{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:09:24Z","timestamp":1785254964312,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23141901500"],"award-info":[{"award-number":["23141901500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1422000"],"award-info":[{"award-number":["22ZR1422000"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC22023302"],"award-info":[{"award-number":["SHDC22023302"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"DOI":"10.1007\/s40520-025-03213-2","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:30:14Z","timestamp":1761651014000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Low skeletal muscle index combined with reduced bone density increases mortality rate in older adults with heart failure"],"prefix":"10.1007","volume":"37","author":[{"given":"Qinyue","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinkai","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"3213_CR1","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41569-024-01046-6","volume":"21","author":"MS Khan","year":"2024","unstructured":"Khan MS, Shahid I, Bennis A et al (2024) Global epidemiology of heart failure. Nat Rev Cardiol 21:717\u2013734. https:\/\/doi.org\/10.1038\/s41569-024-01046-6","journal-title":"Nat Rev Cardiol"},{"key":"3213_CR2","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1002\/ehf2.14377","volume":"10","author":"M B\u00e4ck","year":"2023","unstructured":"B\u00e4ck M, von Haehling S, Papp Z, Piepoli MF (2023) A year in heart failure: updates of clinical and preclinical findings. ESC Heart Fail 10:2150\u20132158. https:\/\/doi.org\/10.1002\/ehf2.14377","journal-title":"ESC Heart Fail"},{"key":"3213_CR3","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/clc.23970","volume":"46","author":"R Chen","year":"2023","unstructured":"Chen R, Xu J, Wang Y et al (2023) Prevalence of sarcopenia and its association with clinical outcomes in heart failure: an updated meta-analysis and systematic review. Clin Cardiol 46:260\u2013268. https:\/\/doi.org\/10.1002\/clc.23970","journal-title":"Clin Cardiol"},{"key":"3213_CR4","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1007\/s00198-022-06454-3","volume":"33","author":"P-L Xiao","year":"2022","unstructured":"Xiao P-L, Cui A-Y, Hsu C-J et al (2022) Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis. Osteoporos Int 33:2137\u20132153. https:\/\/doi.org\/10.1007\/s00198-022-06454-3","journal-title":"Osteoporos Int"},{"key":"3213_CR5","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/ejhf.2794","volume":"25","author":"G Loncar","year":"2023","unstructured":"Loncar G, Garfias-Veitl T, Valentova M et al (2023) Bone status in men with heart failure: results from the studies investigating co-morbidities aggravating heart failure. Eur J Heart Fail 25:714\u2013723. https:\/\/doi.org\/10.1002\/ejhf.2794","journal-title":"Eur J Heart Fail"},{"key":"3213_CR6","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1001\/jamacardio.2024.0911","volume":"9","author":"P Solla-Suarez","year":"2024","unstructured":"Solla-Suarez P, Arif SG, Ahmad F et al (2024) Osteosarcopenia and mortality in older adults undergoing transcatheter aortic valve replacement. JAMA Cardiol 9:611\u2013618. https:\/\/doi.org\/10.1001\/jamacardio.2024.0911","journal-title":"JAMA Cardiol"},{"key":"3213_CR7","doi-asserted-by":"publisher","first-page":"e222162","DOI":"10.1148\/radiol.222162","volume":"306","author":"MA Ohliger","year":"2023","unstructured":"Ohliger MA (2023) Body composition at CT and risk of future disease. Radiology 306:e222162. https:\/\/doi.org\/10.1148\/radiol.222162","journal-title":"Radiology"},{"key":"3213_CR8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s11547-020-01245-4","volume":"126","author":"E Di Cesare","year":"2021","unstructured":"Di Cesare E, Carerj S, Palmisano A et al (2021) Multimodality imaging in chronic heart failure. Radiol Med 126:231\u2013242. https:\/\/doi.org\/10.1007\/s11547-020-01245-4","journal-title":"Radiol Med"},{"key":"3213_CR9","doi-asserted-by":"publisher","first-page":"152168","DOI":"10.1016\/j.semarthrit.2023.152168","volume":"59","author":"DS da Rocha","year":"2023","unstructured":"da Rocha DS, Tessari JA, Mainardi NB et al (2023) Assessment of muscle mass using chest computed tomography-based quantitative and qualitative measurements in patients with systemic sclerosis: A retrospective study with cross-sectional and longitudinal analyses. Semin Arthritis Rheum 59:152168. https:\/\/doi.org\/10.1016\/j.semarthrit.2023.152168","journal-title":"Semin Arthritis Rheum"},{"key":"3213_CR10","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1002\/jbmr.1678","volume":"27","author":"EAPM Romme","year":"2012","unstructured":"Romme EAPM, Murchison JT, Phang KF et al (2012) Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD. J Bone Miner Res 27:2338\u20132343. https:\/\/doi.org\/10.1002\/jbmr.1678","journal-title":"J Bone Miner Res"},{"key":"3213_CR11","doi-asserted-by":"publisher","first-page":"112558","DOI":"10.1016\/j.nut.2024.112558","volume":"128","author":"J Tao","year":"2024","unstructured":"Tao J, Shi H, Shen B et al (2024) The chest CT perspective on sarcopenia: exploring reference values for muscle mass quantity\/quality and its application in elderly adults. Nutrition 128:112558. https:\/\/doi.org\/10.1016\/j.nut.2024.112558","journal-title":"Nutrition"},{"key":"3213_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ahj.2016.08.016","volume":"182","author":"V Dahya","year":"2016","unstructured":"Dahya V, Xiao J, Prado CM et al (2016) Computed tomography-derived skeletal muscle index: a novel predictor of frailty and hospital length of stay after transcatheter aortic valve replacement. Am Heart J 182:21\u201327. https:\/\/doi.org\/10.1016\/j.ahj.2016.08.016","journal-title":"Am Heart J"},{"key":"3213_CR13","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1002\/jcsm.12948","volume":"13","author":"Y Shen","year":"2022","unstructured":"Shen Y, Luo L, Fu H et al (2022) Chest computed tomography-derived muscle mass and quality indicators, in\u2010hospital outcomes, and costs in older inpatients. J Cachexia Sarcopenia Muscle 13:966\u2013975. https:\/\/doi.org\/10.1002\/jcsm.12948","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3213_CR14","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.2147\/DMSO.S462065","volume":"17","author":"C Xue","year":"2024","unstructured":"Xue C, Lu X, Sun G et al (2024) Efficacy of opportunistic screening with chest CT in identifying osteoporosis and osteopenia in patients with T2DM. Diabetes Metab Syndr Obes 17:2155\u20132163. https:\/\/doi.org\/10.2147\/DMSO.S462065","journal-title":"Diabetes Metab Syndr Obes"},{"key":"3213_CR15","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1007\/s10554-024-03169-w","volume":"40","author":"S Mirzai","year":"2024","unstructured":"Mirzai S, Persits I, Estep JD et al (2024) Skeletal muscle quantity and quality evaluation in heart failure: comparing thoracic versus abdominopelvic CT approaches. Int J Cardiovasc Imaging 40:1787\u20131796. https:\/\/doi.org\/10.1007\/s10554-024-03169-w","journal-title":"Int J Cardiovasc Imaging"},{"key":"3213_CR16","doi-asserted-by":"publisher","first-page":"155533","DOI":"10.1016\/j.metabol.2023.155533","volume":"144","author":"S Yuan","year":"2023","unstructured":"Yuan S, Larsson SC (2023) Epidemiology of sarcopenia: prevalence, risk factors, and consequences. Metabolism 144:155533. https:\/\/doi.org\/10.1016\/j.metabol.2023.155533","journal-title":"Metabolism"},{"key":"3213_CR17","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1161\/CIRCULATIONAHA.124.068624","volume":"150","author":"J-R Jheng","year":"2024","unstructured":"Jheng J-R, Bai Y, Noda K et al (2024) Skeletal muscle SIRT3 deficiency contributes to pulmonary vascular remodeling in pulmonary hypertension due to heart failure with preserved ejection fraction. Circulation 150:867\u2013883. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.068624","journal-title":"Circulation"},{"key":"3213_CR18","doi-asserted-by":"publisher","first-page":"R76","DOI":"10.1152\/ajpregu.1999.277.1.R76","volume":"277","author":"M Kj\u00e6r","year":"1999","unstructured":"Kj\u00e6r M, Hanel B, Worm L et al (1999) Cardiovascular and neuroendocrine responses to exercise in hypoxia during impaired neural feedback from muscle. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 277:R76\u2013R85. https:\/\/doi.org\/10.1152\/ajpregu.1999.277.1.R76","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"3213_CR19","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1093\/eurjpc\/zwaa117","volume":"28","author":"M Konishi","year":"2021","unstructured":"Konishi M, Kagiyama N, Kamiya K et al (2021) Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction. Eur J Prev Cardiol 28:1022\u20131029. https:\/\/doi.org\/10.1093\/eurjpc\/zwaa117","journal-title":"Eur J Prev Cardiol"},{"key":"3213_CR20","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004344","volume":"6","author":"RB Fohtung","year":"2017","unstructured":"Fohtung RB, Brown DL, Koh WJH et al (2017) Bone mineral density and risk of heart failure in older adults: the cardiovascular health study. J Am Heart Assoc 6:e004344. https:\/\/doi.org\/10.1161\/JAHA.116.004344","journal-title":"J Am Heart Assoc"},{"key":"3213_CR21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/eurheartj\/ehp483","volume":"31","author":"L Carbone","year":"2010","unstructured":"Carbone L, Buzkov\u00e1 P, Fink HA et al (2010) Hip fractures and heart failure: findings from the cardiovascular health