{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:24:47Z","timestamp":1789496687172,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ20H170002"],"award-info":[{"award-number":["LQ20H170002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s40520-021-01963-3","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T07:05:56Z","timestamp":1630047956000},"page":"715-724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Meta-analysis of clinical trials focusing on hypertonic dextrose prolotherapy (HDP) for knee osteoarthritis"],"prefix":"10.1007","volume":"34","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Tian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang Chao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8799-7178","authenticated-orcid":false,"given":"Tao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"1963_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.berh.2014.01.004","volume":"28","author":"VL Johnson","year":"2014","unstructured":"Johnson VL, Hunter DJ (2014) The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol 28:5\u201315. https:\/\/doi.org\/10.1016\/j.berh.2014.01.004","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"1963_CR2","doi-asserted-by":"publisher","first-page":"CD005321","DOI":"10.1002\/14651858.CD005321.pub2","volume":"19","author":"N Bellamy","year":"2006","unstructured":"Bellamy N, Campbell J, Robinson V et al (2006) Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 19:CD005321. https:\/\/doi.org\/10.1002\/14651858.CD005321.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"1963_CR3","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1093\/rheumatology\/kes368","volume":"52","author":"N Maricar","year":"2013","unstructured":"Maricar N, Callaghan MJ, Felson DT et al (2013) Predictors of response to intra-articular steroid injections in knee osteoarthritisd: a systematic review. Rheumatology 52:1022\u20131032. https:\/\/doi.org\/10.1093\/rheumatology\/kes368","journal-title":"Rheumatology"},{"key":"1963_CR4","doi-asserted-by":"publisher","first-page":"CD003115","DOI":"10.1002\/14651858.CD003115.pub4","volume":"4","author":"E Nuesch","year":"2009","unstructured":"Nuesch E, Rutjes AWS, Husni E et al (2009) Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev 4:CD003115. https:\/\/doi.org\/10.1002\/14651858.CD003115.pub4","journal-title":"Cochrane Database Syst Rev"},{"key":"1963_CR5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/194318","volume":"2014","author":"B Kristj\u00e1nsson","year":"2014","unstructured":"Kristj\u00e1nsson B, Honsawek S (2014) Current perspectives in mesenchymal stem cell therapies for osteoarthritis. Stem Cells Int 2014:194318. https:\/\/doi.org\/10.1155\/2014\/194318","journal-title":"Stem Cells Int"},{"key":"1963_CR6","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.pmr.2016.06.001","volume":"27","author":"KD Reeves","year":"2016","unstructured":"Reeves KD, Sit RWS, Rabago DP (2016) Dextrose prolotherapy: a narrative review of basic science, clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am 27:783\u2013823. https:\/\/doi.org\/10.1016\/j.pmr.2016.06.001","journal-title":"Phys Med Rehabil Clin N Am"},{"key":"1963_CR7","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3109\/15360288.2012.734900","volume":"26","author":"A Goswami","year":"2012","unstructured":"Goswami A (2012) Prolotherapy. J Pain Palliat Care Pharmacother 26:376\u2013378. https:\/\/doi.org\/10.3109\/15360288.2012.734900","journal-title":"J Pain Palliat Care Pharmacother"},{"key":"1963_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1053\/j.trap.2011.05.002","volume":"15","author":"DM DeChellis","year":"2011","unstructured":"DeChellis DM, Cortazzo MH (2011) Regenerative medicine in the field of pain medicine: prolotherapy, platelet-rich plasma, and stem cell therapy-theory and evidence. Tech Reg Anesth Pain Manag 15:74\u201380. https:\/\/doi.org\/10.1053\/j.trap.2011.05.002","journal-title":"Tech Reg Anesth Pain Manag"},{"key":"1963_CR9","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1016\/j.pmrj.2015.02.005","volume":"7","author":"K