{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:18:18Z","timestamp":1792624698371,"version":"4.5.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Ricerca Corrente 2023"],"award-info":[{"award-number":["Ricerca Corrente 2023"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"DOI":"10.1007\/s40520-025-03064-x","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:39:12Z","timestamp":1748227152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Adherence to the mediterranean diet and physical activity in relation to sarcopenia: a cross-sectional epidemiological cohort study"],"prefix":"10.1007","volume":"37","author":[{"given":"Alejandro","family":"\u00c1lvarez-Bustos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio Jos\u00e9","family":"Coelho-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Carnicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Marzetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leocadio","family":"Rodriguez-Ma\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"3064_CR1","doi-asserted-by":"publisher","first-page":"2145","DOI":"10.1016\/S0140-6736(15)00516-4","volume":"387","author":"JR Beard","year":"2016","unstructured":"Beard JR, Officer A, De Carvalho IA et al (2016) The world report on ageing and health: A policy framework for healthy ageing. Lancet 387:2145\u20132154","journal-title":"Lancet"},{"key":"3064_CR2","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/S2666-7568(23)00271-4","volume":"5","author":"The Lancet Healthy Longevity","year":"2024","unstructured":"The Lancet Healthy Longevity (2024) The decade of healthy ageing: progress and challenges ahead. Lancet Healthy Longev 5:e1\u2013e1. https:\/\/doi.org\/10.1016\/S2666-7568(23)00271-4","journal-title":"Lancet Healthy Longev"},{"key":"3064_CR3","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1002\/jcsm.12147","volume":"7","author":"SD Anker","year":"2016","unstructured":"Anker SD, Morley JE, von Haehling S (2016) Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle 7:512\u2013514. https:\/\/doi.org\/10.1002\/jcsm.12147","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afy169","journal-title":"Age Ageing"},{"key":"3064_CR5","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.12783","author":"F Petermann-Rocha","year":"2021","unstructured":"Petermann-Rocha F, Balntzi V, Gray SR et al (2021) Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle. https:\/\/doi.org\/10.1002\/JCSM.12783","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR6","doi-asserted-by":"publisher","unstructured":"Beaudart C, Zaaria M, Pasleau F et al (2017) Health outcomes of sarcopenia: A systematic review and meta-analysis. PLoS ONE 12. https:\/\/doi.org\/10.1371\/journal.pone.0169548","DOI":"10.1371\/journal.pone.0169548"},{"key":"3064_CR7","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/jcsm.12411","volume":"10","author":"SSY Yeung","year":"2019","unstructured":"Yeung SSY, Reijnierse EM, Pham VK et al (2019) Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 10:485\u2013500. https:\/\/doi.org\/10.1002\/jcsm.12411","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR8","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1002\/jcsm.13055","volume":"13","author":"A \u00c1lvarez-Bustos","year":"2022","unstructured":"\u00c1lvarez-Bustos A, Carnicero\u2010Carre\u00f1o JA, Davies B et al (2022) Role of sarcopenia in the frailty transitions in older adults: a population\u2010based cohort study. J Cachexia Sarcopenia Muscle 13:2352\u20132360. https:\/\/doi.org\/10.1002\/jcsm.13055","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR9","doi-asserted-by":"publisher","unstructured":"\u00c1lvarez-Bustos A, Carnicero JA, Coelho-Junior