{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:54:20Z","timestamp":1792288460754,"version":"4.4.0"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Epidemiol Rep"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s40471-020-00231-8","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T17:02:37Z","timestamp":1587834157000},"page":"68-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Trends in the public health significance, definitions of disease, and implications for prevention of Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"7","author":[{"given":"Carol A.","family":"Derby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,25]]},"reference":[{"key":"231_CR1","unstructured":"United Nations Department of Economic and Social Affairs, Population Division. World Population Prospects 2019: Highlights. ST\/ESA\/SER.A\/423. 2019."},{"key":"231_CR2","unstructured":"World Health Organization. Global action plan on the public health response to dementia 2017\u20132025. 2017."},{"key":"231_CR3","doi-asserted-by":"publisher","first-page":"44-019-1161-2","DOI":"10.1007\/s11892-019-1161-2","volume":"19","author":"R Jagannathan","year":"2019","unstructured":"Jagannathan R, Patel SA, Ali MK, Narayan KMV. Global updates on cardiovascular disease mortality trends and attribution of traditional risk factors. Curr Diab Rep. 2019;19:44-019-1161-2.","journal-title":"Curr Diab Rep"},{"key":"231_CR4","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/S0140-6736(16)00618-8","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","unstructured":"NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387:1513\u201330.","journal-title":"Lancet"},{"key":"231_CR5","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/gerona\/glv133","volume":"70","author":"K Bandeen-Roche","year":"2015","unstructured":"Bandeen-Roche K, Seplaki CL, Huang J, Buta B, Kalyani RR, Varadhan R, et al. Frailty in older adults: a nationally representative profile in the United States. J Gerontol A Biol Sci Med Sci. 2015;70:1427\u201334.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"231_CR6","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/00002093-200210000-00001","volume":"16","author":"WW Barker","year":"2002","unstructured":"Barker WW, Luis CA, Kashuba A, Luis M, Harwood DG, Loewenstein D, et al. Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Dis Assoc Disord. 2002;16:203\u201312.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"231_CR7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jalz.2019.01.010","volume":"3","author":"Alzheimer\u2019s Association","year":"2019","unstructured":"Alzheimer\u2019s Association. Alzheimer\u2019s Association Report. 2019 Alzheimer\u2019s disease facts and figures. Alzheimers Dement (New York, N.Y.). 2019;3:321.","journal-title":"Alzheimers Dement"},{"key":"231_CR8","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1212\/WNL.51.3.728","volume":"51","author":"AF Jorm","year":"1998","unstructured":"Jorm AF, Jolley D. The incidence of dementia: a meta-analysis. Neurology. 1998;51:728\u201333.","journal-title":"Neurology"},{"key":"231_CR9","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","volume":"80","author":"LE Hebert","year":"2013","unstructured":"Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology. 2013;80:1778\u201383.","journal-title":"Neurology"},{"key":"231_CR10","unstructured":"ALzheimer\u2019s Disease International. World Alzheimer\u2019s Report 2015: The global impact of dementia an analysis of prevalence, incidence and trends. 2015."},{"key":"231_CR11","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","volume":"3","author":"R Brookmeyer","year":"2007","unstructured":"Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer\u2019s disease. Alzheimers Dement. 2007;3:186\u201391.","journal-title":"Alzheimers Dement"},{"key":"231_CR12","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1001\/jamaneurol.2017.1964","volume":"74","author":"CA Derby","year":"2017","unstructured":"Derby CA, Katz MJ, Lipton RB, Hall CB. Trends in dementia incidence in a birth cohort analysis of the Einstein Aging Study. JAMA Neurol. 2017;74:1345\u201351.","journal-title":"JAMA Neurol"},{"key":"231_CR13","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1212\/WNL.0b013e3182553be6","volume":"78","author":"EM Schrijvers","year":"2012","unstructured":"Schrijvers EM, Verhaaren BF, Koudstaal PJ, Hofman A, Ikram MA, Breteler MM. Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study. Neurology. 2012;78:1456\u201363.","journal-title":"Neurology"},{"key":"231_CR14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1056\/NEJMoa1504327","volume":"374","author":"CL Satizabal","year":"2016","unstructured":"Satizabal CL, Beiser AS, Chouraki V, Chene G, Dufouil C, Seshadri S. Incidence of dementia over three decades in the Framingham Heart Study. N Engl J Med. 2016;374:523\u201332.","journal-title":"N Engl J Med"},{"key":"231_CR15","doi-asserted-by":"publisher","first-page":"11398","DOI":"10.1038\/ncomms11398","volume":"7","author":"FE Matthews","year":"2016","unstructured":"Matthews FE, Stephan BC, Robinson L, Jagger C, Barnes LE, Arthur A, et al. A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II. Nat Commun. 