{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:08:25Z","timestamp":1790806105344,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur Arch Paediatr Dent"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s40368-025-01091-w","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:58:28Z","timestamp":1757768308000},"page":"1193-1200","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the cytotoxicity and efficacy of nanoemulsion containing propolis plus Nigella sativa nanoparticles for pulpotomy of primary teeth: randomised split-mouth clinical trial pilot study"],"prefix":"10.1007","volume":"26","author":[{"given":"A.-M.","family":"Osanloo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Hamze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Haghgoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mashhadi-Abbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Papi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"1091_CR1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s00784-007-0161-9","volume":"12","author":"M Accorinte","year":"2008","unstructured":"Accorinte M, Loguercio A, Reis A, Costa CADS. Response of human pulps capped with different self-etch adhesive systems. Clin Oral Investig. 2008;12:119\u201327.","journal-title":"Clin Oral Investig"},{"key":"1091_CR2","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.jobcr.2024.12.020","volume":"15","author":"A Agarwal","year":"2025","unstructured":"Agarwal A, Verma P, Yadav R, Bharti R, Bains R, Kumar M, Shastri D. Evaluation of pulpal response at varying remaining dentin thickness in teeth restored with resin bulk fill composite, conventional glass ionomer cement and silver amalgam: histomorphometric analysis. J Oral Biol Craniofac Res. 2025;15:347\u201354.","journal-title":"J Oral Biol Craniofac Res"},{"key":"1091_CR3","doi-asserted-by":"publisher","first-page":"508","DOI":"10.22037\/iej.v13i4.21335","volume":"13","author":"S Aghazadeh","year":"2018","unstructured":"Aghazadeh S, Haghgoo R, Mehran M, Kadkhodaei F. Comparative evaluation of clinical and radiographic success of MTA and propolis in pulpotomy of primary molars. Iran Endod J. 2018;13:508. https:\/\/doi.org\/10.22037\/iej.v13i4.21335.","journal-title":"Iran Endod J"},{"key":"1091_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/j.1834-7819.2009.01179.x","volume":"5","author":"NA Ahmad","year":"2022","unstructured":"Ahmad NA, Gad NA, Abdulmonaem MH. A comparative histological analysis of human pulp following direct pulp capping with propolis or biodentine. J Nat Sci Med. 2022;5:281\u20135. https:\/\/doi.org\/10.1111\/j.1834-7819.2009.01179.x.","journal-title":"J Nat Sci Med"},{"key":"1091_CR5","doi-asserted-by":"publisher","DOI":"10.4314\/BCSE.V26I1.6","author":"MA Ali","year":"2012","unstructured":"Ali MA, Sayeed MA, Alam MS, Yeasmin MS, Khan AM, Muhamad II. Characteristics of oils and nutrient contents of Nigella sativa Linn. and Trigonella foenum-graecum seeds. Bull Chem Soc Ethiop. 2012. https:\/\/doi.org\/10.4314\/BCSE.V26I1.6.","journal-title":"Bull Chem Soc Ethiop"},{"key":"1091_CR6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.22038\/jmds.2010.1201","volume":"34","author":"S Asgari","year":"2010","unstructured":"Asgari S. Vital pulp therapy for permanent dentition using calcium enriched mixture cement: a review article. J Mashhad Dent Sch. 2010;34:161\u201370. https:\/\/doi.org\/10.22038\/jmds.2010.1201.","journal-title":"J Mashhad Dent Sch"},{"key":"1091_CR7","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1002\/jbm.a.31678","volume":"87","author":"S Asgary","year":"2008","unstructured":"Asgary S, Eghbal MJ, Parirokh M. Sealing ability of a novel endodontic cement as a root-end filling material. J Biomed Mater Res. 2008;87:706\u20139. https:\/\/doi.org\/10.1002\/jbm.a.31678.","journal-title":"J Biomed Mater Res"},{"key":"1091_CR8","doi-asserted-by":"publisher","first-page":"3287","DOI":"10.1007\/s00784-021-04310-y","volume":"26","author":"S Asgary","year":"2022","unstructured":"Asgary S, Eghbal MJ, Shahravan A, Saberi E, Baghban AA, Parhizkar A. Outcomes of root canal therapy or full pulpotomy using two endodontic biomaterials in mature permanent teeth: a randomized controlled trial. Clin Oral Investig. 