{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:26:32Z","timestamp":1764332792601,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T00:00:00Z","timestamp":1567123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s40520-019-01289-1","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T06:07:35Z","timestamp":1567145255000},"page":"1219-1232","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vertebral fragility fractures: clinical and radiological results of augmentation and fixation\u2014a systematic review of randomized controlled clinical trials"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2319-2108","authenticated-orcid":false,"given":"Andrea","family":"Piazzolla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7516-2333","authenticated-orcid":false,"given":"Davide","family":"Bizzoca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Solarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-8616","authenticated-orcid":false,"given":"Biagio","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,30]]},"reference":[{"key":"1289_CR1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S0272-2712(18)30046-5","volume":"20","author":"DM Black","year":"2000","unstructured":"Black DM, Cooper C (2000) Epidemiology of fractures and assessment of fracture risk. Clin Lab Med 20:439\u2013454. \nhttps:\/\/doi.org\/10.1016\/S0272-2712(18)30046-5","journal-title":"Clin Lab Med"},{"key":"1289_CR2","first-page":"29","volume":"8","author":"P Piscitelli","year":"2011","unstructured":"Piscitelli P, Brandi ML, Chitano G et al (2011) Epidemiology of fragility fractures in Italy. Clin Cases Miner Bone Metab 8:29\u201334","journal-title":"Clin Cases Miner Bone Metab"},{"key":"1289_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s40520-013-0071-4","volume":"25","author":"C Ratti","year":"2013","unstructured":"Ratti C, Vulcano E, La Barbera G et al (2013) The incidence of fragility fractures in Italy. Aging Clin Exp Res 25:13\u201314. \nhttps:\/\/doi.org\/10.1007\/s40520-013-0071-4","journal-title":"Aging Clin Exp Res"},{"key":"1289_CR4","first-page":"637","volume":"29","author":"A Piazzolla","year":"2015","unstructured":"Piazzolla A, Solarino G, Bizzoca D et al (2015) Capacitive coupling electric fields in the treatment of vertebral compression fractures. J Biol Regul Homeost Agents 29:637\u2013646","journal-title":"J Biol Regul Homeost Agents"},{"key":"1289_CR5","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000973","author":"A Piazzolla","year":"2015","unstructured":"Piazzolla A, Solarino G, Lamartina C et al (2015) Vertebral bone marrow edema (VBME) in conservatively treated acute vertebral compression fractures (VCFs): evolution and clinical correlations. Spine (Phila Pa 1976). \nhttps:\/\/doi.org\/10.1097\/BRS.0000000000000973","journal-title":"Spine (Phila Pa 1976)"},{"key":"1289_CR6","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s00586-018-5602-4","volume":"27","author":"A Piazzolla","year":"2018","unstructured":"Piazzolla A, Solarino G, Bizzoca D et al (2018) The pedicle instrumentation and percutaneous elevation (Pi.Pe): a new cementless surgical technique in type A post-traumatic vertebral fractures. Eur Spine J 27:182\u2013189. \nhttps:\/\/doi.org\/10.1007\/s00586-018-5602-4","journal-title":"Eur Spine J"},{"key":"1289_CR7","doi-asserted-by":"publisher","first-page":"50S","DOI":"10.1177\/2192568217745823","volume":"8","author":"TR Blattert","year":"2018","unstructured":"Blattert TR, Schnake KJ, Gonschorek O et al (2018) Nonsurgical and surgical management of osteoporotic vertebral body fractures: recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU). Glob Spine J 8:50S\u201355S. \nhttps:\/\/doi.org\/10.1177\/2192568217745823","journal-title":"Glob Spine J"},{"key":"1289_CR8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1302\/2058-5241.2.160057","volume":"2","author":"A Sebaaly","year":"2017","unstructured":"Sebaaly A, Rizkallah M, Bachour F et al (2017) Percutaneous cement augmentation for osteoporotic vertebral fractures. EFORT Open Rev 2:293\u2013299. \nhttps:\/\/doi.org\/10.1302\/2058-5241.2.160057","journal-title":"EFORT Open Rev"},{"key":"1289_CR9","first-page":"166","volume":"33","author":"P Galibert","year":"1987","unstructured":"Galibert P, Deramond H, Rosat P et al (1987) Preliminary note on the treatment of vertebral angioma by percutaneous acrylic vertebroplasty. Neurochirurgie 33:166\u2013168","journal-title":"Neurochirurgie"},{"key":"1289_CR10","first-page":"71","volume":"19","author":"ME