{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T19:13:33Z","timestamp":1648840413303},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s40520-015-0383-7","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T09:38:27Z","timestamp":1432633107000},"page":"991-995","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Familial late-onset Alzheimer\u2019s disease: description of an Italian family with four affected siblings and one case of early-onset dementia in the preceding generation"],"prefix":"10.1007","volume":"28","author":[{"given":"Carlo","family":"Abbate","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Arosio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Cantatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niccol\u00f2","family":"Viti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Giunco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo","family":"Bagarolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Nicolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gussago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Casati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Dionigi","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Cas\u00e8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Bergamaschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vergani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Mari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,5,27]]},"reference":[{"key":"383_CR1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1097\/GIM.0b013e31821d69b8","volume":"13","author":"JS Goldman","year":"2011","unstructured":"Goldman JS, Hahn SE, Catania JW et al (2011) Genetic counseling and testing for Alzheimer disease: joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors. Genet Med 13:597\u2013605","journal-title":"Genet Med"},{"key":"383_CR2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1001\/archneur.63.9.1307","volume":"63","author":"KL Brickell","year":"2006","unstructured":"Brickell KL, Steinbart EJ, Rumbaugh M et al (2006) Early-onset Alzheimer disease in families with late-onset Alzheimer disease: a potential important subtype of familial Alzheimer disease. Arch Neurol 63:1307\u20131311","journal-title":"Arch Neurol"},{"key":"383_CR3","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","volume":"65","author":"D Campion","year":"1999","unstructured":"Campion D, Dumanchin C, Hannequin D et al (1999) Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 65:664\u2013670","journal-title":"Am J Hum Genet"},{"key":"383_CR4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng0594-74","volume":"7","author":"CM Duijn van","year":"1994","unstructured":"van Duijn CM, de Knijff P, Cruts M et al (1994) Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer\u2019s disease. Nat Genet 7:74\u201378","journal-title":"Nat Genet"},{"key":"383_CR5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1046\/j.1529-8817.2004.00110.x","volume":"68","author":"MI Kamboh","year":"2004","unstructured":"Kamboh MI (2004) Molecular genetics of late-onset Alzheimer\u2019s disease. Ann Hum Genet 68:381\u2013404","journal-title":"Ann Hum Genet"},{"key":"383_CR6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/03014460600594513","volume":"33","author":"PP Singh","year":"2006","unstructured":"Singh PP, Singh M, Mastana SS (2006) APOE distribution in world populations with new data from India and the UK. Ann Hum Biol 33:279\u2013308","journal-title":"Ann Hum Biol"},{"key":"383_CR7","first-page":"1005","volume":"12","author":"T Wyss-Coray","year":"2006","unstructured":"Wyss-Coray T (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12:1005\u20131015","journal-title":"Nat Med"},{"key":"383_CR8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neurobiolaging.2003.10.009","volume":"25","author":"B Arosio","year":"2004","unstructured":"Arosio B, Trabattoni D, Galimberti L et al (2004) Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer\u2019s disease. Neurobiol Aging 25:1009\u20131015","journal-title":"Neurobiol Aging"},{"key":"383_CR9","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0197-4580(03)00013-7","volume":"24","author":"F Licastro","year":"2003","unstructured":"Licastro F, Grimaldi LM, Bonafe M et al (2003) Interleukin-6 gene alleles affect the risk of Alzheimer\u2019s disease and levels of the cytokine in blood and brain. Neurobiol Aging 24:921\u2013926","journal-title":"Neurobiol Aging"},{"issue":"Suppl 1","key":"383_CR10","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1742-4933-7-S1-S4","volume":"7","author":"F Licastro","year":"2010","unstructured":"Licastro F, Porcellini E, Forti P et al (2010) Multi factorial interactions in the pathogenesis pathway of Alzheimer\u2019s disease: a new risk charts for prevention of dementia. Immun Ageing 7(Suppl 1):S4","journal-title":"Immun Ageing"},{"key":"383_CR11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"G McKhann","year":"2011","unstructured":"McKhann G, Knopman DS, Chertkow H et al (2011) The diagnosis of dementia due to Alzheimer\u2019s disease: recommendation from the National Institute on Aging and the Alzheimer\u2019s Association workgroup. Alzheimers Dement 7:263\u2013269","journal-title":"Alzheimers Dement"},{"key":"383_CR12","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M et al (1984) Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS\u2013ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology 34:939\u2013944","journal-title":"Neurology"},{"key":"383_CR13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.mad.2006.01.015","volume":"127","author":"D Lio","year":"2006","unstructured":"Lio D, Annoni G, Licastro F et al (2006) Tumor necrosis factor-alpha -308A\/G polymorphism is associated with age at onset of Alzheimer\u2019s disease. Mech Ageing Dev 127:567\u2013571","journal-title":"Mech Ageing Dev"},{"key":"383_CR14","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/854527","author":"B Arosio","year":"2010","unstructured":"Arosio B, Mastronardi L, Vergani C et al (2010) Interleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution. Int J Alzheimers Dis. doi: 10.4061\/2010\/854527","journal-title":"Int J Alzheimers Dis"},{"key":"383_CR15","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.imlet.2008.02.002","volume":"117","author":"P Bermejo","year":"2008","unstructured":"Bermejo P, Martin-Aragon S, Benedi J et al (2008) Differences of peripheral inflammatory markers between mild cognitive impairment and Alzheimer\u2019s disease. Immunol Lett 117:198\u2013202","journal-title":"Immunol Lett"},{"key":"383_CR16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1055\/s-0031-1299784","volume":"31","author":"HL Paulson","year":"2011","unstructured":"Paulson HL, Igo I (2011) Genetics of Dementia. Semin Neurol 31:449\u2013460","journal-title":"Semin Neurol"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-015-0383-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40520-015-0383-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-015-0383-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-015-0383-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T18:59:53Z","timestamp":1559501993000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40520-015-0383-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,27]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["383"],"URL":"https:\/\/doi.org\/10.1007\/s40520-015-0383-7","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,27]]}}}