Mautner","year":"2015","unstructured":"Mautner K, Malanga GA, Smith J et al (2015) A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature. PMR 7:S53\u2013S59. https:\/\/doi.org\/10.1016\/j.pmrj.2015.02.005","journal-title":"PMR"},{"key":"1963_CR10","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1177\/0363546515582027","volume":"43","author":"G Filardo","year":"2015","unstructured":"Filardo G, Di Matteo B, Di Martino A et al (2015) Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med 43:1575\u20131582. https:\/\/doi.org\/10.1177\/0363546515582027","journal-title":"Am J Sports Med"},{"key":"1963_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.pop.2009.09.013","volume":"37","author":"D Rabago","year":"2010","unstructured":"Rabago D, Slattengren A, Zgierska A (2010) Prolotherapy in primary care practice. Prim Care 37:65\u201380. https:\/\/doi.org\/10.1016\/j.pop.2009.09.013","journal-title":"Prim Care"},{"key":"1963_CR12","doi-asserted-by":"publisher","first-page":"264","DOI":"10.7326\/0003-4819-151-4-200908180-00135","volume":"151","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:264\u2013269. https:\/\/doi.org\/10.7326\/0003-4819-151-4-200908180-00135","journal-title":"Ann Intern Med"},{"key":"1963_CR13","doi-asserted-by":"publisher","first-page":"243","DOI":"10.18502\/ijaai.v19i3.3452","volume":"19","author":"A Pishgahi","year":"2020","unstructured":"Pishgahi A, Abolhasan R, Kazem S et al (2020) Effect of dextrose prolotherapy, platelet rich plasma and autologous conditioned serum on knee osteoarthritis: a randomized clinical trial. Iran J Allergy Asthma Immunol 19:243\u2013252. https:\/\/doi.org\/10.18502\/ijaai.v19i3.3452","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"1963_CR14","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/CIA.S147757","volume":"13","author":"R Poupak","year":"2018","unstructured":"Poupak R, Farnad I, Reza FSH et al (2018) The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis. Clin Interv Aging 13:73\u201379. https:\/\/doi.org\/10.2147\/CIA.S147757","journal-title":"Clin Interv Aging"},{"key":"1963_CR15","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1089\/acm.2013.0225","volume":"20","author":"D Rabago","year":"2014","unstructured":"Rabago D, Patterson JJ, Mundt M et al (2014) Dextrose and morrhuate sodium injections (prolotherapy) for knee osteoarthritis: a prospective open-label trial. J Altern Complement Med 20:383. https:\/\/doi.org\/10.1089\/acm.2013.0225","journal-title":"J Altern Complement Med"},{"key":"1963_CR16","first-page":"187","volume":"14","author":"J Higgins","year":"2011","unstructured":"Higgins J, Green S (2011) Cochrane handbook for systematic reviews of interventions. Cochrane Book Series 14:187\u2013241","journal-title":"Cochrane Book Series"},{"key":"1963_CR17","first-page":"1833","volume":"15","author":"N Bellamy","year":"1988","unstructured":"Bellamy N, Buchanan WW, Goldsmith CH et al (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833\u20131840","journal-title":"J Rheumatol"},{"key":"1963_CR18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1477-7525-1-64","volume":"1","author":"EM Roos","year":"2003","unstructured":"Roos EM, Lohmander LS (2003) The knee injury and osteoarthritis outcome score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes 1:64. https:\/\/doi.org\/10.1186\/1477-7525-1-64","journal-title":"Health Qual Life Outcomes"},{"key":"1963_CR19","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/j.1526-4637.2012.01422.x","volume":"13","author":"R Dumais","year":"2012","unstructured":"Dumais R, Benoit C, Dumais A et al (2012) Effect of regenerative injection therapy on function and pain in patients with knee osteoarthritis: a randomized crossover study. Pain Med 13:990\u2013999. https:\/\/doi.org\/10.1111\/j.1526-4637.2012.01422.x","journal-title":"Pain Med"},{"key":"1963_CR20","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1370\/afm.1504","volume":"11","author":"D Rabago","year":"2013","unstructured":"Rabago D, Jeffrey J, Patterson J, Marlon M et al (2013) Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Ann Fam Med 11:229\u2013237. https:\/\/doi.org\/10.1370\/afm.1504","journal-title":"Ann Fam Med"},{"key":"1963_CR21","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1097\/MRR.0000000000000411","volume":"43","author":"Z Rezasoltani","year":"2020","unstructured":"Rezasoltani Z, Azizi S, Najafi S et al (2020) Physical therapy, intra-articular dextrose prolotherapy, botulinum neurotoxin, and hyaluronic acid for knee osteoarthritis: randomized clinical trial. Int J Rehabil Res 43:219\u2013227. https:\/\/doi.org\/10.1097\/MRR.0000000000000411","journal-title":"Int J Rehabil Res"},{"key":"1963_CR22","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1089\/acm.2019.0335","volume":"26","author":"AT Sert","year":"2020","unstructured":"Sert AT, Sen EI, Esmaeilzadeh S et al (2020) The effects of dextrose prolotherapy in symptomatic knee osteoarthritis: a randomized controlled study. J Altern Complement Med 26:409\u2013417. https:\/\/doi.org\/10.1089\/acm.2019.0335","journal-title":"J Altern Complement Med"},{"key":"1963_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1370\/afm.2520","volume":"183","author":"RWS Sit","year":"2020","unstructured":"Sit RWS, Wu RWK, Rabago D et al (2020) Efficacy of intra-articular hypertonic dextrose (prolotherapy) for knee osteoarthritis: a randomized controlled trial. Ann Fam Med 183:235\u2013242. https:\/\/doi.org\/10.1370\/afm.2520","journal-title":"Ann Fam Med"},{"key":"1963_CR24","first-page":"2635","volume":"27","author":"E Ehrich","year":"2000","unstructured":"Ehrich E, Davies G, Watson D et al (2000) Minimal perceptible clinical improvement with the Western Ontario and McMaster Universities osteoarthritis index questionnaire and global assessments in patients with osteoarthritis. J Rheumatol 27:2635\u20132641","journal-title":"J Rheumatol"},{"key":"1963_CR25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1093\/bmb\/lds038","volume":"105","author":"A Litwic","year":"2013","unstructured":"Litwic A, Edwards MH, Dennison EM et al (2013) Epidemiology and burden of osteoarthritis. Br Med Bull 105:185\u2013199. https:\/\/doi.org\/10.1093\/bmb\/lds038","journal-title":"Br Med Bull"},{"key":"1963_CR26","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1002\/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V","volume":"41","author":"RC Lawrence","year":"1998","unstructured":"Lawrence RC, Helmick CG, Arnett FC et al (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41:778\u2013799. https:\/\/doi.org\/10.1002\/1529-0131(199805)41:5%3c778::AID-ART4%3e3.0.CO;2-V","journal-title":"Arthritis Rheum"},{"key":"1963_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/art.23176","volume":"58","author":"RC Lawrence","year":"2008","unstructured":"Lawrence RC, Felson DT, Helmick CG et al (2008) National Arthritis Data Workgroup. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II Arthritis Rheum 58:26\u201335. https:\/\/doi.org\/10.1002\/art.23176","journal-title":"Part II Arthritis Rheum"},{"key":"1963_CR28","doi-asserted-by":"publisher","first-page":"25247","DOI":"10.1038\/srep25247","volume":"6","author":"RW Sit","year":"2016","unstructured":"Sit RW, Chung VCh, Reeves KD et al (2016) Hypertonic dextrose injections (prolotherapy) in the treatment of symptomatic knee osteoarthritis: a systematic review and meta-analysis. Sci Rep 6:25247. https:\/\/doi.org\/10.1038\/srep25247","journal-title":"Sci Rep"},{"key":"1963_CR29","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s42358-019-0083-7","volume":"59","author":"PI Arias-V\u00e1zquez","year":"2019","unstructured":"Arias-V\u00e1zquez PI, Tovilla-Z\u00e1rate CA, Legorreta-Ram\u00edrez BG et al (2019) Prolotherapy for knee osteoarthritis using hypertonic dextrose vs other interventional treatments: systematic review of clinical trials. Adv Rheumatol 59:39. https:\/\/doi.org\/10.1186\/s42358-019-0083-7","journal-title":"Adv Rheumatol"},{"key":"1963_CR30","doi-asserted-by":"publisher","first-page":"S208","DOI":"10.1002\/acr.20632","volume":"63","author":"NJ Collins","year":"2011","unstructured":"Collins