2016;7:11398.","journal-title":"Nat Commun"},{"key":"231_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1212\/WNL.0000000000000069","volume":"82","author":"E Kovari","year":"2014","unstructured":"Kovari E, Herrmann FR, Bouras C, Gold G. Amyloid deposition is decreasing in aging brains: an autopsy study of 1,599 older people. Neurology. 2014;82:326\u201331.","journal-title":"Neurology"},{"key":"231_CR17","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1016\/j.jalz.2017.02.010","volume":"13","author":"JO Cerasuolo","year":"2017","unstructured":"Cerasuolo JO, Cipriano LE, Sposato LA, Kapral MK, Fang J, Gill SS, et al. Population-based stroke and dementia incidence trends: age and sex variations. Alzheimers Dement. 2017;13:1081\u20138.","journal-title":"Alzheimers Dement"},{"key":"231_CR18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jalz.2017.10.009","volume":"14","author":"R Brookmeyer","year":"2018","unstructured":"\u2022 Brookmeyer R, Abdalla N, Kawas CH, Corrada MM. Forecasting the prevalence of preclinical and clinical Alzheimer\u2019s disease in the United States. Alzheimers Dement. 2018;14:121\u20139 This is a key article regarding the current and projected burden of AD, including a discussion of methodological issues.","journal-title":"Alzheimers Dement"},{"key":"231_CR19","doi-asserted-by":"publisher","first-page":"j2856","DOI":"10.1136\/bmj.j2856","volume":"358","author":"S Ahmadi-Abhari","year":"2017","unstructured":"Ahmadi-Abhari S, Guzman-Castillo M, Bandosz P, Shipley MJ, Muniz-Terrera G, Singh-Manoux A, et al. Temporal trend in dementia incidence since 2002 and projections for prevalence in England and Wales to 2040: modelling study. BMJ. 2017;358:j2856.","journal-title":"BMJ"},{"key":"231_CR20","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1111\/j.1600-0447.2006.00859.x","volume":"115","author":"S Li","year":"2007","unstructured":"Li S, Yan F, Li G, Chen C, Zhang W, Liu J, et al. Is the dementia rate increasing in Beijing? Prevalence and incidence of dementia 10 years later in an urban elderly population. Acta Psychiatr Scand. 2007;115:73\u20139.","journal-title":"Acta Psychiatr Scand"},{"key":"231_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/j.1600-0447.2010.01587.x","volume":"122","author":"A Sekita","year":"2010","unstructured":"Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, et al. Trends in prevalence of Alzheimer\u2019s disease and vascular dementia in a Japanese community: the Hisayama Study. Acta Psychiatr Scand. 2010;122:319\u201325.","journal-title":"Acta Psychiatr Scand"},{"key":"231_CR22","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1212\/WNL.0000000000003932","volume":"88","author":"T Ohara","year":"2017","unstructured":"Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, et al. Trends in dementia prevalence, incidence, and survival rate in a Japanese community. Neurology. 2017;88:1925\u201332.","journal-title":"Neurology"},{"key":"231_CR23","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.jalz.2015.06.1894","volume":"12","author":"S Gao","year":"2016","unstructured":"Gao S, Ogunniyi A, Hall KS, Baiyewu O, Unverzagt FW, Lane KA, et al. Dementia incidence declined in African-Americans but not in Yoruba. Alzheimers Dement. 2016;12:244\u201351.","journal-title":"Alzheimers Dement"},{"key":"231_CR24","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/B978-0-12-804766-8.00009-1","volume":"167","author":"OL Lopez","year":"2019","unstructured":"Lopez OL, Kuller LH. Epidemiology of aging and associated cognitive disorders: prevalence and incidence of Alzheimer\u2019s disease and other dementias. Handb Clin Neurol. 2019;167:139\u201348.","journal-title":"Handb Clin Neurol"},{"key":"231_CR25","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","volume":"18","author":"GBD 2016 Dementia Collaborators","year":"2019","unstructured":"GBD 2016 Dementia Collaborators. Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18:88\u2013106.","journal-title":"Lancet Neurol"},{"key":"231_CR26","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1212\/WNL.0000000000000240","volume":"82","author":"BD James","year":"2014","unstructured":"James BD, Leurgans SE, Hebert LE, Scherr PA, Yaffe K, Bennett DA. Contribution of Alzheimer disease to mortality in the United States. Neurology. 2014;82:1045\u201350.","journal-title":"Neurology"},{"key":"231_CR27","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1111\/j.1532-5415.2012.04077.x","volume":"60","author":"ME Tinetti","year":"2012","unstructured":"Tinetti ME, McAvay GJ, Murphy TE, Gross CP, Lin H, Allore HG. Contribution of individual diseases to death in older adults with multiple diseases. J Am Geriatr Soc. 2012;60:1448\u201356.","journal-title":"J Am Geriatr Soc"},{"key":"231_CR28","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1001\/jama.2018.0158","volume":"319","author":"AH Mokdad","year":"2018","unstructured":"US Burden of Disease Collaborators, Mokdad AH, Ballestros K, Echko M, Glenn S, Olsen HE, et al. The state of US health, 1990-2016: burden of diseases, injuries, and risk factors among US states. JAMA. 2018;319:1444\u201372.","journal-title":"JAMA"},{"key":"231_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0197-4580(98)00052-9","volume":"19","author":"NC Berchtold","year":"1998","unstructured":"Berchtold NC, Cotman CW. Evolution in the conceptualization of dementia and Alzheimer\u2019s disease: Greco-Roman period to the 1960s. Neurobiol Aging. 