HJ et al (2024) Diagnostic and prognostic value of calf circumference for sarcopenia in community-dwelling older adults. J Nutr Health Aging 28. https:\/\/doi.org\/10.1016\/J.JNHA.2024.100290","DOI":"10.1016\/J.JNHA.2024.100290"},{"key":"3064_CR10","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1016\/j.jamda.2022.03.013","volume":"23","author":"B Davies","year":"2022","unstructured":"Davies B, Walter S, Rodr\u00edguez-Laso A et al (2022) Differential association of frailty and sarcopenia with mortality and disability: insight supporting clinical subtypes of frailty. J Am Med Dir Assoc 23:1712\u20131716e3. https:\/\/doi.org\/10.1016\/j.jamda.2022.03.013","journal-title":"J Am Med Dir Assoc"},{"key":"3064_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/JCSM.12651","volume":"12","author":"A Kitamura","year":"2021","unstructured":"Kitamura A, Seino S, Abe T et al (2021) Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults. J Cachexia Sarcopenia Muscle 12:30\u201338. https:\/\/doi.org\/10.1002\/JCSM.12651","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR12","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000517099","volume":"68","author":"J Xu","year":"2022","unstructured":"Xu J, Wan CS, Ktoris K et al (2022) Sarcopenia is associated with mortality in adults: A systematic review and Meta-Analysis. Gerontology 68:361\u2013376. https:\/\/doi.org\/10.1159\/000517099","journal-title":"Gerontology"},{"key":"3064_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/JCSM.13064","author":"RL Jones","year":"2022","unstructured":"Jones RL, Paul L, Steultjens MPM, Smith SL (2022) Biomarkers associated with lower limb muscle function in individuals with sarcopenia: a systematic review. J Cachexia Sarcopenia Muscle. https:\/\/doi.org\/10.1002\/JCSM.13064","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR14","doi-asserted-by":"publisher","first-page":"4","DOI":"10.14283\/JFA.2019.32","volume":"9","author":"L Rodriguez-Ma\u00f1as","year":"2020","unstructured":"Rodriguez-Ma\u00f1as L, Araujo de Carvalho I, Bhasin S et al (2020) ICFSR task force perspective on biomarkers for sarcopenia and frailty. J Frailty Aging 9:4\u20138. https:\/\/doi.org\/10.14283\/JFA.2019.32","journal-title":"J Frailty Aging"},{"key":"3064_CR15","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s12603-022-1801-0","volume":"26","author":"RM Daly","year":"2022","unstructured":"Daly RM, Iuliano S, Fyfe JJ et al (2022) Screening, diagnosis and management of sarcopenia and frailty in hospitalized older adults: recommendations from the Australian and new Zealand society for sarcopenia and frailty research (ANZSSFR) expert working group. J Nutr Health Aging 26:637\u2013651. https:\/\/doi.org\/10.1007\/s12603-022-1801-0","journal-title":"J Nutr Health Aging"},{"key":"3064_CR16","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1007\/S12603-018-1139-9","volume":"22","author":"E Dent","year":"2018","unstructured":"Dent E, Morley JE, Cruz-Jentoft AJ et al (2018) International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging 22:1148\u20131161. https:\/\/doi.org\/10.1007\/S12603-018-1139-9","journal-title":"J Nutr Health Aging"},{"key":"3064_CR17","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1016\/S2666-7568(23)00241-6\/ATTACHMENT\/685FB606-21E1-4102-A78D-8367C831A1C8\/MMC2.PDF","volume":"5","author":"JL S\u00e1nchez-S\u00e1nchez","year":"2024","unstructured":"S\u00e1nchez-S\u00e1nchez JL, He L, Morales JS et al (2024) Association of physical behaviours with sarcopenia in older adults: a systematic review and meta-analysis of observational studies. Lancet Healthy Longev 5:e108\u2013e119. https:\/\/doi.org\/10.1016\/S2666-7568(23)00241-6\/ATTACHMENT\/685FB606-21E1-4102-A78D-8367C831A1C8\/MMC2.PDF","journal-title":"Lancet