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This study aimed to explore the associations between tooth loss severity, denture status, and geriatric syndromes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In 2019, 1094 participants were recruited and subjected to face-to-face interview to assess tooth loss severity, along with grip strength and body composition. In 2023, a follow-up was conducted with a subsample of the participants. Logistic regression analysis was utilized to explore the association between tooth loss severity at baseline and geriatric syndromes (sarcopenia, malnutrition risk, frailty, fall) at fourth year follow-up, as well as association between denture status and geriatric syndromes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The multivariate analyses showed that having tooth loss affecting daily life at baseline was associated with a 1.80-fold higher prevalence of sarcopenia and 2.31-fold higher prevalence of malnutrition risk after four years. Participants with fewer than 10 teeth had significantly higher odds of geriatric syndromes compared to those with 21 or more teeth: 1.87-fold for sarcopenia (95% CI: 1.07 to 3.26), 2.99-fold for malnutrition risk (95% CI: 1.93 to 4.62), and 1.68-fold for frailty (95% CI: 1.10 to 2.56). Older adults with tooth loss who did not have dentures exhibited a significantly higher odds of sarcopenia, malnutrition risk, frailty, and falls, more number of geriatric syndromes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Higher severity level of tooth loss at baseline were associated with higher odds of geriatric syndromes at fourth year in older adults. Dentures partially mitigate the association between tooth loss and the higher odds of geriatric syndromes. Screening and intervening oral health is important for the prevention of geriatric syndromes in older adults.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Clinical trial number<\/jats:title>\n            <jats:p>Not applicable.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s40520-025-03032-5","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T08:26:56Z","timestamp":1744964816000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between tooth loss and geriatric syndromes in older adults: a cohort study from a rural area in eastern China"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-0095","authenticated-orcid":false,"given":"Caihong","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9157-6947","authenticated-orcid":false,"given":"Yihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7199-3668","authenticated-orcid":false,"given":"Chengfan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0456-4767","authenticated-orcid":false,"given":"Nan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4979-1248","authenticated-orcid":false,"given":"Yichen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-050X","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4161-1871","authenticated-orcid":false,"given":"Qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"issue":"Suppl 2","key":"3032_CR1","doi-asserted-by":"publisher","first-page":"S163","DOI":"10.1093\/geront\/gnw037","volume":"56","author":"JR Beard","year":"2016","unstructured":"Beard JR, Officer AM, Cassels AK (2016) The world report on ageing and health. 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