{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T03:10:15Z","timestamp":1794107415599,"version":"4.8.0"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Aging Clin Exp Res"],"DOI":"10.1007\/s40520-025-03216-z","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T15:46:34Z","timestamp":1763739994000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of host and gut microbiota-altering interventions on sarcopenia or its defining parameters: a systematic review and meta-analysis of nutrition-based intervention studies"],"prefix":"10.1007","volume":"38","author":[{"given":"Laurence","family":"Lapauw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadjia","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel","family":"Switsers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolan","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Vercauteren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Derrien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Raes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Gielen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"issue":"1","key":"3216_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruy\u00e8re O, Cederholm T et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(1):16\u201331","journal-title":"Age Ageing"},{"issue":"1","key":"3216_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/jcsm.12783","volume":"13","author":"F Petermann-Rocha","year":"2022","unstructured":"Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP et al (2022) Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis. J Cachexia Sarcopenia Muscle 13(1):86\u201399","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3216_CR3","doi-asserted-by":"crossref","unstructured":"Yuan S, Larsson SC (2023) Epidemiology of sarcopenia: Prevalence, risk factors, and consequences. Metabolism. :155533","DOI":"10.1016\/j.metabol.2023.155533"},{"issue":"2","key":"3216_CR4","doi-asserted-by":"publisher","first-page":"93","DOI":"10.14283\/jfa.2019.10","volume":"8","author":"SGKD Mb","year":"2019","unstructured":"Mb SGKD, T A, Sl GJG (2019) Economic impact of hospitalizations in US adults with sarcopenia. J Frailty Aging 8(2):93\u201399","journal-title":"J Frailty Aging"},{"issue":"4","key":"3216_CR5","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/jcsm.12589","volume":"11","author":"JE Morley","year":"2020","unstructured":"Morley JE, Kalantar-Zadeh K, Anker SD (2020) COVID-19: a major cause of cachexia and sarcopenia? J Cachexia Sarcopenia Muscle 11(4):863\u2013865","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3216_CR6","doi-asserted-by":"publisher","first-page":"101319","DOI":"10.1016\/j.mam.2024.101319","volume":"100","author":"M Grima-Terren","year":"2024","unstructured":"Grima-Terren M, Campanario S, Ramirez-Pardo I, Cisneros A, Hong X, Perdiguero E et al (2024) Muscle aging and sarcopenia: the pathology, etiology, and most promising therapeutic targets. Mol Aspects Med 100:101319","journal-title":"Mol Aspects Med"},{"key":"3216_CR7","doi-asserted-by":"crossref","unstructured":"Lapauw L, Rutten A, Dupont J, Amini N, Vercauteren L, Derrien M et al (2024) Associations between gut microbiota and sarcopenia or its defining parameters in older adults: A systematic review. J Cachexia Sarcopenia Muscle","DOI":"10.1002\/jcsm.13569"},{"key":"3216_CR8","doi-asserted-by":"crossref","unstructured":"Nikkhah A, Ejtahed HS, Ettehad Marvasti F, Taghavi M, Pakmehr A, Hajipour F et al (2023) The critical role of gut microbiota dysbiosis in skeletal muscle wasting: a systematic review. J Appl Microbiol. ;134(1)","DOI":"10.1093\/jambio\/lxac014"},{"issue":"2","key":"3216_CR9","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.numecd.2022.09.005","volume":"33","author":"M Zarezadeh","year":"2023","unstructured":"Zarezadeh M, Musazadeh V, Ghalichi F, Kavyani Z, Nasernia R, Parang M et al (2023) Effects of probiotics supplementation on blood pressure: an umbrella meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis 33(2):275\u2013286","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"3216_CR10","doi-asserted-by":"publisher","first-page":"107398","DOI":"10.1016\/j.phrs.2024.107398","volume":"208","author":"V Musazadeh","year":"2024","unstructured":"Musazadeh V, Assadian K, Rajabi F, Faghfouri AH, Soleymani Y, Kavyani Z et al (2024) The effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 208:107398","journal-title":"Pharmacol Res"},{"key":"3216_CR11","doi-asserted-by":"publisher","first-page":"105074","DOI":"10.1016\/j.jff.2022.105074","volume":"92","author":"MA Farhangi","year":"2022","unstructured":"Farhangi MA, Dehghan P, Musazadeh V, Kavyani M, Maleki P (2022) Effectiveness of omega-3 and prebiotics on adiponectin, leptin, liver enzymes lipid profile and anthropometric indices in patients with non-alcoholic fatty liver disease: A randomized controlled trial. J Funct Foods 92:105074","journal-title":"J Funct Foods"},{"key":"3216_CR12","doi-asserted-by":"publisher","first-page":"1121541","DOI":"10.3389\/fnut.2023.1121541","volume":"10","author":"V Musazadeh","year":"2023","unstructured":"Musazadeh V, Mohammadi Anilou M, Vajdi M, Karimi A, Sedgh Ahrabi S, Dehghan P (2023) Effects of synbiotics supplementation on anthropometric and lipid profile parameters: finding from an umbrella meta-analysis. Front Nutr 10:1121541","journal-title":"Front Nutr"},{"issue":"8","key":"3216_CR13","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B et al (2014) Expert consensus document. The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506\u2013514","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"8","key":"3216_CR14","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","volume":"14","author":"GR