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N. Bedlington\u2019s organisation has received grants from GSK, Abbvie, Pfizer, Janssen, CSL Behring, Almirall, Baxter, Sanofi-Pasteur, EUPATI project (IMI-JU) industry consortium (UCB, Amgen, Genzyme, VFA, AZ, Novo Nordisk, Bayer, Merck, Janssen, GSK, Chiesi, Hoffmann, Lilly, Novartis, Esteve), Gilead, Eli-Lilly, Johnson & Johnson, MSD, Alexion, Mylan, Servier, Teva, Celgene, Novartis, Vertex, AIPP, Bosch Foundation, Sanofi Aventis, Hoffman La Roche, Grunenthal, European Commission. She has an advisory role with Janssen, Teva and GSK, outside of the submitted work. M.L. Brandi reports personal fees from Amgen, Bruno Farmaceutici, Kyowa Kirin, grants and personal fees from Abiogen, Alexion, Amgen, Bruno Farmaceutici, Eli Lilly, Kyowa Kirin, MSD, NPS, Servier, Shire, SPA, personal fees from Alexion, Bruno Farmaceutici, Kyowa Kirin, Servier, Shire, outside the submitted work. N. Burlet is a full-time employee at Sanofi Pasteur headquarters, Lyon, France. P.G. Conaghan is supported in part by the National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, outside of the submitted work. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. C. Cooper reports personal fees from Alliance for Better Bone Health, Amgen, Eli Lilly, GSK, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, Takeda and UCB, outside of the submitted work. M. de Wit has received fees for lectures or consultancy through Stichting Tools from Abbvie, BMS, Celgene, Eli Lilly, Janssen-Cilag, Novartis, Pfizer and Roche, outside of the submitted work. J.A. Kanis reports grants from Amgen, grants from Lilly, grants from Radius Health, grants from UCB, other from Meda, outside the submitted work; and is a member of the National Osteoporosis Guideline Group (NOGG) and the principal architect of FRAX but derives no financial benefit. W. Lawrence reports personal fees from Danone Nutricia, outside the submitted work. J.Y. Reginster reports personal fees and other from Servier, IBSA, Genevrier, UCB, Asahi, Radius Health, Meda, Pierre Fabre, grants from Merck Sharp & Dohme (MSD), Amgen, Lilly, Servier, Pfizer, Danone, Meda, Cniel, IBSA, Genevrier, personal fees from MSD, IBSA, Genevrier, Servier, Danone, Pharmevo, Cniel, Meda, and the Dairy Research Council (DRC), outside of the submitted work. R. Rizzoli reports personal fees from Radius Health, Effryx and Danone, outside of the submitted work. M. Scholte-Voshaar has received a grant for her PhD research from Roche and fees for lectures from Pfizer, outside of the submitted work. All other authors report nothing to disclose relating to the submitted work: N. Al-Daghri, I. Araujo de Carvalho, I. Aujoulat, N. Bere, M. Barker, P. Halbout, M. Hiligsmann, F. Jiwa, J. Kirwan, A. Laslop, D. Pinto, C. Prieto Yerro, V. Rabenda, C. Roberts, P. Tugwell, M. 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