{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:32:53Z","timestamp":1791462773237,"version":"4.3.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773513"],"award-info":[{"award-number":["81773513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Projects from Shanghai Science and Technology Municipality","award":["17411950106"],"award-info":[{"award-number":["17411950106"]}]},{"name":"Scientific Research Projects from Shanghai Science and Technology Municipality","award":["17411950701"],"award-info":[{"award-number":["17411950701"]}]},{"name":"Shanghai Brain-Intelligence Project from STCSM","award":["16JC1420500"],"award-info":[{"award-number":["16JC1420500"]}]},{"name":"Natural Science Foundation and Major Basic Research Program of Shanghai","award":["16JC1420100"],"award-info":[{"award-number":["16JC1420100"]}]},{"name":"National Chronic Disease Project","award":["2016YFC1306402"],"award-info":[{"award-number":["2016YFC1306402"]}]},{"name":"STCSM Major Project","award":["2018SHZDZX01"],"award-info":[{"award-number":["2018SHZDZX01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s40520-020-01661-6","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T08:02:46Z","timestamp":1595923366000},"page":"1667-1675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["TOMM40 and APOE variants synergistically increase the risk of Alzheimer\u2019s disease in a Chinese population"],"prefix":"10.1007","volume":"33","author":[{"given":"Zheng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5655-158X","authenticated-orcid":false,"given":"Qianhua","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoniu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"1661_CR1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s11033-010-0132-0","volume":"38","author":"P Hu","year":"2011","unstructured":"Hu P, Qing YH, Jing CX et al (2011) Does the geographical gradient of ApoE4 allele exist in China? A systemic comparison among multiple Chinese populations. Mol Biol Rep 38:489\u2013494. https:\/\/doi.org\/10.1007\/s11033-010-0132-0","journal-title":"Mol Biol Rep"},{"key":"1661_CR2","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s11033-008-9305-5","volume":"36","author":"S Liang","year":"2009","unstructured":"Liang S, Pan M, Geng HH et al (2009) Apolipoprotein E polymorphism in normal Han Chinese population: frequency and effect on lipid parameters. Mol Biol Rep 36:1251\u20131256. https:\/\/doi.org\/10.1007\/s11033-008-9305-5","journal-title":"Mol Biol Rep"},{"key":"1661_CR3","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1212\/wnl.49.3.779","volume":"49","author":"R Katzman","year":"1997","unstructured":"Katzman R, Zhang MY, Chen PJ et al (1997) Effects of apolipoprotein E on dementia and aging in the Shanghai Survey of Dementia. Neurology 49:779\u2013785. https:\/\/doi.org\/10.1212\/wnl.49.3.779","journal-title":"Neurology"},{"key":"1661_CR4","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1001\/archneurol.2010.201","volume":"67","author":"G Jun","year":"2010","unstructured":"Jun G, Naj A, Beecham GW et al (2010) Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer\u2019s disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 67:1473\u20131484. https:\/\/doi.org\/10.1001\/archneurol.2010.201","journal-title":"Arch Neurol"},{"key":"1661_CR5","volume-title":"World Alzheimer report 2015: the global impact of dementia: an analysis of prevalence, incidence, cost and trends","author":"M Prince","year":"2015","unstructured":"Prince M, Wimo A, Guerchet M et al (2015) World Alzheimer report 2015: the global impact of dementia: an analysis of prevalence, incidence, cost and trends. Alzheimer\u2019s Disease International, London"},{"key":"1661_CR6","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1212\/WNL.54.1.4","volume":"54","author":"A Lobo","year":"2000","unstructured":"Lobo A, Launer LJ, Fratiglioni L et al (2000) Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54:S4\u2013S9","journal-title":"Neurology"},{"key":"1661_CR7","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.expneurol.2009.01.011","volume":"218","author":"RH Swerdlow","year":"2009","unstructured":"Swerdlow RH, Khan SM (2009) The Alzheimer\u2019s disease mitochondrial cascade