{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:24:01Z","timestamp":1792783441268,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Jiaxing Supporting Disciplines - Anesthesiology","award":["2023-ZC-001"],"award-info":[{"award-number":["2023-ZC-001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"DOI":"10.1007\/s40520-025-03166-6","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:53:50Z","timestamp":1755780830000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Remimazolam versus propofol for postoperative delirium prevention in geriatric surgery: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1007","volume":"37","author":[{"given":"Rui-jun","family":"Tong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-zhong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-fen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-hong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"issue":"9920","key":"3166_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","volume":"383","author":"SK Inouye","year":"2014","unstructured":"Inouye SK, Westendorp RG, Saczynski JS (2014) Delirium in elderly people. Lancet (London England) 383(9920):911\u2013922","journal-title":"Lancet (London England)"},{"issue":"4","key":"3166_CR2","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.bja.2020.06.063","volume":"125","author":"Z Jin","year":"2020","unstructured":"Jin Z, Hu J, Ma D (2020) Postoperative delirium: perioperative assessment, risk reduction, and management. Br J Anaesth 125(4):492\u2013504","journal-title":"Br J Anaesth"},{"issue":"3","key":"3166_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1001\/jamasurg.2024.6602","volume":"160","author":"J Spence","year":"2025","unstructured":"Spence J, Devereaux PJ, Lee SF, D\u2019Aragon F, Avidan MS, Whitlock RP, Mazer CD, Rousseau-Saine N, Rajamohan RR, Pryor KO et al (2025) Benzodiazepine-Free cardiac anesthesia for reduction of postoperative delirium: A cluster randomized crossover trial. JAMA Surg 160(3):286\u2013294","journal-title":"JAMA Surg"},{"issue":"4","key":"3166_CR4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/rapm-2021-102989","volume":"47","author":"V Athanassoglou","year":"2022","unstructured":"Athanassoglou V, Cozowicz C, Zhong H, Illescas A, Poeran J, Liu J, Poultsides L, Memtsoudis SG (2022) Association of perioperative Midazolam use and complications: a population-based analysis. Reg Anesth Pain Med 47(4):228\u2013233","journal-title":"Reg Anesth Pain Med"},{"issue":"10","key":"3166_CR5","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.23736\/S0375-9393.21.16006-7","volume":"87","author":"L Cardia","year":"2021","unstructured":"Cardia L (2021) Remimazolam: an ultrashort-acting intravenous anesthetic suitable for general anesthesia. Minerva Anestesiol 87(10):1059\u20131063","journal-title":"Minerva Anestesiol"},{"issue":"11","key":"3166_CR6","doi-asserted-by":"publisher","first-page":"939","DOI":"10.23736\/S0375-9393.22.16631-9","volume":"88","author":"Y Tang","year":"2022","unstructured":"Tang Y, Yang X, Yu Y, Shu H, Xu J, Li R, Zou X, Yuan S, Shang Y (2022) Remimazolam versus traditional sedatives for procedural sedation: a systematic review and meta-analysis of efficacy and safety outcomes. Minerva Anestesiol 88(11):939\u2013949","journal-title":"Minerva Anestesiol"},{"issue":"2","key":"3166_CR7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1007\/s00540-022-03148-2","volume":"37","author":"S Kaneko","year":"2023","unstructured":"Kaneko S, Morimoto T, Ichinomiya T, Murata H, Yoshitomi O, Hara T (2023) Effect of remimazolam on the incidence of delirium after transcatheter aortic valve implantation under general anesthesia: a retrospective exploratory study. J Anesth 37(2):210\u2013218","journal-title":"J