{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:59:23Z","timestamp":1781128763016,"version":"3.54.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>At present, although cholecalciferol represents the form of vitamin D of choice for the treatment of vitamin D deficiency, there is a growing interest in calcifediol.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>This study aimed to evaluate the efficacy and the safety of two different daily doses of calcifediol.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty osteopenic\/osteoporotic women with serum levels of 25-hydroxyvitamin D (25OHD) between 10 and 20\u00a0ng\/ml were randomized to a 6-month treatment with oral calcifediol 20\u00a0\u00b5g\/day (<jats:italic>n<\/jats:italic>\u2009=\u200925) or oral calcifediol 30\u00a0\u00b5g\/day (<jats:italic>n<\/jats:italic>\u2009=\u200925). In all, we measured the time course of the levels of 25OHD and other biochemical parameters. Moreover, we evaluated handgrip strength and serum levels of myostatin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The peak increase in 25OHD levels was reached after 90\u00a0days of treatment in group 1 (59.3\u00a0ng\/ml) and after only 60\u00a0days in group 2 (72.3\u00a0ng\/ml); thereafter in both groups, the levels of 25OHD showed a tendency towards stabilization. After 30\u00a0days, all the patients treated with 30\u00a0\u00b5g\/day had values of 25OHD\u2009&gt;\u200930\u00a0ng\/ml. Handgrip strength showed a modest but progressive increase which reached the statistical significance in the 30\u00a0\u00b5g\/day group. This latter group also presented a modest and non-significant decrease in serum levels of myostatin.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Calcifediol is able to rapidly normalize the vitamin D deficiency, and the 30\u00a0\u00b5g daily dosage could be suggested in those patients who need to rapidly reach optimal 25OHD levels. Moreover, the 6-month treatment with calcifediol at a dose of 30\u00a0\u00b5g results in a modest but significant increase in upper limb strength.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-020-01779-7","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T02:08:56Z","timestamp":1611799736000},"page":"2539-2547","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetic profile and effect on bone markers and muscle strength of two daily dosage regimens of calcifediol in osteopenic\/osteoporotic postmenopausal women"],"prefix":"10.1007","volume":"33","author":[{"given":"Stefano","family":"Gonnelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dea","family":"Tomai Pitinca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Camarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Lucani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Franci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranuccio","family":"Nuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Caffarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"1779_CR1","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. 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