1998;19:173\u201389.","journal-title":"Neurobiol Aging"},{"key":"231_CR30","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1002\/ca.980080612","volume":"8","author":"A Alzheimer","year":"1995","unstructured":"Alzheimer A, Stelzmann RA, Schnitzlein HN, Murtagh FR. An English translation of Alzheimer\u2019s 1907 paper, \u201cUber eine eigenartige Erkankung der Hirnrinde\u201d. Clin Anat. 1995;8:429\u201331.","journal-title":"Clin Anat"},{"key":"231_CR31","doi-asserted-by":"crossref","unstructured":"Budelier MM, Bateman RJ. Biomarkers of Alzheimer disease. J Appl Lab Med; 2019.","DOI":"10.1373\/jalm.2019.030080"},{"key":"231_CR32","doi-asserted-by":"publisher","first-page":"32-019-0333-5","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW. The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener. 2019;14:32-019-0333-5.","journal-title":"Mol Neurodegener"},{"key":"231_CR33","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:263\u20139.","journal-title":"Alzheimers Dement"},{"key":"231_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, et al. National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach. Acta Neuropathol. 2012;123:1\u201311.","journal-title":"Acta Neuropathol"},{"key":"231_CR35","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3389\/fnins.2014.00327","volume":"8","author":"PA Adlard","year":"2014","unstructured":"Adlard PA, Tran BA, Finkelstein DI, Desmond PM, Johnston LA, Bush AI, et al. A review of beta-amyloid neuroimaging in Alzheimer\u2019s disease. Front Neurosci. 2014;8:327.","journal-title":"Front Neurosci"},{"key":"231_CR36","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1093\/oxfordjournals.aje.a112315","volume":"104","author":"LH Kuller","year":"1976","unstructured":"Kuller LH. Epidemiology of cardiovascular diseases: current perspectives. Am J Epidemiol. 1976;104:425\u201396.","journal-title":"Am J Epidemiol"},{"key":"231_CR37","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology. 1984;34:939\u201344.","journal-title":"Neurology"},{"issue":"114","key":"231_CR38","doi-asserted-by":"publisher","first-page":"114ps48","DOI":"10.1126\/scitranslmed.3003529","volume":"3","author":"D. M. Holtzman","year":"2011","unstructured":"Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer\u2019s disease. Sci Transl Med. 2011;3 114ps48.","journal-title":"Science Translational Medicine"},{"key":"231_CR39","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1017\/S135561771700100X","volume":"23","author":"MW Bondi","year":"2017","unstructured":"Bondi MW, Edmonds EC, Salmon DP. Alzheimer\u2019s disease: past, present, and future. J Int Neuropsychol Soc. 2017;23:818\u201331.","journal-title":"J Int Neuropsychol Soc"},{"key":"231_CR40","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.jalz.2011.03.004","volume":"7","author":"CR Jack Jr","year":"2011","unstructured":"Jack CR Jr, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:257\u201362.","journal-title":"Alzheimers Dement"},{"key":"231_CR41","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1212\/WNL.53.6.1292","volume":"53","author":"OL Lopez","year":"1999","unstructured":"Lopez OL, Litvan I, Catt KE, Stowe R, Klunk W, Kaufer DI, et al. Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias. Neurology. 1999;53:1292\u20139.","journal-title":"Neurology"},{"key":"231_CR42","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/00002093-200310000-00010","volume":"17","author":"JC Morris","year":"2003","unstructured":"Morris JC. Dementia update 2003. Alzheimer Dis Assoc Disord. 2003;17:245\u201358.","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"231_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1177\/1533317508328602","volume":"24","author":"L Minati","year":"2009","unstructured":"Minati L, Edginton T, Bruzzone MG, Giaccone G. Current concepts in Alzheimer\u2019s disease: a multidisciplinary review. Am J Alzheimers Dis Other Dement. 2009;24:95\u2013121.","journal-title":"Am J Alzheimers Dis Other Dement"},{"key":"231_CR44","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1146\/annurev-publhealth-040218-043758","volume":"40","author":"BD James","year":"2019","unstructured":"\u2022 James BD, Bennett DA. Causes and patterns of dementia: an update in the era of redefining Alzheimer\u2019s disease. Annu Rev Public Health. 2019;40:65\u201384 An in-depth summary of how changing definitions of AD impacts the approach to targeting risk factors with preventive interventions.","journal-title":"Annu Rev Public Health"},{"key":"231_CR45","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","volume":"7","author":"RA Sperling","year":"2011","unstructured":"Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, et al. Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:280\u201392.","journal-title":"Alzheimers Dement"},{"key":"231_CR46","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","volume":"84","author":"R Sperling","year":"2014","unstructured":"Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer\u2019s disease: implications for prevention trials. Neuron. 