hypothesis: an update. Exp Neurol 218:308\u2013315. https:\/\/doi.org\/10.1016\/j.expneurol.2009.01.011","journal-title":"Exp Neurol"},{"key":"1661_CR8","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41398-018-0150-6","volume":"9","author":"RE Marioni","year":"2019","unstructured":"Marioni RE, Harris SE, Zhang Q et al (2019) GWAS on family history of Alzheimer\u2019s disease. Transl Psychiatry 9:161. https:\/\/doi.org\/10.1038\/s41398-018-0150-6","journal-title":"Transl Psychiatry"},{"key":"1661_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1001\/jamaneurol.2015.3135","volume":"73","author":"B Lehallier","year":"2016","unstructured":"Lehallier B, Essioux L, Gayan J et al (2016) Combined plasma and cerebrospinal fluid signature for the prediction of midterm progression from mild cognitive impairment to Alzheimer Disease. JAMA Neurol 73:203\u2013212. https:\/\/doi.org\/10.1001\/jamaneurol.2015.3135","journal-title":"JAMA Neurol"},{"key":"1661_CR10","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1159\/000366163","volume":"43","author":"D Ding","year":"2014","unstructured":"Ding D, Zhao Q, Guo Q et al (2014) The Shanghai aging study: study design, baseline characteristics, and prevalence of dementia. Neuroepidemiology 43:114\u2013122. https:\/\/doi.org\/10.1159\/000366163","journal-title":"Neuroepidemiology"},{"key":"1661_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3121\/cmr.2007.693","volume":"5","author":"WS Lim","year":"2007","unstructured":"Lim WS, Chong MS, Sahadevan S (2007) Utility of the clinical dementia rating in Asian populations. Clin Med Res 5:61\u201370. https:\/\/doi.org\/10.3121\/cmr.2007.693","journal-title":"Clin Med Res"},{"key":"1661_CR12","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9:179\u2013186","journal-title":"Gerontologist"},{"key":"1661_CR13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1212\/wnl.34.7.939","volume":"34","author":"G McKhann","year":"1984","unstructured":"McKhann G, Drachman D, Folstein M et al (1984) Clinical-diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease. Neurology 34:939\u2013944. https:\/\/doi.org\/10.1212\/wnl.34.7.939","journal-title":"Neurology"},{"key":"1661_CR14","doi-asserted-by":"publisher","first-page":"2107.e7","DOI":"10.1016\/j.neurobiolaging.2011.05.023","volume":"32","author":"S Cervantes","year":"2011","unstructured":"Cervantes S, Samaranch L, Vidal-Taboada JM et al (2011) Genetic variation in APOE cluster region and Alzheimer\u2019s disease risk. Neurobiol Aging 32:2107.e7\u20132107.e17. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2011.05.023","journal-title":"Neurobiol Aging"},{"key":"1661_CR15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12017-012-8217-7","volume":"15","author":"XY Ma","year":"2013","unstructured":"Ma XY, Yu JT, Wang W et al (2013) Association of TOMM40 polymorphisms with late-onset Alzheimer\u2019s disease in a Northern Han Chinese population. Neuromol Med 15:279\u2013287. https:\/\/doi.org\/10.1007\/s12017-012-8217-7","journal-title":"Neuromol Med"},{"key":"1661_CR16","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s40520-015-0489-y","volume":"28","author":"Y He","year":"2016","unstructured":"He Y, Li C, Yang Y et al (2016) Meta-analysis of the rs2075650 polymorphism and risk of Alzheimer disease. Aging Clin Exp Res 28:805\u2013811. https:\/\/doi.org\/10.1007\/s40520-015-0489-y","journal-title":"Aging Clin Exp Res"},{"key":"1661_CR17","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3233\/JAD-2011-110743","volume":"28","author":"A Maruszak","year":"2012","unstructured":"Maruszak A, Pep\u0142o\u0144ska B, Safranow K et al (2012) TOMM40 rs10524523 polymorphism\u2019s role in late-onset Alzheimer\u2019s disease and in longevity. J Alzheimers Dis. 28:309\u2013322. https:\/\/doi.org\/10.3233\/JAD-2011-110743","journal-title":"J Alzheimers Dis."