{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:41:31Z","timestamp":1740170491728,"version":"3.37.3"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Netherlands Asthma Foundation, Leusden, The Netherlands","award":["[Grant 3.4.06.082]"],"award-info":[{"award-number":["[Grant 3.4.06.082]"]}]},{"name":"Proteion Thuis, Horn, The Netherlands"},{"name":"CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands"},{"name":"Stichting Wetenschapsbevordering Verpleeghuiszorg (SWBV), Utrecht, The Netherlands"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s40520-020-01711-z","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T13:02:10Z","timestamp":1600606930000},"page":"419-428","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Symptom-based clusters in patients with advanced chronic organ failure identify different trajectories of symptom variations"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-9223","authenticated-orcid":false,"given":"Panaiotis","family":"Finamore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy J. A.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos M. G. A.","family":"Schols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Els R. N.","family":"Verstraeten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Antonelli Incalzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiel F. M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn A.","family":"Spruit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"1711_CR1","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s11136-011-9892-9","volume":"20","author":"DJA Janssen","year":"2011","unstructured":"Janssen DJA, Franssen FME, Wouters EFM et al (2011) Impaired health status and care dependency in patients with advanced COPD or chronic heart failure. Qual Life Res 20:1679\u20131688","journal-title":"Qual Life Res"},{"key":"1711_CR2","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1136\/thorax.55.12.1000","volume":"55","author":"J Gore","year":"2000","unstructured":"Gore J, Brophy C, Greenstone M (2000) How well do we care for patients with end stage chronic obstructive pulmonary disease (COPD)? A comparison of palliative care and quality of life in COPD and lung cancer. Thorax 55:1000\u20131006","journal-title":"Thorax"},{"key":"1711_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/j.1365-2702.2007.01965.x","volume":"16","author":"D O\u2019Sullivan","year":"2007","unstructured":"O\u2019Sullivan D, McCarthy G (2007) An exploration of the relationship between fatigue and physical functioning in patients with end stage renal disease receiving haemodialysis. J Clin Nurs 16:276\u2013284","journal-title":"J Clin Nurs"},{"key":"1711_CR4","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1089\/jpm.2010.0479","volume":"14","author":"DJA Janssen","year":"2011","unstructured":"Janssen DJA, Spruit MA, Uszko-Lencer NH et al (2011) Symptoms, comorbidities, and health care in advanced chronic obstructive pulmonary disease or chronic heart failure. J Palliat Med 14:735\u2013743","journal-title":"J Palliat Med"},{"key":"1711_CR5","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jpainsymman.2005.06.007","volume":"31","author":"JP Solano","year":"2006","unstructured":"Solano JP, Gomes B, Higginson IJ (2006) A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symp Manage 31:58\u201369","journal-title":"J Pain Symp Manage"},{"key":"1711_CR6","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1001\/archinte.164.21.2321","volume":"164","author":"LM Walke","year":"2004","unstructured":"Walke LM, Gallo WT, Tinetti ME et al (2004) The burden of symptoms among community-dwelling older persons with advanced chronic disease. Arch Intern Med 164:2321\u20132324","journal-title":"Arch Intern Med"},{"key":"1711_CR7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1053\/j.ackd.2006.10.001","volume":"14","author":"FEM Murtagh","year":"2007","unstructured":"Murtagh FEM, Addington-Hall J, Higginson IJ (2007) The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis 14:82\u201399","journal-title":"Adv Chronic Kidney Dis"},{"key":"1711_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12904-016-0089-4","volume":"15","author":"N Siouta","year":"2016","unstructured":"Siouta N, van Beek K, Preston N et al (2016) Towards integration of palliative care in patients with chronic heart failure and chronic obstructive pulmonary disease: a systematic literature review of European guidelines and pathways. BMC Palliat Care 15:18","journal-title":"BMC Palliat Care"},{"key":"1711_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01549-5","author":"P Finamore","year":"2020","unstructured":"Finamore P, Spruit MA, Schols JMGA et al (2020) Clustering of patients with end-stage chronic diseases by symptoms: a new approach to identify health needs. Aging Clin Exp Res. https:\/\/doi.org\/10.1007\/s40520-020-01549-5","journal-title":"Aging Clin Exp Res"},{"key":"1711_CR10","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1111\/jocn.12526","volume":"23","author":"SK Park","year":"2014","unstructured":"Park SK, Larson JL (2014) Symptom cluster, healthcare use and mortality in patients with severe chronic obstructive pulmonary disease. J Clin Nurs 23:2658\u20132671","journal-title":"J Clin Nurs"},{"key":"1711_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1472-684X-7-5","volume":"7","author":"DJA Janssen","year":"2008","unstructured":"Janssen DJA, Wouters EFM, Schols JMGA et al (2008) Self-perceived symptoms and care needs of patients with severe to very severe chronic