Anesth"},{"issue":"1","key":"3166_CR8","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1097\/JS9.0000000000001908","volume":"111","author":"PP Fang","year":"2025","unstructured":"Fang PP, Hu J, Wei QF, Liang YJ, Fan YG, Shen QY, Lu Y, Liu XS, Maze M (2025) Effect of remimazolam besylate vs Propofol on incidence of postoperative delirium in older patients undergoing hip surgery: a randomized noninferiority trial. Int J Surg (London England) 111(1):1469\u20131472","journal-title":"Int J Surg (London England)"},{"key":"3166_CR9","doi-asserted-by":"publisher","first-page":"e943784","DOI":"10.12659\/MSM.943784","volume":"30","author":"T Liu","year":"2024","unstructured":"Liu T, Zhao H, Zhao X, Qu M (2024) Comparison of remimazolam and Propofol on postoperative delirium in elderly patients undergoing radical resection of colon cancer: A Single-Center prospective randomized controlled study. Med Sci Monitor: Int Med J Experimental Clin Res 30:e943784","journal-title":"Med Sci Monitor: Int Med J Experimental Clin Res"},{"issue":"1","key":"3166_CR10","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13741-025-00500-4","volume":"14","author":"L Yaqiu","year":"2025","unstructured":"Yaqiu L, Heng Z, Ruimin W, Xuri W (2025) Effects of remimazolam and Propofol on sleep rhythm and delirium after spinal surgery in elderly patients. Perioperative Med (London England) 14(1):18","journal-title":"Perioperative Med (London England)"},{"key":"3166_CR11","doi-asserted-by":"publisher","first-page":"111735","DOI":"10.1016\/j.jclinane.2024.111735","volume":"101","author":"M Suga","year":"2025","unstructured":"Suga M, Yasuhara J, Watanabe A, Takagi H, Kuno T, Nishimura T, Ijuin S, Taira T, Inoue A, Ishihara S et al (2025) Postoperative delirium under general anaesthesia by remimazolam versus propofol: A systematic review and meta-analysis of randomised controlled trials. J Clin Anesth 101:111735","journal-title":"J Clin Anesth"},{"issue":"1","key":"3166_CR12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s40001-025-02383-z","volume":"30","author":"M Wang","year":"2025","unstructured":"Wang M, Liu J, Liu W, Zhang X, Zhang G, Sun L, Bi Y, Wang H, Dong R (2025) Effectiveness of perioperative remimazolam in preventing postoperative delirium: a systematic review and meta-analysis. Eur J Med Res 30(1):122","journal-title":"Eur J Med Res"},{"issue":"1","key":"3166_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00540-022-03119-7","volume":"37","author":"Y Aoki","year":"2023","unstructured":"Aoki Y, Kurita T, Nakajima M, Imai R, Suzuki Y, Makino H, Kinoshita H, Doi M, Nakajima Y (2023) Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study. J Anesth 37(1):13\u201322","journal-title":"J Anesth"},{"issue":"4","key":"3166_CR14","first-page":"e8","volume":"35","author":"L Bichajian","year":"2023","unstructured":"Bichajian L, Ostroff R, Greenberg M (2023) Comparing relative effects on cognitive function following sedation with remimazolam vs Midazolam as measured by the Hopkins verbal learning test. J Neurosurg Anesthesiol 35(4):e8\u2013e9","journal-title":"J Neurosurg Anesthesiol"},{"issue":"4","key":"3166_CR15","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1097\/ALN.0000000000003102","volume":"132","author":"A Eisenried","year":"2020","unstructured":"Eisenried A, Sch\u00fcttler J, Lerch M, Ihmsen H, Jeleazcov C (2020) Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part II. pharmacodynamics of electroencephalogram effects. Anesthesiology 132(4):652\u2013666","journal-title":"Anesthesiology"},{"issue":"4","key":"3166_CR16","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1097\/ALN.0000000000003103","volume":"132","author":"J Sch\u00fcttler","year":"2020","unstructured":"Sch\u00fcttler J, Eisenried A, Lerch M, Fechner J, Jeleazcov C, Ihmsen H (2020) Pharmacokinetics