2022;26:3287\u201397.","journal-title":"Clin Oral Investig"},{"key":"1091_CR9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12938-024-01290-4","volume":"23","author":"S Asgary","year":"2024","unstructured":"Asgary S, Aram M, Fazlyab M. Comprehensive review of composition, properties, clinical applications, and future perspectives of calcium-enriched mixture (CEM) cement: a systematic analysis. Biomed Eng Online. 2024;23:96.","journal-title":"Biomed Eng Online"},{"key":"1091_CR10","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1515\/gps-2022-0059","volume":"11","author":"B Barsola","year":"2022","unstructured":"Barsola B, Kumari P. Green synthesis of nano-propolis and nanoparticles (Se and Ag) from ethanolic extract of propolis, their biochemical characterization: a review. Green Process Synth. 2022;11:659\u201373. https:\/\/doi.org\/10.1515\/gps-2022-0059.","journal-title":"Green Process Synth"},{"key":"1091_CR11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s12903-024-03917-3","volume":"24","author":"O Celiksoz","year":"2024","unstructured":"Celiksoz O, Irmak O. Delayed vs. immediate placement of restorative materials over Biodentine and RetroMTA: a micro-shear bond strength study. BMC Oral Health. 2024;24:130.","journal-title":"BMC Oral Health"},{"key":"1091_CR12","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/S0109-5641(00)00076-2","volume":"17","author":"C De Souza Costa","year":"2001","unstructured":"De Souza Costa C, Do Nascimento AL, Teixeira H, Fontana U. Response of human pulps capped with a self-etching adhesive system. Dent Mater. 2001;17:230\u201340.","journal-title":"Dent Mater"},{"key":"1091_CR13","doi-asserted-by":"publisher","first-page":"967","DOI":"10.21608\/edj.2021.56216.1440","volume":"67","author":"RN Fathy","year":"2021","unstructured":"Fathy RN, El Bardissy A, Abdelgawad F, AbdAlsamad AM. Postoperative pain evaluation of mineral trioxide aggregate and propolis after pulpotomy in carious primary molars: a randomized control trial. Egypt Dent J. 2021;67:967\u201376. https:\/\/doi.org\/10.21608\/edj.2021.56216.1440.","journal-title":"Egypt Dent J"},{"key":"1091_CR14","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/ipd.12633","volume":"30","author":"A Garrocho-Rangel","year":"2020","unstructured":"Garrocho-Rangel A, Esparza-Villalpando V, Pozos-Guillen A. Outcomes of direct pulp capping in vital primary teeth with cariously and non-cariously exposed pulp: a systematic review. Int J Paediatr Dent. 2020;30:536\u201346. https:\/\/doi.org\/10.1111\/ipd.12633.","journal-title":"Int J Paediatr Dent"},{"key":"1091_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/1735-3327.367914","volume":"20","author":"C Goinka","year":"2023","unstructured":"Goinka C, Galla PK, Madhavi K, Malempet A, Suryadevara S, Reddy KS. A histopathological comparison of formocresol, propolis, and growth factor as pulpotomy medicaments in primary teeth: an in vivo study. Dent Res J. 2023;20:15. https:\/\/doi.org\/10.4103\/1735-3327.367914.","journal-title":"Dent Res J"},{"key":"1091_CR16","first-page":"148","volume":"3","author":"E Halawani","year":"2009","unstructured":"Halawani E. Antibacterial activity of thymoquinone and thymohydroquinone of Nigella sativa L. and their interaction with some antibiotics. Adv Biol Res. 2009;3:148\u201352.","journal-title":"Adv Biol Res"},{"key":"1091_CR17","first-page":"335","volume":"8","author":"RW Hassan","year":"2021","unstructured":"Hassan RW, Mostafa MH, Darwish WM, Metwally NI. Clinical and radiographic assessment of propolis and propolis mixed with chitosan effect on pulp of primary molars versus formocresol: a randomized controlled trial. Al-Azhar Dent J Girls. 