Gibson","year":"2017","unstructured":"Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ et al (2017) Expert consensus document: the international scientific association for probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491\u2013502","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3216_CR15","doi-asserted-by":"crossref","unstructured":"Besora-Moreno M, Llaurado E, Valls RM, Pedret A, Sola R (2024) Effects of Probiotics, Prebiotics, and synbiotics on sarcopenia parameters in older adults: A systematic review and Meta-Analysis of randomized controlled trials. Nutr Rev","DOI":"10.1093\/nutrit\/nuae145"},{"key":"3216_CR16","doi-asserted-by":"crossref","unstructured":"Badal VD, Vaccariello ED, Murray ER, Yu KE, Knight R, Jeste DV et al (2020) The gut Microbiome, Aging, and longevity: A systematic review. Nutrients. ;12(12)","DOI":"10.3390\/nu12123759"},{"issue":"8","key":"3216_CR17","doi-asserted-by":"publisher","first-page":"107471","DOI":"10.1016\/j.isci.2023.107471","volume":"26","author":"I Attaye","year":"2023","unstructured":"Attaye I, Lassen PB, Adriouch S, Steinbach E, Patino-Navarrete R, Davids M et al (2023) Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes. iScience 26(8):107471","journal-title":"iScience"},{"issue":"20","key":"3216_CR18","doi-asserted-by":"publisher","first-page":"9407","DOI":"10.1039\/D3FO02766J","volume":"14","author":"SS Chang","year":"2023","unstructured":"Chang SS, Chen LH, Huang KC, Huang SW, Chang CC, Liao KW et al (2023) Plant-based polyphenol rich protein supplementation attenuated skeletal muscle loss and Lowered the LDL level via gut microbiota remodeling in taiwan\u2019s community-dwelling elderly. Food Funct 14(20):9407\u20139418","journal-title":"Food Funct"},{"issue":"9","key":"3216_CR19","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41575-021-00440-6","volume":"18","author":"S Salminen","year":"2021","unstructured":"Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EMM et al (2021) The international scientific association of probiotics and prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 18(9):649\u2013667","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"3216_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.2307\/2529310","volume":"33","author":"JR Landis","year":"1977","unstructured":"Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159\u2013174","journal-title":"Biometrics"},{"key":"3216_CR21","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"key":"3216_CR22","doi-asserted-by":"crossref","unstructured":"Sterne JA, Hern\u00e1n MA, Reeves BC, Savovi\u0107 J, Berkman ND, Viswanathan M et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. :i4919","DOI":"10.1136\/bmj.i4919"},{"issue":"9","key":"3216_CR23","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s12603-022-1834-4","volume":"26","author":"S Ahles","year":"2022","unstructured":"Ahles S, Cuijpers I, Hartgens F, Troost FJ (2022) The effect of a citrus and pomegranate complex on physical fitness and mental Well-Being in healthy elderly: a randomized Placebo-Controlled trial. J Nutr Health Aging 26(9):839\u2013846","journal-title":"J Nutr Health Aging"},{"key":"3216_CR24","doi-asserted-by":"crossref","unstructured":"Abshirini M, Coad J, Wolber FM, Von Hurst P, Miller MR, Tian HS et al (2023) Effect of green-lipped mussel (Perna canaliculus) supplementation on faecal microbiota, body composition and iron status markers in overweight and obese postmenopausal women: a randomised, double-blind, placebo-controlled trial. J Nutritional Sci. ;12","DOI":"10.1017\/jns.2023.41"},{"key":"3216_CR25","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.2147\/CIA.S67449","volume":"9","author":"H Aleman-Mateo","year":"2014","unstructured":"Aleman-Mateo H, Carreon VR, Macias L, Astiazaran-Garcia H, Gallegos-Aguilar AC, Enriquez JR (2014) Nutrient-rich dairy proteins improve appendicular skeletal muscle mass and physical performance, and attenuate the loss of muscle strength in older men and women subjects: a single-blind randomized clinical trial. Clin Interv Aging 9:1517\u20131525","journal-title":"Clin Interv Aging"},{"key":"3216_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.2147\/CIA.S32356","volume":"7","author":"H Aleman-Mateo","year":"2012","unstructured":"Aleman-Mateo H, Macias L, Esparza-Romero J, Astiazaran-Garcia H, Blancas AL (2012) Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food. Clin Interv Aging 7:225\u2013234","journal-title":"Clin Interv Aging"},{"issue":"2","key":"3216_CR27","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00198-013-2450-2","volume":"25","author":"R Armamento-Villareal","year":"2014","unstructured":"Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore DR et al (2014) Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. Osteoporos Int 25(2):551\u2013558","journal-title":"Osteoporos Int"},{"issue":"3","key":"3216_CR28","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s12603-016-0698-x","volume":"20","author":"R Armamento-Villareal","year":"2016","unstructured":"Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT (2016) Effect of lifestyle intervention on the hormonal profile of frail, obese older men. J Nutr Health Aging 20(3):334\u2013340","journal-title":"J Nutr Health Aging"},{"issue":"6","key":"3216_CR29","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1093\/gerona\/gly146","volume":"74","author":"KM Beavers","year":"2019","unstructured":"Beavers KM, Nesbit BA, Kiel JR, Sheedy JL, Arterburn LM, Collins AE et al (2019) Effect of an Energy-Restricted, nutritionally Complete, higher protein meal plan on body composition