and pharmacodynamics of remimazolam (CNS 7056) after continuous infusion in healthy male volunteers: part I. Pharmacokinetics and clinical pharmacodynamics. Anesthesiology 132(4):636\u2013651","journal-title":"Anesthesiology"},{"issue":"5","key":"3166_CR17","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1213\/ANE.0b013e3182a705ae","volume":"117","author":"MT Worthington","year":"2013","unstructured":"Worthington MT, Antonik LJ, Goldwater DR, Lees JP, Wilhelm-Ogunbiyi K, Borkett KM, Mitchell MC (2013) A phase ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy. Anesth Analg 117(5):1093\u20131100","journal-title":"Anesth Analg"},{"key":"3166_CR18","doi-asserted-by":"crossref","unstructured":"Song X, Wang F, Dong R, Zhu K, Wang C (2022) Efficacy and safety of remimazolam tosilate combined with Esketamine for analgesic sedation in mechanically ventilated ICU patients: A Single-Arm clinical study protocol. Front Med (Lausanne). 2022;9:832105.","DOI":"10.3389\/fmed.2022.832105"},{"key":"3166_CR19","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.2147\/DDDT.S373772","volume":"16","author":"Y Deng","year":"2022","unstructured":"Deng Y, Qin Z, Wu Q, Liu L, Yang X, Ju X, Zhang Y, Liu L (2022) Efficacy and safety of remimazolam besylate versus Dexmedetomidine for sedation in Non-Intubated older patients with agitated delirium after orthopedic surgery: A randomized controlled trial. Drug Des Devel Ther 16:2439\u20132451","journal-title":"Drug Des Devel Ther"},{"key":"3166_CR20","doi-asserted-by":"crossref","unstructured":"Dong SA, Guo Y, Liu SS, Wu LL, Wu LN, Song K, Wang JH, Chen HR, Li WZ, Li HX et al (2023) A randomized, controlled clinical trial comparing remimazolam to Propofol when combined with alfentanil for sedation during ERCP procedures. J Clin Anesth. 2023;86:111077.","DOI":"10.1016\/j.jclinane.2023.111077"},{"key":"3166_CR21","doi-asserted-by":"publisher","first-page":"2669","DOI":"10.2147\/DDDT.S419146","volume":"17","author":"J Duan","year":"2023","unstructured":"Duan J, Ju X, Wang X, Liu N, Xu S, Wang S (2023) Effects of remimazolam and Propofol on emergence agitation in elderly patients undergoing hip replacement: a clinical, randomized, controlled study. Drug Des Devel Ther 17:2669\u20132678","journal-title":"Drug Des Devel Ther"},{"issue":"10","key":"3166_CR22","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1053\/j.jvca.2023.06.027","volume":"37","author":"Q Kuang","year":"2023","unstructured":"Kuang Q, Zhong N, Ye C, Zhu X, Wei F (2023) Propofol versus remimazolam on cognitive function, hemodynamics, and oxygenation during One-Lung ventilation in older patients undergoing pulmonary lobectomy: A randomized controlled trial. J Cardiothorac Vasc Anesth 37(10):1996\u20132005","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"3166_CR23","doi-asserted-by":"publisher","first-page":"121","DOI":"10.2147\/DDDT.S441622","volume":"18","author":"J Lee","year":"2024","unstructured":"Lee J, Han DW, Kim NY, Kim KS, Yang Y, Yang J, Lee HS, Kim MH (2024) Comparison of remimazolam versus Sevoflurane on the postoperative quality of recovery in cervical spine surgery: A prospective randomized controlled Double-Blind trial. Drug Des Devel Ther 18:121\u2013132","journal-title":"Drug Des Devel Ther"},{"key":"3166_CR24","doi-asserted-by":"crossref","unstructured":"Lee S, Kang HY, Ahn YN, You AH (2023) Comparison of the incidence of postoperative acute kidney injury following the administration of remimazolam or Sevoflurane in elderly patients undergoing total knee arthroplasty: A randomized controlled trial. J Personalized Med. 2023;13(5):789.","DOI":"10.3390\/jpm13050789"},{"issue":"3","key":"3166_CR25","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.gie.2018.04.2351","volume":"88","author":"DK Rex","year":"2018","unstructured":"Rex