Healthy Longev"},{"key":"3064_CR18","doi-asserted-by":"publisher","first-page":"664","DOI":"10.3390\/NU15030664","volume":"15","author":"SS Gropper","year":"2023","unstructured":"Gropper SS (2023) The role of nutrition in chronic disease. Nutrients 15:664. https:\/\/doi.org\/10.3390\/NU15030664","journal-title":"Nutrients"},{"key":"3064_CR19","unstructured":"Odphp (2015) 2015\u20132020 Dietary Guidelines for Americans"},{"key":"3064_CR20","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/JOIM.13333","volume":"290","author":"M Guasch-Ferr\u00e9","year":"2021","unstructured":"Guasch-Ferr\u00e9 M, Willett WC (2021) The mediterranean diet and health: a comprehensive overview. J Intern Med 290:549\u2013566. https:\/\/doi.org\/10.1111\/JOIM.13333","journal-title":"J Intern Med"},{"key":"3064_CR21","doi-asserted-by":"publisher","unstructured":"Willett WC, Sacks F, Trichopoulou A et al (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61. https:\/\/doi.org\/10.1093\/AJCN\/61.6.1402S","DOI":"10.1093\/AJCN\/61.6.1402S"},{"key":"3064_CR22","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.3390\/NU15041026\/S1","volume":"15","author":"S Cacciatore","year":"2023","unstructured":"Cacciatore S, Calvani R, Marzetti E et al (2023) Low adherence to mediterranean diet is associated with probable sarcopenia in Community-Dwelling older adults: results from the longevity Check-Up (Lookup) 7\u2009+\u2009Project. Nutrients 15:1026. https:\/\/doi.org\/10.3390\/NU15041026\/S1","journal-title":"Nutrients"},{"key":"3064_CR23","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/J.CLNU.2018.03.012","volume":"38","author":"L Barrea","year":"2019","unstructured":"Barrea L, Muscogiuri G, Di Somma C et al (2019) Association between mediterranean diet and hand grip strength in older adult women. Clin Nutr 38:721\u2013729. https:\/\/doi.org\/10.1016\/J.CLNU.2018.03.012","journal-title":"Clin Nutr"},{"key":"3064_CR24","doi-asserted-by":"publisher","first-page":"101395","DOI":"10.1016\/J.ARR.2021.101395","volume":"70","author":"HJ Coelho-J\u00fanior","year":"2021","unstructured":"Coelho-J\u00fanior HJ, Trichopoulou A, Panza F (2021) Cross-sectional and longitudinal associations between adherence to mediterranean diet with physical performance and cognitive function in older adults: A systematic review and meta-analysis. Ageing Res Rev 70:101395. https:\/\/doi.org\/10.1016\/J.ARR.2021.101395","journal-title":"Ageing Res Rev"},{"key":"3064_CR25","doi-asserted-by":"publisher","unstructured":"Granic A, Sayer AA, Robinson SM (2019) Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults. Nutrients 2019, Vol 11, Page 745 11:745. https:\/\/doi.org\/10.3390\/NU11040745","DOI":"10.3390\/NU11040745"},{"key":"3064_CR26","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1007\/S00394-024-03370-6","volume":"63","author":"E Mazza","year":"2024","unstructured":"Mazza E, Ferro Y, Maurotti S et al (2024) Association of dietary patterns with sarcopenia in adults aged 50 years and older. Eur J Nutr 63:1651\u20131662. https:\/\/doi.org\/10.1007\/S00394-024-03370-6","journal-title":"Eur J Nutr"},{"issue":"13","key":"3064_CR27","doi-asserted-by":"publisher","first-page":"Page8","DOI":"10.3390\/NU13010008","volume":"2021","author":"PJ Marcos-Pardo","year":"2020","unstructured":"Marcos-Pardo PJ, Gonz\u00e1lez-G\u00e1lvez N, L\u00f3pez-Vivancos A et al (2020) Sarcopenia, diet, physical activity and obesity in European Middle-Aged and older adults: the lifeage study. Nutrients 2021(13):Page8\u2013138. https:\/\/doi.org\/10.3390\/NU13010008","journal-title":"Nutrients"},{"key":"3064_CR28","doi-asserted-by":"publisher","first-page":"nzac001","DOI":"10.1093\/CDN\/NZAC001","volume":"6","author":"ME