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The increasing use of pharmacological treatment options has stimulated debates on several fundamental issues, including (1) full recognition of obesity as a disease, and (2) optimization of the diagnostic criteria of obesity and the timing for offering different treatment options. We aim at critically discussing here the similarities, discrepancies, and potential misunderstandings suggested by the European Association for the Study of Obesity (EASO) and Lancet Diabetes Endocrinology Commission statements. In particular, two aspects are discussed: (1) the BMI limitations and the necessity to include visceral fat and, more in general, body composition assessment in the diagnosis of obesity; (2) the opportunity to consider obesity always as a clinically relevant chronic disease due to its biological, psychological, and social characteristics.<\/jats:p>","DOI":"10.1007\/s40519-026-01820-0","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T12:00:27Z","timestamp":1776513627000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Obesity is always a clinically relevant chronic disease"],"prefix":"10.1007","volume":"31","author":[{"given":"Lorenzo M.","family":"Donini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Ballesteros-Pomar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Batsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Boirie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca Gortan","family":"Cappellari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Poggiogalle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Barazzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"issue":"10387","key":"1820_CR1","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/S0140-6736(24)02332-1","volume":"404","author":"WT Garvey","year":"2023","unstructured":"Garvey WT, Batterham R, Bhatta M, Buscemi S, Christensen R, Farpour-Lambert NJ et al (2023) Tirzepatide once weekly for the treatment of obesity in adults. 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