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Our working hypothesis was that the current LSC threshold would not be applicable in obese populations. <jats:bold>Aims<\/jats:bold>: The aim of this study was to calculate the LSC in an obese population. <jats:bold>Methods<\/jats:bold>: We performed an interventional study among 120 obesity patients, in whom two measurements of BMD were performed at 3 sites. Pairs of measures were used to calculate the LSC, using the Bland and Altman method. <jats:bold>Results<\/jats:bold>: We calculated that the LSC was 0.046\u00a0g\/cm\u00b2 at the lumbar spine, 0.069\u00a0g\/cm\u00b2 at the femoral neck, and 0.06\u00a0g\/cm\u00b2 at the total hip. We also calculated the LSC for each class of obesity and observed an increase in LSC with increasing body mass index (BMI). We calculated a LSC of 0.05\u00a0g\/cm\u00b2 in patients with class 2 or class 3 obesity, whereas the LSC in patients with class 1 obesity is similar to the threshold used in the general population. <jats:bold>Discussion<\/jats:bold>: In obese population, like BMD, LSC is higher than the threshold value of the general population, and increases with increasing BMI.<jats:bold>Conclusion<\/jats:bold>: LSC of 0.05\u00a0g\/cm\u00b2 could be used in clinical practice in patients with class 2 or 3 obesity. These findings should help to improve the interpretation of BMD scans in these patients and optimize their management. <jats:bold>Trial registration number<\/jats:bold>: Comit\u00e9 de Protection des Personnes Ile-de France VII, France.<\/jats:p>","DOI":"10.1007\/s40520-024-02736-4","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T10:02:05Z","timestamp":1713866525000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["\u201cThe least significant change on bone mineral density scan increased in patients with higher degrees of obesity\u201d"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9397-4087","authenticated-orcid":false,"given":"Claire","family":"Dorilleau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3685-8407","authenticated-orcid":false,"given":"Lukshe","family":"Kanagaratnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Charlot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-4436","authenticated-orcid":false,"given":"Ambre","family":"Hittinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1003-6061","authenticated-orcid":false,"given":"Jean-Hugues","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-7104","authenticated-orcid":false,"given":"Marion","family":"Geoffroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"2736_CR1","unstructured":"World Health Organization (2017) Obesity and Overweight Factsheet No. 311"},{"key":"2736_CR2","doi-asserted-by":"publisher","unstructured":"Shapses SA, Pop LC, Wang Y (2017) Obesity is a concern for bone health with aging. 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Patients were informed about the objectives of the study by the physician prescribing the DXA scan, and were informed about the study again on the day of the examination by the investigator. An information leaflet was given to each participant, and they were required to provide written informed consent before the scans. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved on 09 October 2019 by the Ethics Committee (Comit\u00e9 de protection de personnes Ile de France VII, Protocole N 19\u2013076. Num\u00e9ro d\u2019autorisation AU19-06\u201309\/10\/2019).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of ethic"}},{"value":"Informed consent was obtained from all individual partipants included in the study. Patients signed informed consent regarding publishing their data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare that they have no financial or non-financial conflict of interest directly or indirectly related to the completion of this research work and the publication of the work submitted for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}