{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:09:23Z","timestamp":1791864563065,"version":"4.3.4"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Angiomas and blue nevi are common benign skin lesions with overlapping clinical appearances that can mimic malignancy, such as melanoma. This study evaluates the role of dermoscopy-assisted high-frequency ultrasound (DA-HFUS) in characterizing these lesions. Five cases (2 angiomas, 3 blue nevi) were examined using the Dermus SkinScanner, a handheld 33\u00a0MHz device with integrated optical guidance. Dermoscopy revealed blue nevi as regular, slate blue or brown lesions, occasionally with white veils; angiomas appeared as blue-purple papules with homogeneous purple lacunes. On ultrasound, blue nevi were well-demarcated, hypoechoic lesions with occasional hyperechoic foci suggestive of fibrosis, while angiomas showed heterogeneous echotexture with mixed echogenicity reflecting vascular and fibrous components. Fibrotic blue nevi exhibited deep dermal extensions and hyperechogenic columns not visible on dermoscopy. These findings highlight the complementary role of DA-HFUS and dermoscopy in non-invasive diagnosis and structural assessment of benign pigmented lesions.<\/jats:p>","DOI":"10.1007\/s40477-025-01066-z","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:44:13Z","timestamp":1756471453000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reddish\/bluish benign lesions evaluated by dermus SkinScanner"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-951X","authenticated-orcid":false,"given":"Carmen","family":"Cantisani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllida Kerstin","family":"Hamilton-Maikle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Di Segni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-1364","authenticated-orcid":false,"given":"Andras","family":"Banvolgyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-2217","authenticated-orcid":false,"given":"Giovanni","family":"Paolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9282-4784","authenticated-orcid":false,"given":"Salvador","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-1117","authenticated-orcid":false,"given":"Mehdi","family":"Boostani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7222-2951","authenticated-orcid":false,"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-9267","authenticated-orcid":false,"given":"Gyorgy","family":"Paragh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-1755","authenticated-orcid":false,"given":"Norbert","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"1066_CR1","doi-asserted-by":"publisher","first-page":"692060","DOI":"10.3389\/fmed.2021.692060","volume":"8","author":"J Gao","year":"2021","unstructured":"Gao J, Fei W, Shen C, Shen X, Sun M, Xu N, Li Q, Huang C, Zhang T, Ko R, Cui Y, Yang C (2021) Dermoscopic features summarization and comparison of four types of cutaneous vascular anomalies. Front Med Lausanne 8:692060. https:\/\/doi.org\/10.3389\/fmed.2021.692060","journal-title":"Front Med Lausanne"},{"issue":"2","key":"1066_CR2","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1159\/000516468","volume":"238","author":"K Lallas","year":"2022","unstructured":"Lallas K, Arceu M, Martinez G, Manoli SM, Papageorgiou C, Ilieva A, Todorovska V, Vakirlis E, Sotiriou E, Ioannides D, Apalla Z, Lallas A (2022) Dermoscopic predictors of benignity and malignancy in equivocal lesions predominated by blue color. Dermatology 238(2):301\u2013306. https:\/\/doi.org\/10.1159\/000516468","journal-title":"Dermatology"},{"issue":"3","key":"1066_CR3","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.clindermatol.2024.09.003","volume":"43","author":"E Moscarella","year":"2025","unstructured":"Moscarella E, Ronchi A, Brancaccio G, Scharf C, Briatico G, Franco R, Argenziano G (2025) Spectrum of blue nevus-like lesions, including blue nevus, pigmented epithelioid melanocytoma, and animal-type melanoma. Clin Dermatol 43(3):323\u2013333","journal-title":"Clin Dermatol"},{"issue":"10","key":"1066_CR4","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1001\/jamadermatol.2016.2201","volume":"152","author":"M Shive","year":"2016","unstructured":"Shive M, Ho D, Lai O, Mamalis A, Miller KM, Jagdeo J (2016) The role of subtractive color mixing in the perception of blue nevi and veins-beyond the Tyndall effect. JAMA Dermatol 152(10):1167\u20131169. https:\/\/doi.org\/10.1001\/jamadermatol.2016.2201","journal-title":"JAMA Dermatol"},{"issue":"21","key":"1066_CR5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jdin.2025.05.006","volume":"10","author":"M Boostani","year":"2025","unstructured":"Boostani M, Pellacani G, Wortsman X, Suppa M, Goldust M, Cantisani C, Pietkiewicz P, L\u0151rincz K, B\u00e1nv\u00f6lgyi A, Wikonk\u00e1l NM, Huss WJ, Avanaki K, Paragh G, Kiss N (2025) FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: a systematic review. JAAD Int 10(21):73\u201386. https:\/\/doi.org\/10.1016\/j.jdin.2025.05.006","journal-title":"JAAD Int"},{"issue":"1","key":"1066_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3390\/diagnostics12010204","volume":"12","author":"G Cs\u00e1ny","year":"2022","unstructured":"Cs\u00e1ny G, Gergely LH, Kiss N, Szalai K, L\u0151rincz K, Strobel L, Csabai D, Heged\u00fcs I, Maros\u00e1n-Vilimszky P, F\u00fczesi K, S\u00e1rdy M, Gy\u00f6ngy M (2022) Preliminary clinical experience with a novel optical-ultrasound imaging device on various skin lesions. Diagnostics (Basel) 12(1):204. https:\/\/doi.org\/10.3390\/diagnostics12010204","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"1066_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/1947-2714.125852","volume":"6","author":"G Gianfranco","year":"2014","unstructured":"Gianfranco G, Eloisa F, Vito C, Raffaele G, Gianluca T, Umberto R (2014) Color-doppler ultrasound in the diagnosis of oral vascular anomalies. N Am J Med Sci 6(1):1\u20135. https:\/\/doi.org\/10.4103\/1947-2714.125852","journal-title":"N Am J Med Sci"}],"container-title":["Journal of Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-025-01066-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40477-025-01066-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-025-01066-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:20:21Z","timestamp":1765178421000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40477-025-01066-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":7,"alternative-id":["1066"],"URL":"https:\/\/doi.org\/10.1007\/s40477-025-01066-z","relation":{},"ISSN":["1876-7931"],"issn-type":[{"value":"1876-7931","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"31 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that human research participants provided informed consent for publication of the images in Figs.\u00a0\n                      \n                      \u2013\n                      \n                      .","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}