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Parkinson\u2019s disease (PD) is a neurodegenerative disorder characterized by loss of the dopaminergic neurons, accompanied by chronic inflammation and neuroinflammation. Previous research shows that interval training can bring a beneficial effect on the inflammation and neuroplasticity in PD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>The objective of this study was to investigate the effect of 12\u00a0weeks of HIIT on the inflammation levels and antioxidant capacity in the serum of PD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-eight people diagnosed with PD were enrolled in this study. Fifteen PD patients performed 12\u00a0weeks of HIIT on a cycloergometer. Thirteen non-exercised PD patients constitute the control group. Concentrations of inflammation markers and antioxidants\u2019 capacity in the serum were measured at 3 sampling points (a week before, a week after, and 3\u00a0months after the HIIT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Twelve weeks of HIIT decreases the level of TNF-\u03b1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.034) and increases the level of IL-10 (<jats:italic>p<\/jats:italic>\u2009=\u20090.024). Those changes were accompanied by a\u00a0decreased level of neutrophils (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), neutrophil\/lymphocyte ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.048) and neutrophil\/monocyte ratio (<jats:italic>p<\/jats:italic>\u2009=\u20090.0049) with increases in superoxide dismutase levels (<jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Twelve weeks of HIIT can decrease systemic inflammation in PD patients and improve the antioxidant capacity in their serum, which can slow down the progression\u00a0of the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-022-02153-5","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T05:02:38Z","timestamp":1655182958000},"page":"2165-2176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["High-intensity interval training modulates inflammatory response in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5461-7036","authenticated-orcid":false,"given":"Paulina","family":"Malczynska-Sims","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Chalimoniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Wronski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw","family":"Marusiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sulek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"2153_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb07458.x","volume":"991","author":"S Fahn","year":"2003","unstructured":"Fahn S (2003) Description of Parkinson\u2019s disease as a clinical syndrome. 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