Jensen","year":"1997","unstructured":"Jensen ME, Dion JE (1997) Vertebroplasty relieves osteoporosis pain. Diagn. Imaging 19:71\u201372","journal-title":"Imaging"},{"key":"1289_CR11","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.3171\/foc.2005.18.3.6","volume":"18","author":"C Feltes","year":"2005","unstructured":"Feltes C, Fountas KN, Machinis T et al (2005) Immediate and early postoperative pain relief after kyphoplasty without significant restoration of vertebral body height in acute osteoporotic vertebral fractures. Neurosurg Focus 18:e5","journal-title":"Neurosurg Focus"},{"key":"1289_CR12","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2106\/JBJS.L.00024","volume":"95","author":"CML Werner","year":"2013","unstructured":"Werner CML, Osterhoff G, Schlickeiser J et al (2013) Vertebral body stenting versus kyphoplasty for the treatment of osteoporotic vertebral compression fractures. J Bone Jt Surg 95:577\u2013584. \nhttps:\/\/doi.org\/10.2106\/JBJS.L.00024","journal-title":"J Bone Jt Surg"},{"key":"1289_CR13","doi-asserted-by":"publisher","DOI":"10.14444\/5036","author":"D Beall","year":"2018","unstructured":"Beall D, Lorio MP, Yun BM et al (2018) Review of vertebral augmentation: an updated meta-analysis of the effectiveness. Int J Spine Surg. \nhttps:\/\/doi.org\/10.14444\/5036","journal-title":"Int J Spine Surg"},{"key":"1289_CR14","doi-asserted-by":"publisher","first-page":"b2700","DOI":"10.1136\/bmj.b2700","volume":"339","author":"A Liberati","year":"2009","unstructured":"Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700. \nhttps:\/\/doi.org\/10.1136\/bmj.b2700","journal-title":"BMJ"},{"key":"1289_CR15","unstructured":"(2017) AAOS Clinical Practice Guideline and Systematic Review Methodology. \nhttps:\/\/www.mendeley.com\/catalogue\/aaos-clinical-practice-guideline-systematic-review-methodology\/\n\n. Accessed 2 Mar 2019"},{"key":"1289_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1056\/NEJMoa0900429","volume":"361","author":"R Buchbinder","year":"2009","unstructured":"Buchbinder R, Osborne RH, Ebeling PR et al (2009) A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med 361:557\u2013568. \nhttps:\/\/doi.org\/10.1056\/NEJMoa0900429","journal-title":"N Engl J Med"},{"key":"1289_CR17","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1002\/jbmr.364","volume":"26","author":"S Boonen","year":"2011","unstructured":"Boonen S, Van Meirhaeghe J, Bastian L et al (2011) Balloon kyphoplasty for the treatment of acute vertebral compression fractures: 2-year results from a randomized trial. J Bone Miner Res 26:1627\u20131637. \nhttps:\/\/doi.org\/10.1002\/jbmr.364","journal-title":"J Bone Miner Res"},{"key":"1289_CR18","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.3174\/ajnr.A4127","volume":"35","author":"M Dohm","year":"2014","unstructured":"Dohm M, Black CM, Dacre A et al (2014) A randomized trial comparing balloon kyphoplasty and vertebroplasty for vertebral compression fractures due to osteoporosis. Am J Neuroradiol 35:2227\u20132236. \nhttps:\/\/doi.org\/10.3174\/ajnr.A4127","journal-title":"Am J Neuroradiol"},{"key":"1289_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2015-011811","author":"AJ Evans","year":"2016","unstructured":"Evans AJ, Kip KE, Brinjikji W et al (2016) Randomized controlled trial of vertebroplasty versus kyphoplasty in the treatment of vertebral compression fractures. J Neurointerv Surg. \nhttps:\/\/doi.org\/10.1136\/neurintsurg-2015-011811","journal-title":"J Neurointerv Surg"},{"key":"1289_CR20","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1097\/BRS.0000000000000906","volume":"40","author":"SM Tutton","year":"2015","unstructured":"Tutton SM, Pflugmacher R, Davidian M et al (2015) KAST study. Spine (Phila Pa 1976) 40:865\u2013875. \nhttps:\/\/doi.org\/10.1097\/BRS.0000000000000906","journal-title":"Spine (Phila Pa 1976)"},{"key":"1289_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s13018-015-0172-1","volume":"10","author":"Y-T Gu","year":"2015","unstructured":"Gu Y-T, Zhu D-H, Liu H-F et al (2015) Minimally invasive pedicle screw fixation combined with percutaneous vertebroplasty for preventing secondary fracture after vertebroplasty. J Orthop Surg Res 10:31. \nhttps:\/\/doi.org\/10.1186\/s13018-015-0172-1","journal-title":"J Orthop Surg Res"},{"key":"1289_CR22","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1056\/NEJMoa0900563","volume":"361","author":"DF Kallmes","year":"2009","unstructured":"Kallmes DF, Comstock BA, Heagerty PJ et al (2009) A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med 