DK, Bhandari R, Desta T, DeMicco MP, Schaeffer C, Etzkorn K, Barish CF, Pruitt R, Cash BD, Quirk D et al (2018) A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and Midazolam in patients undergoing colonoscopy. Gastrointest Endosc 88(3):427\u2013437e426","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"3166_CR26","doi-asserted-by":"publisher","first-page":"301","DOI":"10.30773\/pi.2022.0323","volume":"20","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhang J, Feng S (2023) Remimazolam supplemented to general anesthesia alleviates stress and cognitive impairment in elder patients after hip surgery. Psychiatry Invest 20(4):301\u2013306","journal-title":"Psychiatry Invest"},{"issue":"2","key":"3166_CR27","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1213\/ANE.0b013e318241f68a","volume":"115","author":"HR Wiltshire","year":"2012","unstructured":"Wiltshire HR, Kilpatrick GJ, Tilbrook GS, Borkett KM (2012) A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, Pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part II. Population Pharmacokinetic and pharmacodynamic modeling and simulation. Anesth Analg 115(2):284\u2013296","journal-title":"Anesth Analg"},{"issue":"8","key":"3166_CR28","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.4314\/tjpr.v21i8.26","volume":"21","author":"LS Zhan","year":"2022","unstructured":"Zhan LS, Xu XF, Zhang YF, Huang G, Li D, Lan YP (2022) Effect of the of remazolam toluenesulfonate and IPACK on postoperative rehabilitation and sedation in elderly patients undergoing knee arthroplasty. Trop J Pharm Res 21(8):1771\u20131778","journal-title":"Trop J Pharm Res"},{"issue":"49","key":"3166_CR29","doi-asserted-by":"publisher","first-page":"e36440","DOI":"10.1097\/MD.0000000000036440","volume":"102","author":"YG Jeon","year":"2023","unstructured":"Jeon YG, Kim S, Park JH, Lee J, Song SA, Lim HK, Song SW (2023) Incidence of intraoperative hypotension in older patients undergoing total intravenous anesthesia by remimazolam versus propofol: A randomized controlled trial. Medicine 102(49):e36440","journal-title":"Medicine"},{"key":"3166_CR30","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/DDDT.S392569","volume":"17","author":"JJ Yang","year":"2023","unstructured":"Yang JJ, Lei L, Qiu D, Chen S, Xing LK, Zhao JW, Mao YY, Yang JJ (2023) Effect of remimazolam on postoperative delirium in older adult patients undergoing orthopedic surgery: A prospective randomized controlled clinical trial. Drug Des Devel Ther 17:143\u2013153","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"3166_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10143-021-01619-w","volume":"45","author":"PR Kappen","year":"2022","unstructured":"Kappen PR, Kakar E, Dirven CMF, van der Jagt M, Klimek M, Osse RJ, Vincent A (2022) Delirium in neurosurgery: a systematic review and meta-analysis. Neurosurg Rev 45(1):329\u2013341","journal-title":"Neurosurg Rev"},{"key":"3166_CR32","doi-asserted-by":"publisher","first-page":"110704","DOI":"10.1016\/j.jpsychores.2021.110704","volume":"153","author":"S Lee","year":"2022","unstructured":"Lee S, Okoro UE, Swanson MB, Mohr N, Faine B, Carnahan R (2022) Opioid and benzodiazepine use in the emergency department and the recognition of delirium within the first 24 hours of hospitalization. J Psychosom Res 153:110704","journal-title":"J Psychosom Res"},{"issue":"1","key":"3166_CR33","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00000542-200601000-00005","volume":"104","author":"P Pandharipande","year":"2006","unstructured":"Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW (2006) Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology 104(1):21\u201326","journal-title":"Anesthesiology"},{"issue":"7","key":"3166_CR34","doi-asserted-by":"publisher","first-page":"e045087","DOI":"10.1136\/bmjopen-2020-045087","volume":"11","author":"C