2014;84:608\u201322.","journal-title":"Neuron"},{"key":"231_CR47","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jalz.2018.08.005","volume":"15","author":"DP Veitch","year":"2019","unstructured":"Veitch DP, Weiner MW, Aisen PS, Beckett LA, Cairns NJ, Green RC, et al. Understanding disease progression and improving Alzheimer\u2019s disease clinical trials: recent highlights from the Alzheimer\u2019s Disease Neuroimaging Initiative. Alzheimers Dement. 2019;15:106\u201352.","journal-title":"Alzheimers Dement"},{"key":"231_CR48","doi-asserted-by":"publisher","first-page":"21-019-0325-5","DOI":"10.1186\/s13024-019-0325-5","volume":"14","author":"F Marquez","year":"2019","unstructured":"Marquez F, Yassa MA. Neuroimaging biomarkers for Alzheimer\u2019s disease. Mol Neurodegener. 2019;14:21-019-0325-5.","journal-title":"Mol Neurodegener"},{"key":"231_CR49","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1001\/archneur.56.3.303","volume":"56","author":"RC Petersen","year":"1999","unstructured":"Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56:303\u20138.","journal-title":"Arch Neurol"},{"key":"231_CR50","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1001\/archneurol.2009.266","volume":"66","author":"RC Petersen","year":"2009","unstructured":"Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66:1447\u201355.","journal-title":"Arch Neurol"},{"key":"231_CR51","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/ana.410230206","volume":"23","author":"R Katzman","year":"1988","unstructured":"Katzman R, Terry R, DeTeresa R, Brown T, Davies P, Fuld P, et al. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol. 1988;23:138\u201344.","journal-title":"Ann Neurol"},{"key":"231_CR52","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3233\/JAD-2009-1227","volume":"18","author":"JA Schneider","year":"2009","unstructured":"Schneider JA, Aggarwal NT, Barnes L, Boyle P, Bennett DA. The neuropathology of older persons with and without dementia from community versus clinic cohorts. J Alzheimers Dis. 2009;18:691\u2013701.","journal-title":"J Alzheimers Dis"},{"key":"231_CR53","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1212\/WNL.38.11.1682","volume":"38","author":"H Crystal","year":"1988","unstructured":"Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, et al. Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer\u2019s disease. Neurology. 1988;38:1682\u20137.","journal-title":"Neurology"},{"key":"231_CR54","doi-asserted-by":"publisher","first-page":"101002","DOI":"10.1016\/j.arr.2019.101002","volume":"58","author":"MR Azarpazhooh","year":"2020","unstructured":"\u2022 Azarpazhooh MR, Avan A, Cipriano LE, Munoz DG, Erfanian M, Amiri A, et al. A third of community-dwelling elderly with intermediate and high level of Alzheimer\u2019s neuropathologic changes are not demented: a meta-analysis. Ageing Res Rev. 2020;58:101002 A recent meta-analysis describing the prevalence of AD pathology in persons who remain cognitively normal, and the implications.","journal-title":"Ageing Res Rev"},{"key":"231_CR55","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1093\/brain\/awm213","volume":"130","author":"S Alladi","year":"2007","unstructured":"Alladi S, Xuereb J, Bak T, Nestor P, Knibb J, Patterson K, et al. Focal cortical presentations of Alzheimer\u2019s disease. Brain. 2007;130:2636\u201345.","journal-title":"Brain"},{"key":"231_CR56","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1002\/ana.21451","volume":"64","author":"GD Rabinovici","year":"2008","unstructured":"Rabinovici GD, Jagust WJ, Furst AJ, Ogar JM, Racine CA, Mormino EC, et al. Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Ann Neurol. 2008;64:388\u2013401.","journal-title":"Ann Neurol"},{"key":"231_CR57","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","volume":"69","author":"JA Schneider","year":"2007","unstructured":"Schneider JA, Arvanitakis Z, Bang W, Bennett DA. Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology. 2007;69:2197\u2013204.","journal-title":"Neurology"},{"key":"231_CR58","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1212\/WNL.0000000000001831","volume":"85","author":"CH Kawas","year":"2015","unstructured":"Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM. Multiple pathologies are common and related to dementia in the oldest-old: the 90+ Study. Neurology. 2015;85:535\u201342.","journal-title":"Neurology"},{"key":"231_CR59","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1212\/WNL.0000000000002480","volume":"86","author":"LR White","year":"2016","unstructured":"White LR, Edland SD, Hemmy LS, Montine KS, Zarow C, Sonnen JA, et al. Neuropathologic comorbidity and cognitive impairment in the Nun and Honolulu-Asia Aging Studies. Neurology. 2016;86:1000\u20138.","journal-title":"Neurology"},{"key":"231_CR60","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-017-1717-7","volume":"134","author":"A Kapasi","year":"2017","unstructured":"Kapasi A, DeCarli C, Schneider JA. Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol. 2017;134:171\u201386.","journal-title":"Acta Neuropathol"},{"key":"231_CR61","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.neurobiolaging.2008.09.011","volume":"31","author":"D Strozyk","year":"2010","unstructured":"Strozyk D, Dickson DW, Lipton RB, Katz M, Derby CA, Lee S, et al. Contribution of vascular pathology to the clinical expression of dementia. Neurobiol Aging. 