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However, investigation of the additional mortality risk explained by these measures, over and above other factors, is limited.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aim<\/jats:title>\n                <jats:p>We examined whether grip strength and gait speed improve discriminative capacity for mortality over and above more readily obtainable clinical risk factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Participants from the Health, Aging and Body Composition Study, Osteoporotic Fractures in Men Study, and the Hertfordshire Cohort Study were analysed. Appendicular lean mass (ALM) was ascertained using DXA; muscle strength by grip dynamometry; and usual gait speed over 2.4\u20136\u00a0m. Verified deaths were recorded. Associations between sarcopenia components and mortality were examined using Cox regression with cohort as a random effect; discriminative capacity was assessed using Harrell\u2019s Concordance Index (C-index).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean (SD) age of participants (<jats:italic>n<\/jats:italic>\u2009=\u20098362) was 73.8(5.1) years; 5231(62.6%) died during a median follow-up time of 13.3\u00a0years. Grip strength (hazard ratio (95%\u00a0CI) per SD decrease: 1.14 (1.10,1.19)) and gait speed (1.21 (1.17,1.26)), but not ALM index (1.01 (0.95,1.06)), were associated with mortality in mutually-adjusted models after accounting for age, sex, BMI, smoking status, alcohol consumption, physical activity, ethnicity, education, history of fractures and falls, femoral neck bone mineral density (BMD), self-rated health, cognitive function and number of comorbidities. However, a model containing only age and sex as exposures gave a C-index\u00a0(95% CI) of 0.65(0.64,0.66), which only increased to 0.67(0.67,0.68) after inclusion of grip strength and gait speed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Grip strength and gait speed may generate only modest adjunctive risk information for mortality compared with other more readily obtainable risk factors.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-024-02783-x","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T15:02:08Z","timestamp":1717686128000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Predictive value of sarcopenia components for all-cause mortality: findings from population-based 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Nicholas Harvey reports consultancy, lecture fees and honoraria (outside the submitted work) from Alliance for Better Bone Health, AMGEN, MSD, Eli Lilly, Servier, Shire, UCB, Kyowa Kirin, Consilient Healthcare, Radius Health, Theramex and Internis Pharma. Roger Fielding reports grants from National Institutes of Health (National Institute on Aging) and the USDA, during the conduct of the study; grants, personal fees and other from Axcella Health, other from Inside Tracker, grants and personal fees from Biophytis, grants and personal fees from Astellas, personal fees from Pfizer, Reneo, Cytokinetics, Embion, Glaxo Smith Kline and Amazentis, and grants and personal fees from Nestle' outside the submitted work. John Kanis and Eugene McCloskey are directors of Osteoporosis Research Ltd that develops and maintains FRAX. Peggy Cawthon declares personal fees from MyoCorps and owns stock in MyoCorps. The remaining authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Hertfordshire and Bedfordshire Local Research Ethics Committee provided approval for the baseline Hertfordshire Cohort Study home interview and research clinic; all follow-up studies of this cohort also had ethical approval. Institutional review boards at the University of Pittsburgh and the University of Tennessee approved the Health, Aging and Body Composition Study. The Osteoporotic Fractures in Men (MrOS) Study (USA) was approved by institutional review boards at each site. For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided informed consent prior to their inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"126"}}