Casault","year":"2021","unstructured":"Casault C, Soo A, Lee CH, Couillard P, Niven D, Stelfox T, Fiest K (2021) Sedation strategy and ICU delirium: a multicentre, population-based propensity score-matched cohort study. BMJ Open 11(7):e045087","journal-title":"BMJ Open"},{"key":"3166_CR35","doi-asserted-by":"publisher","first-page":"111356","DOI":"10.1016\/j.jclinane.2023.111356","volume":"93","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhang J, Wang Y, Bai X, Guo Q, Liu W, Li H, Zhu F, Wang X, Jiang X et al (2024) Effect of remimazolam vs Propofol on emergence from general anesthesia in patients undergoing cerebral endovascular procedures: A randomized controlled, non-inferiority trial. J Clin Anesth 93:111356","journal-title":"J Clin Anesth"},{"key":"3166_CR36","doi-asserted-by":"crossref","unstructured":"Fujimoto D, Obata N, Mizobuchi S (2024) Effectiveness of remimazolam in preventing postoperative delirium in elderly patients with proximal femoral fractures. J Anesth. 2024;38(4):475\u2013482.","DOI":"10.1007\/s00540-024-03339-z"},{"issue":"2","key":"3166_CR37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1213\/ANE.0b013e31823f0c28","volume":"115","author":"LJ Antonik","year":"2012","unstructured":"Antonik LJ, Goldwater DR, Kilpatrick GJ, Tilbrook GS, Borkett KM (2012) A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): part I. Safety, efficacy, and basic pharmacokinetics. Anesth Analg 115(2):274\u2013283","journal-title":"Anesth Analg"},{"issue":"4","key":"3166_CR38","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/s00540-020-02755-1","volume":"34","author":"K Masui","year":"2020","unstructured":"Masui K (2020) Remimazolam besilate, a benzodiazepine, has been approved for general anesthesia!! J Anesth 34(4):479\u2013482","journal-title":"J Anesth"},{"key":"3166_CR39","doi-asserted-by":"publisher","first-page":"641866","DOI":"10.3389\/fmed.2021.641866","volume":"8","author":"BJ Jhuang","year":"2021","unstructured":"Jhuang BJ, Yeh BH, Huang YT, Lai PC (2021) Efficacy and safety of remimazolam for procedural sedation: A Meta-Analysis of randomized controlled trials with trial sequential analysis. Front Med (Lausanne) 8:641866","journal-title":"Front Med (Lausanne)"},{"key":"3166_CR40","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnagi.2019.00043","volume":"11","author":"S Ouanes","year":"2019","unstructured":"Ouanes S, Popp J (2019) High cortisol and the risk of dementia and alzheimer\u2019s disease: A review of the literature. Front Aging Neurosci 11:43","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"3166_CR41","doi-asserted-by":"publisher","first-page":"301","DOI":"10.30773\/pi.2022.0323","volume":"20","author":"Y Sun","year":"2023","unstructured":"Sun Y, Zhang J, Feng S (2023) Remimazolam supplemented to general anesthesia alleviates stress and cognitive impairment in elder patients after hip surgery. Psychiatry Investig 20(4):301\u2013306","journal-title":"Psychiatry Investig"},{"key":"3166_CR42","doi-asserted-by":"publisher","first-page":"111125","DOI":"10.1016\/j.jclinane.2023.111125","volume":"88","author":"W Duan","year":"2023","unstructured":"Duan W, Zhou CM, Yang JJ, Zhang Y, Li ZP, Ma DQ, Yang JJ (2023) A long duration of intraoperative hypotension is associated with postoperative delirium occurrence following thoracic and orthopedic surgery in elderly. J Clin Anesth 88:111125","journal-title":"J Clin Anesth"},{"key":"3166_CR43","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.2147\/DDDT.S359496","volume":"16","author":"Y Mao","year":"2022","unstructured":"Mao Y, Guo J, Yuan J, Zhao E, Yang J (2022) Quality of recovery after general anesthesia with remimazolam in patients\u2019 undergoing urologic