},{"key":"1661_CR18","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1007\/s00415-014-7368-x","volume":"261","author":"X Liu","year":"2014","unstructured":"Liu X, Bai F, Yue C et al (2014) The association between TOMM40 gene polymorphism and spontaneous brain activity in amnestic mild cognitive impairment. J Neurol 261:1499\u20131507. https:\/\/doi.org\/10.1007\/s00415-014-7368-x","journal-title":"J Neurol"},{"key":"1661_CR19","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nature07940","volume":"459","author":"DA Smirnov","year":"2009","unstructured":"Smirnov DA, Morley M, Shin E et al (2009) Genetic analysis of radiation-induced changes in human gene expression. Nature 459:587\u2013591. https:\/\/doi.org\/10.1038\/nature07940","journal-title":"Nature"},{"key":"1661_CR20","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/s41582-019-0228-7","volume":"15","author":"Y Yamazaki","year":"2019","unstructured":"Yamazaki Y, Zhao N, Caulfield TR et al (2019) Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. Nat Rev Neurol 15:501\u2013518. https:\/\/doi.org\/10.1038\/s41582-019-0228-7","journal-title":"Nat Rev Neurol"},{"key":"1661_CR21","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1111\/1755-5922.12186","volume":"34","author":"WY Yu","year":"2016","unstructured":"Yu WY, Sun X, Wadelius M et al (2016) Influence of APOE Gene polymorphism on interindividual and interethnic warfarin dosage requirement: a systematic review and meta-analysis apolipoprotein E and Alzheimer disease. Cardiovasc Ther 34:297\u2013307. https:\/\/doi.org\/10.1111\/1755-5922.12186","journal-title":"Cardiovasc Ther"},{"key":"1661_CR22","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1007\/s11910-016-0643-8","volume":"16","author":"MW Lutz","year":"2016","unstructured":"Lutz MW, Crenshaw D, Welsh-Bohmer KA et al (2016) New genetic approaches to AD: lessons from APOE-TOMM40 phylogenetics. Curr Neurol Neurosci Rep 16:48. https:\/\/doi.org\/10.1007\/s11910-016-0643-8","journal-title":"Curr Neurol Neurosci Rep"},{"key":"1661_CR23","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuroscience.2017.09.049","volume":"370","author":"P Petschner","year":"2018","unstructured":"Petschner P, Gonda X, Baksa D et al (2018) Genes linking mitochondrial function, cognitive impairment and depression are associated with endophenotypes serving precision medicine. Neuroscience 370:207\u2013217. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.09.049","journal-title":"Neuroscience"},{"key":"1661_CR24","doi-asserted-by":"publisher","first-page":"e00045","DOI":"10.1042\/AN20100019","volume":"2","author":"A Cheng","year":"2010","unstructured":"Cheng A, Hou Y, Mattson MP (2010) Mitochondria and neuroplasticity. ASN Neuro 2:e00045. https:\/\/doi.org\/10.1042\/AN20100019","journal-title":"ASN Neuro"},{"key":"1661_CR25","doi-asserted-by":"publisher","first-page":"35207","DOI":"10.18632\/oncotarget.26184","volume":"9","author":"M Prendecki","year":"2018","unstructured":"Prendecki M, Florczak-Wyspianska J, Kowalska M et al (2018) Biothiols and oxidative stress markers and polymorphisms of TOMM40 and APOC1 genes in Alzheimer\u2019s disease patients. Oncotarget 9:35207\u201335225. https:\/\/doi.org\/10.18632\/oncotarget.26184","journal-title":"Oncotarget"},{"key":"1661_CR26","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.neulet.2016.05.050","volume":"628","author":"H Huang","year":"2016","unstructured":"Huang H, Zhao J, Xu B et al (2016) The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer\u2019s disease in Caucasian, and Asian populations. Neurosci Lett 628:142\u2013146. https:\/\/doi.org\/10.1016\/j.neulet.2016.05.050","journal-title":"Neurosci Lett"},{"key":"1661_CR27","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1097\/WAD.0b013e31826d7281","volume":"27","author":"SJ Chung","year":"2013","unstructured":"Chung SJ, Lee JH, Kim SY et al (2013) Association of GWAS top hits with late-onset Alzheimer disease in Korean population. Alzheimer Dis Assoc Disord 27:250\u2013257. https:\/\/doi.org\/10.1097\/WAD.0b013e31826d7281","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"1661_CR28","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s10072-013-1425-6","volume":"34","author":"S Bagnoli","year":"2013","unstructured":"Bagnoli S, Piaceri I, Tedde A et al (2013) TOMM40 polymorphisms in Italian Alzheimer\u2019s disease and frontotemporal dementia patients. Neurol Sci 34:995\u2013998. https:\/\/doi.org\/10.1007\/s10072-013-1425-6","journal-title":"Neurol Sci"},{"key":"1661_CR29","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1038\/npp.2014.22","volume":"39","author":"M