2010;31:1710\u201320.","journal-title":"Neurobiol Aging"},{"key":"231_CR62","doi-asserted-by":"publisher","first-page":"206-014-0206-2","DOI":"10.1186\/s12916-014-0206-2","volume":"12","author":"J Attems","year":"2014","unstructured":"Attems J, Jellinger KA. The overlap between vascular disease and Alzheimer\u2019s disease--lessons from pathology. BMC Med. 2014;12:206-014-0206-2.","journal-title":"BMC Med"},{"key":"231_CR63","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/ana.21706","volume":"66","author":"JA Schneider","year":"2009","unstructured":"Schneider JA, Arvanitakis Z, Leurgans SE, Bennett DA. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol. 2009;66:200\u20138.","journal-title":"Ann Neurol"},{"key":"231_CR64","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00702-014-1288-x","volume":"122","author":"KA Jellinger","year":"2015","unstructured":"Jellinger KA, Attems J. Challenges of multimorbidity of the aging brain: a critical update. J Neural Transm (Vienna). 2015;122:505\u201321.","journal-title":"J Neural Transm (Vienna)"},{"key":"231_CR65","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","volume":"62","author":"DS Knopman","year":"2003","unstructured":"Knopman DS, Parisi JE, Salviati A, Floriach-Robert M, Boeve BF, Ivnik RJ, et al. Neuropathology of cognitively normal elderly. J Neuropathol Exp Neurol. 2003;62:1087\u201395.","journal-title":"J Neuropathol Exp Neurol"},{"key":"231_CR66","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.2002.tb04794.x","volume":"977","author":"L White","year":"2002","unstructured":"White L, Petrovitch H, Hardman J, Nelson J, Davis DG, Ross GW, et al. Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci. 2002;977:9\u201323.","journal-title":"Ann N Y Acad Sci"},{"key":"231_CR67","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1001\/jama.1997.03540340047031","volume":"277","author":"DA Snowdon","year":"1997","unstructured":"Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA. 1997;277:813\u20137.","journal-title":"JAMA"},{"key":"231_CR68","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/ana.21009","volume":"60","author":"HC Chui","year":"2006","unstructured":"Chui HC, Zarow C, Mack WJ, Ellis WG, Zheng L, Jagust WJ, et al. Cognitive impact of subcortical vascular and Alzheimer\u2019s disease pathology. Ann Neurol. 2006;60:677\u201387.","journal-title":"Ann Neurol"},{"key":"231_CR69","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1111\/jgs.14903","volume":"65","author":"A Ezzati","year":"2017","unstructured":"Ezzati A, Wang C, Lipton RB, Altschul D, Katz MJ, Dickson DW, et al. Association between vascular pathology and rate of cognitive decline independent of Alzheimer\u2019s disease pathology. J Am Geriatr Soc. 2017;65:1836\u201341.","journal-title":"J Am Geriatr Soc"},{"key":"231_CR70","first-page":"735","volume":"140","author":"A Dong","year":"2017","unstructured":"Dong A, Toledo JB, Honnorat N, Doshi J, Varol E, Sotiras A, et al. Heterogeneity of neuroanatomical patterns in prodromal Alzheimer\u2019s disease: links to cognition, progression and biomarkers. Brain. 2017;140:735\u201347.","journal-title":"Brain"},{"key":"231_CR71","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/joim.12191","volume":"275","author":"LS Schneider","year":"2014","unstructured":"Schneider LS, Mangialasche F, Andreasen N, Feldman H, Giacobini E, Jones R, et al. Clinical trials and late-stage drug development for Alzheimer\u2019s disease: an appraisal from 1984 to 2014. J Intern Med. 2014;275:251\u201383.","journal-title":"J Intern Med"},{"key":"231_CR72","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.trci.2019.05.008","volume":"5","author":"J Cummings","year":"2019","unstructured":"\u2022 Cummings J, Lee G, Ritter A, Sabbagh M, Zhong K. Alzheimer\u2019s disease drug development pipeline: 2019. Alzheimers Dement (N Y). 2019;5:272\u201393 An up to date summary of the pipeline for development of AD drugs.","journal-title":"Alzheimers Dement (N Y)"},{"key":"231_CR73","doi-asserted-by":"publisher","first-page":"757","DOI":"10.2183\/pjab.93.048","volume":"93","author":"K Suzuki","year":"2017","unstructured":"Suzuki K, Iwata A, Iwatsubo T. The past, present, and future of disease-modifying therapies for Alzheimer\u2019s disease. Proc Jpn Acad Ser B Phys Biol Sci. 2017;93:757\u201371.","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"231_CR74","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack Jr","year":"2018","unstructured":"\u2022 Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement. 2018;14:535\u201362 This paper presents the most recent NIA-AA framework for defining Alzheimer\u2019s disease in research studies.","journal-title":"Alzheimers Dement"},{"key":"231_CR75","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1093\/brain\/awv050","volume":"138","author":"ME Murray","year":"2015","unstructured":"Murray ME, Lowe VJ, Graff-Radford NR, Liesinger AM, Cannon A, Przybelski SA, et al. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer\u2019s disease spectrum. Brain. 