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The socio-demographic Index (SDI) served as a metric to examine the influence of socioeconomic development on the burden of MNBAC. Furthermore, joinpoint regression analysis was employed to identify the years marked by the most significant temporal changes over the study period.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In 2021, an estimated 163,561 prevalent cases of MNBAC were recorded among individuals aged\u2009\u2265\u200965\u00a0years, alongside 28,100 newly diagnosed cases, 27,588 deaths, and 508,202 DALYs. The age-standardized rates per 100,000 population were 21.30 for prevalence, 3.69 for incidence, 3.66 for mortality, and 65.85 for DALYs. Notably, Cuba reported the highest prevalence rate (42.42), while the Philippines exhibited the greatest DALY burden (161.78). Egypt demonstrated the highest incidence (7.44) and mortality rates (8.90). A significant inverse correlation was observed between age-standardized DALY rates and SDI across regions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This analysis underscores the substantial global burden of MNBAC among older adults, accentuating the imperative for tailored public health interventions, alongside advancements in diagnostic and therapeutic approaches, particularly within resource-constrained settings.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40520-024-02926-0","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T08:42:18Z","timestamp":1736325738000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Global, regional, and national burden of malignant neoplasm of bone and articular cartilage in adults aged 65\u00a0years and older, 1990\u20132021: a systematic analysis based on the global burden of disease study 2021"],"prefix":"10.1007","volume":"37","author":[{"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2926_CR1","unstructured":"Fletcher C, Bridge JA, Hogendoorn PCW, Mertens F (2013) WHO classification of tumours of soft tissue and bone: WHO classification of tumours, vol. 5 World Health Organization"},{"key":"2926_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21590","volume":"70","author":"RL Siegel","year":"2020","unstructured":"Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. 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