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A safety upper limit of 4000\u00a0IU\/day, which is consistently accepted, has been challenged, since the risk of adverse events in other systems than calcium-phosphate homeostasis may depend not only on the dose, but on the outcome, the treatment regimen, and possibly the age, sex and vitamin D status. The therapeutic window of vitamin D supplementation may be narrower than hitherto recognized. The prevention and\/or correction of vitamin D deficiency\/insufficiency with 800\u20131000\u00a0IU\/daily of vitamin D or 10\u00a0\u00b5g\/day of calcifediol are safe. Because of their potential harm, larger doses given on the long term or in intermittent regimens should not be selected.<\/jats:p>","DOI":"10.1007\/s40520-020-01678-x","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:02:54Z","timestamp":1598601774000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":110,"title":["Vitamin D supplementation: upper limit for safety revisited?"],"prefix":"10.1007","volume":"33","author":[{"given":"Ren\u00e9","family":"Rizzoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,28]]},"reference":[{"key":"1678_CR1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","volume":"96","author":"S Christakos","year":"2016","unstructured":"Christakos S, Dhawan P, Verstuyf A et al (2016) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. 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