{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:56:33Z","timestamp":1780592193704,"version":"3.54.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012352","name":"Universit\u00e0 degli Studi di Milano","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Intestinal ultrasound (IUS) is widely used as the first exam in patients with suspected inflammatory bowel disease (IBD). This study investigated the accuracy of several IUS parameters, including increased bowel wall thickening (BWT), in detecting IBD in a paediatric population.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study included an unselected series of 113 patients aged 2\u201318\u00a0years (mean age 10.8\u00a0years, 65 male), referred for recurrent abdominal pain or altered bowel habits, without known organic diseases, to perform an IUS as first investigation of a diagnostic workup. Patients with full systematic IUS examination, clinical and biochemical exams, and ileocolonoscopy or an uneventful follow-up at least one year follow up were eligible.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>23 IBD patients (20.4%; 8 ulcerative colitis, 12 Crohn\u2019s disease and 3 indeterminate colitis) were diagnosed. We found that increased BWT\u2009&gt;\u20093\u00a0mm (OR 5.4), altered IUS bowel pattern (IUS-BP, OR 9.8) and mesenteric hypertrophy (MH, OR 5.2) accurately identified IBD at the multivariate analysis. IUS-BP, MH and BWT\u2009&gt;\u20093\u00a0mm had a sensitivity of 78.3%, 65.2% and 69.6% and a specificity of 93.3%, 92.2% and 96.7%, respectively. The combination of these three alterations increased the specificity up to 100%, whilst decreased sensitivity to 56.5%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Among several US parameters suggestive of IBD, the increased BWT, MH and altered echopattern are independent predictors of IBD. The ultrasonographic diagnosis of IBD could be more accurate if relied on combination of different sonographic parameters, than on the sole BWT evaluation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40477-023-00800-9","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T13:02:29Z","timestamp":1688994149000},"page":"815-822","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relevance of sonographic parameters for inflammatory bowel disease in children"],"prefix":"10.1007","volume":"26","author":[{"given":"Alessandra","family":"Dell\u2019Era","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Cannatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Manzotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Dilillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianvincenzo","family":"Zuccotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Meneghin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Ardizzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-4026","authenticated-orcid":false,"given":"Giovanni","family":"Maconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"800_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/829040","volume":"2013","author":"M Gasparetto","year":"2013","unstructured":"Gasparetto M, Guariso G (2013) Highlights in IBD epidemiology and its natural history in the paediatric age. 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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Milano Area 1 (ASST Fatebenefratelli Sacco).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This is an observational retrospective study. Informed consent by patients was not needed for the study.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"AD: made the statistical analysis, interpreted data, revised and approved the final version of the manuscript. RC: cared for the patients, helped in data collection, interpreted data, wrote the manuscript, revised and approved the final version of the manuscript. FF: cared for the patients, helped in data collection, interpreted data, wrote the manuscript, revised and approved the final version of the manuscript. CM: cared for the patients, revised and approved the final version of the manuscript. DD: cared for the patients, helped in data collection, revised and approved the final version of the manuscript. GZ: cared for the patients, revised and approved the final version of the manuscript. FM: cared for the patients, revised and approved the final version of the manuscript. SA: cared for the patients, revised and approved the final version of the manuscript. GM: designed the study, cared for the patients, performed ultrasound, helped in data collection, wrote the manuscript, interpreted data, revised and approved the final version of the manuscript.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}