NJ, Misra D, Felson DT et al (2011) Measures of knee function: International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Knee Injury and Osteoarthritis Outcome Score (KOOS), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Knee Outcome Survey Activities of Daily Living Scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Activity Rating Scale (ARS), and Tegner Activity Score (TAS). Arthritis Care Res (Hoboken) 63:S208\u2013S228. https:\/\/doi.org\/10.1002\/acr.20632","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"1963_CR31","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2147\/JPR.S127633","volume":"10","author":"Z Rezasoltani","year":"2017","unstructured":"Rezasoltani Z, Taheri M, Mofrad MK et al (2017) Periarticular dextrose prolotherapy instead of intra-articular injection for pain and functional improvement in knee osteoarthritis. J Pain Res 10:1179\u20131187. https:\/\/doi.org\/10.2147\/JPR.S127633","journal-title":"J Pain Res"},{"key":"1963_CR32","doi-asserted-by":"publisher","first-page":"R8","DOI":"10.1186\/ar2114","volume":"9","author":"YS Park","year":"2007","unstructured":"Park YS, Lim SW, Lee IH et al (2007) Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial. Arthritis Res Ther 9:R8. https:\/\/doi.org\/10.1186\/ar2114","journal-title":"Arthritis Res Ther"},{"key":"1963_CR33","first-page":"173","volume":"30","author":"SA Kim","year":"2006","unstructured":"Kim SA, Kim EH, Kim SY et al (2006) The effects of hyperosmolar dextrose and autologous serum injection in the experimental articular defect of rabbit. J Kor Acad Rehabil Med 30:173\u2013178","journal-title":"J Kor Acad Rehabil Med"},{"key":"1963_CR34","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/tox.22618","volume":"33","author":"TJ Wu","year":"2018","unstructured":"Wu TJ, Lin CY, Tsai CH et al (2018) Glucose suppresses IL-1\u03b2-induced MMP-1 expression through the FAK, MEK, ERK, and AP-1 signaling pathways. Environ Toxicol 33:1061\u20131068. https:\/\/doi.org\/10.1002\/tox.22618","journal-title":"Environ Toxicol"},{"key":"1963_CR35","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.neuron.2006.04.032","volume":"50","author":"D Burdakov","year":"2006","unstructured":"Burdakov D, Jensen LT, Alexopoulos H et al (2006) Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron 50:711\u2013722. https:\/\/doi.org\/10.1016\/j.neuron.2006.04.032","journal-title":"Neuron"},{"key":"1963_CR36","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.neulet.2015.11.051","volume":"612","author":"U Breitinger","year":"2016","unstructured":"Breitinger U, Breitinger HG (2016) Augmentation of glycine receptor alpha3 currents suggests a mechanism for glucose-mediated analgesia. Neurosci Lett 612:110\u2013115. https:\/\/doi.org\/10.1016\/j.neulet.2015.11.051","journal-title":"Neurosci Lett"},{"key":"1963_CR37","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1002\/jor.20600","volume":"26","author":"KT Jensen","year":"2008","unstructured":"Jensen KT, Rabago DP, Best TM et al (2008) Early inflammatory response of knee ligaments to prolotherapy in a rat model. J Orthop Res 26:816\u2013823. https:\/\/doi.org\/10.1002\/jor.20600","journal-title":"J Orthop Res"},{"key":"1963_CR38","first-page":"16","volume":"10","author":"J Lyftogt","year":"2005","unstructured":"Lyftogt J (2005) Prolotherapy and achilles tendinopathy: a prospective pilot study of an old treatment. Aust Musculoskelet Med 10:16\u201319","journal-title":"Aust Musculoskelet Med"},{"issue":"17","key":"1963_CR39","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1001\/jama.2010.520","volume":"303","author":"JV Robertde","year":"2010","unstructured":"Robertde JV, Johannes LT, Jan ANV (2010) Platelet-rich plasma for treatment of achilles tendinopathy. JAMA 303:1696\u20131697","journal-title":"JAMA"},{"key":"1963_CR40","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s11926-017-0659-3","volume":"19","author":"D Rabago","year":"2017","unstructured":"Rabago D, Nourani B (2017) Prolotherapy for osteoarthritis and tendinopathy: a descriptive