Van Elswyk","year":"2022","unstructured":"Van Elswyk ME, Teo L, Lau CS, Shanahan CJ (2022) Dietary patterns and the risk of sarcopenia: A systematic review and Meta-Analysis. Curr Dev Nutr 6:nzac001. https:\/\/doi.org\/10.1093\/CDN\/NZAC001","journal-title":"Curr Dev Nutr"},{"key":"3064_CR29","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.mayocp.2013.09.018","volume":"89","author":"PD Loprinzi","year":"2014","unstructured":"Loprinzi PD, Smit E, Mahoney S (2014) Physical activity and dietary behavior in US adults and their combined influence on health. Mayo Clin Proc 89:190\u2013198. https:\/\/doi.org\/10.1016\/j.mayocp.2013.09.018","journal-title":"Mayo Clin Proc"},{"key":"3064_CR30","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1007\/s12603-011-0075-8","volume":"15","author":"FJ Garcia-Garcia","year":"2011","unstructured":"Garcia-Garcia FJ, Gutierrez Avila G, Alfaro-Acha A et al (2011) The prevalence of frailty syndrome in an older population from Spain. The Toledo study for healthy aging. J Nutr Health Aging 15:852\u2013856. https:\/\/doi.org\/10.1007\/s12603-011-0075-8","journal-title":"J Nutr Health Aging"},{"key":"3064_CR31","doi-asserted-by":"publisher","unstructured":"Studenski SA, Peters KW, Alley DE et al (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A Biol Sci Med Sci 69:547\u2013558. https:\/\/doi.org\/10.1093\/GERONA\/GLU010","DOI":"10.1093\/GERONA\/GLU010"},{"key":"3064_CR32","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1093\/gerona\/glu013","volume":"69","author":"T-T Dam","year":"2014","unstructured":"Dam T-T, Peters KW, Fragala M et al (2014) An Evidence-Based comparison of operational criteria for the presence of sarcopenia. J Gerontol Biol Sci Med Sci 69:584\u2013590. https:\/\/doi.org\/10.1093\/gerona\/glu013","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"3064_CR33","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.jamda.2017.09.014","volume":"19","author":"B Davies","year":"2018","unstructured":"Davies B, Garc\u00eda F, Ara I et al (2018) Relationship between sarcopenia and frailty in the Toledo study of healthy aging: A population based Cross-Sectional study. J Am Med Dir Assoc 19:282\u2013286. https:\/\/doi.org\/10.1016\/j.jamda.2017.09.014","journal-title":"J Am Med Dir Assoc"},{"key":"3064_CR34","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1053\/apmr.2002.34619","volume":"83","author":"KJ Ottenbacher","year":"2002","unstructured":"Ottenbacher KJ, Branch LG, Ray L et al (2002) The reliability of upper- and lower-extremity strength testing in a community survey of older adults. Arch Phys Med Rehabil 83:1423\u20131427. https:\/\/doi.org\/10.1053\/apmr.2002.34619","journal-title":"Arch Phys Med Rehabil"},{"key":"3064_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","volume":"145","author":"R Estruch","year":"2006","unstructured":"Estruch R, Mart\u00ednez-Gonz\u00e1lez MA, Corella D et al (2006) Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial. Ann Intern Med 145:1\u201311. https:\/\/doi.org\/10.7326\/0003-4819-145-1-200607040-00004","journal-title":"Ann Intern Med"},{"key":"3064_CR36","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0895-4356(93)90053-4","volume":"46","author":"RA Washburn","year":"1993","unstructured":"Washburn RA, Smith KW, Jette AM, Janney CA (1993) The physical activity scale for the elderly (PASE): development and evaluation. J Clin Epidemiol 46:153\u2013162. https:\/\/doi.org\/10.1016\/0895-4356(93)90053-4","journal-title":"J Clin Epidemiol"},{"key":"3064_CR37","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373\u2013383. https:\/\/doi.org\/10.1016\/0021-9681(87)90171-8","journal-title":"J