{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:41:10Z","timestamp":1792784470416,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The Second Affiliated Hospital of Fujian Medical University","award":["BS201902"],"award-info":[{"award-number":["BS201902"]}],"id":[{"id":"https:\/\/ror.org\/03wnxd135","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2021J01267"],"award-info":[{"award-number":["2021J01267"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Individuals with chronic obstructive pulmonary disease (COPD) are prone to malnutrition and sarcopenia as a result of nutritional deficiencies and increased energy metabolism. However, the effects of nutrient supplements (NS) on treating sarcopenia in patients with COPD are not well established from systematic evidence. This meta-analysis examined the effect of NS on sarcopenia in patients with COPD. A systematic search of multiple databases was conducted, and 29 randomized controlled trials involving 1625 participants (age, mean [SD]\u2009=\u200967.9 [7.8] years) were analyzed. NS demonstrated significant improvements in body weight (MD,1.33\u00a0kg; 95% CI, 0.60, 2.05\u00a0kg; P\u2009=\u20090.0003; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200987%), fat-free mass index (MD, 0.74\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; 95% CI, 0.21, 1.27\u00a0kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; P\u2009=\u20090.007; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200975%), and 6-min walk test (MD, 19.43\u00a0m; 95% CI, 4.91, 33.94\u00a0m; P\u2009=\u20090.009; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200981%) compared with control. However, NS had nonsignificant effects on handgrip strength (SMD, 0.36; 95% CI, \u2212\u00a00.15, 0.88; P\u2009=\u20090.16; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200987%) and quadriceps muscle strength (SMD, 0.11; 95% CI, \u2212\u00a0 0.06, 0.27; P\u2009=\u20090.20; I\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u200925%) compared with the control. In conclusion, NS may be an effective treatment for improving body composition and physical performance in COPD. Future studies should explore the effects of intervention durations, specific NS types, or combined training in patients with COPD and sarcopenia.\n                  <\/jats:p>","DOI":"10.1007\/s40520-024-02722-w","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:05:50Z","timestamp":1710414350000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Systematic review and meta-analysis of nutrient supplements for treating sarcopenia in people with chronic obstructive pulmonary disease"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3948-0032","authenticated-orcid":false,"given":"Wen-Jian","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-3041","authenticated-orcid":false,"given":"Chih-Yuan","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"2722_CR1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2471\/BLT.21.286870","volume":"100","author":"P Jarhyan","year":"2022","unstructured":"Jarhyan P, Hutchinson A, Khaw D et al (2022) Prevalence of chronic obstructive pulmonary disease and chronic bronchitis in eight countries: a systematic review and meta-analysis. Bull World Health Organ 100:216\u2013230. https:\/\/doi.org\/10.2471\/BLT.21.286870","journal-title":"Bull World Health Organ"},{"key":"2722_CR2","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/S0140-6736(22)00470-6","volume":"399","author":"SA Christenson","year":"2022","unstructured":"Christenson SA, Smith BM, Bafadhel M et al (2022) Chronic obstructive pulmonary disease. Lancet 399:2227\u20132242. https:\/\/doi.org\/10.1016\/S0140-6736(22)00470-6","journal-title":"Lancet"},{"key":"2722_CR3","doi-asserted-by":"publisher","first-page":"e069679","DOI":"10.1136\/bmj-2021-069679","volume":"378","author":"S Safiri","year":"2022","unstructured":"Safiri S, Carson-Chahhoud K, Noori M et al (2022) Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990\u20132019: results from the Global Burden of Disease Study 2019. BMJ 