McFarquhar","year":"2014","unstructured":"McFarquhar M, Elliott R, McKie S et al (2014) TOMM40 rs2075650 may represent a new candidate gene for vulnerability to major depressive disorder. Neuropsychopharmacology 39:1743\u20131753. https:\/\/doi.org\/10.1038\/npp.2014.22","journal-title":"Neuropsychopharmacology"},{"key":"1661_CR30","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3233\/JAD-171043","volume":"64","author":"LE Korthauer","year":"2018","unstructured":"Korthauer LE, Awe E, Frahmand M et al (2018) Genetic risk for age-related cognitive impairment does not predict cognitive performance in middle age. J Alzheimers Dis 64:459\u2013471. https:\/\/doi.org\/10.3233\/JAD-171043","journal-title":"J Alzheimers Dis"},{"key":"1661_CR31","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.neurobiolaging.2014.01.006","volume":"35","author":"DM Lyall","year":"2014","unstructured":"Lyall DM, Harris SE, Bastin ME et al (2014) Alzheimer\u2019s disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiol Aging 35:1513. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.01.006","journal-title":"Neurobiol Aging"},{"key":"1661_CR32","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jalz.2010.01.011","volume":"6","author":"MW Lutz","year":"2010","unstructured":"Lutz MW, Crenshaw DG, Saunders AM et al (2010) Genetic variation at a single locus and age of onset for Alzheimer\u2019s disease. Alzheimers Dement 6:125\u2013131. https:\/\/doi.org\/10.1016\/j.jalz.2010.01.011","journal-title":"Alzheimers Dement"},{"key":"1661_CR33","doi-asserted-by":"publisher","first-page":"e0144898","DOI":"10.1371\/journal.pone.0144898","volume":"10","author":"B Jiao","year":"2015","unstructured":"Jiao B, Liu X, Zhou L et al (2015) Polygenic analysis of late-onset Alzheimer\u2019s Disease from Mainland China. PLoS ONE 10:e0144898. https:\/\/doi.org\/10.1371\/journal.pone.0144898","journal-title":"PLoS ONE"},{"key":"1661_CR34","doi-asserted-by":"publisher","DOI":"10.13188\/2376-922X.1000003","author":"WK Gottschalk","year":"2014","unstructured":"Gottschalk WK, Lutz MW, Hce YT et al (2014) The broad impact of TOM40 on neurodegenerative diseases in aging. J Parkinsons Dis Alzheimers Dis. https:\/\/doi.org\/10.13188\/2376-922X.1000003","journal-title":"J Parkinsons Dis Alzheimers Dis"},{"key":"1661_CR35","doi-asserted-by":"publisher","first-page":"e62277","DOI":"10.1371\/journal.pone.0062277","volume":"8","author":"A Bender","year":"2013","unstructured":"Bender A, Desplats P, Spencer B et al (2013) TOM40 mediates mitochondrial dysfunction induced by \u03b1-synuclein accumulation in Parkinson\u2019s disease. PLoS ONE 8:e62277. https:\/\/doi.org\/10.1371\/journal.pone.0062277","journal-title":"PLoS ONE"},{"key":"1661_CR36","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.jalz.2016.03.015","volume":"12","author":"A Roses","year":"2016","unstructured":"Roses A, Sundseth S, Saunders A et al (2016) Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer\u2019s disease. Alzheimers Dement 12:687\u2013694. https:\/\/doi.org\/10.1016\/j.jalz.2016.03.015","journal-title":"Alzheimers Dement"},{"key":"1661_CR37","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1001\/archneurol.2010.88","volume":"67","author":"AD Roses","year":"2010","unstructured":"Roses AD (2010) An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Arch Neurol 67:536\u2013541. https:\/\/doi.org\/10.1001\/archneurol.2010.88","journal-title":"Arch Neurol"},{"key":"1661_CR38","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1038\/s41467-019-10945-z","volume":"10","author":"X Zhou","year":"2019","unstructured":"Zhou X, Chen Y, Mok KY et al (2019) Non-coding variability at the APOE locus contributes to the Alzheimer\u2019s risk. Nat Commun 10:3310. https:\/\/doi.org\/10.1038\/s41467-019-10945-z","journal-title":"Nat Commun"},{"key":"1661_CR39","doi-asserted-by":"publisher","first-page":"141.e1","DOI":"10.1016\/j.neurobiolaging.2019.11.007","volume":"87","author":"AM Kulminski","year":"2020","unstructured":"Kulminski AM, Shu L, Loika Y et al (2020) APOE region molecular signatures of Alzheimer\u2019s disease across races\/ethnicities. Neurobiol Aging 87:141.e1\u2013141.e8. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2019.11.007","journal-title":"Neurobiol Aging"},{"key":"1661_CR40","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.1132814","volume":"314","author":"M Goedert","year":"2006","unstructured":"Goedert M, Spillantini MG (2006) A century of Alzheimer\u2019s disease. Science 314:777\u2013781. https:\/\/doi.org\/10.1126\/science.1132814","journal-title":"Science"},{"key":"1661_CR41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jalz.2005.12.001","volume":"2","author":"AD Roses","year":"2006","unstructured":"Roses AD, Saunders AM (2006) Perspective on a pathogenesis and treatment of Alzheimer\u2019s disease. Alzheimer\u2019s Dementia 2:59\u201370. https:\/\/doi.org\/10.1016\/j.jalz.2005.12.001","journal-title":"Alzheimer\u2019s Dementia"},{"key":"1661_CR42","doi-asserted-by":"publisher","first-page":"731","DOI":"10.3233\/JAD-2012-120403","volume":"31","author":"D Seripa","year":"2012","unstructured":"Seripa D, Bizzarro A, Pilotto A et al (2012) TOMM40, APOE, and APOC1 in primary progressive aphasia and frontotemporal dementia. J Alzheimers Dis 31:731\u2013740. https:\/\/doi.org\/10.3233\/JAD-2012-120403","journal-title":"J Alzheimers Dis"},{"key":"1661_CR43","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.trci.2017.07.003","volume":"3","author":"A Nishimura","year":"2017","unstructured":"Nishimura A, Nonomura H, Tanaka S et al (2017) Characterization of APOE and TOMM40 allele frequencies in the Japanese population. Alzheimers Dement (N Y) 3:524\u2013530. https:\/\/doi.org\/10.1016\/j.trci.2017.07.003","journal-title":"Alzheimers Dement (N Y)"},{"key":"1661_CR44","doi-asserted-by":"publisher","first-page":"e0180356","DOI":"10.1371\/journal.pone.0180356","volume":"12","author":"L Yu","year":"2017","unstructured":"Yu L, Lutz MW, Wilson RS et al (2017) APOE epsilon4-TOMM40 \u2018523 haplotypes and the risk of Alzheimer\u2019s disease in older Caucasian and African Americans. PLoS ONE 12:e0180356. https:\/\/doi.org\/10.1371\/journal.pone.0180356","journal-title":"PLoS ONE"},{"key":"1661_CR45","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3233\/JPD-150693","volume":"6","author":"D Lindqvist","year":"2016","unstructured":"Lindqvist D, Prokopenko I, Londos E et al (2016) Associations between TOMM40 Poly-T repeat variants and Dementia in cases with Parkinsonism. J Parkinsons Dis 6:99\u2013108. https:\/\/doi.org\/10.3233\/JPD-150693","journal-title":"J Parkinsons Dis"},{"key":"1661_CR46","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/clpt.2012.222","volume":"93","author":"DG Crenshaw","year":"2013","unstructured":"Crenshaw DG, Gottschalk WK, Lutz MW et al (2013) Using genetics to enable studies on the prevention of Alzheimer\u2019s Disease. Clin PharmacolTher 93:177\u2013185. https:\/\/doi.org\/10.1038\/clpt.2012.222","journal-title":"Clin PharmacolTher"},{"key":"1661_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12920-018-0363-9","volume":"11","author":"J Liu","year":"2018","unstructured":"Liu J, Zhao W, Ware EB et al (2018) DNA methylation in the APOE genomic region is associated with cognitive function in African Americans. BMC Med Genomics 11:43. https:\/\/doi.org\/10.1186\/s12920-018-0363-9","journal-title":"BMC Med Genomics"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01661-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-020-01661-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01661-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T19:14:02Z","timestamp":1627413242000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-020-01661-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["1661"],"URL":"https:\/\/doi.org\/10.1007\/s40520-020-01661-6","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"6 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All human rights were respected.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human rights"}},{"value":"All subjects (or their legal guardians) provided written informed consent for their participation in the study, which was approved by the Medical Ethics Committee of Huashan Hospital, Fudan University, Shanghai, China.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants have signed written informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}