{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:15:07Z","timestamp":1793690107759,"version":"4.5.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871092"],"award-info":[{"award-number":["81871092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1007\/s40520-019-01415-z","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T17:02:57Z","timestamp":1574528577000},"page":"2217-2223","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Carotid plague formation is associated with ankle\u2013brachial index in elderly people"],"prefix":"10.1007","volume":"32","author":[{"given":"Feng-Feng","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan-Chan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Xiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,23]]},"reference":[{"key":"1415_CR1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/HYPERTENSIONAHA.107.090464","volume":"55","author":"RA Payne","year":"2010","unstructured":"Payne RA, Wilkinson IB, Webb DJ (2010) Arterial stiffness and hypertension: emerging concepts. Hypertension 55:9\u201314. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.107.090464","journal-title":"Hypertension"},{"key":"1415_CR2","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1161\/hy1201.099291","volume":"38","author":"A Scuteri","year":"2001","unstructured":"Scuteri A, Chen CH, Yin FC et al (2001) Functional correlates of central arterial geometric phenotypes. Hypertension 38:1471\u20131475. https:\/\/doi.org\/10.1161\/hy1201.099291","journal-title":"Hypertension"},{"key":"1415_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0741-5214(00)70066-8","volume":"31","author":"MM Sabetai","year":"2000","unstructured":"Sabetai MM, Tegos TJ, Nicolaides AN et al (2000) Hemispheric symptoms and carotid plaque echomorphology. J Vasc Surg 31:39\u201349","journal-title":"J Vasc Surg"},{"key":"1415_CR4","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1161\/01.STR.31.3.615","volume":"31","author":"PM Rothwell","year":"2000","unstructured":"Rothwell PM, Gibson R, Warlow CP (2000) Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists\u2019 Collaborative group. Stroke 31:615\u2013621","journal-title":"Stroke"},{"key":"1415_CR5","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s10554-006-9197-1","volume":"23","author":"PJ Touboul","year":"2007","unstructured":"Touboul PJ, Hernandez-Hernandez R, Kucukoglu S et al (2007) Carotid artery intima media thickness, plaque and Framingham cardiovascular score in Asia, Africa\/Middle East and Latin America: the PARC-AALA study. Int J Cardiovasc Imaging 23:557\u2013567. https:\/\/doi.org\/10.1007\/s10554-006-9197-1","journal-title":"Int J Cardiovasc Imaging"},{"key":"1415_CR6","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","volume":"7","author":"TZ Naqvi","year":"2014","unstructured":"Naqvi TZ, Lee MS (2014) Carotid intima-media thickness and plaque in cardiovascular risk assessment. JACC Cardiovasc Imaging 7:1025\u20131038. https:\/\/doi.org\/10.1016\/j.jcmg.2013.11.014","journal-title":"JACC Cardiovasc Imaging"},{"key":"1415_CR7","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/j.jacc.2015.01.017","volume":"65","author":"U Baber","year":"2015","unstructured":"Baber U, Mehran R, Sartori S et al (2015) Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: the BioImage study. J Am Coll Cardiol 65:1065\u20131074. https:\/\/doi.org\/10.1016\/j.jacc.2015.01.017","journal-title":"J Am Coll Cardiol"},{"key":"1415_CR8","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.5551\/jat.38901","volume":"24","author":"H Matsushima","year":"2017","unstructured":"Matsushima H, Hosomi N, Hara N et al (2017) Ability of the ankle brachial index and brachial-ankle pulse wave velocity to predict the 3-month outcome in patients with non-cardioembolic stroke. J Atheroscler Thromb 24:1167\u20131173. https:\/\/doi.org\/10.5551\/jat.38901","journal-title":"J Atheroscler Thromb"},{"key":"1415_CR9","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1007\/s12013-014-0043-0","volume":"70","author":"G Zuo","year":"2014","unstructured":"Zuo G, Zhang M, Jia X et al (2014) Correlation between brachial-ankle pulse wave velocity, carotid artery intima-media thickness, ankle-brachial index, and the severity of coronary lesions. Cell Biochem Biophys 70:1205\u20131211. https:\/\/doi.org\/10.1007\/s12013-014-0043-0","journal-title":"Cell Biochem Biophys"},{"key":"1415_CR10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1080\/00365513.2018.1499124","volume":"78","author":"K Winckler","year":"2018","unstructured":"Winckler K, Wiinberg N, Jensen AK et al (2018) Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes. Scand J Clin Lab Invest 78:464\u2013469. https:\/\/doi.org\/10.1080\/00365513.2018.1499124","journal-title":"Scand J Clin Lab Invest"},{"key":"1415_CR11","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.002","volume":"25","author":"JG Garcia","year":"2016","unstructured":"Garcia JG, Roquer J, Serena J et al (2016) Carotid intima-media thickness is not associated with markers of atherosclerosis in stroke patients. J Stroke Cerebrovasc Dis 25:1070\u20131075. