{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:56:15Z","timestamp":1760597775609},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Mol Bio Rep"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1007\/s40610-017-0075-5","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T02:40:48Z","timestamp":1508380848000},"page":"236-246","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Skeletal Stem Cells: Origins, Functions, and Uncertainties"],"prefix":"10.1007","volume":"3","author":[{"given":"Fatma F.","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renny T.","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"issue":"4","key":"75_CR1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.stem.2008.03.002","volume":"2","author":"P Bianco","year":"2008","unstructured":"Bianco P, Robey PG, Simmons PJ. Mesenchymal stem cells: revisiting history, concepts, and assays. Cell Stem Cell. 2008;2(4):313\u20139.","journal-title":"Cell Stem Cell"},{"key":"75_CR2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2307\/3570892","volume":"14","author":"JE Till","year":"1961","unstructured":"Till JE, Mc CE. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res. 1961;14:213\u201322.","journal-title":"Radiat Res"},{"key":"75_CR3","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/197452a0","volume":"197","author":"AJ Becker","year":"1963","unstructured":"Becker AJ, Mc CE, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature. 1963;197:452\u20134.","journal-title":"Nature"},{"issue":"1\u20132","key":"75_CR4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2014.12.002","volume":"160","author":"CK Chan","year":"2015","unstructured":"\u2022 Chan CK, Seo EY, Chen JY, Lo D, McArdle A, Sinha R, et al. Identification and specification of the mouse skeletal stem cell. Cell. 2015;160(1\u20132):285\u201398. Novel use of \"rainbow\" mouse model to establish the clonal nature of SSC in vivo","journal-title":"Cell"},{"key":"75_CR5","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-62703-989-5_21","volume":"1130","author":"PG Robey","year":"2014","unstructured":"\u2022\u2022 Robey PG, Kuznetsov SA, Riminucci M, Bianco P. Bone marrow stromal cell assays: in vitro and in vivo. Methods Mol Biol. 2014;1130:279\u201393. Description of methods for clonal analysis of marrow SSCs ex vivo","journal-title":"Methods Mol Biol"},{"issue":"3","key":"75_CR6","first-page":"381","volume":"16","author":"AJ Friedenstein","year":"1966","unstructured":"Friedenstein AJ, Piatetzky S II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol. 1966;16(3):381\u201390.","journal-title":"J Embryol Exp Morphol"},{"issue":"4","key":"75_CR7","first-page":"393","volume":"3","author":"AJ Friedenstein","year":"1970","unstructured":"Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3(4):393\u2013403.","journal-title":"Cell Tissue Kinet"},{"issue":"2","key":"75_CR8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/00007890-196803000-00009","volume":"6","author":"AJ Friedenstein","year":"1968","unstructured":"Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation. 1968;6(2):230\u201347.","journal-title":"Transplantation"},{"issue":"4","key":"75_CR9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00007890-197404000-00001","volume":"17","author":"AJ Friedenstein","year":"1974","unstructured":"Friedenstein AJ, Chailakhyan RK, Latsinik NV, Panasyuk AF, Keiliss-Borok IV. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation. 1974;17(4):331\u201340.","journal-title":"Transplantation"},{"key":"75_CR10","first-page":"42","volume":"136","author":"M Owen","year":"1988","unstructured":"Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. CIBA Found Symp. 1988;136:42\u201360.","journal-title":"CIBA Found Symp"},{"issue":"19","key":"75_CR11","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1242\/dev.02568","volume":"133","author":"HK Mikkola","year":"2006","unstructured":"Mikkola HK, Orkin SH. The journey of developing hematopoietic stem cells. Development. 2006;133(19):3733\u201344.","journal-title":"Development"},{"issue":"2","key":"75_CR12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1182\/blood.V87.2.518.bloodjournal872518","volume":"87","author":"RS Taichman","year":"1996","unstructured":"Taichman RS, Reilly MJ, Emerson SG. Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures. Blood. 