361:569\u2013579. \nhttps:\/\/doi.org\/10.1056\/NEJMoa0900563","journal-title":"N Engl J Med"},{"key":"1289_CR23","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/S0140-6736(10)60954-3","volume":"376","author":"CA Klazen","year":"2010","unstructured":"Klazen CA, Lohle PN, de Vries J et al (2010) Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial. Lancet 376:1085\u20131092. \nhttps:\/\/doi.org\/10.1016\/S0140-6736(10)60954-3","journal-title":"Lancet"},{"key":"1289_CR24","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3171\/2010.12.SPINE10286","volume":"14","author":"MR Farrokhi","year":"2011","unstructured":"Farrokhi MR, Alibai E, Maghami Z (2011) Randomized controlled trial of percutaneous vertebroplasty versus optimal medical management for the relief of pain and disability in acute osteoporotic vertebral compression fractures. J Neurosurg Spine 14:561\u2013569. \nhttps:\/\/doi.org\/10.3171\/2010.12.SPINE10286","journal-title":"J Neurosurg Spine"},{"key":"1289_CR25","first-page":"E187","volume":"18","author":"C Wang","year":"2015","unstructured":"Wang C, Ma J, Zhang C et al (2015) Comparison of high-viscosity cement vertebroplasty and balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. Pain Physician 18:E187\u2013E194","journal-title":"Pain Physician"},{"key":"1289_CR26","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3171\/2014.11.SPINE14579","volume":"23","author":"J-T Liu","year":"2015","unstructured":"Liu J-T, Li C, Chang C-S et al (2015) Long-term follow-up study of osteoporotic vertebral compression fracture treated using balloon kyphoplasty and vertebroplasty. J Neurosurg Spine 23:94\u201398. \nhttps:\/\/doi.org\/10.3171\/2014.11.SPINE14579","journal-title":"J Neurosurg Spine"},{"key":"1289_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31341-1","author":"W Clark","year":"2016","unstructured":"Clark W, Bird P, Gonski P et al (2016) Articles safety and efficacy of vertebroplasty for acute painful osteoporotic fractures (VAPOUR): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet. \nhttps:\/\/doi.org\/10.1016\/S0140-6736(16)31341-1","journal-title":"Lancet"},{"key":"1289_CR28","doi-asserted-by":"publisher","first-page":"CD006349","DOI":"10.1002\/14651858.CD006349.pub3","volume":"4","author":"R Buchbinder","year":"2018","unstructured":"Buchbinder R, Johnston RV, Rischin KJ et al (2018) Percutaneous vertebroplasty for osteoporotic vertebral compression fracture. Cochrane Database Syst Rev 4:CD006349. \nhttps:\/\/doi.org\/10.1002\/14651858.CD006349.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"1289_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy017","author":"DP Beall","year":"2019","unstructured":"Beall DP, Chambers MR, Thomas S et al (2019) Prospective and multicenter evaluation of outcomes for quality of life and activities of daily living for balloon kyphoplasty in the treatment of vertebral compression fractures: the EVOLVE trial. Soc Interv Radiol. \nhttps:\/\/doi.org\/10.1093\/neuros\/nyy017","journal-title":"Soc Interv Radiol"},{"key":"1289_CR30","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/BRS.0000000000000135","volume":"39","author":"A Lange","year":"2014","unstructured":"Lange A, Kasperk C, Alvares L et al (2014) Survival and cost comparison of kyphoplasty and percutaneous vertebroplasty using German claims data. Spine (Phila Pa 1976) 39:318\u2013326. \nhttps:\/\/doi.org\/10.1097\/BRS.0000000000000135","journal-title":"Spine (Phila Pa 1976)"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-019-01289-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40520-019-01289-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-019-01289-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T23:20:47Z","timestamp":1598656847000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40520-019-01289-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,30]]},"references-count":30,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["1289"],"URL":"https:\/\/doi.org\/10.1007\/s40520-019-01289-1","relation":{},"ISSN":["1720-8319"],"issn-type":[{"type":"electronic","value":"1720-8319"}],"subject":[],"published":{"date-parts":[[2019,8,30]]},"assertion":[{"value":"13 March 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this type of study, formal consent is not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"This type of study is based on aggregated data of already published studies. Informed consent cannot be obtained from patients.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}