378:e069679. https:\/\/doi.org\/10.1136\/bmj-2021-069679","journal-title":"BMJ"},{"key":"2722_CR4","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/jcsm.12483","volume":"10","author":"J Bauer","year":"2019","unstructured":"Bauer J, Morley JE, Schols AMWJ et al (2019) Sarcopenia: a time for action An SCWD position paper. J Cachexia Sarcopenia Muscle 10:956\u2013961. https:\/\/doi.org\/10.1002\/jcsm.12483","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2722_CR5","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/jcsm.12600","volume":"11","author":"W Sep\u00falveda-Loyola","year":"2020","unstructured":"Sep\u00falveda-Loyola W, Osadnik C, Phu S et al (2020) Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 11:1164\u20131176. https:\/\/doi.org\/10.1002\/jcsm.12600","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2722_CR6","doi-asserted-by":"publisher","first-page":"127S","DOI":"10.1378\/chest.121.5_suppl.127s","volume":"121","author":"EF Wouters","year":"2002","unstructured":"Wouters EF, Creutzberg EC, Schols AM (2002) Systemic effects in COPD. Chest 121:127S-130S. https:\/\/doi.org\/10.1378\/chest.121.5_suppl.127s","journal-title":"Chest"},{"key":"2722_CR7","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1136\/thoraxjnl-2018-212630","volume":"74","author":"JP Ng-Blichfeldt","year":"2019","unstructured":"Ng-Blichfeldt JP, Gosens R, Dean C et al (2019) Regenerative pharmacology for COPD: breathing new life into old lungs. Thorax 74:890\u2013897. https:\/\/doi.org\/10.1136\/thoraxjnl-2018-212630","journal-title":"Thorax"},{"key":"2722_CR8","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2147\/COPD.S280540","volume":"16","author":"SIJ van Bakel","year":"2021","unstructured":"van Bakel SIJ, Gosker HR, Langen RC et al (2021) Towards personalized management of sarcopenia in COPD. Int J Chron Obstruct Pulmon Dis 16:25\u201340. https:\/\/doi.org\/10.2147\/COPD.S280540","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2722_CR9","doi-asserted-by":"publisher","first-page":"106642","DOI":"10.1016\/j.rmed.2021.106642","volume":"189","author":"C de Bisschop","year":"2021","unstructured":"de Bisschop C, Caron F, Ingrand P et al (2021) Does branched-chain amino acid supplementation improve pulmonary rehabilitation effect in COPD? Respir Med 189:106642. https:\/\/doi.org\/10.1016\/j.rmed.2021.106642","journal-title":"Respir Med"},{"key":"2722_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jamda.2012.08.001","volume":"14","author":"V Malafarina","year":"2013","unstructured":"Malafarina V, Uriz-Otano F, Iniesta R et al (2013) Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review. J Am Med Dir Assoc 14:10\u201317. https:\/\/doi.org\/10.1016\/j.jamda.2012.08.001","journal-title":"J Am Med Dir Assoc"},{"key":"2722_CR11","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.3945\/ajcn.116.143594","volume":"106","author":"CD Liao","year":"2017","unstructured":"Liao CD, Tsauo JY, Wu YT et al (2017) Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults: a systematic review and meta-analysis. Am J Clin Nutr 106:1078\u20131091. https:\/\/doi.org\/10.3945\/ajcn.116.143594","journal-title":"Am J Clin Nutr"},{"key":"2722_CR12","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/advances\/nmy065","volume":"10","author":"NI Hanach","year":"2019","unstructured":"Hanach NI, McCullough F, Avery A (2019) The impact of dairy protein intake on muscle mass, muscle strength, and physical performance in middle-aged to older adults with or without existing sarcopenia: a systematic review and meta-analysis. Adv Nutr 10:59\u201369. https:\/\/doi.org\/10.1093\/advances\/nmy065","journal-title":"Adv Nutr"},{"key":"2722_CR13","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522000976","author":"S Bernardes","year":"2022","unstructured":"Bernardes S, Eckert IC, Burgel CF et al (2022) Increased energy and\/or protein intake improves anthropometry and muscle strength in COPD patients: a systematic review with meta-analysis on randomized controlled clinical trials. Br J Nutr. https:\/\/doi.org\/10.1017\/S0007114522000976","journal-title":"Br J Nutr"},{"key":"2722_CR14","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/resp.12070","volume":"18","author":"PF