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We also studied the impact of age, BMI, number of medications, thyroid-stimulating hormone (TSH) concentration, levothyroxine (L-T4) substitution and Mini-Mental State Examination (MMSE) on HRQoL.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Overall HRQoL was impaired in older people with stable CVD (mean 15D score 0.777 vs 0.801, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and also on single dimensions of breathing, sleeping, discomfort and symptoms, distress, vitality (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and depression (<jats:italic>p<\/jats:italic>\u2009=\u20090.016) compared to the age- and gender-matched general population. Furthermore, in the patients, L-T4 substitution associated with impaired sleeping (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) and sexual activity (<jats:italic>p<\/jats:italic>\u2009=\u20090.030). Moreover, MMSE points, number of medications used, age (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and BMI (<jats:italic>p<\/jats:italic>\u2009=\u20090.009) predicted impaired HRQoL.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Older people with stable CVD are characterized by impaired HRQoL compared to age- and gender-matched controls. We demonstrate that this is the consequence of impaired breathing, sleeping, discomfort and symptoms, distress, vitality, and depression. L-T4 substitution has a negative impact on HRQoL in old patients with stable CVD. MMSE score, number of medications, age and BMI predict worse HRQoL.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s40520-020-01537-9","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T08:03:45Z","timestamp":1586505825000},"page":"2041-2047","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired breathing, sleeping, vitality, and depression, and negative impact of L-T4 treatment characterize health-related quality of life in older people with stable CVD"],"prefix":"10.1007","volume":"32","author":[{"given":"Anna K.","family":"Ojala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harri","family":"Sintonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto P.","family":"Roine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo E.","family":"Strandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2428-0161","authenticated-orcid":false,"given":"Camilla","family":"Schalin-J\u00e4ntti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"1537_CR1","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","volume":"139","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin EJ, Muntner P, Alonso A et al (2019) Heart disease and stroke statistics-2019 update: a report from the American Heart Association. 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The other authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. All stages of the DEBATE study have been approved by the Ethics Committee of the Department of Medicine, University of Helsinki (in 1999).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"Informed consent according to the Declaration of Helsinki was obtained from all patients before any study procedures, which are performed according to good clinical trial practice.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}