and mobility in older adults with obesity: A randomized controlled trial. J Gerontol Biol Sci Med Sci 74(6):929\u2013935","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"3216_CR30","doi-asserted-by":"crossref","unstructured":"Bales CW, Starr KNP, Orenduff MC, McDonald SR, Molnar K, Jarman AK et al (2017) Influence of protein Intake, Race, and age on responses to a Weight-Reduction intervention in obese women. Curr Developments Nutr. ;1(5)","DOI":"10.3945\/cdn.117.000703"},{"issue":"3","key":"3216_CR31","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/jgs.16252","volume":"68","author":"JA Blumenthal","year":"2020","unstructured":"Blumenthal JA, Smith PJ, Mabe S, Hinderliter A, Welsh-Bohmer K, Browndyke JN et al (2020) Longer term effects of diet and exercise on neurocognition: 1-Year Follow-up of the ENLIGHTEN trial. J Am Geriatr Soc 68(3):559\u2013568","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"3216_CR32","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1093\/gerona\/glab240","volume":"77","author":"AM Brennan","year":"2022","unstructured":"Brennan AM, Standley RA, Anthony SJ, Grench KE, Helbling NL, DeLany JP et al (2022) Weight loss and exercise differentially affect insulin Sensitivity, body Composition, cardiorespiratory Fitness, and muscle strength in older adults with obesity: A randomized controlled trial. J Gerontol Biol Sci Med Sci 77(5):1088\u20131097","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"5","key":"3216_CR33","first-page":"476","volume":"42","author":"L Ceglia","year":"2023","unstructured":"Ceglia L, Shea K, Rasmussen H, Gilhooly CH, Dawson-Hughes B (2023) A randomized study on the effect of dried fruit on Acid-Base Balance, diet Quality, and markers of musculoskeletal health in community dwelling adults. J Am Nutr Assoc 42(5):476\u2013483","journal-title":"J Am Nutr Assoc"},{"issue":"1","key":"3216_CR34","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12986-024-00838-4","volume":"21","author":"J Chen","year":"2024","unstructured":"Chen J, Wang Y, Yang Y, Su C, Wang M, Chen Y et al (2024) Effects of cheese ingestion on muscle mass and strength in possible sarcopenia women: an open-label, parallel-group study. Nutr Metab (Lond) 21(1):64","journal-title":"Nutr Metab (Lond)"},{"issue":"3","key":"3216_CR35","first-page":"486","volume":"46","author":"J Collins","year":"2017","unstructured":"Collins J, Porter J, Truby H, Huggins CE (2017) A foodservice approach to enhance energy intake of elderly subacute patients: a pilot study to assess impact on patient outcomes and cost. Age Ageing 46(3):486\u2013493","journal-title":"Age Ageing"},{"issue":"3","key":"3216_CR36","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/JCN.0b013e31819846b9","volume":"24","author":"LS Evangelista","year":"2009","unstructured":"Evangelista LS, Heber D, Li Z, Bowerman S, Hamilton MA, Fonarow GC (2009) Reduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study. J Cardiovasc Nurs 24(3):207\u2013215","journal-title":"J Cardiovasc Nurs"},{"key":"3216_CR37","first-page":"S255","volume":"11","author":"D Gonzalez","year":"2012","unstructured":"Gonzalez D, Castillo L, Orea A, Olvera G, Balderas K, Utrera M et al (2012) Effect of a low-carbohydrate diet on clinical status in stable chronic heart failure patients. Eur J Heart Fail Supplement 11:S255","journal-title":"Eur J Heart Fail Supplement"},{"issue":"2","key":"3216_CR38","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1001\/archinte.164.2.210","volume":"164","author":"NP Hays","year":"2004","unstructured":"Hays NP, Starling RD, Liu X, Sullivan DH, Trappe TA, Fluckey JD et al (2004) Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition, and fat distribution in older men and women: a randomized controlled trial. Arch Intern Med 164(2):210\u2013217","journal-title":"Arch Intern Med"},{"issue":"3","key":"3216_CR39","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1210\/jc.2015-2315","volume":"101","author":"NC Horie","year":"2016","unstructured":"Horie NC, Serrao VT, Simon SS, Gascon MR, Dos Santos AX, Zambone MA et al (2016) Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment. J Clin Endocrinol Metab 101(3):1104\u20131112","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"3216_CR40","doi-asserted-by":"publisher","first-page":"e2025454","DOI":"10.1001\/jamanetworkopen.2020.25454","volume":"3","author":"H Kahleova","year":"2020","unstructured":"Kahleova H, Petersen KF, Shulman GI, Alwarith J, Rembert E, Tura A et al (2020) Effect of a Low-Fat vegan diet on body Weight, insulin Sensitivity, postprandial Metabolism, and intramyocellular and hepatocellular lipid levels in overweight adults: a randomized clinical trial. JAMA Netw Open 3(11):e2025454","journal-title":"JAMA Netw Open"},{"key":"3216_CR41","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.clnesp.2023.07.018","volume":"57","author":"MC Kruger","year":"2023","unstructured":"Kruger MC, Mazahery H, Mugridge O, Turner S, von Hurst P (2023) A comparative intervention trial of deer milk and an oral nutritional supplement efficacy for improving older adults\u2019 nutritional status, muscle mass and physical performance. Clin Nutr ESPEN 57:346\u2013357","journal-title":"Clin Nutr ESPEN"},{"issue":"5","key":"3216_CR42","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.clnu.2005.02.010","volume":"24","author":"F Manguso","year":"2005","unstructured":"Manguso F, D\u2019Ambra G, Menchise A, Sollazzo R, D\u2019Agostino L (2005) Effects of an appropriate oral diet on the nutritional status of patients with HCV-related liver cirrhosis: a prospective study. Clin Nutr 24(5):751\u2013759","journal-title":"Clin