Collins","year":"2013","unstructured":"Collins PF, Elia M, Stratton RJ (2013) Nutritional support and functional capacity in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Respirology 18:616\u2013629. https:\/\/doi.org\/10.1111\/resp.12070","journal-title":"Respirology"},{"key":"2722_CR15","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s12603-022-1822-8","volume":"26","author":"WJ Huang","year":"2022","unstructured":"Huang WJ, Fan XX, Yang YH et al (2022) A review on the role of oral nutritional supplements in chronic obstructive pulmonary disease. J Nutr Health Aging 26:723\u2013731. https:\/\/doi.org\/10.1007\/s12603-022-1822-8","journal-title":"J Nutr Health Aging"},{"key":"2722_CR16","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/nu10111733","volume":"10","author":"W Gong","year":"2018","unstructured":"Gong W, Liu A, Yao Y et al (2018) Nutrient supplement use among the Chinese Population: a cross-sectional study of the 2010\u20132012 China nutrition and health surveillance. Nutrients 10:1733. https:\/\/doi.org\/10.3390\/nu10111733","journal-title":"Nutrients"},{"key":"2722_CR17","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"2722_CR18","unstructured":"Higgins JPT, Li T, Deeks JJ (2021) Choosing effect measures and computing estimates of effect. In: Higgins JPT, Thomas J, Chandler J, et al (eds) Cochrane handbook for systematic reviews of interventions, 6.2rd edn, Cochrane, section-6\u20135\u20132\u20138 Online document. Available from www.training.cochrane.org\/handbook. Accessed 25 Aug 2022"},{"key":"2722_CR19","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https:\/\/doi.org\/10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"2722_CR20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s40520-021-01921-z","volume":"34","author":"BM Zanforlini","year":"2022","unstructured":"Zanforlini BM, Ceolin C, Trevisan C et al (2022) Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients. Aging Clin Exp Res 34:167\u2013174. https:\/\/doi.org\/10.1007\/s40520-021-01921-z","journal-title":"Aging Clin Exp Res"},{"key":"2722_CR21","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.clnu.2020.08.031","volume":"40","author":"NE Deutz","year":"2021","unstructured":"Deutz NE, Ziegler TR, Matheson EM et al (2021) Reduced mortality risk in malnourished hospitalized older adult patients with COPD treated with a specialized oral nutritional supplement: Sub-group analysis of the NOURISH study. Clin Nutr 40:1388\u20131395. https:\/\/doi.org\/10.1016\/j.clnu.2020.08.031","journal-title":"Clin Nutr"},{"key":"2722_CR22","doi-asserted-by":"publisher","first-page":"00077","DOI":"10.1183\/23120541.00077-2021","volume":"7","author":"AM Aldhahir","year":"2021","unstructured":"Aldhahir AM, Aldabayan YS, Alqahtani JS et al (2021) A double-blind randomised controlled trial of protein supplementation to enhance exercise capacity in COPD during pulmonary rehabilitation: a pilot study. ERJ Open Res 7:00077\u201302021. https:\/\/doi.org\/10.1183\/23120541.00077-2021","journal-title":"ERJ Open Res"},{"key":"2722_CR23","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s12931-020-01466-1","volume":"21","author":"A Ahmadi","year":"2020","unstructured":"Ahmadi A, Eftekhari MH, Mazloom Z et al (2020) Fortified whey beverage for improving muscle mass in chronic obstructive pulmonary disease: a single-blind, randomized clinical trial. Respir Res 21:216. https:\/\/doi.org\/10.1186\/s12931-020-01466-1","journal-title":"Respir Res"},{"key":"2722_CR24","doi-asserted-by":"publisher","first-page":"5496346","DOI":"10.1155\/2019\/5496346","volume":"2019","author":"F Gouzi","year":"2019","unstructured":"Gouzi F, Maury J, H\u00e9raud N et al (2019) Additional effects of nutritional antioxidant supplementation on peripheral muscle during pulmonary rehabilitation in COPD patients: a randomized controlled trial. Oxid Med Cell Longev 2019:5496346. https:\/\/doi.org\/10.1155\/2019\/5496346","journal-title":"Oxid Med Cell Longev"},{"key":"2722_CR25","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.rmed.2018.08.002","volume":"142","author":"F De Benedetto","year":"2018","unstructured":"De