Chronic Dis"},{"key":"3064_CR38","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1093\/geront\/10.1_Part_1.20","volume":"10","author":"S Katz","year":"1970","unstructured":"Katz S, Downs T, Cash H (1970) Progress in development of the index of ADL - PubMed. Gerontologist 10:20\u201330. https:\/\/doi.org\/10.1093\/geront\/10.1_Part_1.20","journal-title":"Gerontologist"},{"key":"3064_CR39","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9:179\u2013186","journal-title":"Gerontologist"},{"key":"3064_CR40","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/J.NUT.2014.05.003","volume":"31","author":"R Hashemi","year":"2015","unstructured":"Hashemi R, Motlagh AD, Heshmat R et al (2015) Diet and its relationship to sarcopenia in community dwelling Iranian elderly: a cross-sectional study. Nutrition 31:97\u2013104. https:\/\/doi.org\/10.1016\/J.NUT.2014.05.003","journal-title":"Nutrition"},{"key":"3064_CR41","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/J.JAMDA.2015.12.004","volume":"17","author":"R Chan","year":"2016","unstructured":"Chan R, Leung J, Woo J (2016) A prospective cohort study to examine the association between dietary patterns and sarcopenia in Chinese Community-Dwelling older people in Hong Kong. J Am Med Dir Assoc 17:336\u2013342. https:\/\/doi.org\/10.1016\/J.JAMDA.2015.12.004","journal-title":"J Am Med Dir Assoc"},{"key":"3064_CR42","doi-asserted-by":"publisher","first-page":"146","DOI":"10.14283\/JFA.2018.46","volume":"8","author":"A Stanton","year":"2019","unstructured":"Stanton A, Buckley J, Villani A (2019) Adherence to a mediterranean diet is not associated with risk of sarcopenic symptomology: A Cross-Sectional analysis of overweight and obese older adults in Australia. J Frailty Aging 8:146\u2013149. https:\/\/doi.org\/10.14283\/JFA.2018.46","journal-title":"J Frailty Aging"},{"key":"3064_CR43","doi-asserted-by":"publisher","unstructured":"Zaragoza-Mart\u00ed A, Caba\u00f1ero-Mart\u00ednez MJ, Hurtado-S\u00e1nchez JA et al (2018) Evaluation of mediterranean diet adherence scores: a systematic review. BMJ Open 8. https:\/\/doi.org\/10.1136\/BMJOPEN-2017-019033","DOI":"10.1136\/BMJOPEN-2017-019033"},{"key":"3064_CR44","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez-Gonz\u00e1lez M\u00c1, Hershey MS, Zazpe I, Trichopoulou A (2017) Transferability of the mediterranean diet to Non-Mediterranean countries. what is and what is not the mediterranean diet. Nutrients 9. https:\/\/doi.org\/10.3390\/NU9111226","DOI":"10.3390\/NU9111226"},{"key":"3064_CR45","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1017\/S1368980010000480","volume":"13","author":"E Bere","year":"2010","unstructured":"Bere E, Brug J (2010) Is the term mediterranean diet a misnomer? Public Health Nutr 13:2127\u20132129. https:\/\/doi.org\/10.1017\/S1368980010000480","journal-title":"Public Health Nutr"},{"key":"3064_CR46","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.2147\/CIA.S253535","volume":"15","author":"M Billot","year":"2020","unstructured":"Billot M, Calvani R, Urtamo A et al (2020) Preserving mobility in older adults with physical frailty and sarcopenia: opportunities, challenges, and recommendations for physical activity interventions. Clin Interv Aging 15:1675\u20131690. https:\/\/doi.org\/10.2147\/CIA.S253535","journal-title":"Clin Interv Aging"},{"key":"3064_CR47","doi-asserted-by":"publisher","first-page":"8713","DOI":"10.3390\/IJMS23158713","volume":"23","author":"M El Assar","year":"2022","unstructured":"El Assar M, \u00c1lvarez-Bustos A, Sosa P et al (2022) Effect of physical activity\/exercise on oxidative stress and inflammation in muscle and vascular aging. Int J Mol Sci 