2015;138:1370\u201381.","journal-title":"Brain"},{"key":"231_CR76","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.jalz.2015.05.018","volume":"11","author":"DR Thal","year":"2015","unstructured":"Thal DR, Beach TG, Zanette M, Heurling K, Chakrabarty A, Ismail A, et al. [18F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer\u2019s disease: specific detection of advanced phases of amyloid-beta pathology. Alzheimers Dement. 2015;11:975\u201385.","journal-title":"Alzheimers Dement"},{"key":"231_CR77","doi-asserted-by":"crossref","unstructured":"Shaw LM, Korecka M, Figurski M, Toledo J, Irwin D, Hee Kang J, Trojanowski JQ. Detection of Alzheimer disease pathology in patients using biochemical biomarkers: prospects and challenges for use in clinical practice. J Appl Lab Med; 2019.","DOI":"10.1373\/jalm.2019.029587"},{"key":"231_CR78","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1056\/NEJMoa1202753","volume":"367","author":"RJ Bateman","year":"2012","unstructured":"Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, et al. Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease. N Engl J Med. 2012;367:795\u2013804.","journal-title":"N Engl J Med"},{"key":"231_CR79","doi-asserted-by":"publisher","first-page":"e1295","DOI":"10.1212\/WNL.0000000000006277","volume":"91","author":"E McDade","year":"2018","unstructured":"McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. 2018;91:e1295\u2013306.","journal-title":"Neurology"},{"key":"231_CR80","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/NEN.0b013e318177eaf4","volume":"67","author":"RJ Castellani","year":"2008","unstructured":"Castellani RJ, Lee HG, Zhu X, Perry G, Smith MA. Alzheimer disease pathology as a host response. J Neuropathol Exp Neurol. 2008;67:523\u201331.","journal-title":"J Neuropathol Exp Neurol"},{"key":"231_CR81","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s10654-018-0418-4","volume":"33","author":"MM Glymour","year":"2018","unstructured":"\u2022 Glymour MM, Brickman AM, Kivimaki M, Mayeda ER, Chene G, Dufouil C, et al. Will biomarker-based diagnosis of Alzheimer\u2019s disease maximize scientific progress? Evaluating proposed diagnostic criteria. Eur J Epidemiol. 2018;33:607\u201312 A key article outlining concerns and potential limitations of the NIA-AA 2018 framework for defining AD.","journal-title":"Eur J Epidemiol"},{"key":"231_CR82","doi-asserted-by":"publisher","first-page":"e1002256","DOI":"10.1371\/journal.pmed.1002256","volume":"14","author":"DA Bennett","year":"2017","unstructured":"Bennett DA. Mixed pathologies and neural reserve: implications of complexity for Alzheimer disease drug discovery. PLoS Med. 2017;14:e1002256.","journal-title":"PLoS Med"},{"key":"231_CR83","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1111\/j.1532-5415.2009.02521.x","volume":"57","author":"JA Schneider","year":"2009","unstructured":"Schneider JA. High blood pressure and microinfarcts: a link between vascular risk factors, dementia, and clinical Alzheimer\u2019s disease. J Am Geriatr Soc. 2009;57:2146\u20137.","journal-title":"J Am Geriatr Soc"},{"key":"231_CR84","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1016\/j.neuron.2013.12.003","volume":"80","author":"CR Jack Jr","year":"2013","unstructured":"Jack CR Jr, Holtzman DM. Biomarker modeling of Alzheimer\u2019s disease. Neuron. 2013;80:1347\u201358.","journal-title":"Neuron"},{"issue":"4","key":"231_CR85","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/biomedicines7040097","volume":"7","author":"Konstantina G. Yiannopoulou","year":"2019","unstructured":"Yiannopoulou KG, Anastasiou AI, Zachariou V, Pelidou SH. Reasons for failed trials of disease-modifying treatments for Alzheimer disease and their contribution in recent research. Biomedicines. 2019:7. https:\/\/doi.org\/10.3390\/biomedicines7040097.","journal-title":"Biomedicines"},{"key":"231_CR86","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/ana.23964","volume":"74","author":"PA Boyle","year":"2013","unstructured":"Boyle PA, Wilson RS, Yu L, Barr AM, Honer WG, Schneider JA, et al. Much of late life cognitive decline is not due to common neurodegenerative pathologies. Ann Neurol. 2013;74:478\u201389.","journal-title":"Ann Neurol"},{"key":"231_CR87","doi-asserted-by":"publisher","first-page":"e1000180","DOI":"10.1371\/journal.pmed.1000180","volume":"6","author":"FE Matthews","year":"2009","unstructured":"Matthews FE, Brayne C, Lowe J, McKeith I, Wharton SB, Ince P. Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study. PLoS Med. 2009;6:e1000180.","journal-title":"PLoS Med"},{"key":"231_CR88","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.jalz.2018.03.005","volume":"14","author":"R Brookmeyer","year":"2018","unstructured":"Brookmeyer R, Abdalla N. Estimation of lifetime risks of Alzheimer\u2019s disease dementia using biomarkers for preclinical disease. Alzheimers Dement. 2018;14:981\u20138.","journal-title":"Alzheimers Dement"},{"key":"231_CR89","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.jalz.2013.11.009","volume":"10","author":"JJ Gomar","year":"2014","unstructured":"\u2022 Gomar JJ, Conejero-Goldberg C, Davies P, Goldberg TE, Alzheimer\u2019s Disease Neuroimaging Initiative. Extension and refinement of the predictive value of different classes of markers in ADNI: four-year follow-up data. Alzheimers Dement. 