{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:25:28Z","timestamp":1776209128679,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT107467"],"award-info":[{"award-number":["WT107467"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hospitals pose a high risk for frailty to develop or accelerate. Still, few community-based cohort studies follow patients before, during, and after hospitalisation. We investigated the degree of immobility during hospitalisation and its impact on subsequent frailty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective population-based cohort of individuals aged\u2009\u2265\u200970 from a London UK borough, we performed comprehensive community assessments at baseline and after two years. At each hospitalisation, we measured daily mobility and other clinical variables. Acute immobility burden, a summative level of poor mobility for all hospitalisations, was calculated for each participant and operationalized as low\/high based on the population median. A frailty index was calculated for all participants during baseline and follow-up assessments. We estimated the effect of these exposures on follow-up frailty index scores using linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 1177 participants. Those admitted (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009114) were assessed over 1999 bed-days. The degree of baseline frailty had the largest association with subsequent frailty. However, a high immobility burden during hospitalisation was consistently related to additional increases in frailty (low burden: \u03b2\u2009=\u20090.02 per unit increase in FI (95%CI: -0.002-0.04), high burden: \u03b2\u2009=\u20090.07, (95%CI: 0.041-0.10)). Immobility burden remained associated with subsequent frailty even when limiting the analysis to: those who were independently mobile; the first seven days of hospitalisation; and accounting for illness severity. High immobility burden was prognostic of subsequent death.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The degree of immobility during hospitalisation, a potentially modifiable risk factor, may determine whether hospitalisation contributes to increasing frailty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40520-025-03178-2","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:42:48Z","timestamp":1761295368000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In a prospective population-based study, the degree of mobility impairment during hospitalisation is associated with higher degrees of frailty"],"prefix":"10.1007","volume":"37","author":[{"given":"Samuel D.","family":"Searle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petronella","family":"Chitalu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh Logan","family":"Ellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Rawle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Seeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Rockwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"issue":"6","key":"3178_CR1","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1056\/NEJMra2301292","volume":"391","author":"DH Kim","year":"2024","unstructured":"Kim DH, Rockwood K (2024) Frailty in older adults. 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KR currently chairs a data safety monitoring board for EIP Pharma Inc. on a study funded jointly by them an the National Institute on Aging. In the past three years has served as a member of the NIA-funded ADMET-2 advisory board (Johns Hopkins), and the Wake Forest University Medical School Centre advisory board. KR is co-founder of Ardea Outcomes (DGI Clinical until 2021), which in the past 3 years has had contracts with pharma and device manufacturers (Danone, Hollister, INmune, Novartis, Takeda) as well as the LuMind IDSC Down Syndrome Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"297"}}