2021;8:335\u201341.","journal-title":"Al-Azhar Dent J Girls"},{"key":"1091_CR18","doi-asserted-by":"publisher","DOI":"10.34172\/johoe.2305.1555","author":"H Khanabadi","year":"2024","unstructured":"Khanabadi H, Hamze F, Amiri M, Behzadi S, EmamiRazavi HS, Karimi M. Evaluating the protective effect of a nano-emulsion containing propolis and nigella sativa nano-particles on enamel surface. J Oral Health Oral Epidemiol. 2024. https:\/\/doi.org\/10.34172\/johoe.2305.1555.","journal-title":"J Oral Health Oral Epidemiol"},{"key":"1091_CR19","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.joen.2015.04.012","volume":"41","author":"Z Li","year":"2015","unstructured":"Li Z, Cao L, Fan M, Xu Q. Direct pulp capping with calcium hydroxide or mineral trioxide aggregate: a meta-analysis. J Endod. 2015;41:1412\u20137. https:\/\/doi.org\/10.1016\/j.joen.2015.04.012.","journal-title":"J Endod"},{"key":"1091_CR20","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/j.1365-2591.2008.01396.x","volume":"41","author":"Y Lu","year":"2008","unstructured":"Lu Y, Liu T, Li H, Pi G. Histological evaluation of direct pulp capping with a self-etching adhesive and calcium hydroxide on human pulp tissue. Int Endod J. 2008;41:643\u201350.","journal-title":"Int Endod J"},{"key":"1091_CR21","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.14260\/jemds\/2020\/273","volume":"9","author":"K Madan","year":"2020","unstructured":"Madan K, Baliga S, Deulkar P, Thosar N, Rathi N, Deshpande M, Bane S. A comparative evaluation between propolis and mineral trioxide aggregate as pulpotomy medicaments in primary molars. J Evol Med Dent Sci. 2020;9:1256\u201361. https:\/\/doi.org\/10.14260\/jemds\/2020\/273.","journal-title":"J Evol Med Dent Sci"},{"key":"1091_CR22","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1080\/14756360400002072","volume":"19","author":"M Mansour","year":"2004","unstructured":"Mansour M, Tornhamre S. Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone. J Enzyme Inhib Med Chem. 2004;19:431\u20136. https:\/\/doi.org\/10.1080\/14756360400002072.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"1091_CR23","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3153\/JFHS18003","volume":"4","author":"A Mendi","year":"2018","unstructured":"Mendi A. Nigella sativa oil could induce osteogenic differentiation of dental pulp mesenchymal stem cells: clinical nutrition for dentistry. Food Health. 2018;4:19\u201324.","journal-title":"Food Health"},{"key":"1091_CR24","first-page":"185","volume":"9","author":"F Moazami","year":"2014","unstructured":"Moazami F, Sahebi S, Jamshidi D, Alavi A. The long-term effect of calcium hydroxide, calcium-enriched mixture cement and mineral trioxide aggregate on dentin strength. Iran Endod J. 2014;9:185.","journal-title":"Iran Endod J"},{"key":"1091_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.21608\/adjg.2022.29419.1257","volume":"9","author":"EN Mohamed","year":"2022","unstructured":"Mohamed EN, El-Shall OS, Mostafa MH, Ahmed NE-MB. Effect of propolis and castor oil cement as pulpotomy materials on the properties and osteogenic differentiation of stem cells isolated from human exfoliated deciduous teeth (SHED). Al-Azhar Dent J Girls. 