{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T01:02:30Z","timestamp":1767142950945,"version":"build-2238731810"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal transplant (RT) remains the optimal treatment for end-stage renal disease and early complications might be detected in the postoperative period to improve long-term outcomes. To this regard, contrast enhanced ultrasound (CEUS) could be utilized to evaluate RT functional recovery and potentially detect acute rejection (AR) and\/or renal ischemia signs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Observational study of 107 consecutive patients waitlisted for RT. Participants underwent conventional ultrasound (CUS) and color-doppler-ultrasound (CDUS) to evaluate resistive index of segmental and interlobar arteries and quantitative CEUS techniques recording the following perfusion parameters: peak intensity (PI-c), rising time (RT-c), area under (AUC-c) the time intensity curve (TIC), time to peak (TTP-c) and mean transit time (MTT-c).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CEUS parameters sensibility and specificity to predict AR in the early post-operative period resulted in: 90% and 69% for PI-c, 95% and 64% for RT-c, 85% and 65% for AUC-c. The overall diagnostic performance of these three CEUS parameters in comparison to the same in CUS and CDUS resulted in a sensitivity and specificity of 95% and 49%, versus 85% and 46%, respectively, therefore CEUS examination with the analysis of PI-c, RT-c and AUC-c values increases the diagnostic sensitivity in predicting AR by approximately 15\u201320% compared to CDUS and by 30\u201340% compared to CUS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CEUS could be routinely included in RT follow-up, as it shows to be a non-invasive helpful diagnostic tool for early detection of renal graft complications, selecting patients eventually in need of further confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40477-025-00989-x","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T08:48:04Z","timestamp":1743842884000},"page":"269-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiparametric ultrasound for non-invasive evaluation of kidney graft function"],"prefix":"10.1007","volume":"28","author":[{"given":"Maria Irene","family":"Bellini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8998-5376","authenticated-orcid":false,"given":"Sergio","family":"Angeletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Fresilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Di Segni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gian Marco Lo","family":"Conte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raponi","family":"Flavia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Pretagostini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"De Vito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pacini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"D\u2019Andrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Barbato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco M.","family":"Drudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Caratozzolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Cantisani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"issue":"7","key":"989_CR1","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.3390\/jcm9072118","volume":"9","author":"MI Bellini","year":"2020","unstructured":"Bellini MI, Courtney AE, McCaughan JA (2020) Living donor kidney transplantation improves graft and recipient survival in patients with multiple kidney transplants. 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