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Randomized controlled trials that assessed the effects of different wavelengths of LLLT on alleviating pain of patients with KOA were included. A conventional meta-analysis and network meta-analysis were preformed, and standardized mean differences (SMD) with 95% confidence interval (CI) were calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirteen studies involving 673 participants with KOA met inclusion criteria. Overall, LLLT was superior to sham LLLT for relieving pain (SMD\u2009=\u20090.96, 95% CI 0.31\u20131.61) but not for improving function (SMD\u2009=\u20090.21, 95% CI \u2212\u00a00.11 to 0.53) or stiffness (SMD\u2009=\u20090.07, 95% CI \u2212\u00a00.25 to 0.39). Surface under the cumulative ranking curve (SUCRA) value ranking showed the most effective wavelength of LLLT in reducing KOA pain was 904\u2013905\u00a0nm (SUCRA, 86.90%), followed by multi-wavelengths (MWL) (SUCRA, 56.43%) and 785\u2013850\u00a0nm (SUCRA, 54.97%). Compared to sham LLLT, L2 (SMD\u2009=\u20091.42, 95% CI\u2009=\u20090.31\u20132.53) and L1 (SMD\u2009=\u20090.82; 95% CI\u2009=\u20090.11\u20131.50) showed a significant reduction in KOA pain. However, MWL (SMD\u2009=\u20090.83; 95% CI\u2009=\u2009\u2212\u00a00.06 to 1.72) showed similar KOA pain reduction compared to sham LLLT. The certainty of evidence showed that the quality of evidence regarding the effectiveness of overall LLLT versus sham, and 904\u2013905\u00a0nm versus sham were low, while the quality of evidence for MWL versus sham, and 785\u2013850\u00a0nm versus sham was very low.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>While the 904\u2013905\u00a0nm wavelength showed potential benefits in reducing KOA pain, the overall quality of the evidence was low. LLLT with 904\u2013905\u00a0nm or 785\u2013850\u00a0nm wavelengths yielded significantly better reduction in KOA pain compared to sham LLLT, but further high-quality research is warranted to validate these findings.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-024-02853-0","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T07:02:21Z","timestamp":1728111741000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A systematic review and network meta-analysis on the optimal wavelength of low-level light therapy (LLLT) in treating knee osteoarthritis symptoms"],"prefix":"10.1007","volume":"36","author":[{"given":"Tianxiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold Y. 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