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For each procedure, we collected procedure operative time, room utilization time, number of CT passes, complications, and O<jats:sub>2<\/jats:sub>\/O<jats:sub>3<\/jats:sub> intradiscal diffusion adequacy. Technical success was defined as the ability to complete the procedure as initially planned to reach the disc. Technical efficacy was based on O<jats:sub>2<\/jats:sub>\/O<jats:sub>3<\/jats:sub> intradiscal diffusion adequacy, as demonstrated by the last CT scan.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Six patients (4 males; mean age: 68\u2009\u00b1\u200915\u00a0years) were included in the Fusion group, six (4 males; mean age: 66\u2009\u00b1\u200912\u00a0years) in Control group. No complications were observed in both groups. In Fusion group we found significantly lower room utilization time (30\u2009\u00b1\u20096\u00a0min vs. 46\u2009\u00b1\u200910\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), procedure operative time (14\u2009\u00b1\u20093\u00a0min vs. 24\u2009\u00b1\u20096\u00a0min, <jats:italic>p<\/jats:italic>\u2009=\u20090.008), and number of CT passes (2 [2,2] vs. 3 [3,3], <jats:italic>p<\/jats:italic>\u2009=\u20090.006) than in Control Group, respectively. Technical success and efficacy were 100% in both Groups.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CT\/US fusion imaging seems to be a feasible and safe guidance for intradiscal O<jats:sub>2<\/jats:sub>\/O<jats:sub>3<\/jats:sub> injections, allowing decrease of procedure time and number of CT passes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40477-023-00835-y","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T19:02:22Z","timestamp":1702666942000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["US\/CT fusion imaging and virtual navigation to guide lumbar intradiscal oxygen-ozone therapy: a pilot study"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7989-9861","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Gitto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Maria","family":"Sconfienza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Bellelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"issue":"777\u2013789","key":"835_CR1","first-page":"xii","volume":"98","author":"N Patrick","year":"2014","unstructured":"Patrick N, Emanski E, Knaub MA (2014) Acute and chronic low back pain. 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