Nutr"},{"key":"3216_CR43","doi-asserted-by":"crossref","unstructured":"Mascar\u00f3 CM, Bouzas C, Montemayor S, Casares M, Llompart I, Ugarriza L et al (2022) Effect of a Six-Month lifestyle intervention on the physical activity and fitness status of adults with NAFLD and metabolic syndrome. Nutrients. ;14(9)","DOI":"10.3390\/nu14091813"},{"issue":"4","key":"3216_CR44","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1249\/MSS.0b013e31827aa3fa","volume":"45","author":"C Mason","year":"2013","unstructured":"Mason C, Xiao L, Imayama I, Duggan CR, Foster-Schubert KE, Kong A et al (2013) Influence of diet, exercise, and serum vitamin d on sarcopenia in postmenopausal women. Med Sci Sports Exerc 45(4):607\u2013614","journal-title":"Med Sci Sports Exerc"},{"issue":"6","key":"3216_CR45","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1007\/s11357-013-9530-2","volume":"35","author":"CE Neville","year":"2013","unstructured":"Neville CE, Young IS, Gilchrist SE, McKinley MC, Gibson A, Edgar JD et al (2013) Effect of increased fruit and vegetable consumption on physical function and muscle strength in older adults. Age (Dordr) 35(6):2409\u20132422","journal-title":"Age (Dordr)"},{"key":"3216_CR46","doi-asserted-by":"publisher","first-page":"1346637","DOI":"10.3389\/fspor.2024.1346637","volume":"6","author":"J Schalla","year":"2024","unstructured":"Schalla J, Frommelt S, Geisler S, Isenmann E (2024) Is there a beneficial effect of a high-protein diet on body composition and strength capacity in physical active middle-aged individuals?-An eight-week randomized controlled trial. Front Sports Act Living 6:1346637","journal-title":"Front Sports Act Living"},{"key":"3216_CR47","doi-asserted-by":"crossref","unstructured":"Rheu KM, Lee BJ, Son WH, Kim DS, Park HT, Ha MS et al (2022) Effect of fermented sarco oyster (Crassostrea gigas) extract on muscle strength enhancement in postmenopausal females: A Randomized, Double-Blind, Placebo-Controlled trial. Int J Environ Res Public Health. ;19(24)","DOI":"10.3390\/ijerph192416450"},{"issue":"11","key":"3216_CR48","doi-asserted-by":"publisher","first-page":"e13471","DOI":"10.1111\/jfbc.13471","volume":"44","author":"R Pan","year":"2020","unstructured":"Pan R, Xu T, Bai J, Xia S, Liu Q, Li J et al (2020) Effect of Lactobacillus plantarum fermented barley on plasma glycolipids and insulin sensitivity in subjects with metabolic syndrome. J Food Biochem 44(11):e13471","journal-title":"J Food Biochem"},{"key":"3216_CR49","unstructured":"Wright C, Zhou J, Sayer R, Kim JE, Campbell W (2015) Effect of a high protein, high egg diet on muscle composition, metabolic health and systemic inflammation in overweight and obese, older adults. FASEB J. ;29(1)"},{"key":"3216_CR50","doi-asserted-by":"crossref","unstructured":"Verreijen AM, Engberink MF, Memelink RG, Van Der Plas SE, Visser M, Weijs PJ (2015) Effect of a high protein diet and\/or resistance exercise on preservation of fat free mass during weight loss in overweight older adults: a randomized controlled trial. 34:S206 Clinical nutrition (Edinburgh, Scotland)","DOI":"10.1016\/S0261-5614(15)30641-5"},{"issue":"13","key":"3216_CR51","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1056\/NEJMoa1008234","volume":"364","author":"DT Villareal","year":"2011","unstructured":"Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R et al (2011) Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 364(13):1218\u20131229","journal-title":"N Engl J Med"},{"issue":"1","key":"3216_CR52","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1080\/21551197.2018.1564200","volume":"38","author":"KN Porter Starr","year":"2019","unstructured":"Porter Starr KN, Orenduff M, McDonald SR, Mulder H, Sloane R, Pieper CF et al (2019) Influence of weight reduction and enhanced protein intake on biomarkers of inflammation in older adults with obesity. J Nutr Gerontol Geriatr 38(1):33\u201349","journal-title":"J Nutr Gerontol Geriatr"},{"issue":"4","key":"3216_CR53","first-page":"762","volume":"20","author":"F Franceschi","year":"2016","unstructured":"Franceschi F, Feregalli B, Togni S, Cornelli U, Giacomelli L, Eggenhoffner R et al (2016) A novel phospholipid delivery system of Curcumin (Meriva\u00ae) preserves muscular mass in healthy aging subjects. Eur Rev Med Pharmacol Sci 20(4):762\u2013766","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"3216_CR54","doi-asserted-by":"crossref","unstructured":"Haroyan A, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, Sargsyan A et al (2018) Efficacy and safety of Curcumin and its combination with Boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. ;18(1)","DOI":"10.1186\/s12906-017-2062-z"},{"key":"3216_CR55","doi-asserted-by":"crossref","unstructured":"Lopresti AL, Smith SJ, Jackson-michel S, Fairchild T (2022) An investigation into the effects of a curcumin extract (Curcugen\u00ae) on osteoarthritis pain of the knee: A randomised, double-blind, placebo-controlled study. Nutrients. ;14(1)","DOI":"10.3390\/nu14010041"},{"issue":"2","key":"3216_CR56","doi-asserted-by":"publisher","first-page":"143","DOI":"10.14283\/jfa.2022.47","volume":"12","author":"RT Mankowski","year":"2023","unstructured":"Mankowski RT, Sibille KT, Leeuwenburgh C, Lin Y, Hsu FC, Qiu P et al (2023) Effects of Curcumin C3 Complex\u00ae on physical function in moderately functioning older adults with Low-Grade Inflammation - A pilot trial. J Frailty Aging 12(2):143\u2013149","journal-title":"J Frailty Aging"},{"issue":"4","key":"3216_CR57","doi-asserted-by":"publisher","first-page":"100323","DOI":"10.1016\/j.jhepr.2021.100323","volume":"3","author":"M Nachit","year":"2021","unstructured":"Nachit M, Lanthier N, Rodriguez J, Neyrinck