{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:30:40Z","timestamp":1788330640407,"version":"build-2803163510"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005727","name":"Universidade de Coimbra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005727","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Paediatr Dent"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>To evaluate and compare the effect of two enzymatic chemo-mechanical caries removal agents with conventional caries removal using rotatory instruments on the adhesion of composite resin to dentin of permanent teeth.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The sample comprised 30 permanent molars with caries lesions extending to the dentin, randomly distributed into three groups (<jats:italic>n<\/jats:italic>\u2009=\u200910 each): 1\u2014Caries removal with rotary instruments (control group); 2\u2014Caries removal with Papac\u00e1rie Duo<jats:sup>\u00ae<\/jats:sup> (F&amp;A Laborat\u00f3rio Farmac\u00eautico, S\u00e3o Paulo, Brazil); 3\u2014Caries removal with Brix 3000\u2122 (Brix S.R.L., Carcara\u00f1\u00e1, Argentina). After caries removal, the specimens were rinsed and dried. Scotchbond Universal\u2122 adhesive (3\u00a0M, Saint Paul, Minnesota, USA) was actively applied in self-etch mode and light-cured. Resin composite increments were applied using a silicone mold (3\u2009\u00d7\u20093\u2009\u00d7\u20092\u00a0mm) and light-cured. Shear bond strength (MPa), work-to-debonding (J\/m<jats:sup>2<\/jats:sup>), and shear modulus (kPa) were evaluated. For statistical analysis, the level of significance was set at 5%.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The control group presented significantly higher shear bond strength values (8.50\u2009\u00b1\u20092.69\u00a0MPa) compared to the Brix 3000\u2122 group (5.72\u2009\u00b1\u20091.55\u00a0MPa, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). There were no significant differences between Papac\u00e1rie Duo<jats:sup>\u00ae<\/jats:sup> (6.66\u2009\u00b1\u20090.86\u00a0MPa) and the other groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Regarding work-to-debonding, the Papac\u00e1rie Duo<jats:sup>\u00ae<\/jats:sup> group had a significantly higher result (2944.41\u2009\u00b1\u2009450.21\u00a0J\/m<jats:sup>2<\/jats:sup>) than the Brix 3000\u2122 group (1189.41\u2009\u00b1\u2009504.13\u00a0J\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the control group (967.10\u2009\u00b1\u2009270.01\u00a0J\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Concerning shear modulus, the control group showed a significantly higher result (558.67\u2009\u00b1\u2009168.96\u00a0kPa) than the Brix 3000\u2122 group (339.79\u2009\u00b1\u2009143.78\u00a0kPa, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) and the Papac\u00e1rie Duo<jats:sup>\u00ae<\/jats:sup> group (223.04\u2009\u00b1\u2009127.30\u00a0kPa, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>While the application of Papac\u00e1rie Duo<jats:sup>\u00ae<\/jats:sup> did not negatively affect composite resin adhesion to dentin of permanent teeth, the application of Brix 3000\u2122 reduced adhesive forces, potentially limiting its clinical use. Further investigations are warranted to elucidate the effects of these materials on dentin substrate, particularly through clinical studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s40368-024-00949-9","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T13:03:36Z","timestamp":1730466216000},"page":"95-108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of enzymatic chemo-mechanical agents on adhesion of composite resin to dentin of permanent teeth: an in vitro study"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2924-7926","authenticated-orcid":false,"given":"A. 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The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study received approval from the Ethics Committee of the Faculty of Medicine of the University of Coimbra (CE-161\/2022), adhering to applicable laws, regulations, and the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. The authors have no financial or proprietary interests in any material discussed in this article.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent publication"}}]}}