7","key":"720_CR8","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/iej.13080","volume":"52","author":"HF Duncan","year":"2019","unstructured":"European Society of Endodontology (ESE), Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bj\u00f8rndal L. European society of endodontology position statement: management of deep caries and the exposed pulp. Int Endod J. 2019;52(7):923\u201334. https:\/\/doi.org\/10.1111\/iej.13080.","journal-title":"Int Endod J"},{"issue":"1","key":"720_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s10266-009-0116-5","volume":"98","author":"JL Ferracane","year":"2010","unstructured":"Ferracane JL, Cooper PR, Smith AJ. Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration? Odontology. 2010;98(1):2\u201314. https:\/\/doi.org\/10.1007\/s10266-009-0116-5.","journal-title":"Odontology"},{"issue":"5","key":"720_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127495","volume":"10","author":"PS Fleming","year":"2015","unstructured":"Fleming PS, Koletsi D, Dwan K, Pandis N. Outcome discrepancies and selective reporting: impacting the leading journals? PLoS ONE. 2015;10(5): e0127495. https:\/\/doi.org\/10.1371\/journal.pone.0127495.","journal-title":"PLoS ONE"},{"key":"720_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.joen.2008.02.031","volume":"34","author":"AB Fuks","year":"2008","unstructured":"Fuks AB. Vital pulp therapy with new materials for primary teeth: new directions and treatment perspectives. J Endod. 2008;34:18\u201324. https:\/\/doi.org\/10.1016\/j.joen.2008.02.031.","journal-title":"J Endod"},{"key":"720_CR12","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1365-263x.2008.00962.x","volume":"19","author":"D Kassa","year":"2009","unstructured":"Kassa D, Day P, High A, Duggal M. Histological comparison of pulpal inflammation in primary teeth with occlusal or proximal caries. Int J Paediatr Dent. 2009;19:26\u201333. https:\/\/doi.org\/10.1111\/j.1365-263x.2008.00962.x.","journal-title":"Int J Paediatr Dent"},{"key":"720_CR13","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jdent.2014.11.004","volume":"43","author":"JR Kim","year":"2015","unstructured":"Kim JR, Nosrat A, Fouad AF. Interfacial characteristics of Biodentine and MTA with dentine in simulated body fluid. J Dent. 2015;43:241\u20137. https:\/\/doi.org\/10.1016\/j.jdent.2014.11.004.","journal-title":"J Dent"},{"issue":"4","key":"720_CR14","doi-asserted-by":"publisher","first-page":"307","DOI":"10.17796\/jcpd.38.4.k651814611318430","volume":"38","author":"N Kotsanos","year":"2014","unstructured":"Kotsanos N, Arapostathis KN, Arhakis A, Menexes G. Direct pulp capping of carious primary molars a specialty practice-based study. J Clin Pediatr Dent. 2014;38(4):307\u201312. https:\/\/doi.org\/10.17796\/jcpd.38.4.k651814611318430.","journal-title":"J Clin Pediatr Dent"},{"issue":"3","key":"720_CR15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/ejo\/cjy046","volume":"41","author":"M Koufatzidou","year":"2019","unstructured":"Koufatzidou M, Koletsi D, Fleming PS, Polychronopoulou A, Pandis N. Outcome reporting discrepancies between trial entries and published final reports of orthodontic randomized controlled trials. Eur J Orthod. 2019;41(3):225\u201330. https:\/\/doi.org\/10.1093\/ejo\/cjy046.","journal-title":"Eur J Orthod"},{"key":"720_CR16","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/j.1365-2591.2011.01995.x","volume":"45","author":"P Laurent","year":"2012","unstructured":"Laurent P, Camps J, About I. Biodentine induces TGF-b1 release from human pulp cells and early dental pulp mineralization. Int Endod J. 2012;45:439\u201348. https:\/\/doi.org\/10.1111\/j.1365-2591.2011.01995.x.","journal-title":"Int Endod J"},{"key":"720_CR17","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1365-2591.2008.01396.x","volume":"41","author":"Y Lu","year":"2008","unstructured":"Lu Y, Liu T, Li H, Pi G. Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue. Int Endod J. 2008;41:643\u201350. https:\/\/doi.org\/10.1111\/j.1365-2591.2008.01396.x.","journal-title":"Int Endod J"},{"key":"720_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/iej.12281","volume":"48","author":"LC Natale","year":"2015","unstructured":"Natale LC, Rodrigues MC, Xavier TA, et al. Ion release and mechanical properties of calcium silicate and calcium hydroxide materials used for pulp capping. Int Endod J. 2015;48:89\u201394. https:\/\/doi.org\/10.1111\/iej.12281.","journal-title":"Int Endod J"},{"key":"720_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.joen.2013.01.005","volume":"39","author":"A Nowicka","year":"2013","unstructured":"Nowicka A, Lipski M, Parafiniuk M, Sporniak-Tutak K, Lichota D, Kosierkiewicz \u0391, Kaczmarek W, Buczkowska-Radli\u0144ska J. Response of human dental pulp capped with Biodentine and mineral trioxide aggregate. J Endod. 2013;39:743\u20137. https:\/\/doi.org\/10.1016\/j.joen.2013.01.005.","journal-title":"J Endod"},{"key":"720_CR20","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1365-2591.2006.01116.x","volume":"39","author":"H Olsson","year":"2006","unstructured":"Olsson H, Petersson K, Rohlin M. Formation of a hard tissue barrier after pulp cappings in humans. A Syst Rev Int Endod J. 2006;39:429\u201342. https:\/\/doi.org\/10.1111\/j.1365-2591.2006.01116.x.","journal-title":"A Syst Rev Int Endod J"},{"issue":"1","key":"720_CR21","first-page":"6","volume":"10","author":"I Parisay","year":"2015","unstructured":"Parisay I, Ghoddusi J, Forghani M. A review on vital pulp therapy in primary teeth. Iran Endod J. 2015;10(1):6\u201315.","journal-title":"Iran Endod J"},{"issue":"5","key":"720_CR22","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s00784-013-1107-z","volume":"18","author":"MA Petrou","year":"2014","unstructured":"Petrou MA, Alhamoui FA, Welk A, Altarabulsi MB, Alkilzy M, Splieth H, C. A randomized clinical trial on the use of medical Portland cement, MTA and calcium hydroxide in indirect pulp treatment. Clin Oral Investig. 