AM, Cani PD, Bindels LB et al (2021) A dynamic association between myosteatosis and liver stiffness: results from a prospective interventional study in obese patients. JHEP Rep 3(4):100323","journal-title":"JHEP Rep"},{"issue":"3","key":"3216_CR58","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/ajcn\/nqy121","volume":"108","author":"CM Peterson","year":"2018","unstructured":"Peterson CM, Beyl RA, Marlatt KL, Martin CK, Aryana KJ, Marco ML et al (2018) Effect of 12 Wk of resistant starch supplementation on cardiometabolic risk factors in adults with prediabetes: a randomized controlled trial. Am J Clin Nutr 108(3):492\u2013501","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"3216_CR59","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3233\/NHA-170029","volume":"4","author":"JR Santos-Parker","year":"2018","unstructured":"Santos-Parker JR, Lubieniecki KL, Rossman MJ, Van Ark HJ, Bassett CJ, Strahler TR et al (2018) Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults. Nutr Healthy Aging 4(4):323\u2013333","journal-title":"Nutr Healthy Aging"},{"key":"3216_CR60","doi-asserted-by":"crossref","unstructured":"Thota RN, Rosato JI, Dias CB, Burrows TL, Martins RN, Garg ML (2020) Dietary supplementation with Curcumin reduce Circulating levels of glycogen synthase kinase-3\u0392 and islet amyloid polypeptide in adults with high risk of type 2 diabetes and alzheimer\u2019s disease. Nutrients. ;12(4)","DOI":"10.3390\/nu12041032"},{"issue":"1","key":"3216_CR61","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1089\/jmf.2020.4778","volume":"24","author":"K Varma","year":"2021","unstructured":"Varma K, Amalraj A, Divya C, Gopi S (2021) The efficacy of the novel bioavailable Curcumin (Cureit) in the management of sarcopenia in healthy elderly subjects: A Randomized, Placebo-Controlled, Double-Blind clinical study. J Med Food 24(1):40\u201349","journal-title":"J Med Food"},{"key":"3216_CR62","doi-asserted-by":"crossref","unstructured":"Yang J, Hou LM, Wang AH, Shang L, Jia X, Xu R et al (2024) Prebiotics improve frailty status in community-dwelling older individuals in a double-blind, randomized, controlled trial. J Clin Invest. ;134(18)","DOI":"10.1172\/JCI176507"},{"key":"3216_CR63","doi-asserted-by":"crossref","unstructured":"Chaiyasut C, Sivamaruthi BS, Lailerd N, Sirilun S, Khongtan S, Fukngoen P et al (2022) Probiotics supplementation improves intestinal Permeability, obesity index and metabolic biomarkers in elderly Thai subjects: A randomized controlled trial. Foods. ;11(3)","DOI":"10.3390\/foods11030268"},{"issue":"5","key":"3216_CR64","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3920\/BM2016.0067","volume":"7","author":"M Lei","year":"2016","unstructured":"Lei M, Hua LM, Wang DW (2016) The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial. Benef Microbes 7(5):631\u2013637","journal-title":"Benef Microbes"},{"issue":"3","key":"3216_CR65","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/joim.12805","volume":"284","author":"AG Nilsson","year":"2018","unstructured":"Nilsson AG, Sundh D, Backhed F, Lorentzon M (2018) Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J Intern Med 284(3):307\u2013317","journal-title":"J Intern Med"},{"issue":"6","key":"3216_CR66","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s00223-024-01211-6","volume":"114","author":"R Qaisar","year":"2024","unstructured":"Qaisar R, Burki A, Karim A, Iqbal MS, Ahmad F (2024) Probiotics supplements improve the Sarcopenia-Related quality of life in older adults with Age-Related muscle decline. Calcif Tissue Int 114(6):583\u2013591","journal-title":"Calcif Tissue Int"},{"key":"3216_CR67","doi-asserted-by":"crossref","unstructured":"Lee MC, Tu YT, Lee CC, Tsai SC, Hsu HY, Tsai TY et al (2021) Lactobacillus plantarum TWK10 improves muscle mass and functional performance in frail older adults: A Randomized, Double-Blind clinical trial. Microorganisms. ;9(7)","DOI":"10.3390\/microorganisms9071466"},{"key":"3216_CR68","doi-asserted-by":"crossref","unstructured":"Sharafedtinov KK, Plotnikova OA, Alexeeva RI, Sentsova TB, Songisepp E, Stsepetova J et al (2013) Hypocaloric diet supplemented with probiotic cheese improves body mass index and blood pressure indices of obese hypertensive patients - A randomized double-blind placebo-controlled pilot study. Nutr J. ;12(1)","DOI":"10.1186\/1475-2891-12-138"},{"issue":"5","key":"3216_CR69","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/hep4.1325","volume":"3","author":"E Rom\u00e1n","year":"2019","unstructured":"Rom\u00e1n E, Nieto JC, Gely C, Vidal S, Pozuelo M, Poca M et al (2019) Effect of a multistrain probiotic on cognitive function and risk of falls in patients with cirrhosis: A randomized trial. Hepatol Commun 3(5):632\u2013645","journal-title":"Hepatol Commun"},{"key":"3216_CR70","doi-asserted-by":"crossref","unstructured":"Karim A, Muhammad T, Shahid Iqbal M, Qaisar R (2022) A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial. Arch Gerontol Geriatr. ;102","DOI":"10.1016\/j.archger.2022.104721"},{"key":"3216_CR71","doi-asserted-by":"crossref","unstructured":"Karim A, Muhammad T, Shah I, Khan J, Qaisar R (2022) A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure. J Cardiol","DOI":"10.1016\/j.jjcc.2022.06.006"},{"issue":"12","key":"3216_CR72","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1017\/S0007114524002824","volume":"132","author":"A Karim","year":"2024","unstructured":"Karim A, Khan HA, Iqbal MS, Ahmad F, Qaisar R (2024) Probiotics\u2019 supplementation alleviates disease severity and improves postural balance by repairing intestinal leak in patients suffering from osteoarthritis: a double-blinded clinical