{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:01:26Z","timestamp":1781056886213,"version":"3.54.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Pann\u00f3nia Scholarship Programme","award":["VI\/309-2\/2024\/F\u00c1FIN\/SM_RESEARCH_LONG\/001"],"award-info":[{"award-number":["VI\/309-2\/2024\/F\u00c1FIN\/SM_RESEARCH_LONG\/001"]}]},{"name":"University Research Fellowship Programme","award":["EK\u00d6P-2024-145"],"award-info":[{"award-number":["EK\u00d6P-2024-145"]}]},{"name":"Universit\u00e0 degli Studi di Roma La Sapienza"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Ultrasound"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Epidermoid cysts and dermatofibromas may resemble malignant lesions, requiring accurate non-invasive differentiation. Our objective was to assess dermoscopy-guided high-frequency ultrasound (DG-HFUS) in distinguishing these lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Nine lesions (four epidermoid cysts, five dermatofibromas) were examined using DG-HFUS with a 33\u00a0MHz linear probe in B-mode. The dermoscopic modality guided probe placement. For each lesion, a minimum of 10 consecutive frames were acquired to ensure measurement reproducibility. Lesions were evaluated based on predetermined characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Epidermoid cysts presented as well-circumscribed, oval lesions located in the dermis or dermal\u2013subcutaneous border, with depths of 1.4\u20138.7\u00a0mm. All showed mixed echogenicity with hyperechoic foci and bands. Dermatofibromas were smaller (2.4\u20133.5\u00a0mm), within the dermis, hypoechoic with scattered hyperechoic areas, poorly defined margins, and 3\u20135 hypoechoic bands extending into surrounding structures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DG-HFUS reliably correlated dermoscopic and sonographic features, enhancing non-invasive diagnosis of benign cutaneous lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40477-026-01131-1","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T10:34:38Z","timestamp":1774607678000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of dermatofibromas and epidermoid cysts using dermoscopy-guided high-frequency ultrasound imaging"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9615-0189","authenticated-orcid":false,"given":"P.","family":"Hamilton-Meikle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Boostani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Holl\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wikonk\u00e1l","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bozs\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"B\u00e1nv\u00f6lgy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2181-951X","authenticated-orcid":false,"given":"C.","family":"Cantisani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"3","key":"1131_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.pop.2025.05.004","volume":"52","author":"JL Wilson","year":"2025","unstructured":"Wilson JL (2025) Benign skin tumors. Prim Care Clin Office Pract 52(3):513\u2013535. https:\/\/doi.org\/10.1016\/j.pop.2025.05.004","journal-title":"Prim Care Clin Office Pract"},{"key":"1131_CR2","volume-title":"StatPearls","author":"PM Zito","year":"2025","unstructured":"Zito PM, Scharf R (2025) Epidermoid cyst. StatPearls. StatPearls Publishing, Treasure Island"},{"key":"1131_CR3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.ejro.2019.08.003","volume":"6","author":"VT Hoang","year":"2019","unstructured":"Hoang VT, Trinh CT, Nguyen CH, Chansomphou V, Chansomphou V, Tran TTT (2019) Overview of epidermoid cyst. Eur J Radiol Open 6:291\u2013301. https:\/\/doi.org\/10.1016\/j.ejro.2019.08.003","journal-title":"Eur J Radiol Open"},{"key":"1131_CR4","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.2147\/CCID.S526191","volume":"18","author":"L Wan","year":"2025","unstructured":"Wan L, Park A, Almatroud L, Khachemoune A (2025) Dermatofibroma: reappraisal and updated review. Clin Cosmet Investig Dermatol 18:1873\u20131887. https:\/\/doi.org\/10.2147\/CCID.S526191","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"1131_CR5","volume-title":"StatPearls","author":"DJ Myers","year":"2025","unstructured":"Myers DJ, Fillman EP (2025) Dermatofibroma. StatPearls. StatPearls Publishing, Treasure Island"},{"issue":"2","key":"1131_CR6","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/ijd.17496","volume":"64","author":"M Boostani","year":"2025","unstructured":"Boostani M et al (2025) Novel imaging techniques for tumor margin detection in basal cell carcinoma: a systematic scoping review of FDA and EMA-approved imaging modalities. Int J Dermatol 64(2):287\u2013301. https:\/\/doi.org\/10.1111\/ijd.17496","journal-title":"Int J Dermatol"},{"issue":"10","key":"1131_CR7","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1111\/ijd.17828","volume":"64","author":"NN Varga","year":"2025","unstructured":"Varga NN et al (2025) Diagnostic accuracy of novel optical imaging techniques for melanoma detection: a systematic review and meta-analysis. Int J Dermatol 64(10):1813\u20131824. https:\/\/doi.org\/10.1111\/ijd.17828","journal-title":"Int J Dermatol"},{"key":"1131_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jdin.2025.05.006","volume":"21","author":"M Boostani","year":"2025","unstructured":"Boostani M et al (2025) FDA and EMA-approved noninvasive imaging techniques for basal cell carcinoma subtyping: a systematic review. JAAD Int 21:73\u201386. https:\/\/doi.org\/10.1016\/j.jdin.2025.05.006","journal-title":"JAAD Int"},{"issue":"3","key":"1131_CR9","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1093\/bjd\/ljaf209","volume":"193","author":"M Boostani","year":"2025","unstructured":"Boostani M et al (2025) Dermoscopy-guided high-frequency ultrasound for preoperative assessment of basal cell carcinoma lateral margins: a pilot study. Br J Dermatol 193(3):572\u2013574. https:\/\/doi.org\/10.1093\/bjd\/ljaf209","journal-title":"Br J Dermatol"},{"key":"1131_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16010157","author":"NN Varga","year":"2023","unstructured":"Varga NN et al (2023) Optically guided high-frequency ultrasound shows superior efficacy for preoperative estimation of Breslow thickness in comparison with multispectral imaging: a single-center prospective validation study. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers16010157","journal-title":"Cancers (Basel)"},{"key":"1131_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12216910","author":"S Bozs\u00e1nyi","year":"2023","unstructured":"Bozs\u00e1nyi S et al (2023) Optically guided high-frequency ultrasound to differentiate high-risk basal cell carcinoma subtypes: A single-centre prospective study. J Clin Med. https:\/\/doi.org\/10.3390\/jcm12216910","journal-title":"J Clin Med"},{"key":"1131_CR12","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-025-01066-z","author":"C Cantisani","year":"2025","unstructured":"Cantisani C et al (2025) Reddish\/bluish benign lesions evaluated by dermus SkinScanner. J Ultrasound. https:\/\/doi.org\/10.1007\/s40477-025-01066-z","journal-title":"J Ultrasound"},{"issue":"1","key":"1131_CR13","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/s0929-8266(99)00043-9","volume":"10","author":"M Berson","year":"1999","unstructured":"Berson M et al (1999) High frequency (20 MHz) ultrasonic devices: advantages and applications. Eur J Ultrasound 10(1):53\u201363. https:\/\/doi.org\/10.1016\/s0929-8266(99)00043-9","journal-title":"Eur J Ultrasound"},{"key":"1131_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12010204","author":"G Cs\u00e1ny","year":"2022","unstructured":"Cs\u00e1ny G et al (2022) Preliminary clinical experience with a novel optical-ultrasound imaging device on various skin lesions. Diagnostics. https:\/\/doi.org\/10.3390\/diagnostics12010204","journal-title":"Diagnostics"},{"key":"1131_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030484","author":"C Soare","year":"2024","unstructured":"Soare C, Cozma EC, Celarel AM, Rosca AM, Lupu M, Voiculescu VM (2024) Digitally enhanced methods for the diagnosis and monitoring of treatment responses in actinic keratoses: a new avenue in personalized skin care. Cancers (Basel). https:\/\/doi.org\/10.3390\/cancers16030484","journal-title":"Cancers (Basel)"},{"key":"1131_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2025.100446","author":"M Boostani","year":"2025","unstructured":"Boostani M et al (2025) Dermoscopy-guided high-frequency ultrasound: principles and applications in dermatology. JID Innov. https:\/\/doi.org\/10.1016\/j.xjidi.2025.100446","journal-title":"JID Innov"},{"issue":"10","key":"1131_CR17","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.3348\/kjr.2019.0241","volume":"20","author":"DH Lee","year":"2019","unstructured":"Lee DH et al (2019) Ultrasound feature-based diagnostic model focusing on the \u2018Submarine Sign\u2019 for epidermal cysts among superficial soft tissue lesions. Korean J Radiol 20(10):1409\u20131421. https:\/\/doi.org\/10.3348\/kjr.2019.0241","journal-title":"Korean J Radiol"},{"key":"1131_CR18","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.2147\/CCID.S493437","volume":"17","author":"B Dong","year":"2024","unstructured":"Dong B, Xia H, Liu Y, Tao H, Xia Y, Zhu F (2024) Evaluation of very-high-frequency ultrasound imaging characteristics of dermatofibroma. Clin Cosmet Investig Dermatol 17:2795\u20132802. https:\/\/doi.org\/10.2147\/CCID.S493437","journal-title":"Clin Cosmet Investig Dermatol"}],"container-title":["Journal of Ultrasound"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-026-01131-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40477-026-01131-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40477-026-01131-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T01:33:10Z","timestamp":1781055190000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40477-026-01131-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["1131"],"URL":"https:\/\/doi.org\/10.1007\/s40477-026-01131-1","relation":{},"ISSN":["1876-7931"],"issn-type":[{"value":"1876-7931","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"5 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Author P.H-M. has a contractual professional relationship with Dermus Ltd. Author C.C is an associate editor. Author N.K. is collaborating with Dermus.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Comitte of Semmelweis University (SE RKEB 16\/2022.).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors affirm that research participants provided informed consent for publication of the images in Figs. 1, 2, 3, 4 and 5.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}