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Pepper Older Americans Independence Center, University of California San Francisco","doi-asserted-by":"publisher","award":["P30 AG044281"],"award-info":[{"award-number":["P30 AG044281"]}],"id":[{"id":"10.13039\/100010512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Changes in well-being of patients with multiple myeloma (MM) before and after diagnosis have not been quantified.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Aims<\/jats:title>\n<jats:p>Explore the use of secondary data to examine the changes in the well-being of older patients with MM.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We used the Health and Retirement Study (HRS), linked to Medicare claims to identify older MM patients. We compared patient-reported measures (PRM), including physical impairment, sensory impairment, and patient experience (significant pain, self-rated health, depression) in the interviews before and after MM diagnosis using McNemar\u2019s test. We propensity-matched each MM patient to five HRS participants without MM diagnosis based on baseline characteristics. We compared the change in PRM between the MM patients and their matches.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We identified 92 HRS patients with MM diagnosis (mean age\u2009=\u200974.6, SD\u2009=\u20098.4). Among the surviving patients, there was a decline in well-being across most measures, including ADL difficulty (23% to 40%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.016), poor or fair self-rated health (38% to 61%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.004), and depression (15% to 30%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.021). Surviving patients reported worse health than participants without MM across most measures, including ADL difficulty (40% vs. 27%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.04), significant pain (38% vs. 22%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.01), and depression (29% vs. 11%, <jats:italic>p<\/jats:italic> value\u2009=\u20090.003).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Discussion<\/jats:title>\n<jats:p>Secondary data were used to identify patients with MM diagnosis, and examine changes across multiple measures of well-being. MM diagnosis negatively affects several aspects of patients\u2019 well-being, and these declines are larger than those experienced by similar participants without MM.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The results of this study are valuable addition to understanding the experience of patients with MM, despite several data limitations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s40520-019-01465-3","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T15:02:40Z","timestamp":1579705360000},"page":"1153-1160","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient-reported measures of well-being in older multiple myeloma patients: use of secondary data source"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5839-1070","authenticated-orcid":false,"given":"Irena","family":"Cenzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette M.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Ostermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Covinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,22]]},"reference":[{"key":"1465_CR1","volume-title":"SEER cancer statistics review, 1975-2014","author":"N Howlader","year":"2017","unstructured":"Howlader N, Noone AM, Krapcho M et al (2017) SEER cancer statistics review, 1975-2014. 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