{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:57:28Z","timestamp":1785891448104,"version":"3.56.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Italian Ministry of Health"},{"DOI":"10.13039\/501100002954","name":"Universit\u00e0 degli Studi di Milano - Bicocca","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002954","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>This study compares the performance at the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) across the healthy adult lifespan in an Italian population sample.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The MMSE and MoCA were administered to 407 Italian healthy native-speakers (165 males; age <jats:italic>range<\/jats:italic>\u200920\u201393\u00a0years; education range\u20094\u201325\u00a0years). A generalized Negative Binomial mixed model was run to profile MMSE and MoCA scores across 8 different age classes (\u2264\u200930; 31\u201340; 41\u201350; 51\u201360; 61\u201370; 71\u201380; 81\u201385;\u2009\u2265\u200986) net of education and sex.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>MMSE and MoCA total scores declined with age (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), with the MoCA proving to be \u201cmore difficult\u201d than the MMSE (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The <jats:italic>Age<\/jats:italic>*<jats:italic>Test<\/jats:italic> interaction (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) indicates that the MoCA proved to profile a sufficiently linear involutional trend in cognition with advancing age and to be able to detect poorer cognitive performances in individuals aged\u2009\u2265\u200971\u00a0years. By contrast, MMSE scores failed in capturing the expected age-related trajectory, reaching a plateau in the aforementioned age classes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The MoCA seems to be more sensitive than the MMSE in detecting age-related physiological decline of cognitive functioning across the healthy adult lifespan. The MoCA might be therefore more useful than the MMSE as a test for general cognitive screening aims.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-022-02174-0","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T16:02:32Z","timestamp":1656777752000},"page":"2417-2420","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Trajectories of MMSE and MoCA scores across the healthy adult lifespan in the Italian population"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-7733","authenticated-orcid":false,"given":"Edoardo Nicol\u00f2","family":"Aiello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Pasotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildebrando","family":"Appollonio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Bolognini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"2174_CR1","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s12603-010-0268-6","volume":"14","author":"J Bond","year":"2010","unstructured":"Bond J, Graham N, Padovani A et al (2010) Screening for cognitive impairment, Alzheimer\u2019s disease and other dementias: opinions of European caregivers, payors, physicians and the general public. 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