review. Curr Rheumatol Rep 19:34. https:\/\/doi.org\/10.1007\/s11926-017-0659-3","journal-title":"Curr Rheumatol Rep"},{"key":"1963_CR41","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1089\/acm.2011.0030","volume":"18","author":"D Rabago","year":"2012","unstructured":"Rabago D, Zgierska A, Fortney L et al (2012) Hypertonic dextrose injections (prolotherapy) for knee osteoarthritis: results of a single-arm uncontrolled study with 1-year follow-up. J Alternative Complement Med 18:408\u2013414. https:\/\/doi.org\/10.1089\/acm.2011.0030","journal-title":"J Alternative Complement Med"},{"key":"1963_CR42","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ctim.2015.04.003","volume":"23","author":"D Rabago","year":"2015","unstructured":"Rabago D, Mundt M, Zgierska A et al (2015) Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: long term outcomes. Complement Ther Med 23:388\u2013395. https:\/\/doi.org\/10.1016\/j.ctim.2015.04.003","journal-title":"Complement Ther Med"},{"key":"1963_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.ijsu.2017.01.087","volume":"39","author":"WW He","year":"2017","unstructured":"He WW, Kuang MJ, Zhao J et al (2017) Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: a meta-analysis. Int J Surg (London, England) 39:95\u2013103. https:\/\/doi.org\/10.1016\/j.ijsu.2017.01.087","journal-title":"Int J Surg (London, England)"},{"key":"1963_CR44","first-page":"37","volume":"2","author":"M Hashemi","year":"2017","unstructured":"Hashemi M, Khameneh SMH, Dadkhah P et al (2017) Effect of intraarticular injection of ozone on inflammatory cytokines in knee osteoarthritis. J Cellular Molecul Anesth 2:37\u201342","journal-title":"J Cellular Molecul Anesth"},{"key":"1963_CR45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13018-017-0521-3","volume":"12","author":"L Shen","year":"2017","unstructured":"Shen L, Yuan T, Chen S et al (2017) The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res 12:16. https:\/\/doi.org\/10.1186\/s13018-017-0521-3","journal-title":"J Orthop Surg Res"},{"key":"1963_CR46","doi-asserted-by":"publisher","first-page":"8909","DOI":"10.4081\/ejtm.2019.8909","volume":"30","author":"C Pirri","year":"2020","unstructured":"Pirri C, Stecco A, Fede C et al (2020) Ultrasound imaging of a scar on the knee: sonopalpation for fascia and subcutaneous tissues. Eur J Transl Myol 30:8909. https:\/\/doi.org\/10.4081\/ejtm.2019.8909","journal-title":"Eur J Transl Myol"},{"issue":"68\u201374","key":"1963_CR47","first-page":"7","volume":"6","author":"KD Reeves","year":"2000","unstructured":"Reeves KD, Hassanein K (2000) Randomized prospective double-blind placebocontrolled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity. Altern Ther Health Med 6:68-74:77\u201380","journal-title":"Altern Ther Health Med"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-021-01963-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-021-01963-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-021-01963-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:20:01Z","timestamp":1651882801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-021-01963-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["1963"],"URL":"https:\/\/doi.org\/10.1007\/s40520-021-01963-3","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]},"assertion":[{"value":"29 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We declare that the manuscript has not been and will not be submitted elsewhere for publication. All authors declare no conflicts of interest. All authors have participated sufficiently to take public responsibility for this work and agreed to its submission Aging Clin Exp Res<i>.<\/i>","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"This is meta-analysis study without any Human Participants and\/or Animals. The Sir Run Shaw Hospital Research Ethics Committee has confirmed that no ethical approval is required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This is meta-analysis study. Informed consent is not necessary to obtain in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}