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However, the relationship between dietary acrylamide and osteoporotic fractures has been explored by a few\u00a0cross-sectional studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>To investigate if dietary acrylamide is associated with the onset of fractures in North American participants at high risk\/having knee osteoarthritis (OA), over 8\u00a0years of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A Cox\u2019s regression analysis, adjusted for baseline confounders was run and the data were reported as hazard ratios (HRs) and 95% confidence intervals (CIs). Dietary acrylamide intake was assessed at the baseline using a food frequency questionnaire\u00a0and categorized in tertiles (T), whilst fractures\u2019 history was recorded using self-reported information.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Altogether, 4,436 participants were included. Compared to participants with lower acrylamide intake (T1;\u2009&lt;\u20093,313\u00a0\u03bcg), those with a higher acrylamide intake (T3;\u2009&gt;\u200910,180\u00a0\u03bcg) reported a significantly higher risk of any fracture (HR\u2009=\u20091.37; 95% CI 1.12\u20131.68; <jats:italic>p<\/jats:italic> for trend\u2009=\u20090.009), forearm (HR\u2009=\u20091.73; 95% CI 1.09\u20132.77; <jats:italic>p<\/jats:italic> for trend\u2009=\u20090.04), spine (HR\u2009=\u20092.21; 95% CI 1.14\u20134.31; <jats:italic>p<\/jats:italic> for trend\u2009=\u20090.04), and hip fracture (HR\u2009=\u20094.09; 95% CI 1.29\u201312.96; <jats:italic>p<\/jats:italic> for trend\u2009=\u20090.046).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our study is the first to report that high dietary acrylamide may be associated with an increased risk of osteoporotic fractures.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-022-02214-9","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T14:02:42Z","timestamp":1660399362000},"page":"2441-2448","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary acrylamide and incident osteoporotic fractures: an 8-year prospective cohort study"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-289X","authenticated-orcid":false,"given":"Nicola","family":"Veronese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bolzetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Cester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Demurtas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e8","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Gabriella","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Notarnicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Reginster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Barbagallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Trott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia J.","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"2214_CR1","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1038\/419449a","volume":"419","author":"RH Stadler","year":"2002","unstructured":"Stadler RH, Blank I, Varga N et al (2002) Acrylamide from Maillard reaction products. 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These authors reported that these grants and personal fees are outside the submitted work. The other authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the OAI Coordinating Center, at University of California in San Francisco.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consent was obtained from all subjects involved in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}