2014;18(5):1383\u20139. https:\/\/doi.org\/10.1007\/s00784-013-1107-z.","journal-title":"Clin Oral Investig"},{"key":"720_CR23","first-page":"343","volume-title":"Dentistry for the child and adolescent","author":"EM Ralph","year":"2011","unstructured":"Ralph EM, David RA, Jeffrey AD. Treatment of deep caries, vital pulp exposure, and pulpless teeth. In: Ralph EM, David RA, Jeffrey AD, editors. Dentistry for the child and adolescent. St. Louis: Mosby Elsevier Inc; 2011. p. 343."},{"key":"720_CR24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3290\/j.jad.a25690","volume":"14","author":"A Raskin","year":"2012","unstructured":"Raskin A, Eschrich G, Dejou J, About I. In vitro microleakage of Biodentine as a dentin substitute compared to Fuji II LC in cervical lining restorations. J Adhes Dent. 2012;14:535\u201342. https:\/\/doi.org\/10.3290\/j.jad.a25690.","journal-title":"J Adhes Dent"},{"issue":"6","key":"720_CR25","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s00784-016-1802-7","volume":"20","author":"F Schwendicke","year":"2016","unstructured":"Schwendicke F, Brouwer F, Schwendicke A, Paris S. Different materials for direct pulp capping: systematic review and meta-analysis and trial sequential analysis. Clin Oral Investig. 2016;20(6):1121\u201332. https:\/\/doi.org\/10.1007\/s00784-016-1802-7.","journal-title":"Clin Oral Investig"},{"issue":"4","key":"720_CR26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1111\/j.1600-9657.2009.00799.x","volume":"25","author":"A Shayegan","year":"2009","unstructured":"Shayegan A, Petein M, Vanden AA. The use of beta- tricalcium phosphate, white MTA, white Portland cement and calcium hydroxide for direct pulp capping of primary pig teeth. Dent Traumatol. 2009;25(4):413\u20139. https:\/\/doi.org\/10.1111\/j.1600-9657.2009.00799.x.","journal-title":"Dent Traumatol"},{"key":"720_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.cd003220.pub3","author":"V Sma\u00efl-Faugeron","year":"2018","unstructured":"Sma\u00efl-Faugeron V, Glenny AM, Courson F, Durieux P, Muller-Bolla M, Fron CH. Pulp treatment for extensive decay in primary teeth. Cochrane Database Syst Rev. 2018. https:\/\/doi.org\/10.1002\/14651858.cd003220.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"720_CR28","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10266-015-0215-4","volume":"104","author":"S Songsiripradubboon","year":"2016","unstructured":"Songsiripradubboon S, Banlunara W, Sangvanich P, Trairatvorakul C, Thunyakitpisal P. Clinical, radiographic and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short- term outcomes. Odontology. 2016;104(3):329\u201337. https:\/\/doi.org\/10.1007\/s10266-015-0215-4.","journal-title":"Odontology"},{"issue":"2","key":"720_CR29","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/bf03321608","volume":"10","author":"R Steffen","year":"2009","unstructured":"Steffen R, van Waes H. Understanding mineral trioxide aggregate\/Portland-cement: a review of literature and background factors. Eur Arch Paediatr Dent. 2009;10(2):93\u20137. https:\/\/doi.org\/10.1007\/bf03321608.","journal-title":"Eur Arch Paediatr Dent"},{"key":"720_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pdj.2016.10.001","volume":"27","author":"A Sujlana","year":"2017","unstructured":"Sujlana A, Pannu PK. Direct pulp capping: a treatment option in primary teeth? Pediatric Dent J. 2017;27:1\u20137.","journal-title":"Pediatric Dent J"},{"key":"720_CR31","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1365-2591.2007.01339.x","volume":"41","author":"D Tuna","year":"2008","unstructured":"Tuna D, Olmez A. Clinical long-term evaluation of MTA as a direct pulp capping material in primary teeth. Int Endod J. 2008;41:273\u20138. https:\/\/doi.org\/10.1111\/j.1365-2591.2007.01339.x.","journal-title":"Int Endod J"},{"key":"720_CR32","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1016\/j.joen.2012.04.018","volume":"38","author":"M Zanini","year":"2012","unstructured":"Zanini M, Sautier JM, Berdal A, Simon S. Biodentine induces immortalized murine pulp cell differentiation into odontoblast-like cells and stimulates biomineralization. J Endod. 2012;38:1220\u20136. https:\/\/doi.org\/10.1016\/j.joen.2012.04.018.","journal-title":"J Endod"}],"container-title":["European Archives of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-022-00720-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40368-022-00720-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-022-00720-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,6]],"date-time":"2022-11-06T17:21:48Z","timestamp":1667755308000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40368-022-00720-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["720"],"URL":"https:\/\/doi.org\/10.1007\/s40368-022-00720-y","relation":{},"ISSN":["1818-6300","1996-9805"],"issn-type":[{"value":"1818-6300","type":"print"},{"value":"1996-9805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]},"assertion":[{"value":"19 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}]}}