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2016.01.002","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1415_CR12","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1177\/039139880602900802","volume":"29","author":"T Stompor","year":"2006","unstructured":"Stompor T, Rajzer M, Pasowicz M et al (2006) Coronary artery calcification, common carotid artery intima-media thickness and aortic pulse wave velocity in patients on peritoneal dialysis. Int J Artif Organs 29:736\u2013744","journal-title":"Int J Artif Organs"},{"key":"1415_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.atherosclerosis.2003.10.013","volume":"173","author":"K Kobayashi","year":"2004","unstructured":"Kobayashi K, Akishita M, Yu W et al (2004) Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity. Atherosclerosis 173:13\u201318. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2003.10.013","journal-title":"Atherosclerosis"},{"key":"1415_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-019-01260-0","author":"A Scuteri","year":"2019","unstructured":"Scuteri A, Morrell CH, Fegatelli DA et al (2019) Arterial stiffness and multiple organ damage: a longitudinal study in population. Aging Clin Exp Res. https:\/\/doi.org\/10.1007\/s40520-019-01260-0","journal-title":"Aging Clin Exp Res"},{"key":"1415_CR15","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.atherosclerosis.2011.06.044","volume":"220","author":"Y Inaba","year":"2012","unstructured":"Inaba Y, Chen JA, Bergmann SR (2012) Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis. Atherosclerosis 220:128\u2013133. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2011.06.044","journal-title":"Atherosclerosis"},{"key":"1415_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1291\/hypres.30.767","volume":"30","author":"M Matsumoto","year":"2007","unstructured":"Matsumoto M, Inoue K, Moriki A (2007) Associations of brachial-ankle pulse wave velocity and carotid atherosclerotic lesions with silent cerebral lesions. Hypertens Res 30:767\u2013773. https:\/\/doi.org\/10.1291\/hypres.30.767","journal-title":"Hypertens Res"},{"key":"1415_CR17","first-page":"676","volume":"29","author":"AC Gray-Weale","year":"1988","unstructured":"Gray-Weale AC, Graham JC, Burnett JR et al (1988) Carotid artery atheroma: comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology. J Cardiovasc Surg (Torino) 29:676\u2013681","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"1415_CR18","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.atherosclerosis.2017.05.023","volume":"263","author":"M Amato","year":"2017","unstructured":"Amato M, Veglia F, de Faire U et al (2017) Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification. Atherosclerosis 263:412\u2013419. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.05.023","journal-title":"Atherosclerosis"},{"key":"1415_CR19","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.5551\/jat.33084","volume":"23","author":"HJ Joo","year":"2016","unstructured":"Joo HJ, Cho SA, Cho JY et al (2016) Brachial-ankle pulse wave velocity is associated with composite carotid and coronary atherosclerosis in a middle-aged asymptomatic population. J Atheroscler Thromb 23:1033\u20131046. https:\/\/doi.org\/10.5551\/jat.33084","journal-title":"J Atheroscler Thromb"},{"key":"1415_CR20","doi-asserted-by":"publisher","first-page":"7037","DOI":"10.1038\/s41598-018-25579-2","volume":"8","author":"Y Yang","year":"2018","unstructured":"Yang Y, Fan F, Kou M et al (2018) Brachial-ankle pulse wave velocity is associated with the risk of new carotid plaque formation: data from a Chinese community-based cohort. Sci Rep 8:7037. https:\/\/doi.org\/10.1038\/s41598-018-25579-2","journal-title":"Sci Rep"},{"key":"1415_CR21","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.004168","volume":"6","author":"Y Lu","year":"2017","unstructured":"Lu Y, Zhu M, Bai B et al (2017) Comparison of carotid-femoral and brachial-ankle pulse-wave velocity in association with target organ damage in the community-dwelling elderly Chinese: the northern Shanghai study. J Am Heart Assoc 6:e004168. https:\/\/doi.org\/10.1161\/jaha.116.004168","journal-title":"J Am Heart Assoc"},{"key":"1415_CR22","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1291\/hypres.27.465","volume":"27","author":"H Tomiyama","year":"2004","unstructured":"Tomiyama H, Arai T, Koji Y et al (2004) The age-related increase in arterial stiffness is augmented in phases according to the severity of hypertension. Hypertens Res 27:465\u2013470","journal-title":"Hypertens Res"},{"key":"1415_CR23","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1161\/HYPERTENSIONAHA.109.137653","volume":"54","author":"M Cecelja","year":"2009","unstructured":"Cecelja M, Chowienczyk P (2009) Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension 54:1328\u20131336. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.109.137653","journal-title":"Hypertension"},{"key":"1415_CR24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1161\/STROKEAHA.115.011321","volume":"47","author":"JB Hong","year":"2016","unstructured":"Hong JB, Leonards CO, Endres M et al (2016) Ankle-brachial index and recurrent stroke risk: meta-analysis. Stroke 47:317\u2013322. https:\/\/doi.org\/10.1161\/STROKEAHA.115.011321","journal-title":"Stroke"},{"key":"1415_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.atherosclerosis.2013.05.014","volume":"229","author":"H Fan","year":"2013","unstructured":"Fan H, Hu X, Yu W et al (2013) Low ankle-brachial index and risk of stroke. Atherosclerosis 229:317\u2013323. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2013.05.014","journal-title":"Atherosclerosis"},{"key":"1415_CR26","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1714\/2088.22584","volume":"16","author":"L Naldi","year":"2015","unstructured":"Naldi L, Bernetti M, Baroni F et al (2015) Ankle-brachial index: which clinical use? G Ital Cardiol (Rome) 16:681\u2013689. https:\/\/doi.org\/10.1714\/2088.22584","journal-title":"G Ital Cardiol (Rome)"},{"key":"1415_CR27","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11886-009-0004-1","volume":"11","author":"SH Johnsen","year":"2009","unstructured":"Johnsen SH, Mathiesen EB (2009) Carotid plaque compared with intima-media thickness as a predictor of coronary and cerebrovascular disease. Curr Cardiol Rep 11:21\u201327","journal-title":"Curr Cardiol Rep"},{"key":"1415_CR28","doi-asserted-by":"publisher","first-page":"422","DOI":"10.5935\/abc.20130057","volume":"100","author":"AC Brasileiro","year":"2013","unstructured":"Brasileiro AC, Oliveira DC, Victor EG et al (2013) Association between ankle-brachial index and carotid atherosclerotic disease. Arq Bras Cardiol 100:422\u2013428. https:\/\/doi.org\/10.5935\/abc.20130057","journal-title":"Arq Bras Cardiol"},{"key":"1415_CR29","first-page":"50","volume":"105","author":"RA Wyman","year":"2006","unstructured":"Wyman RA, Keevil JG, Busse KL et al (2006) Is the ankle-brachial index a useful screening test for subclinical atherosclerosis in asymptomatic, middle-aged adults? WMJ 105:50\u201354","journal-title":"WMJ"},{"key":"1415_CR30","first-page":"451","volume":"30","author":"Y Wang","year":"2011","unstructured":"Wang Y, Li J, Guo X et al (2011) A U-shaped relationship between ankle-brachial index and carotid intima-media thickness in a Chinese population of Inner Mongolia. Int Angiol 30:451\u2013457","journal-title":"Int Angiol"},{"key":"1415_CR31","doi-asserted-by":"publisher","first-page":"e0177609","DOI":"10.1371\/journal.pone.0177609","volume":"12","author":"T Miura","year":"2017","unstructured":"Miura T, Minamisawa M, Ueki Y et al (2017) Impressive predictive value of ankle-brachial index for very long-term outcomes in patients with cardiovascular disease: IMPACT-ABI study. PLoS One 12:e0177609. https:\/\/doi.org\/10.1371\/journal.pone.0177609","journal-title":"PLoS One"},{"key":"1415_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0021-9150(97)06089-9","volume":"131","author":"ZJ Zheng","year":"1997","unstructured":"Zheng ZJ, Sharrett AR, Chambless LE et al (1997) Associations of ankle-brachial index with clinical coronary heart disease, stroke and preclinical carotid and popliteal atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. Atherosclerosis 131:115\u2013125","journal-title":"Atherosclerosis"},{"key":"1415_CR33","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.atherosclerosis.2010.10.011","volume":"214","author":"V Aboyans","year":"2011","unstructured":"Aboyans V, McClelland RL, Allison MA et al (2011) Lower extremity peripheral artery disease in the absence of traditional risk factors. The multi-ethnic study of atherosclerosis. Atherosclerosis 214:169\u2013173. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2010.10.011","journal-title":"Atherosclerosis"},{"key":"1415_CR34","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000097034","volume":"23","author":"PJ Touboul","year":"2007","unstructured":"Touboul PJ, Hennerici MG, Meairs S et al (2007) Mannheim carotid intima-media thickness consensus (2004\u20132006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis 23:75\u201380. https:\/\/doi.org\/10.1159\/000097034","journal-title":"Cerebrovasc Dis"},{"key":"1415_CR35","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1161\/01.CIR.103.17.2171","volume":"103","author":"EB Mathiesen","year":"2001","unstructured":"Mathiesen EB, Bonaa KH, Joakimsen O (2001) Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the tromso study. Circulation 103:2171\u20132175","journal-title":"Circulation"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-019-01415-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40520-019-01415-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-019-01415-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:21:01Z","timestamp":1606004461000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40520-019-01415-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,23]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["1415"],"URL":"https:\/\/doi.org\/10.1007\/s40520-019-01415-z","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,23]]},"assertion":[{"value":"26 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"On behalf of all authors, the corresponding author states that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study was approved by the Shanghai Jiao Tong University Affiliated Sixth People\u2019s Hospital Foundation Ethical Committee.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}