obstructive pulmonary disease, congestive heart failure or chronic renal failure and its consequences for their closest relatives: the research protocol. BMC Palliat Care 7:5","journal-title":"BMC Palliat Care"},{"key":"1711_CR12","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1378\/chest.10-1753","volume":"139","author":"DJA Janssen","year":"2011","unstructured":"Janssen DJA, Spruit MA, Schols JMGA et al (2011) A call for high-quality advance care planning in outpatients with severe COPD or chronic heart failure. Chest 139:1081\u20131088","journal-title":"Chest"},{"key":"1711_CR13","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1183\/09031936.05.00034805","volume":"26","author":"MR Miller","year":"2005","unstructured":"Miller MR, Hankinson J, Brusasco V et al (2005) Standardisation of spirometry. Eur Respir J 26:319\u2013338","journal-title":"Eur Respir J"},{"key":"1711_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1164\/rccm.201204-0596PP","volume":"187","author":"J Vestbo","year":"2013","unstructured":"Vestbo J, Hurd SS, Agust\u00ed AG et al (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187:347\u2013365","journal-title":"Am J Respir Crit Care Med"},{"key":"1711_CR15","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"P Ponikowski","year":"2016","unstructured":"Ponikowski P, Voors AA, Anker SD et al (2016) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 18:891\u2013975","journal-title":"Eur J Heart Fail"},{"key":"1711_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2010.483","volume":"80","author":"AS Levey","year":"2011","unstructured":"Levey AS, de Jong PE, Coresh J et al (2011) The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int 80:17\u201328","journal-title":"Kidney Int"},{"key":"1711_CR17","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383","journal-title":"J Chronic Dis"},{"key":"1711_CR18","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1177\/0269216308096906","volume":"22","author":"DJA Janssen","year":"2008","unstructured":"Janssen DJA, Spruit MA, Wouters EFM et al (2008) Daily symptom burden in end-stage chronic organ failure: a systematic review. Palliat Med 22:938\u2013948","journal-title":"Palliat Med"},{"key":"1711_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0304-3959(97)00005-5","volume":"72","author":"SL Collins","year":"1997","unstructured":"Collins SL, Moore RA, McQuay HJ (1997) The visual analogue pain intensity scale: what is moderate pain in millimetres? Pain 72:95\u201397","journal-title":"Pain"},{"key":"1711_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1002\/hec.858","volume":"13","author":"R Holland","year":"2004","unstructured":"Holland R, Smith RD, Harvey I et al (2004) Assessing quality of life in the elderly: a direct comparison of the EQ-5D and AQoL. Health Econ 13:793\u2013805","journal-title":"Health Econ"},{"key":"1711_CR21","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S0895-4356(98)00081-X","volume":"51","author":"JE Ware","year":"1998","unstructured":"Ware JE, Gandek B (1998) Overview of the SF-36 Health Survey and the International Quality of Life Assessment (IQOLA) Project. J Clin Epidemiol 51:903\u2013912","journal-title":"J Clin Epidemiol"},{"key":"1711_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0165-0327(02)00099-X","volume":"77","author":"ME Kruijshaar","year":"2003","unstructured":"Kruijshaar ME, Hoeymans N, Bijl RV et al (2003) Levels of disability in major depression: findings from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). J Affect Disord 77:53\u201364","journal-title":"J Affect Disord"},{"key":"1711_CR23","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cardfail.2015.09.018","volume":"22","author":"R Hwang","year":"2016","unstructured":"Hwang R, Morris NR, Mandrusiak A et al (2016) Timed up and go test: a reliable and valid test in patients with chronic heart failure. J Card Fail 22:646\u2013650","journal-title":"J Card Fail"},{"key":"1711_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/HCR.0000000000000143","volume":"36","author":"MA Al Haddad","year":"2016","unstructured":"Al Haddad MA, John M, Hussain S et al (2016) Role of the timed up and go test in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev 36:49\u201355","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"1711_CR25","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1046\/j.1440-172X.2002.00384.x","volume":"8","author":"A Dijkstra","year":"2002","unstructured":"Dijkstra A, Tiesinga LJ, Goossen WTF et al (2002) Further psychometric testing of the Dutch Care Dependency Scale on two different patient groups. Int J Nurs Pract 8:305\u2013314","journal-title":"Int J Nurs Pract"},{"key":"1711_CR26","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1378\/chest.127.1.328","volume":"127","author":"RD Stapleton","year":"2005","unstructured":"Stapleton RD, Nielsen EL, Engelberg RA et al (2005) Association of depression and life-sustaining treatment preferences in patients with COPD. Chest 127:328\u2013334","journal-title":"Chest"},{"key":"1711_CR27","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/1465-9921-13-85","volume":"13","author":"T Oga","year":"2012","unstructured":"Oga T, Tsukino M, Hajiro T et al (2012) Analysis of longitudinal changes in dyspnea of patients with chronic obstructive pulmonary disease: an observational study. Respir Res 13:85","journal-title":"Respir Res"},{"key":"1711_CR28","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.chest.2015.10.081","volume":"149","author":"AM Yohannes","year":"2016","unstructured":"Yohannes