trial. Br J Nutr 132(12):1602\u20131610","journal-title":"Br J Nutr"},{"key":"3216_CR73","doi-asserted-by":"crossref","unstructured":"Lee MC, Hsu YJ, Yang HJ, Huang CC (2025) Enhancement of lower limb muscle strength and reduction of inflammation in the elderly: A Randomized, Double-Blind clinical trial comparing Lacticaseibacillus paracasei PS23 probiotic with Heat-Treated supplementation. Nutrients. ;17(3)","DOI":"10.3390\/nu17030463"},{"issue":"4","key":"3216_CR74","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.3390\/nu5041276","volume":"5","author":"JV Neto","year":"2013","unstructured":"Neto JV, de Melo CM, Ribeiro SM (2013) Effects of three-month intake of synbiotic on inflammation and body composition in the elderly: a pilot study. Nutrients 5(4):1276\u20131286","journal-title":"Nutrients"},{"key":"3216_CR75","doi-asserted-by":"crossref","unstructured":"Ceglia L, Shea K, Rasmussen H, Gilhooly CH, Dawson-Hughes B (2022) A randomized study on the effect of dried fruit on Acid-Base Balance, diet Quality, and markers of musculoskeletal health in community dwelling adults. J Am Nutr Assoc. :1\u20138","DOI":"10.1080\/27697061.2022.2082599"},{"key":"3216_CR76","doi-asserted-by":"crossref","unstructured":"Karim A, Muhammad T, Shahid Iqbal M, Qaisar R (2022) A multistrain probiotic improves handgrip strength and functional capacity in patients with COPD: A randomized controlled trial. Archives Gerontol Geriatr. ;102:N.PAG-N.PAG.","DOI":"10.1016\/j.archger.2022.104721"},{"issue":"5","key":"3216_CR77","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jjcc.2022.06.006","volume":"80","author":"A Karim","year":"2022","unstructured":"Karim A, Muhammad T, Shah I, Khan J, Qaisar R (2022) A multistrain probiotic reduces sarcopenia by modulating Wnt signaling biomarkers in patients with chronic heart failure. J Cardiol 80(5):449\u2013455","journal-title":"J Cardiol"},{"key":"3216_CR78","doi-asserted-by":"crossref","unstructured":"Uchida M, Park J, Fujie S, Hosomi K, Horii N, Watanabe K et al (2024) Effect of resistance training and chicken meat on muscle strength and mass and the gut Microbiome of older women: A randomized controlled trial. Physiological Rep. ;12(12)","DOI":"10.14814\/phy2.16100"},{"key":"3216_CR79","doi-asserted-by":"crossref","unstructured":"Buigues C, Fernandez-Garrido J, Pruimboom L, Hoogland AJ, Navarro-Martinez R, Martinez-Martinez M et al (2016) Effect of a prebiotic formulation on frailty syndrome: A Randomized, Double-Blind clinical trial. Int J Mol Sci ;17(6)","DOI":"10.3390\/ijms17060932"},{"key":"3216_CR80","doi-asserted-by":"publisher","first-page":"112507","DOI":"10.1016\/j.nut.2024.112507","volume":"126","author":"W Yuan","year":"2024","unstructured":"Yuan W, Chen M, Chen Y, Xu D, Li Z, Bai H et al (2024) Effects of soy protein-rich meals on muscle health of older adults in long-term care: A randomized clinical trial. Nutrition 126:112507","journal-title":"Nutrition"},{"key":"3216_CR81","doi-asserted-by":"crossref","unstructured":"Struszczak L, O\u2019Leary M, Metcalf B, Hickson M, McClelland I, Torquati L et al (2024) Provision of a daily high protein and high energy meal: effects on the physical and psychological wellbeing of communitydwelling, malnourished elderly adults. Proceedings of the Nutrition Society. ;83","DOI":"10.1017\/S0029665124006955"},{"key":"3216_CR82","doi-asserted-by":"crossref","unstructured":"Kang CH, Jung ES, Jung SJ, Han YH, Chae SW, Jeong DY et al (2024) Pasteurized Akkermansia muciniphila HB05 (HB05P) improves muscle strength and function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled clinical trial. Nutrients. ;16(23)","DOI":"10.3390\/nu16234037"},{"issue":"1","key":"3216_CR83","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00394-024-03575-9","volume":"64","author":"D Argyropoulou","year":"2025","unstructured":"Argyropoulou D, Nomikos T, Terzis G, Tataki S, Geladas ND, Paschalis V (2025) The effects of dietary protein on physical performance and body composition in middle age and older people having type II diabetes mellitus: a randomized pilot study. Eur J Nutr 64(1):63","journal-title":"Eur J Nutr"},{"issue":"6","key":"3216_CR84","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1007\/s00394-024-03415-w","volume":"63","author":"R Fortuna","year":"2024","unstructured":"Fortuna R, Wang W, Mayengbam S, Tuplin EWN, Sampsell K, Sharkey KA et al (2024) Effect of prebiotic fiber on physical function and gut microbiota in adults, mostly women, with knee osteoarthritis and obesity: a randomized controlled trial. Eur J Nutr 63(6):2149\u20132161","journal-title":"Eur J Nutr"},{"issue":"5","key":"3216_CR85","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1039\/D4FO03307H","volume":"16","author":"CW Norazman","year":"2025","unstructured":"Norazman CW, Mohd Sopian M, Lee LK (2025) Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome. Food Funct 16(5):1847\u20131863","journal-title":"Food Funct"},{"key":"3216_CR86","doi-asserted-by":"crossref","unstructured":"Juesas A, Saez-Berlanga A, Babiloni-Lopez C, Martin EG, Garrigues-Pelufo L, Ferri-Caruana A et al (2025) Effects of accentuated eccentric and maximal strength High-Resistance training programs with or without a Curcumin-Based formulation supplement on body Composition, blood Pressure, and metabolic parameters in older adults. Diseases. ;13(2)","DOI":"10.3390\/diseases13020062"},{"key":"3216_CR87","doi-asserted-by":"crossref","unstructured":"Lyngb\u00e6k MPP, Legaard GE, Nielsen NS, Durrer C, Almdal TP, Lund MAV et al (2025) Effects of caloric restriction with different doses of exercise on fat loss in people living with type 2 diabetes: A secondary analysis of the