Benedetto F, Pastorelli R, Ferrario M et al (2018) Supplementation with Qter\u00ae and creatine improves functional performance in COPD patients on long term oxygen therapy. Respir Med 142:86\u201393. https:\/\/doi.org\/10.1016\/j.rmed.2018.08.002","journal-title":"Respir Med"},{"key":"2722_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/jcsm.12228","volume":"9","author":"PC Calder","year":"2018","unstructured":"Calder PC, Laviano A, Lonnqvist F et al (2018) Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial. J Cachexia Sarcopenia Muscle 9:28\u201340. https:\/\/doi.org\/10.1002\/jcsm.12228","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2722_CR27","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1002\/jcsm.12219","volume":"8","author":"C van de Bool","year":"2017","unstructured":"van de Bool C, Rutten EPA, van Helvoort A et al (2017) A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD. J Cachexia Sarcopenia Muscle 8:748\u2013758. https:\/\/doi.org\/10.1002\/jcsm.12219","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"2722_CR28","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.2147\/COPD.S132117","volume":"12","author":"R Rafiq","year":"2017","unstructured":"Rafiq R, Prins HJ, Boersma WG et al (2017) Effects of daily vitamin D supplementation on respiratory muscle strength and physical performance in vitamin D-deficient COPD patients: a pilot trial. Int J Chron Obstruct Pulmon Dis 12:2583\u20132592. https:\/\/doi.org\/10.2147\/COPD.S132117","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2722_CR29","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.rmed.2016.11.015","volume":"122","author":"FV Paulin","year":"2017","unstructured":"Paulin FV, Zagatto AM, Chiappa GR et al (2017) Addition of vitamin B12 to exercise training improves cycle ergometer endurance in advanced COPD patients: a randomized and controlled study. Respir Med 122:23\u201329. https:\/\/doi.org\/10.1016\/j.rmed.2016.11.015","journal-title":"Respir Med"},{"key":"2722_CR30","doi-asserted-by":"publisher","first-page":"54","DOI":"10.3177\/jnsv.62.54","volume":"62","author":"E Pirabbasi","year":"2016","unstructured":"Pirabbasi E, Shahar S, Manaf ZA et al (2016) Efficacy of ascorbic acid (vitamin C) and\/n-acetylcysteine (NAC) supplementation on nutritional and antioxidant status of male chronic obstructive pulmonary disease (COPD) patients. J Nutr Sci Vitaminol (Tokyo) 62:54\u201361. https:\/\/doi.org\/10.3177\/jnsv.62.54","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"key":"2722_CR31","first-page":"225","volume":"15","author":"NA Khan","year":"2016","unstructured":"Khan NA, Kumar N, Daga MK (2016) Effect of dietary supplementation on body composition, pulmonary function and health-related quality of life in patients with stable COPD. Tanaffos 15:225\u2013235 (PMID: 28469679)","journal-title":"Tanaffos"},{"key":"2722_CR32","first-page":"447","volume":"51","author":"P Ahnfeldt-Mollerup","year":"2015","unstructured":"Ahnfeldt-Mollerup P, Hey H, Johansen C et al (2015) The effect of protein supplementation on quality of life, physical function, and muscle strength in patients with chronic obstructive pulmonary disease. Eur J Phys Rehabil Med 51:447\u2013456 (PMID: 25426541)","journal-title":"Eur J Phys Rehabil Med"},{"key":"2722_CR33","first-page":"100","volume":"15","author":"N Raizada","year":"2014","unstructured":"Raizada N, Daga MK, Kumar N et al (2014) Nutritional intervention in stable COPD patients and its effect on anthropometry, pulmonary function, and health-related quality of life (HRQL). J Indian Acad Clin Med 15:100\u2013105 (PMID: 264553379)","journal-title":"J Indian Acad Clin Med"},{"key":"2722_CR34","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1111\/resp.12019","volume":"18","author":"A Gurgun","year":"2013","unstructured":"Gurgun A, Deniz S, Arg\u0131n M et al (2013) Effects of nutritional supplementation combined with conventional pulmonary rehabilitation in muscle-wasted chronic obstructive pulmonary disease: a prospective, randomized and controlled study. Respirology 