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A total of 94 FNH nodules were included in the final analysis. A significant change in size was defined as an increase or decrease of 0.5\u00a0cm or more, and nodules were classified as increased, decreased or stable. Additionally, we analyzed the association between clinical data and changes in nodule size.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The mean follow-up duration between the initial US examination at diagnosis and the last available examination was 58.3\u2009\u00b1\u200933.5\u00a0months (range: 24.2\u2013186.6). The majority of nodules remained stable (47.9%) or decreased in size (35.1%), while a small proportion of nodules disappeared (11.7%) and only 7.3% showed an increase in size. No significant association was found between size variation and factors such as oral contraceptive use, pregnancy, BMI or follow-up duration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Changes in the size of FNHs during follow-up are relatively common, with most lesions remaining stable or undergoing regression or disappearance over time. These size variations do not appear to be influenced by hormonal factors or other clinical characteristics.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s40477-025-01010-1","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T04:15:40Z","timestamp":1743135340000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evolution of focal nodular hyperplasia during long-term ultrasound follow-up: results from a single-center study"],"prefix":"10.1007","volume":"28","author":[{"given":"Mattia","family":"Paratore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5805-7953","authenticated-orcid":false,"given":"Matteo","family":"Garcovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Amodeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Santopaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Romana","family":"Ponziani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Assunta","family":"Zocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Riccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pompili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"1010_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00261-015-0605-7","volume":"41","author":"TEM Kaltenbach","year":"2016","unstructured":"Kaltenbach TEM, Engler P, Kratzer W et al (2016) Prevalence of benign focal liver lesions: ultrasound investigation of 45,319 hospital patients. 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They have no financial or non-financial interests that could have influenced the research, analysis, or conclusions presented in the manuscript titled \u201cEvolution of Focal Nodular Hyperplasia during Long-Term Ultrasound Follow-Up: Results from a Single-Center Study\u201d.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}