{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:21:22Z","timestamp":1770420082993,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paragangliomas are a rare form of highly vascularized tumors that originate from paraganglia Baysal (J Med Genet 39: 617\u2013622, 2002). In the head and neck PGL arise primarily in four distinct areas: vagal, middle ear, and larynx and more frequently carotid bifurcation. Imaging evaluations include sonography, color Doppler, US-elastosonography and contrast-enhanced ultrasound (CEUS). Additionally, Computed Tomography, Magnetic Resonance Imaging (MRI) as well as digital subtraction angiography can be performed Stoeckli et al. (Laryngoscope 112: 143\u2013146, 2002). We present herein a case of a rare bilateral carotid body tumor assessed with multiparametric ultrasound evaluation, including CEUS and US-elastography.<\/jats:p>","DOI":"10.1007\/s40477-021-00581-z","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:02:53Z","timestamp":1628863373000},"page":"311-315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Multiparametric ultrasound evaluation of a case of bilateral carotid body tumor"],"prefix":"10.1007","volume":"24","author":[{"given":"Patrizia","family":"Pacini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Polti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antongiulio","family":"Faggiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Giannetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Tarsitano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-214X","authenticated-orcid":false,"given":"Vito","family":"Cantisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"issue":"9","key":"581_CR1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/jmg.39.9.617","volume":"39","author":"BE Baysal","year":"2002","unstructured":"Baysal BE (2002) Hereditary paraganglioma targets diverse paraganglia. J Med Genet 39(9):617\u2013622. https:\/\/doi.org\/10.1136\/jmg.39.9.617","journal-title":"J Med Genet"},{"issue":"1","key":"581_CR2","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00005537-200201000-00025","volume":"112","author":"SJ Stoeckli","year":"2002","unstructured":"Stoeckli SJ, Schuknecht B, Alkadhi H, Fisch U (2002) Evaluation of paragangliomas presenting as a cervical mass on color-coded Doppler sonography. Laryngoscope. 112(1):143\u2013146. https:\/\/doi.org\/10.1097\/00005537-200201000-00025","journal-title":"Laryngoscope."},{"issue":"4","key":"581_CR3","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1177\/0194599815627667","volume":"154","author":"MG Moore","year":"2016","unstructured":"Moore MG, Netterville JL, Mendenhall WM, Isaacson B, Nussenbaum B (2016) Head and neck paragangliomas: an update on evaluation and management. Otolaryngol Head Neck Surg 154(4):597\u2013605. https:\/\/doi.org\/10.1177\/0194599815627667","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"3","key":"581_CR4","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/cncr.10252","volume":"94","author":"JH Lee","year":"2002","unstructured":"Lee JH, Barich F, Karnell LH, Robinson RA, Zhen WK, Gantz BJ, Hoffman HT (2002) American College of Surgeons Commission on Cancer; AmericanCancer Society. National Cancer Data Base report on malignant paragangliomas of the head and neck. Cancer 94(3):730\u2013737. https:\/\/doi.org\/10.1002\/cncr.10252","journal-title":"Cancer"},{"issue":"6","key":"581_CR5","doi-asserted-by":"publisher","first-page":"6044","DOI":"10.1038\/ncomms7044.PMID:25625332;PMCID:PMC4354166","volume":"27","author":"LJ Castro-Vega","year":"2015","unstructured":"Castro-Vega LJ, Letouz\u00e9 E, Burnichon N, Buffet A, Disderot PH, Khalifa E, Loriot C, Elarouci N, Morin A, Menara M, Lepoutre-Lussey C, Badoual C, Sibony M, Dousset B, Lib\u00e9 R, Zinzindohoue F, Plouin PF, Bertherat J, Amar L, de Reyni\u00e8s A, Favier J, Gimenez-Roqueplo AP (2015) Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas. Nat Commun 27(6):6044. https:\/\/doi.org\/10.1038\/ncomms7044.PMID:25625332;PMCID:PMC4354166","journal-title":"Nat Commun"},{"issue":"2","key":"581_CR6","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrc3648","volume":"14","author":"PL Dahia","year":"2014","unstructured":"Dahia PL (2014) Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity. Nat Rev Cancer 14(2):108\u2013119. https:\/\/doi.org\/10.1038\/nrc3648 (PMID: 24442145)","journal-title":"Nat Rev Cancer"},{"key":"581_CR7","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1001\/jama.292.8.943","volume":"292","author":"HP Neumann","year":"2004","unstructured":"Neumann HP, Pawlu C, Peczkowska M, Bausch B, McWhinney SR, Muresan M, Buchta M, Franke G, Klisch J, Bley TA et al (2004) Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. JAMA 292:943\u2013951. https:\/\/doi.org\/10.1001\/jama.292.8.943","journal-title":"JAMA"},{"issue":"4","key":"581_CR8","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1055\/a-0838-9937","volume":"40","author":"A