2014;10:704\u201312 The Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) is a seminal study investigating the natural history of AD pathology defined via imaging and its relation to progression of cognitive changes in the preclinical course of AD.","journal-title":"Alzheimers Dement"},{"key":"231_CR90","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3233\/JAD-170786","volume":"63","author":"JH Wang","year":"2018","unstructured":"Wang JH, Wu YJ, Tee BL, Lo RY. Medical comorbidity in Alzheimer\u2019s disease: a nested case-control study. J Alzheimers Dis. 2018;63:773\u201381.","journal-title":"J Alzheimers Dis"},{"key":"231_CR91","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0140-6736(12)60240-2","volume":"380","author":"K Barnett","year":"2012","unstructured":"Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37\u201343.","journal-title":"Lancet"},{"key":"231_CR92","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1111\/jgs.13612","volume":"63","author":"M Vassilaki","year":"2015","unstructured":"Vassilaki M, Aakre JA, Cha RH, Kremers WK, St Sauver JL, Mielke MM, et al. Multimorbidity and risk of mild cognitive impairment. J Am Geriatr Soc. 2015;63:1783\u201390.","journal-title":"J Am Geriatr Soc"},{"key":"231_CR93","doi-asserted-by":"publisher","first-page":"e0177044","DOI":"10.1371\/journal.pone.0177044","volume":"12","author":"ML Haaksma","year":"2017","unstructured":"Haaksma ML, Vilela LR, Marengoni A, Calderon-Larranaga A, Leoutsakos JS, Olde Rikkert MGM, et al. Comorbidity and progression of late onset Alzheimer\u2019s disease: a systematic review. PLoS One. 2017;12:e0177044.","journal-title":"PLoS One"},{"key":"231_CR94","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1017\/S104161021200049X","volume":"24","author":"JM Leoutsakos","year":"2012","unstructured":"Leoutsakos JM, Han D, Mielke MM, Forrester SN, Tschanz JT, Corcoran CD, et al. Effects of general medical health on Alzheimer\u2019s progression: the Cache County Dementia Progression Study. Int Psychogeriatr. 2012;24:1561\u201370.","journal-title":"Int Psychogeriatr"},{"key":"231_CR95","doi-asserted-by":"publisher","first-page":"e84014","DOI":"10.1371\/journal.pone.0084014","volume":"8","author":"RJ Melis","year":"2013","unstructured":"Melis RJ, Marengoni A, Rizzuto D, Teerenstra S, Kivipelto M, Angleman SB, et al. The influence of multimorbidity on clinical progression of dementia in a population-based cohort. PLoS One. 2013;8:e84014.","journal-title":"PLoS One"},{"key":"231_CR96","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1212\/WNL.0000000000002624","volume":"86","author":"M Vassilaki","year":"2016","unstructured":"Vassilaki M, Aakre JA, Mielke MM, Geda YE, Kremers WK, Alhurani RE, et al. Multimorbidity and neuroimaging biomarkers among cognitively normal persons. Neurology. 2016;86:2077\u201384.","journal-title":"Neurology"},{"key":"231_CR97","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1093\/gerona\/gly149","volume":"74","author":"M Vassilaki","year":"2019","unstructured":"Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Alhurani RE, et al. The association of multimorbidity with preclinical AD stages and SNAP in cognitively unimpaired persons. J Gerontol A Biol Sci Med Sci. 2019;74:877\u201383.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"231_CR98","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1001\/jamaneurol.2017.0244","volume":"74","author":"P Vemuri","year":"2017","unstructured":"Vemuri P, Knopman DS, Lesnick TG, Przybelski SA, Mielke MM, Graff-Radford J, et al. Evaluation of amyloid protective factors and Alzheimer disease neurodegeneration protective factors in elderly individuals. JAMA Neurol. 2017;74:718\u201326.","journal-title":"JAMA Neurol"},{"key":"231_CR99","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.arr.2017.05.003","volume":"37","author":"X Xu","year":"2017","unstructured":"Xu X, Mishra GD, Jones M. Evidence on multimorbidity from definition to intervention: an overview of systematic reviews. Ageing Res Rev. 2017;37:53\u201368.","journal-title":"Ageing Res Rev"},{"key":"231_CR100","first-page":"33","volume":"46","author":"F Clague","year":"2017","unstructured":"Clague F, Mercer SW, McLean G, Reynish E, Guthrie B. Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data. Age Ageing. 2017;46:33\u20139.","journal-title":"Age Ageing"},{"key":"231_CR101","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1177\/0897190017710524","volume":"31","author":"N El-Saifi","year":"2018","unstructured":"El-Saifi N, Moyle W, Jones C, Tuffaha H. Medication adherence in older patients with dementia: a systematic literature review. J Pharm Pract. 2018;31:322\u201334.","journal-title":"J Pharm Pract"},{"key":"231_CR102","doi-asserted-by":"publisher","first-page":"120-020-4971-7","DOI":"10.1186\/s12913-020-4971-7","volume":"20","author":"HE Barry","year":"2020","unstructured":"Barry HE, Bedford LE, McGrattan M, Ryan C, Passmore AP, Robinson AL, et al. Improving medicines management for people with dementia in primary care: a qualitative study of healthcare professionals to develop a theory-informed intervention. BMC Health Serv Res. 2020;20:120-020-4971-7.","journal-title":"BMC Health Serv Res"},{"key":"231_CR103","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00125-019-04977-9","volume":"63","author":"GJ Biessels","year":"2020","unstructured":"Biessels GJ, Whitmer RA. Cognitive dysfunction in diabetes: how to implement emerging guidelines. Diabetologia. 