DOSE-EX randomized clinical trial. J Sport Health Sci. ;14","DOI":"10.1016\/j.jshs.2024.100999"},{"issue":"3","key":"3216_CR88","doi-asserted-by":"publisher","first-page":"e13783","DOI":"10.1002\/jcsm.13783","volume":"16","author":"DA Koutoukidis","year":"2025","unstructured":"Koutoukidis DA, Jebb SA, Tomlinson JW, Mozes FE, Pavlides M, Lacharie M et al (2025) Severe dietary energy restriction for compensated cirrhosis due to metabolic Dysfunction-Associated steatotic liver disease: A randomised controlled trial. J Cachexia Sarcopenia Muscle 16(3):e13783","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3216_CR89","doi-asserted-by":"crossref","unstructured":"Fujie S, Horii N, Kajimoto H, Yamazaki H, Inoue K, Iemitsu K et al (2025) Impact of resistance training and chicken intake on vascular and muscle health in elderly women. J Cachexia Sarcopenia Muscle. ;16(1)","DOI":"10.1002\/jcsm.13572"},{"issue":"4","key":"3216_CR90","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1099\/ijsem.0.004107","volume":"70","author":"J Zheng","year":"2020","unstructured":"Zheng J, Wittouck S, Salvetti E, Franz C, Harris HMB, Mattarelli P et al (2020) A taxonomic note on the genus lactobacillus: description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of lactobacillaceae and Leuconostocaceae. Int J Syst Evol Microbiol 70(4):2782\u20132858","journal-title":"Int J Syst Evol Microbiol"},{"key":"3216_CR91","doi-asserted-by":"publisher","first-page":"1307762","DOI":"10.3389\/fragi.2024.1307762","volume":"5","author":"YS Handajani","year":"2024","unstructured":"Handajani YS, Turana Y, Hengky A, Hamid G, Schroeder-Butterfill E, Kristian K (2024) Probiotics supplementation or probiotic-fortified products on sarcopenic indices in older adults: systematic review and meta-analysis from recent randomized controlled trials. Front Aging 5:1307762","journal-title":"Front Aging"},{"issue":"2","key":"3216_CR92","doi-asserted-by":"publisher","first-page":"e0317699","DOI":"10.1371\/journal.pone.0317699","volume":"20","author":"Y Wang","year":"2025","unstructured":"Wang Y, Lei P (2025) Efficacy of probiotic supplements in the treatment of sarcopenia: A systematic review and meta-analysis. PLoS ONE 20(2):e0317699","journal-title":"PLoS ONE"},{"issue":"1","key":"3216_CR93","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/jcsm.13132","volume":"14","author":"K Prokopidis","year":"2023","unstructured":"Prokopidis K, Giannos P, Kirwan R, Ispoglou T, Galli F, Witard OC et al (2023) Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials. J Cachexia Sarcopenia Muscle 14(1):30\u201344","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"1","key":"3216_CR94","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1186\/s40001-025-02788-w","volume":"30","author":"Q Zeng","year":"2025","unstructured":"Zeng Q, Li P, Wu H, Zhuang Y, Zhang Y, Asemani S et al (2025) Probiotics and Gastrointestinal disorders: an umbrella meta-analysis of therapeutic efficacy. Eur J Med Res 30(1):515","journal-title":"Eur J Med Res"},{"issue":"9","key":"3216_CR95","first-page":"1073","volume":"78","author":"B Kligler","year":"2008","unstructured":"Kligler B, Cohrssen A, Probiotics (2008) Am Fam Physician 78(9):1073\u20131078","journal-title":"Am Fam Physician"},{"issue":"2","key":"3216_CR96","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s13668-024-00527-x","volume":"13","author":"MN Aykut","year":"2024","unstructured":"Aykut MN, Erdogan EN, Celik MN, Gurbuz M (2024) An updated view of the effect of probiotic supplement on sports performance: A detailed review. Curr Nutr Rep 13(2):251\u2013263","journal-title":"Curr Nutr Rep"},{"issue":"2","key":"3216_CR97","doi-asserted-by":"publisher","first-page":"e0024024","DOI":"10.1128\/cmr.00240-24","volume":"38","author":"MY Cho","year":"2025","unstructured":"Cho MY, Eom JH, Choi EM, Yang SJ, Lee D, Kim YY et al (2025) Recent advances in therapeutic probiotics: insights from human trials. Clin Microbiol Rev 38(2):e0024024","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"3216_CR98","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1038\/s41467-024-46116-y","volume":"15","author":"M Ni Lochlainn","year":"2024","unstructured":"Ni Lochlainn M, Bowyer RCE, Moll JM, Garcia MP, Wadge S, Baleanu AF et al (2024) Effect of gut Microbiome modulation on muscle function and cognition: the promote randomised controlled trial. Nat Commun 15(1):1859","journal-title":"Nat Commun"},{"issue":"6","key":"3216_CR99","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1007\/s00394-022-02802-5","volume":"61","author":"R Almutairi","year":"2022","unstructured":"Almutairi R, Basson AR, Wearsh P, Cominelli F, Rodriguez-Palacios A (2022) Validity of food additive maltodextrin as placebo and effects on human gut physiology: systematic review of placebo-controlled clinical trials. Eur J Nutr 61(6):2853\u20132871","journal-title":"Eur J Nutr"},{"issue":"11","key":"3216_CR100","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1038\/s41564-024-01831-6","volume":"9","author":"K Whelan","year":"2024","unstructured":"Whelan K, Alexander M, Gaiani C, Lunken G, Holmes A, Staudacher HM et al (2024) Design and reporting of prebiotic and probiotic clinical trials in the context of diet and the gut Microbiome. Nat Microbiol 9(11):2785\u20132794","journal-title":"Nat Microbiol"},{"issue":"2","key":"3216_CR101","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1017\/S0954422410000247","volume":"23","author":"P Guilloteau","year":"2010","unstructured":"Guilloteau P, Martin L, Eeckhaut V, Ducatelle R, Zabielski R, Van Immerseel F (2010) From the gut to the peripheral tissues: the multiple effects of butyrate. Nutr