23:8713. https:\/\/doi.org\/10.3390\/IJMS23158713","journal-title":"Int J Mol Sci"},{"key":"3064_CR48","doi-asserted-by":"publisher","unstructured":"Marzetti E, Lozanoska-Ochser B, Calvani R et al (2024) Restoring mitochondrial function and muscle satellite cell signaling: remedies against Age-Related sarcopenia. https:\/\/doi.org\/10.3390\/BIOM14040415. Biomolecules 14:","DOI":"10.3390\/BIOM14040415"},{"key":"3064_CR49","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2019.08.011","volume":"149","author":"M El Assar","year":"2020","unstructured":"El Assar M, Angulo J, Rodr\u00edguez-Ma\u00f1as L (2020) Frailty as a phenotypic manifestation of underlying oxidative stress. Free Radic Biol Med 149:72\u201377. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.08.011","journal-title":"Free Radic Biol Med"},{"key":"3064_CR50","doi-asserted-by":"publisher","first-page":"101807","DOI":"10.1016\/J.ARR.2022.101807","volume":"83","author":"J Raffin","year":"2023","unstructured":"Raffin J, de Souto Barreto P, Le Traon AP et al (2023) Sedentary behavior and the biological hallmarks of aging. Ageing Res Rev 83:101807. https:\/\/doi.org\/10.1016\/J.ARR.2022.101807","journal-title":"Ageing Res Rev"},{"key":"3064_CR51","doi-asserted-by":"publisher","first-page":"101513","DOI":"10.1016\/j.redox.2020.101513","volume":"35","author":"J Angulo","year":"2020","unstructured":"Angulo J, El Assar M, \u00c1lvarez-Bustos A, Rodr\u00edguez-Ma\u00f1as L (2020) Physical activity and exercise: strategies to manage frailty. Redox Biol 35:101513. https:\/\/doi.org\/10.1016\/j.redox.2020.101513","journal-title":"Redox Biol"},{"key":"3064_CR52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2165\/00007256-200737030-00004","volume":"37","author":"M Wernbom","year":"2007","unstructured":"Wernbom M, Augustsson J, Thome\u00e9 R (2007) The influence of frequency, intensity, volume and mode of strength training on whole muscle cross-sectional area in humans. Sports Med 37:225\u2013264. https:\/\/doi.org\/10.2165\/00007256-200737030-00004","journal-title":"Sports Med"},{"key":"3064_CR53","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1002\/jcsm.12369","volume":"10","author":"JL S\u00e1nchez-S\u00e1nchez","year":"2019","unstructured":"S\u00e1nchez-S\u00e1nchez JL, Ma\u00f1as A, Garc\u00eda\u2010Garc\u00eda FJ et al (2019) Sedentary behaviour, physical activity, and sarcopenia among older adults in the TSHA: isotemporal substitution model. J Cachexia Sarcopenia Muscle 10:188\u2013198. https:\/\/doi.org\/10.1002\/jcsm.12369","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3064_CR54","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/S00726-015-2067-1","volume":"48","author":"Y Duan","year":"2016","unstructured":"Duan Y, Li F, Li Y et al (2016) The role of leucine and its metabolites in protein and energy metabolism. Amino Acids 48:41\u201351. https:\/\/doi.org\/10.1007\/S00726-015-2067-1","journal-title":"Amino Acids"},{"key":"3064_CR55","unstructured":"WHO guidelines on physical activity and sedentary behaviour https:\/\/www.who.int\/publications\/i\/item\/9789240015128. Accessed 20 Dec 2021"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03064-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-025-03064-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03064-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T02:39:14Z","timestamp":1748227154000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-025-03064-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3064"],"URL":"https:\/\/doi.org\/10.1007\/s40520-025-03064-x","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]},"assertion":[{"value":"2 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"164"}}