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Given the neural division of self-processing into interoceptive-, exteroceptive- and mental-self, we hypothesize neural deficits in the interoceptive-processing regions in AN.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>To prove this, we reviewed resting state (rs), task and rest-task studies in AN literature.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Neuronal data demonstrate the following in AN: (i) decreased rs-functional connectivity (rsFC) of subcortical\u2013cortical midline structures (SCMS); (ii) reduced rsFC between medial (default-mode network\/DMN and salience network\/SN) and lateral (executive-control network\/ECN) cortical regions; (iii) decreased rsFC in mainly the regions of the interoceptive-self; (iv) altered activity with overall increased activity in response to sensory\/body image stimuli, especially in the regions of the interoceptive-self; (v) lack of a clear task-related distinction between own\u2019s and others\u2019 body image.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These data may indicate that rs-hypoconnectivity between SCMS, as neural correlate of a reduced intero-exteroceptive integration resulting in self-objectification, might be linked to overall increased activity in interoceptive regions during sensory\/body image stimuli in AN, engendering an \u201canxious bodily self.\u201d<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Level of evidence<\/jats:title>\n                <jats:p>I: Systematic review.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40519-022-01510-7","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T15:04:31Z","timestamp":1668092671000},"page":"3063-3081","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anorexia nervosa as a disorder of the subcortical\u2013cortical interoceptive-self"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6473-7034","authenticated-orcid":false,"given":"Lorenzo","family":"Lucherini Angeletti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Innocenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Felciai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Cassioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Rotella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Castellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Stanghellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdo","family":"Ricca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Northoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"issue":"9355","key":"1510_CR1","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0140-6736(03)12378-1","volume":"361","author":"CG Fairburn","year":"2003","unstructured":"Fairburn CG, Harrison PJ (2003) Eating disorders. 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