18:495\u2013500. https:\/\/doi.org\/10.1111\/resp.12019","journal-title":"Respirology"},{"key":"2722_CR35","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/2049-6958-8-40","volume":"8","author":"S Marinari","year":"2013","unstructured":"Marinari S, Manigrasso MR, De Benedetto F (2013) Effects of nutraceutical diet integration, with coenzyme Q10 (Q-Ter multicomposite) and creatine, on dyspnea, exercise tolerance, and quality of life in COPD patients with chronic respiratory failure. Multidiscip Respir Med 8:40. https:\/\/doi.org\/10.1186\/2049-6958-8-40","journal-title":"Multidiscip Respir Med"},{"key":"2722_CR36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.2147\/COPD.S40885","volume":"8","author":"SM Bjerk","year":"2013","unstructured":"Bjerk SM, Edgington BD, Rector TS et al (2013) Supplemental vitamin D and physical performance in COPD: a pilot randomized trial. Int J Chron Obstruct Pulmon Dis 8:97\u2013104. https:\/\/doi.org\/10.2147\/COPD.S40885","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2722_CR37","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1016\/j.rmed.2012.07.001","volume":"106","author":"K Sugawara","year":"2012","unstructured":"Sugawara K, Takahashi H, Kashiwagura T et al (2012) Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir Med 106:1526\u20131534. https:\/\/doi.org\/10.1016\/j.rmed.2012.07.001","journal-title":"Respir Med"},{"key":"2722_CR38","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4081\/monaldi.2012.154","volume":"77","author":"RW Dal Negro","year":"2012","unstructured":"Dal Negro RW, Testa A, Aquilani R et al (2012) Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation. Monaldi Arch Chest Dis 77:67\u201375. https:\/\/doi.org\/10.4081\/monaldi.2012.154","journal-title":"Monaldi Arch Chest Dis"},{"key":"2722_CR39","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/1465-9921-13-84","volume":"13","author":"M Hornikx","year":"2012","unstructured":"Hornikx M, Van Remoortel H, Lehouck A et al (2012) Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respir Res 13:84. https:\/\/doi.org\/10.1186\/1465-9921-13-84","journal-title":"Respir Res"},{"key":"2722_CR40","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1089\/jmf.2009.0142","volume":"13","author":"L Laviolette","year":"2010","unstructured":"Laviolette L, Lands LC, Dauletbaev N et al (2010) Combined effect of dietary supplementation with pressurized whey and exercise training in chronic obstructive pulmonary disease: a randomized, controlled, double-blind pilot study. J Med Food 13:589\u2013598. https:\/\/doi.org\/10.1089\/jmf.2009.0142","journal-title":"J Med Food"},{"key":"2722_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/copd.s7739","volume":"5","author":"S Baldi","year":"2010","unstructured":"Baldi S, Aquilani R, Pinna GD et al (2010) Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia. Int J Chron Obstruct Pulmon Dis 5:29\u201339. https:\/\/doi.org\/10.2147\/copd.s7739","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2722_CR42","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1164\/rccm.200710-1508OC","volume":"178","author":"SJ Deacon","year":"2008","unstructured":"Deacon SJ, Vincent EE, Greenhaff PL et al (2008) Randomized controlled trial of dietary creatine as an adjunct therapy to physical training in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 178:233\u2013239. https:\/\/doi.org\/10.1164\/rccm.200710-1508OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2722_CR43","doi-asserted-by":"publisher","first-page":"445","DOI":"10.2147\/copd.2006.1.4.445","volume":"1","author":"G Faager","year":"2006","unstructured":"Faager G, S\u00f6derlund K, Sk\u00f6ld CM et al (2006) Creatine supplementation and physical training in patients with COPD: a double blind, placebo-controlled study. Int J Chron Obstruct Pulmon Dis 1:445\u2013453. https:\/\/doi.org\/10.2147\/copd.2006.1.4.445","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"2722_CR44","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1136\/thx.2004.030858","volume":"60","author":"R Broekhuizen","year":"2005","unstructured":"Broekhuizen R, Wouters EF, Creutzberg EC et al (2005) Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 