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Categorical and continuous variables were compared using chi-square\/Fisher\u2019s exact tests and ANOVA. Sex-specific associations between glycemic control and sarcopenia were examined using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>5,728 participants (mean age 72.1\u2009\u00b1\u20096.1 years; 47.9% men) were enrolled. After adjustment, older women with T2DM had a higher odds of possible sarcopenia (OR\u2009=\u20092.07, 95% CI\u2009=\u20091.57\u20132.72). In women aged\u2009\u2265\u200970 years, both good and poor glycemic control were significantly correlated with possible sarcopenia (OR\u2009=\u20091.87 and 2.10; 95% CI\u2009=\u20091.16\u20133.04 and 1.43\u20133.07; p for trend\u2009&lt;\u20090.0001). T2DM patients with hypertension, ischemic heart disease (IHD), or depression showed increased sarcopenia association (OR\u2009=\u20091.71, 1.81, and 2.45, respectively). Poor glycemic control revealed increased odds of sarcopenia in those with hypertension (OR\u2009=\u20091.80) or IHD (OR\u2009=\u20092.42).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Glycemic control could be crucial in preventing possible sarcopenia, especially among older women with T2DM. Comorbid hypertension, IHD, or depression are significantly associated with sarcopenia in T2DM patients, particularly in the presence of poor glycemic control.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s40520-025-03159-5","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T08:19:54Z","timestamp":1755677994000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex\u2011specific effects of aging and glycemic control on the association of possible sarcopenia in older adults with type 2 diabetes: a cross-sectional study"],"prefix":"10.1007","volume":"37","author":[{"given":"Yi-Fang","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hsin","family":"Muo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Ta","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"3159_CR1","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","volume":"21","author":"LK Chen","year":"2020","unstructured":"Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H (2020) Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. 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