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Thereafter, we have selected eight candidate hsa-miRNAs according to the NGS results and after a critical assessment of previous literature. In a validation phase and by real-time qPCR, we then analyzed the expression levels of these 8 hsa-miRNAs at baseline selecting 92 healthy subjects (74.2\u2009\u00b1\u200910\u00a0years) and 92 subjects with sarcopenia (75.3\u2009\u00b1\u20096.8\u00a0years). For both steps, the groups were matched for age and sex.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In the validation phase, serum has-miRNA-133a-3p and has-miRNA-200a-3p were significantly decreased in the group with sarcopenia vs controls [RQ: relative quantification; median (interquartile range)]: \u22120.16 (\u22121.26\/+0.90) vs +0.34 (\u22120.73\/+1.33) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and \u22120.26 (\u22121.07\/+0.68) vs +0.27 (\u22120.55\/+1.10) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) respectively. Has-miRNA-744-5p was decreased and has-miRNA-151a-3p was increased in the group with sarcopenia vs controls, but this barely reached significance:\u2009+0.16 (\u22121.34\/+0.79) vs +0.44 (\u22120.31\/+1.00) (<jats:italic>p<\/jats:italic>\u2009=\u20090.050) and \u2009+0.35 (\u22120.22\/+0.90) vs \u2009+0.03 (\u22120.68\/+0.75) (<jats:italic>p<\/jats:italic>\u2009=\u20090.054).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In subjects with sarcopenia, serum hsa-miRNA-133a-3p and hsa-miRNA-200a-3p expression were downregulated, consistent with their potential targets inhibiting muscle cells proliferation and differentiation.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-024-02711-z","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T17:02:23Z","timestamp":1710435743000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of circulating hsa-miRNAs with sarcopenia: the SarcoPhAge study"],"prefix":"10.1007","volume":"36","author":[{"given":"Marjorie","family":"Millet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Auroux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Beaudart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Demonceau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Ladang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Cavalier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Yves","family":"Reginster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Bruy\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3755-2891","authenticated-orcid":false,"given":"Jean-Charles","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"2711_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/ageing\/afz046","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. 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