Res Rev 23(2):366\u2013384","journal-title":"Nutr Res Rev"},{"issue":"5","key":"3216_CR102","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s10787-019-00607-3","volume":"27","author":"KR Kahkhaie","year":"2019","unstructured":"Kahkhaie KR, Mirhosseini A, Aliabadi A, Mohammadi A, Mousavi MJ, Haftcheshmeh SM et al (2019) Curcumin: a modulator of inflammatory signaling pathways in the immune system. Inflammopharmacology 27(5):885\u2013900","journal-title":"Inflammopharmacology"},{"issue":"2","key":"3216_CR103","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s00394-019-01931-8","volume":"59","author":"A Milajerdi","year":"2020","unstructured":"Milajerdi A, Mousavi SM, Sadeghi A, Salari-Moghaddam A, Parohan M, Larijani B et al (2020) The effect of probiotics on inflammatory biomarkers: a meta-analysis of randomized clinical trials. Eur J Nutr 59(2):633\u2013649","journal-title":"Eur J Nutr"},{"key":"3216_CR104","doi-asserted-by":"crossref","unstructured":"Beane KE, Redding MC, Wang XF, Pan JH, Le B, Cicalo C et al (2021) Effects of dietary fibers, micronutrients, and phytonutrients on gut microbiome: a review. Appl Biol Chem. ;64(1)","DOI":"10.1186\/s13765-021-00605-6"},{"key":"3216_CR105","unstructured":"Dietary recommendations for dietary fibre intake [Web page]. European Commission (2021) [updated 08-04-202124-02-2025]. Available from: https:\/\/knowledge4policy.ec.europa.eu\/health-promotion-knowledge-gateway\/dietary-fibre-recommendations-2_en"},{"key":"3216_CR106","unstructured":"Hazan S, Dave S, Papoutsis AJ, Deshpande N, Howell MC Jr., Martin LM (2022) Vitamin C improves gut bifidobacteria in humans. Future Microbiol"},{"issue":"7","key":"3216_CR107","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1111\/j.1753-4887.2010.00298.x","volume":"68","author":"EM Weinheimer","year":"2010","unstructured":"Weinheimer EM, Sands LP, Campbell WW (2010) A systematic review of the separate and combined effects of energy restriction and exercise on fat-free mass in middle-aged and older adults: implications for sarcopenic obesity. Nutr Rev 68(7):375\u2013388","journal-title":"Nutr Rev"},{"key":"3216_CR108","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/nu16193328","volume":"16","author":"O Anyiam","year":"2024","unstructured":"Anyiam O, Abdul Rashid RS, Bhatti A, Khan-Madni S, Ogunyemi O, Ardavani A et al (2024) A systematic review and Meta-Analysis of the effect of caloric restriction on skeletal muscle mass in individuals with, and without, type 2 diabetes. Nutrients 16:19","journal-title":"Nutrients"},{"issue":"10","key":"3216_CR109","doi-asserted-by":"publisher","first-page":"e1913733","DOI":"10.1001\/jamanetworkopen.2019.13733","volume":"2","author":"RV Seimon","year":"2019","unstructured":"Seimon RV, Wild-Taylor AL, Keating SE, McClintock S, Harper C, Gibson AA et al (2019) Effect of weight loss via severe vs moderate energy restriction on lean mass and body composition among postmenopausal women with obesity: the TEMPO diet randomized clinical trial. JAMA Netw Open 2(10):e1913733","journal-title":"JAMA Netw Open"},{"issue":"2","key":"3216_CR110","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/jcsm.12922","volume":"13","author":"EA Nunes","year":"2022","unstructured":"Nunes EA, Colenso-Semple L, McKellar SR, Yau T, Ali MU, Fitzpatrick-Lewis D et al (2022) Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults. J Cachexia Sarcopenia Muscle 13(2):795\u2013810","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"2","key":"3216_CR111","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1093\/ajcn\/nqab332","volume":"115","author":"A Cotillard","year":"2022","unstructured":"Cotillard A, Cartier-Meheust A, Litwin NS, Chaumont S, Saccareau M, Lejzerowicz F et al (2022) A posteriori dietary patterns better explain variations of the gut Microbiome than individual markers in the American gut project. Am J Clin Nutr 115(2):432\u2013443","journal-title":"Am J Clin Nutr"},{"key":"3216_CR112","doi-asserted-by":"crossref","unstructured":"Di Rosa C, Di Francesco L, Spiezia C, Khazrai YM (2023) Effects of animal and vegetable proteins on gut microbiota in subjects with overweight or obesity. Nutrients. ;15(12)","DOI":"10.3390\/nu15122675"},{"issue":"1","key":"3216_CR113","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/ismej.2015.88","volume":"10","author":"IB Jeffery","year":"2016","unstructured":"Jeffery IB, Lynch DB, O\u2019Toole PW (2016) Composition and Temporal stability of the gut microbiota in older persons. ISME J 10(1):170\u2013182","journal-title":"ISME J"},{"issue":"22","key":"3216_CR114","first-page":"4742","volume":"20","author":"S Bibbo","year":"2016","unstructured":"Bibbo S, Ianiro G, Giorgio V, Scaldaferri F, Masucci L, Gasbarrini A et al (2016) The role of diet on gut microbiota composition. Eur Rev Med Pharmacol Sci 20(22):4742\u20134749","journal-title":"Eur Rev Med Pharmacol Sci"}],"container-title":["Aging Clinical and Experimental Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03216-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40520-025-03216-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40520-025-03216-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T06:05:04Z","timestamp":1767679504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40520-025-03216-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,21]]},"references-count":114,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3216"],"URL":"https:\/\/doi.org\/10.1007\/s40520-025-03216-z","relation":{},"ISSN":["1720-8319"],"issn-type":[{"value":"1720-8319","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,21]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}