2020;63:3\u20139.","journal-title":"Diabetologia"},{"key":"231_CR104","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2147\/CIA.S39434","volume":"8","author":"K Uemura","year":"2013","unstructured":"Uemura K, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, et al. Cognitive function affects trainability for physical performance in exercise intervention among older adults with mild cognitive impairment. Clin Interv Aging. 2013;8:97\u2013102.","journal-title":"Clin Interv Aging"},{"key":"231_CR105","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1016\/j.jacc.2019.03.009","volume":"74","author":"DK Arnett","year":"2019","unstructured":"Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC\/AHA guideline on the primary prevention of cardiovascular disease: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol. 2019;74:1376\u2013414.","journal-title":"J Am Coll Cardiol"},{"key":"231_CR106","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1146\/annurev-publhealth-031210-101211","volume":"32","author":"ES Ford","year":"2011","unstructured":"Ford ES, Capewell S. Proportion of the decline in cardiovascular mortality disease due to prevention versus treatment: public health versus clinical care. Annu Rev Public Health. 2011;32:5\u201322.","journal-title":"Annu Rev Public Health"},{"key":"231_CR107","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","volume":"14","author":"M Kivipelto","year":"2018","unstructured":"\u2022 Kivipelto M, Mangialasche F, Ngandu T. Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease. Nat Rev Neurol. 2018;14:653\u201366 This article provides an important review of the rationale for multi-domain behavioral interventions to slow or prevent cognitive decline.","journal-title":"Nat Rev Neurol"},{"key":"231_CR108","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/S1474-4422(14)70136-X","volume":"13","author":"S Norton","year":"2014","unstructured":"\u2022 Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer\u2019s disease: an analysis of population-based data. Lancet Neurol. 2014;13:788\u201394 This paper provides an in-depth analysis of the population attributable risk for AD that is associated with vascular and other risk factors.","journal-title":"Lancet Neurol"},{"key":"231_CR109","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.jalz.2013.05.1772","volume":"10","author":"LG Exalto","year":"2014","unstructured":"Exalto LG, Quesenberry CP, Barnes D, Kivipelto M, Biessels GJ, Whitmer RA. Midlife risk score for the prediction of dementia four decades later. Alzheimers Dement. 2014;10:562\u201370.","journal-title":"Alzheimers Dement"},{"key":"231_CR110","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1001\/archneur.62.10.1556","volume":"62","author":"M Kivipelto","year":"2005","unstructured":"Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kareholt I, Winblad B, et al. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol. 2005;62:1556\u201360.","journal-title":"Arch Neurol"},{"key":"231_CR111","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/S1474-4422(15)00153-2","volume":"14","author":"S Andrieu","year":"2015","unstructured":"Andrieu S, Coley N, Lovestone S, Aisen PS, Vellas B. Prevention of sporadic Alzheimer\u2019s disease: lessons learned from clinical trials and future directions. Lancet Neurol. 2015;14:926\u201344.","journal-title":"Lancet Neurol"},{"key":"231_CR112","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","volume":"385","author":"T Ngandu","year":"2015","unstructured":"Ngandu T, Lehtisalo J, Solomon A, Levalahti E, Ahtiluoto S, Antikainen R, et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet. 2015;385:2255\u201363.","journal-title":"Lancet"},{"key":"231_CR113","first-page":"29","volume":"7","author":"A Rosenberg","year":"2020","unstructured":"Rosenberg A, Mangialasche F, Ngandu T, Solomon A, Kivipelto M. Multidomain interventions to prevent cognitive impairment, Alzheimer\u2019s disease, and dementia: from FINGER to world-wide FINGERS. J Prev Alzheimers Dis. 2020;7:29\u201336.","journal-title":"J Prev Alzheimers Dis"}],"container-title":["Current Epidemiology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40471-020-00231-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40471-020-00231-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40471-020-00231-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T10:19:24Z","timestamp":1619345964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40471-020-00231-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,25]]},"references-count":113,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["231"],"URL":"https:\/\/doi.org\/10.1007\/s40471-020-00231-8","relation":{},"ISSN":["2196-2995"],"issn-type":[{"value":"2196-2995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,25]]},"assertion":[{"value":"25 April 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance With Ethical Standards"}},{"value":"All reported studies\/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional\/national research committee standards, and international\/national\/institutional guidelines).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}}]}}