2022;9:331\u20139. https:\/\/doi.org\/10.21608\/adjg.2022.29419.1257.","journal-title":"Al-Azhar Dent J Girls"},{"key":"1091_CR26","first-page":"169","volume":"52","author":"K Nagwa","year":"2006","unstructured":"Nagwa K, Ola O. Investigation on the relative efficacy of Nigella sativa oil compared to formocresol as pulp medicaments in non-vital primary molar pulpotomies. Egypt Dent J. 2006;52:169\u201377.","journal-title":"Egypt Dent J"},{"key":"1091_CR27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4103\/1735-3327.344163","volume":"19","author":"Z Nasri","year":"2022","unstructured":"Nasri Z, Jahromi MZ, Aminzadeh A. Clinical and histological response of human pulp tissue to direct pulp capping with mineral trioxide aggregate, Biodentine and propolis. Dent Res J. 2022;19:40. https:\/\/doi.org\/10.4103\/1735-3327.344163.","journal-title":"Dent Res J"},{"key":"1091_CR28","doi-asserted-by":"publisher","first-page":"335","DOI":"10.17796\/jcpd.36.4.n6674435856q86w8","volume":"36","author":"OM Omar","year":"2012","unstructured":"Omar OM, Khattab NM, Khater DS. Nigella sativa oil as a pulp medicament for pulpotomized teeth: a histopathological evaluation. J Clin Pediatr Dent. 2012;36:335\u201341. https:\/\/doi.org\/10.17796\/jcpd.36.4.n6674435856q86w8.","journal-title":"J Clin Pediatr Dent"},{"key":"1091_CR29","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/SCS.0000000000010323","volume":"10","author":"E Ozden","year":"2024","unstructured":"Ozden E, Kaya B, Guler R. Investigation of the effects of thymoquinone and dental pulp-derived mesenchymal stem cells on tibial bone defect models. J Craniofac Surg. 2024;10:1097. https:\/\/doi.org\/10.1097\/SCS.0000000000010323.","journal-title":"J Craniofac Surg"},{"key":"1091_CR30","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1834-7819.2009.01179.x","volume":"55","author":"A Parolia","year":"2010","unstructured":"Parolia A, Kundabala M, Rao N, Acharya S, Agrawal P, Mohan M, Thomas M. A comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal. Aust Dent J. 2010;55:59\u201364. https:\/\/doi.org\/10.1111\/j.1834-7819.2009.01179.x.","journal-title":"Aust Dent J"},{"key":"1091_CR31","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3390\/ma13122670","volume":"13","author":"MS Pedano","year":"2020","unstructured":"Pedano MS, Li X, Yoshihara K, Landuyt KV, Van Meerbeek B. Cytotoxicity and bioactivity of dental pulp-capping agents towards human tooth-pulp cells: a systematic review of in-vitro studies and meta-analysis of randomized and controlled clinical trials. Materials. 2020;13:26\u201370.","journal-title":"Materials"},{"key":"1091_CR32","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.53350\/pjmhs211581864","volume":"15","author":"M Rasheed","year":"2021","unstructured":"Rasheed M, Asghar H, Sana U, Moazzam M, Malik F, Farooq A. Histological analysis of human pulp by comparing propolis, mineral trioxide aggregate and calcium enriched mixture as a direct pulp capping agent in primary molars. Pak J Med Health Sci. 2021;15:1864\u20136. https:\/\/doi.org\/10.53350\/pjmhs211581864.","journal-title":"Pak J Med Health Sci"},{"key":"1091_CR33","doi-asserted-by":"publisher","first-page":"94","DOI":"10.34172\/johoe.2305.1555","volume":"7","author":"MB Rezvani","year":"2018","unstructured":"Rezvani MB, Hemmati MA, Norouzi M, Bakhtiari R, Azinpour F, Hamzeh F. Evaluation of the effect of Kandovan propolis against Streptococcus Mutans. J Oral Health Oral Epidemiol. 