60:376\u2013382. https:\/\/doi.org\/10.1136\/thx.2004.030858","journal-title":"Thorax"},{"key":"2722_CR45","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1136\/thx.2004.030452","volume":"60","author":"JP Fuld","year":"2005","unstructured":"Fuld JP, Kilduff LP, Neder JA et al (2005) Creatine supplementation during pulmonary rehabilitation in chronic obstructive pulmonary disease. Thorax 60:531\u2013537. https:\/\/doi.org\/10.1136\/thx.2004.030452","journal-title":"Thorax"},{"key":"2722_CR46","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1136\/thorax.58.9.745","volume":"58","author":"MC Steiner","year":"2003","unstructured":"Steiner MC, Barton RL, Singh SJ et al (2003) Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease: a randomised controlled trial. Thorax 58:745\u2013751. https:\/\/doi.org\/10.1136\/thorax.58.9.745","journal-title":"Thorax"},{"key":"2722_CR47","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1164\/arrd.1987.135.5.1062","volume":"135","author":"MI Lewis","year":"1987","unstructured":"Lewis MI, Belman MJ, Dorr-Uyemura L (1987) Nutritional supplementation in ambulatory patients with chronic obstructive pulmonary disease. Am Rev Respir Dis 135:1062\u20131068. https:\/\/doi.org\/10.1164\/arrd.1987.135.5.1062","journal-title":"Am Rev Respir Dis"},{"key":"2722_CR48","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1378\/chest.117.3.672","volume":"117","author":"IM Ferreira","year":"2000","unstructured":"Ferreira IM, Brooks D, Lacasse Y et al (2000) Nutritional support for individuals with COPD: a meta-analysis. Chest 117:672\u2013678. https:\/\/doi.org\/10.1378\/chest.117.3.672","journal-title":"Chest"},{"key":"2722_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000998","volume":"2002","author":"IM Ferreira","year":"2002","unstructured":"Ferreira IM, Brooks D, Lacasse Y et al (2002) Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2002:CD000998. https:\/\/doi.org\/10.1002\/14651858.CD000998","journal-title":"Cochrane Database Syst Rev"},{"key":"2722_CR50","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000998.pub2","volume":"2005","author":"IM Ferreira","year":"2005","unstructured":"Ferreira IM, Brooks D, Lacasse Y et al (2005) Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2005:CD000998. https:\/\/doi.org\/10.1002\/14651858.CD000998.pub2","journal-title":"Cochrane Database Syst Rev"},{"key":"2722_CR51","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/j.1440-1843.2010.01770.x","volume":"15","author":"F Al-Ghimlas","year":"2010","unstructured":"Al-Ghimlas F, Todd DC (2010) Creatine supplementation for patients with COPD receiving pulmonary rehabilitation: a systematic review and meta-analysis. Respirology 15:785\u2013795. https:\/\/doi.org\/10.1111\/j.1440-1843.2010.01770.x","journal-title":"Respirology"},{"key":"2722_CR52","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000998.pub3","volume":"2012","author":"IM Ferreira","year":"2012","unstructured":"Ferreira IM, Brooks D, Lacasse Y et al (2012) Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2012:CD000998. https:\/\/doi.org\/10.1002\/14651858.CD000998.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"2722_CR53","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.3945\/ajcn.111.023499","volume":"95","author":"PF Collins","year":"2012","unstructured":"Collins PF, Stratton RJ, Elia M (2012) Nutritional support in chronic obstructive pulmonary disease: a systematic review and meta-analysis. Am J Clin Nutr 95:1385\u20131395. https:\/\/doi.org\/10.3945\/ajcn.111.023499","journal-title":"Am J Clin Nutr"},{"key":"2722_CR54","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1164\/rccm.200506-969OC","volume":"173","author":"J Vestbo","year":"2006","unstructured":"Vestbo J, Prescott E, Almdal T et al (2006) Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study. Am J Respir Crit Care Med 173:79\u201383. https:\/\/doi.org\/10.1164\/rccm.200506-969OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2722_CR55","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.biocel.2013.06.015","volume":"45","author":"RC Langen","year":"2013","unstructured":"Langen RC, Gosker