study. Eur Heart J 31:77\u201384. https:\/\/doi.org\/10.1093\/eurheartj\/ehp483","journal-title":"Eur Heart J"},{"key":"3213_CR22","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1002\/ehf2.14741","volume":"11","author":"N Verheyen","year":"2024","unstructured":"Verheyen N, Schmid J, Kolesnik E et al (2024) Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction. ESC Heart Fail 11:1730\u20131738. https:\/\/doi.org\/10.1002\/ehf2.14741","journal-title":"ESC Heart Fail"},{"key":"3213_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/jcsm.12516","volume":"11","author":"G Loncar","year":"2020","unstructured":"Loncar G, Cvetinovic N, Lainscak M et al (2020) Bone in heart failure. J Cachexia Sarcopenia Muscle 11:381\u2013393. https:\/\/doi.org\/10.1002\/jcsm.12516","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3213_CR24","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.cjco.2020.12.005","volume":"3","author":"S Abe","year":"2021","unstructured":"Abe S, Yoshihisa A, Ichijo Y et al (2021) Serum TRACP5b, a marker of bone resorption, is associated with adverse cardiac prognosis in hospitalized patients with heart failure. CJC Open 3:470\u2013478. https:\/\/doi.org\/10.1016\/j.cjco.2020.12.005","journal-title":"CJC Open"},{"key":"3213_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fresc.2021.782848","volume":"2","author":"JM Leser","year":"2021","unstructured":"Leser JM, Harriot A, Buck HV et al (2021) Aging, osteo-sarcopenia, and musculoskeletal mechano-transduction. Front Rehabil Sci 2:782848. https:\/\/doi.org\/10.3389\/fresc.2021.782848","journal-title":"Front Rehabil Sci"},{"key":"3213_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2024.105486","volume":"125","author":"J Chen","year":"2024","unstructured":"Chen J, Xu J, Gou L et al (2024) Integrating transcriptomic and proteomic data for a comprehensive molecular perspective on the association between sarcopenia and osteoporosis. Arch Gerontol Geriatr 125:105486. https:\/\/doi.org\/10.1016\/j.archger.2024.105486","journal-title":"Arch Gerontol Geriatr"},{"key":"3213_CR27","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/jcsm.12567","volume":"11","author":"B Kirk","year":"2020","unstructured":"Kirk B, Zanker J, Duque G (2020) Osteosarcopenia: epidemiology, diagnosis, and treatment\u2014facts and numbers. J Cachexia Sarcopenia Muscle 11:609\u2013618. https:\/\/doi.org\/10.1002\/jcsm.12567","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3213_CR28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev.med.46.1.249","volume":"46","author":"KM Prestwood","year":"1995","unstructured":"Prestwood KM, Pilbeam CC, Raisz LG (1995) Treatment of osteoporosis. Annu Rev Med 46:249\u2013256. https:\/\/doi.org\/10.1146\/annurev.med.46.1.249","journal-title":"Annu Rev Med"},{"key":"3213_CR29","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1093\/cvr\/cvab241","volume":"118","author":"A Cittadini","year":"2022","unstructured":"Cittadini A, Isidori AM, Salzano A (2022) Testosterone therapy and cardiovascular diseases. Cardiovasc Res 118:2039\u20132057. https:\/\/doi.org\/10.1093\/cvr\/cvab241","journal-title":"Cardiovasc Res"},{"key":"3213_CR30","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1172\/JCI125915","volume":"129","author":"N Bonnet","year":"2019","unstructured":"Bonnet N, Bourgoin L, Biver E et al (2019) Rankl inhibition improves muscle strength and insulin sensitivity and restores bone mass. J Clin Invest 129:3214\u20133223. https:\/\/doi.org\/10.1172\/JCI125915","journal-title":"J Clin Invest"},{"key":"3213_CR31","doi-asserted-by":"publisher","DOI":"10.1172\/JCI179942","volume":"134","author":"T Bellido","year":"2024","unstructured":"Bellido T (2024) Bisphosphonates for osteoporosis: from bench to clinic. J Clin Invest 134:e179942. https:\/\/doi.org\/10.1172\/JCI179942","journal-title":"J Clin Invest"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03213-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-025-03213-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03213-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:03:35Z","timestamp":1761696215000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-025-03213-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,28]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3213"],"URL":"https:\/\/doi.org\/10.1007\/s40520-025-03213-2","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,28]]},"assertion":[{"value":"16 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of Huadong Hospital, Fudan University, Shanghai, China (Approval No. 20250093; Protocol No. 2025K252; approval date: June 17, 2025). Written informed consent was obtained from all participant statement.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}],"article-number":"303"}}