2018;7:94\u20138. https:\/\/doi.org\/10.34172\/johoe.2305.1555.","journal-title":"J Oral Health Oral Epidemiol"},{"key":"1091_CR34","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.5005\/jp-journals-10005-2120","volume":"15","author":"KS Rojaramya","year":"2022","unstructured":"Rojaramya KS, Chandrasekhar R, Uloopi K, Vinay C. Treatment outcomes of pulpotomy with propolis in comparison with MTA in human primary molars: a 24-month follow-up randomized controlled trial. Int J Clin Pediatr Dent. 2022;15:S3. https:\/\/doi.org\/10.5005\/jp-journals-10005-2120.","journal-title":"Int J Clin Pediatr Dent"},{"key":"1091_CR35","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1007\/s00784-020-03724-4","volume":"25","author":"N Sahin","year":"2021","unstructured":"Sahin N, Saygili S, Akcay M. Clinical, radiographic, and histological evaluation of three different pulp-capping materials in indirect pulp treatment of primary teeth: a randomized clinical trial. Clin Oral Investig. 2021;25:3945\u201355.","journal-title":"Clin Oral Investig"},{"key":"1091_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.5005\/jp-journals-10005-2657","volume":"16","author":"RM Sharaf","year":"2023","unstructured":"Sharaf RM, Kabil NS, Youssef FS, Awad BG. Clinical and radiographic evaluation of Nigella sativa and Aloe vera as pulpotomy medicaments in primary teeth: a randomized controlled trial. Int J Clin Pediatr Dent. 2023;16:195. https:\/\/doi.org\/10.5005\/jp-journals-10005-2657.","journal-title":"Int J Clin Pediatr Dent"},{"key":"1091_CR37","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2341\/05-65","volume":"31","author":"GaB Silva","year":"2006","unstructured":"Silva GaB, Lanza LD, Lopes-J\u00fanior N, Moreira A, Alves JB. Direct pulp capping with a dentin bonding system in human teeth: a clinical and histological evaluation. Oper Dent. 2006;31:297\u2013307. https:\/\/doi.org\/10.2341\/05-65.","journal-title":"Oper Dent"},{"key":"1091_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/fqsafe\/fyx031","volume":"2","author":"K Srinivasan","year":"2018","unstructured":"Srinivasan K. Cumin (Cuminum cyminum) and black cumin (Nigella sativa) seeds: traditional uses, chemical constituents, and nutraceutical effects. Food Qual Saf. 2018;2:1\u201316. https:\/\/doi.org\/10.1093\/fqsafe\/fyx031.","journal-title":"Food Qual Saf"},{"key":"1091_CR39","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s00784-019-02999-6","volume":"24","author":"CRG Torres","year":"2020","unstructured":"Torres CRG, Mailart MC, Crastechini \u00c9, Feitosa FA, Esteves SRM, Di Nicol\u00f3 R, Borges AB. A randomized clinical trial of class II composite restorations using direct and semidirect techniques. Clin Oral Investig. 2020;24:1053\u201363. https:\/\/doi.org\/10.1007\/s00784-019-02999-6.","journal-title":"Clin Oral Investig"},{"key":"1091_CR40","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1186\/s12903-024-04820-7","volume":"24","author":"FA Yalin","year":"2024","unstructured":"Yalin FA, Tabibi M, Majidi A, Kabiri F, Rasouli A, Aghaali M. Evaluation and comparison of four types of bio-ceramic materials AGM MTA, Ortho MTA, pro root MTA and Cem cement in oral and dental health. BMC Oral Health. 2024;24:1052.","journal-title":"BMC Oral Health"}],"container-title":["European Archives of Paediatric Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-025-01091-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40368-025-01091-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40368-025-01091-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:51:11Z","timestamp":1763715071000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40368-025-01091-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1091"],"URL":"https:\/\/doi.org\/10.1007\/s40368-025-01091-w","relation":{},"ISSN":["1818-6300","1996-9805"],"issn-type":[{"value":"1818-6300","type":"print"},{"value":"1996-9805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,13]]},"assertion":[{"value":"15 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors of the study declare that they do not have any conflict of interest, competing nor funding interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}