HR, Remels AH et al (2013) Triggers and mechanisms of skeletal muscle wasting in chronic obstructive pulmonary disease. Int J Biochem Cell Biol 45:2245\u20132256. https:\/\/doi.org\/10.1016\/j.biocel.2013.06.015","journal-title":"Int J Biochem Cell Biol"},{"key":"2722_CR56","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"LK Chen","year":"2020","unstructured":"Chen LK, Woo J, Assantachai P et al (2020) Asian Working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc 21:300-307.e2. https:\/\/doi.org\/10.1016\/j.jamda.2019.12.012","journal-title":"J Am Med Dir Assoc"},{"key":"2722_CR57","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/ggi.12213","volume":"14","author":"TW Auyeung","year":"2014","unstructured":"Auyeung TW, Lee SW, Leung J et al (2014) Age-associated decline of muscle mass, grip strength and gait speed: a 4-year longitudinal study of 3018 community-dwelling older Chinese. Geriatr Gerontol Int 14:76\u201384. https:\/\/doi.org\/10.1111\/ggi.12213","journal-title":"Geriatr Gerontol Int"},{"key":"2722_CR58","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1183\/09031936.00150314","volume":"44","author":"AE Holland","year":"2014","unstructured":"Holland AE, Spruit MA, Troosters T et al (2014) An official European Respiratory Society\/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J 44:1428\u20131446. https:\/\/doi.org\/10.1183\/09031936.00150314","journal-title":"Eur Respir J"},{"key":"2722_CR59","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1471-2466-14-97","volume":"14","author":"V Andrianopoulos","year":"2014","unstructured":"Andrianopoulos V, Wagers SS, Groenen MT et al (2014) Characteristics and determinants of endurance cycle ergometry and six-minute walk distance in patients with COPD. BMC Pulm Med 14:97. https:\/\/doi.org\/10.1186\/1471-2466-14-97","journal-title":"BMC Pulm Med"},{"key":"2722_CR60","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/j.clnu.2017.09.004","volume":"37","author":"J Wright","year":"2018","unstructured":"Wright J, Baldwin C (2018) Oral nutritional support with or without exercise in the management of malnutrition in nutritionally vulnerable older people: a systematic review and meta-analysis. Clin Nutr 37:1879\u20131891. https:\/\/doi.org\/10.1016\/j.clnu.2017.09.004","journal-title":"Clin Nutr"},{"key":"2722_CR61","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.jfma.2015.10.008","volume":"115","author":"MJ Hsieh","year":"2016","unstructured":"Hsieh MJ, Yang TM, Tsai YH (2016) Nutritional supplementation in patients with chronic obstructive pulmonary disease. J Formos Med Assoc 115:595\u2013601. https:\/\/doi.org\/10.1016\/j.jfma.2015.10.008","journal-title":"J Formos Med Assoc"},{"key":"2722_CR62","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.clnesp.2021.10.011","volume":"46","author":"JK Bird","year":"2021","unstructured":"Bird JK, Troesch B, Warnke I et al (2021) The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: a scoping systematic review and meta-analysis. Clin Nutr ESPEN 46:73\u201386. https:\/\/doi.org\/10.1016\/j.clnesp.2021.10.011","journal-title":"Clin Nutr ESPEN"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-024-02722-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-024-02722-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-024-02722-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T11:11:30Z","timestamp":1710414690000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-024-02722-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2722"],"URL":"https:\/\/doi.org\/10.1007\/s40520-024-02722-w","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"9 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest regarding the publication of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the Ethical Committee of the Second Affiliated Hospital of Fujian Medical University (Ethics Review No. 2021-31).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This study does not involve any human or animal testing.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"For this type of study, formal consent is not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"69"}}