AM, M\u00fcllerov\u00e1 H, Hanania NA et al (2016) Long-term course of depression trajectories in patients With COPD: a 3-year follow-up analysis of the evaluation of COPD longitudinally to identify predictive surrogate endpoints cohort. Chest 149:916\u2013926","journal-title":"Chest"},{"key":"1711_CR29","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.jpainsymman.2015.06.016","volume":"50","author":"S Freeman","year":"2015","unstructured":"Freeman S, Hirdes JP, Stolee P et al (2015) Correlates and predictors of changes in dyspnea symptoms over time among community-dwelling palliative home care clients. J Pain Symp Manage 50:793\u2013805","journal-title":"J Pain Symp Manage"},{"key":"1711_CR30","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/eurjhf\/hfq075","volume":"12","author":"ORF Smith","year":"2010","unstructured":"Smith ORF, Kupper N, de Jonge P et al (2010) Distinct trajectories of fatigue in chronic heart failure and their association with prognosis. Eur J Heart Fail 12:841\u2013848","journal-title":"Eur J Heart Fail"},{"key":"1711_CR31","doi-asserted-by":"publisher","first-page":"689","DOI":"10.5301\/jn.5000042","volume":"25","author":"M Bossola","year":"2012","unstructured":"Bossola M, Ciciarelli C, Di Stasio E et al (2012) Symptoms of depression and anxiety over time in chronic hemodialysis patients. J Nephrol 25:689\u2013698","journal-title":"J Nephrol"},{"key":"1711_CR32","first-page":"488","volume":"29","author":"M-F Tsai","year":"2013","unstructured":"Tsai M-F, Hwang S-L, Tsay S-L et al (2013) Predicting trends in dyspnea and fatigue in heart failure patients\u2019 outcomes. Acta Cardiol Sin 29:488\u2013495","journal-title":"Acta Cardiol Sin"},{"key":"1711_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.cardfail.2011.04.016","volume":"17","author":"RL Dekker","year":"2011","unstructured":"Dekker RL, Lennie TA, Albert NM et al (2011) Depressive symptom trajectory predicts 1-year health-related quality of life in patients with heart failure. J Card Fail 17:755\u2013763","journal-title":"J Card Fail"},{"key":"1711_CR34","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.cardfail.2015.09.016","volume":"22","author":"N Kupper","year":"2016","unstructured":"Kupper N, Bonhof C, Westerhuis B et al (2016) Determinants of dyspnea in chronic heart failure. J Card Fail 22:201\u2013209","journal-title":"J Card Fail"},{"key":"1711_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1479972310369285","volume":"7","author":"DJA Janssen","year":"2010","unstructured":"Janssen DJA, Spruit MA, Leue C et al (2010) Symptoms of anxiety and depression in COPD patients entering pulmonary rehabilitation. Chron Respir Dis 7:147\u2013157","journal-title":"Chron Respir Dis"},{"key":"1711_CR36","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1111\/j.1365-2702.2010.03218.x","volume":"19","author":"L-H Chen","year":"2010","unstructured":"Chen L-H, Li C-Y, Shieh S-M et al (2010) Predictors of fatigue in patients with heart failure. J Clin Nurs 19:1588\u20131596","journal-title":"J Clin Nurs"},{"key":"1711_CR37","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jpainsymman.2010.11.005","volume":"42","author":"AL Cheville","year":"2011","unstructured":"Cheville AL, Novotny PJ, Sloan JA et al (2011) The value of a symptom cluster of fatigue, dyspnea, and cough in predicting clinical outcomes in lung cancer survivors. J Pain Symp Manage 42:213\u2013221","journal-title":"J Pain Symp Manage"},{"key":"1711_CR38","doi-asserted-by":"publisher","first-page":"2731","DOI":"10.1002\/cam4.860","volume":"5","author":"PC Barata","year":"2016","unstructured":"Barata PC, Cardoso A, Custodio MP et al (2016) Symptom clusters and survival in Portuguese patients with advanced cancer. Cancer Med 5:2731\u20132739","journal-title":"Cancer Med"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01711-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-020-01711-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-020-01711-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T23:31:31Z","timestamp":1632094291000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-020-01711-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,20]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["1711"],"URL":"https:\/\/doi.org\/10.1007\/s40520-020-01711-z","relation":{},"ISSN":["1720-8319"],"issn-type":[{"type":"electronic","value":"1720-8319"}],"subject":[],"published":{"date-parts":[[2020,9,20]]},"assertion":[{"value":"10 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"DJAJ, MAS, JMGAS, EFMW, PF participated in the study concept and design, ERNV performed data collection, PF performed data analysis, DJAJ, MAS, JMGAS, EFMW and RAI reviewed the manuscript for important intellectual content. All the authors fulfill authorship criteria, have revised the final version of the manuscript and gave their consent to publication. EFMW, MAS, DJAJ report personal fees outside from the submitted work; the other Authors deny any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study conforms to the principles outlined in the Declaration of Helsinki. Its protocol was approved by the Ethical Commission of the Maastricht University Medical Centre\u2009+\u2009(MEC 07\u20133-054). The study was registered in the Dutch Trial Register (NTR 1552).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research involving human participants and\/or animals"}},{"value":"All the study participants provided oral and written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}