S\u0103ftoiu","year":"2019","unstructured":"S\u0103ftoiu A, Gilja OH, Sidhu PS, Dietrich CF, Cantisani V, Amy D, Bachmann-Nielsen M, Bob F, Bojunga J, Brock M, Calliada F, Clevert DA, Correas JM, D\u2019Onofrio M, Ewertsen C, Farrokh A, Fodor D, Fusaroli P, Havre RF, Hocke M, Ignee A, Jenssen C, Klauser AS, Kollmann C, Radzina M, Ramnarine KV, Sconfienza LM, Solomon C, Sporea I, \u0218tef\u0103nescu H, Tanter M, Vilmann P (2019) The EFSUMB guidelines and recommendations for the clinical practice of elastography in non-hepatic applications: update 2018. Ultraschall Med 40(4):425\u2013453. https:\/\/doi.org\/10.1055\/a-0838-9937","journal-title":"Ultraschall Med"},{"issue":"3","key":"581_CR9","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2214\/ajr.184.3.01840821","volume":"184","author":"P Ricci","year":"2005","unstructured":"Ricci P, Laghi A, Cantisani V, Paolantonio P, Pacella S, Pagliara E, Arduini F, Pasqualini V, Trippa F, Filpo M, Passariello R (2005) Contrast-enhanced sonography with SonoVue: enhancement patterns of benign focal liver lesions and correlation with dynamic gadobenate dimeglumine-enhanced MRI. AJR Am J Roentgenol 184(3):821\u2013827. https:\/\/doi.org\/10.2214\/ajr.184.3.01840821 (PMID: 15728603)","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"581_CR10","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1055\/s-0044-101254","volume":"39","author":"PS Sidhu","year":"2018","unstructured":"Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D\u2019Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, Wijkstra H (2018) The EFSUMB guidelines and recommendations for the clinical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (short version). Ultraschall Med 39(2):154\u2013180. https:\/\/doi.org\/10.1055\/s-0044-101254 (PMID: 29510440)","journal-title":"Ultraschall Med"},{"issue":"10","key":"581_CR11","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1016\/j.ultrasmedbio.2020.04.030","volume":"46","author":"CF Dietrich","year":"2020","unstructured":"Dietrich CF, Nols\u00f8e CP, Barr RG, Berzigotti A, Burns PN, Cantisani V, Chammas MC, Chaubal N, Choi BI, Clevert DA, Cui X, Dong Y, D\u2019Onofrio M, Fowlkes JB, Gilja OH, Huang P, Ignee A, Jenssen C, Kono Y, Kudo M, Lassau N, Lee WJ, Lee JY, Liang P, Lim A, Lyshchik A, Meloni MF, Correas JM, Minami Y, Moriyasu F, Nicolau C, Piscaglia F, Saftoiu A, Sidhu PS, Sporea I, Torzilli G, Xie X, Zheng R (2020) Guidelines and good clinical practice recommendations for contrast-enhanced ultrasound (CEUS) in the Liver-Update 2020 WFUMB in cooperation with EFSUMB, AFSUMB, AIUM, and FLAUS. Ultrasound Med Biol 46(10):2579\u20132604. https:\/\/doi.org\/10.1016\/j.ultrasmedbio.2020.04.030 (PMID: 32713788)","journal-title":"Ultrasound Med Biol"},{"issue":"6","key":"581_CR12","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1055\/s-0035-1552392","volume":"36","author":"J R\u00fcbenthaler","year":"2015","unstructured":"R\u00fcbenthaler J, Lutz J, Reiser M, Clevert DA (2015) Titelbildbeitrag - Paragangliome des Kopfes und des Halses: Follow-Up von Interventionen mittels kontrast-verst\u00e4rkter Sonographie (CEUS). Ultraschall Med 36(6):541\u2013543. https:\/\/doi.org\/10.1055\/s-0035-1552392 (PMID: 26841712)","journal-title":"Ultraschall Med"},{"issue":"2","key":"581_CR13","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3390\/jcm9020588","volume":"9","author":"G Puliani","year":"2020","unstructured":"Puliani G, Sesti F, Feola T, Di Leo N, Polti G, Verrico M, Modica R, Colao A, Lenzi A, Isidori AM, Cantisani V, Giannetta E, Faggiano A (2020) Natural history and management of familial paraganglioma syndrome type 1: long-term data from a large family. J Clin Med 9(2):588. https:\/\/doi.org\/10.3390\/jcm9020588 (PMID:32098148; PMCID:PMC7074269)","journal-title":"J Clin Med"}],"container-title":["Journal of Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-021-00581-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40477-021-00581-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-021-00581-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T14:32:48Z","timestamp":1628865168000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40477-021-00581-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["581"],"URL":"https:\/\/doi.org\/10.1007\/s40477-021-00581-z","relation":{},"ISSN":["1876-7931"],"issn-type":[{"value":"1876-7931","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]},"assertion":[{"value":"17 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statements"}},{"value":"Duly signed informed consent was taken from the patient in question to include personal case details and clinical images. Confidentiality was ensured at all stages.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Infomed consent"}}]}}