surgery: A randomized controlled trial comparing remimazolam with Propofol. Drug Des Devel Ther 16:1199\u20131209","journal-title":"Drug Des Devel Ther"},{"key":"3166_CR44","doi-asserted-by":"crossref","unstructured":"Huang X, Cao H, Zhang C, Lan H, Gong X, Li R, Lin Y, Xu B, Chen H, Guan X (2023) The difference in mean arterial pressure induced by remimazolam compared to etomidate in the presence of Fentanyl at tracheal intubation: A randomized controlled trial. Front Pharmacol 2023;14:1143784.","DOI":"10.3389\/fphar.2023.1143784"},{"key":"3166_CR45","doi-asserted-by":"crossref","unstructured":"Jeon YG, Kim S, Park JH, Lee J, Song SA, Lim HK, Song SW (2023) Incidence of intraoperative hypotension in older patients undergoing total intravenous anesthesia by remimazolam versus propofol: A randomized controlled trial. Medicine 102(49)","DOI":"10.1097\/MD.0000000000036440"},{"key":"3166_CR46","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.2147\/CIA.S327311","volume":"16","author":"B Zhao","year":"2021","unstructured":"Zhao B, Chen X, Chen Q, Li G, Chen Z, Yang Z, Gu L, Xiao X, Wang Z, Ning J et al (2021) Intraoperative hypotension and related risk factors for postoperative mortality after noncardiac surgery in elderly patients: A retrospective analysis report. Clin Interv Aging 16:1757\u20131767","journal-title":"Clin Interv Aging"},{"issue":"2","key":"3166_CR47","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/anae.15546","volume":"77","author":"MN Frandsen","year":"2022","unstructured":"Frandsen MN, Mehlsen J, Foss NB, Kehlet H (2022) Pre-operative autonomic nervous system function - a missing link for post-induction hypotension? Anaesthesia 77(2):139\u2013142","journal-title":"Anaesthesia"},{"issue":"6","key":"3166_CR48","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1113\/EP091143","volume":"108","author":"P Svorc Jr","year":"2023","unstructured":"Svorc P Jr., Svorc P, Gresova S (2023) Sex differences, chronobiology and general anaesthesia in activities of the autonomic nervous system in rats. Exp Physiol 108(6):810\u2013817","journal-title":"Exp Physiol"},{"issue":"5","key":"3166_CR49","doi-asserted-by":"publisher","first-page":"e0285120","DOI":"10.1371\/journal.pone.0285120","volume":"18","author":"K Tajima","year":"2023","unstructured":"Tajima K, Yamakawa K, Kuwabara Y, Miyazaki C, Sunaga H, Uezono S (2023) Propofol anesthesia decreases the incidence of new-onset postoperative atrial fibrillation compared to desflurane in patients undergoing video-assisted thoracoscopic surgery: A retrospective single-center study. PLoS ONE 18(5):e0285120","journal-title":"PLoS ONE"},{"issue":"1","key":"3166_CR50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/01.anes.0000267503.85085.c0","volume":"107","author":"GJ Kilpatrick","year":"2007","unstructured":"Kilpatrick GJ, McIntyre MS, Cox RF, Stafford JA, Pacofsky GJ, Lovell GG, Wiard RP, Feldman PL, Collins H, Waszczak BL et al (2007) CNS 7056: a novel ultra-short-acting benzodiazepine. Anesthesiology 107(1):60\u201366","journal-title":"Anesthesiology"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03166-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-025-03166-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03166-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:16:56Z","timestamp":1757416616000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-025-03166-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,21]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3166"],"URL":"https:\/\/doi.org\/10.1007\/s40520-025-03166-6","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,21]]},"assertion":[{"value":"24 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors agreed to the publication of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"253"}}