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The serum creatinine\/serum cystatin C ratio (Scr\/Cys C ratio) has recently been recognized as a valuable indicator for assessing sarcopenia. However, few studies have examined the association between serum creatinine\/serum cystatin C ratio and frailty. The objective of this study is to investigate the relationship between the serum creatinine\/serum cystatin C ratio and frailty among older adults residing in the community.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods and materials<\/jats:title>\n                <jats:p>A Total of 1926 community-dwelling older adults aged\u2009\u2265\u200960\u00a0years in the 2011 waves of the China Health and Retirement Longitudinal Study (CHARLS) were included. The participants\u2019 frailty status was determined using a 39\u00a0item frailty index (FI), which classified individuals as \u201crobust\u201d (FI\u2009\u2264\u20090.1), \u201cpre-frailty\u201d (0.1\u2009&lt;\u2009FI\u2009&lt;\u20090.25), or \u201cfrailty\u201d (FI\u2009\u2265\u20090.25). The Scr\/Cys C ratio was determined by dividing the serum creatinine level (mg\/dL) by the cystatin C level (mg\/L). The one-way analysis of variance(ANOVA) and Chi-squared test (\u03c72)were applied to compare the differences between the 3 groups. Both linear regression and logistic regression models were used to further investigate the relationship between Scr\/Cys C ratio and frailty.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After adjusting for potential confounding factors, the study revealed that participants in the Q1 quartile of Scr\/Cys C ratio had increased odds of frailty (Q1vs.Q4: OR\u2009=\u20091.880, 95% CI 1.126\u20133.139, p\u2009=\u20090.016) compared with those in the Q4 quartile group. In fully adjusted logistic regression models, male participants in the Q2 quartile of Scr\/Cys C ratio were significantly correlated with higher odds of pre-frailty (Q2 vs.Q4: OR\u2009=\u20091.693, 95%CI 1.040\u20132.758, p\u2009=\u20090.034). However, this correlation was not observed in females (OR\u2009=\u20090.984, 95% CI 0.589\u20131.642, p\u2009=\u20090.950,). Additionally, the study observed an increase in both the frailty index and the incidence of frailty as age increased in both males and females.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Among community-dwelling older adults, lower Serum creatinine to cystatin C ratio were found to be associated with increased odds of frailty prevalence in males.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-024-02787-7","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T16:02:33Z","timestamp":1720108953000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lower serum creatinine to cystatin C ratio associated with increased incidence of frailty in community-dwelling elderly men but not in elderly women"],"prefix":"10.1007","volume":"36","author":[{"given":"Shixian","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JingJin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"2787_CR1","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/gerona\/glv133","volume":"70","author":"K Bandeen-Roche","year":"2015","unstructured":"Bandeen-Roche K, Seplaki CL, Huang J et al (2015) Frailty in older adults: a nationally representative profile in the United States. 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