{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:24:01Z","timestamp":1792783441196,"version":"4.5.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"General Research Plan of Zhejiang Provincial Medical and Health Science and Technology Program","award":["2016KYA042"],"award-info":[{"award-number":["2016KYA042"]}]},{"name":"General Project of the Zhejiang Provincial Health Science and Technology Plan","award":["2021KY546"],"award-info":[{"award-number":["2021KY546"]}]},{"name":"General Project of the Zhejiang Provincial Health Science and Technology Plan","award":["2021KY548"],"award-info":[{"award-number":["2021KY548"]}]},{"name":"Zhejiang Provincial Health Science and Technology Program Young Innovative Talents Project","award":["2022RC015"],"award-info":[{"award-number":["2022RC015"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postoperative delirium (POD) is a common clinical complication in elderly patients after surgery and predicts poor outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We researched whether postoperative infusion of dexmedetomidine (DEX) had prophylactic effect on POD in elderly patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 236 patients over the age of 60\u00a0years undergoing thoracoabdominal tumor surgery were enrolled in Zhejiang Cancer Hospital from November 2016 to October 2020. The patients were randomly assigned into DEX group (group D) and control group (Group C). DEX was provided via PCIA pump 1\u20133\u00a0days after surgery, which consisted of 3 ug\/kg sufentanil and 3 ug\/kg DEX in group D, and 3 ug\/kg sufentanil without DEX in group C. The PCIA parameters were programmed as follows: total amount 150\u00a0ml, 2\u00a0ml bolus dose with a lock-out of 10\u00a0min and background infusion rate 2\u00a0ml\/h. The primary endpoint was the incidence of POD, assessed twice daily within 7\u00a0days after surgery by Richmond Agitation-Sedation Scale (RASS) and the Confusion Assessment Method\u2013Intensive Care Unit (CAM-ICU). The secondary endpoint was postoperative hospitalization days, ICU stay time, adverse events and non-delirium complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The incidence of POD in all patients was 7%. The incidence of POD in group C was significantly higher than that in group D (10.1% vs 3.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.042). There were no significant differences in length of hospital stay after operation, ICU stay time, the percentage of patients discharged within 7\u00a0days after surgery, non-delirium complications, and 30-day all-cause deaths between the two groups. The incidence of hypertension in group D was lower than that in group C (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.003), and there were no differences in other adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients aged over 60\u00a0years received DEX in addition to intravenous patient-controlled analgesia (PCIA) for major thoracoabdominal surgery experienced less delirium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40520-023-02497-6","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T10:12:46Z","timestamp":1689847966000},"page":"2137-2144","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Postoperative infusion of dexmedetomidine via intravenous patient-controlled analgesia for prevention of postoperative delirium in elderly patients undergoing surgery"],"prefix":"10.1007","volume":"35","author":[{"given":"Kangjie","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0490-5726","authenticated-orcid":false,"given":"Huidan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"2497_CR1","doi-asserted-by":"publisher","unstructured":"Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS, Oh ES, Crosby G, Berger M, Eckenhoff RG, The Nomenclature Consensus Working Group (2018) Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. 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