{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:28:00Z","timestamp":1762957680962,"version":"3.44.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004769","name":"Universit\u00e0 degli Studi di Pavia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004769","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Ibrutinib, a Bruton\u2019s tyrosine kinase (BTK) inhibitor, has transformed the management of mantle cell lymphoma (MCL) but is associated with an elevated risk of bleeding. We report a rare case of hepatic subcapsular hematoma due to ibrutinib in a patient with relapsed MCL. Ultrasound was crucial in the early detection, monitoring, and management of this rare but potentially severe complication.<\/jats:p>","DOI":"10.1007\/s40477-025-01059-y","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T01:32:50Z","timestamp":1757381570000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ibrutinib-associated hematoma of the liver: role of ultrasound in diagnosis and clinical management"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0103-6609","authenticated-orcid":false,"given":"Rosa","family":"Buonamassa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Cappello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Di Matteo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Maestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Frattola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"1059_CR1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13651","author":"JJ Shatzel","year":"2017","unstructured":"Shatzel JJ, Olson SR, Tao DL, McCarty OJT, Danilov AV, DeLoughery TG (2017) Ibrutinib-associated bleeding: pathogenesis, management and risk reduction strategies. J Thromb Haemost. https:\/\/doi.org\/10.1111\/jth.13651","journal-title":"J Thromb Haemost"},{"key":"1059_CR2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016001883","author":"F Caron","year":"2017","unstructured":"Caron F, Leong DP, Hillis C, Fraser G, Siegal D (2017) Current understanding of bleeding with ibrutinib use: a systematic review and meta-analysis. Blood Adv. https:\/\/doi.org\/10.1182\/bloodadvances.2016001883","journal-title":"Blood Adv"},{"key":"1059_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.580622","author":"J Wang","year":"2020","unstructured":"Wang J, Zhao A, Zhou H, Zhu J, Niu T (2020) Risk of bleeding associated with ibrutinib in patients with B-cell malignancies: a systematic review and meta-analysis of randomized controlled trials. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2020.580622","journal-title":"Front Pharmacol"},{"key":"1059_CR4","doi-asserted-by":"publisher","DOI":"10.1159\/000502605","author":"ZH Tafesh","year":"2019","unstructured":"Tafesh ZH, Coleman M, Fulmer C, Nagler J (2019) Severe hepatotoxicity due to ibrutinib with a review of published cases. Case Rep Gastroenterol. https:\/\/doi.org\/10.1159\/000502605","journal-title":"Case Rep Gastroenterol"},{"key":"1059_CR5","doi-asserted-by":"publisher","unstructured":"Seiter K et al (2016) Successful treatment of ibrutinib-associated central nervous system hemorrhage with platelet transfusion support. Stem Cell Investig https:\/\/doi.org\/10.21037\/sci.2016.06.08","DOI":"10.21037\/sci.2016.06.08"},{"key":"1059_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102821","author":"V Schwarze","year":"2020","unstructured":"Schwarze V et al (2020) Advanced fusion imaging and contrast-enhanced imaging (CT\/MRI\u2013CEUS) in oncology. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers12102821","journal-title":"Cancers (Basel)"},{"key":"1059_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s41747-021-00250-0","author":"F Vernuccio","year":"2021","unstructured":"Vernuccio F, Cannella R, Bartolotta TV, Galia M, Tang A, Brancatelli G (2021) Advances in liver US, CT, and MRI: moving toward the future. Eur Radiol Experim. https:\/\/doi.org\/10.1186\/s41747-021-00250-0","journal-title":"Eur Radiol Experim"},{"key":"1059_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/pl00007498","author":"P Xavier","year":"2002","unstructured":"Xavier P, Melo R, Am\u00e2ndio V, Beires J, Pereira-Leite L (2002) Subcapsular hepatic hematoma in an otherwise uncomplicated pregnancy. Arch Gynecol Obstet. https:\/\/doi.org\/10.1007\/pl00007498","journal-title":"Arch Gynecol Obstet"},{"issue":"4","key":"1059_CR9","first-page":"212","volume":"89","author":"KA Behranwala","year":"2004","unstructured":"Behranwala KA, Tisdall M, Habib NH, Canelo R (2004) Spontaneous bilobar subcapsular hematoma of the liver while undergoing anticoagulation therapy: our experience and review of the literature. 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