1996;87(2):518\u201324.","journal-title":"Blood"},{"issue":"1","key":"75_CR13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/stem.160007","volume":"16","author":"RS Taichman","year":"1998","unstructured":"Taichman RS, Emerson SG. The role of osteoblasts in the hematopoietic microenvironment. Stem Cells. 1998;16(1):7\u201315.","journal-title":"Stem Cells"},{"issue":"5","key":"75_CR14","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1084\/jem.179.5.1677","volume":"179","author":"RS Taichman","year":"1994","unstructured":"Taichman RS, Emerson SG. Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor. J Exp Med. 1994;179(5):1677\u201382.","journal-title":"J Exp Med"},{"issue":"1","key":"75_CR15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1182\/blood.V46.1.65.65","volume":"46","author":"BI Lord","year":"1975","unstructured":"Lord BI, Testa NG, Hendry JH. The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood. 1975;46(1):65\u201372.","journal-title":"Blood"},{"issue":"4336","key":"75_CR16","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.75570","volume":"199","author":"JK Gong","year":"1978","unstructured":"Gong JK. Endosteal marrow: a rich source of hematopoietic stem cells. Science. 1978;199(4336):1443\u20135.","journal-title":"Science"},{"issue":"6960","key":"75_CR17","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","volume":"425","author":"LM Calvi","year":"2003","unstructured":"Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841\u20136.","journal-title":"Nature"},{"issue":"6960","key":"75_CR18","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nature02041","volume":"425","author":"J Zhang","year":"2003","unstructured":"Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003;425(6960):836\u201341.","journal-title":"Nature"},{"issue":"2","key":"75_CR19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1182\/blood-2011-09-377853","volume":"120","author":"O Bromberg","year":"2012","unstructured":"Bromberg O, Frisch BJ, Weber JM, Porter RL, Civitelli R, Calvi LM. Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells. Blood. 2012;120(2):303\u201313.","journal-title":"Blood"},{"issue":"6","key":"75_CR20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","volume":"25","author":"T Sugiyama","year":"2006","unstructured":"Sugiyama T, Kohara H, Noda M, Nagasawa T. Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006;25(6):977\u201388.","journal-title":"Immunity"},{"issue":"3","key":"75_CR21","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1182\/blood.V92.3.908","volume":"92","author":"O Ohneda","year":"1998","unstructured":"Ohneda O, Fennie C, Zheng Z, Donahue C, La H, Villacorta R, et al. Hematopoietic stem cell maintenance and differentiation are supported by embryonic aorta-gonad-mesonephros region-derived endothelium. Blood. 1998;92(3):908\u201319.","journal-title":"Blood"},{"issue":"12","key":"75_CR22","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.exphem.2004.09.001","volume":"32","author":"W Li","year":"2004","unstructured":"Li W, Johnson SA, Shelley WC, Yoder MC. Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells. Exp Hematol. 2004;32(12):1226\u201337.","journal-title":"Exp Hematol"},{"issue":"4","key":"75_CR23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nri2279","volume":"8","author":"MJ Kiel","year":"2008","unstructured":"Kiel MJ, Morrison SJ. Uncertainty in the niches that maintain haematopoietic stem cells. Nat Rev Immunol. 2008;8(4):290\u2013301.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"75_CR24","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.stem.2015.02.019","volume":"16","author":"Y Kfoury","year":"2015","unstructured":"\u2022\u2022 Kfoury Y, Scadden DT. Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell. 2015;16(3):239\u201353. Review of relationship between SSCs and the hematopoeitic niche","journal-title":"Cell Stem Cell"},{"issue":"7483","key":"75_CR25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","volume":"505","author":"SJ Morrison","year":"2014","unstructured":"\u2022 Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature. 2014;505(7483):327\u201334. Review on the hematopoietic niche with emphasis on questions related to the identity of perivascular cells","journal-title":"Nature"},{"issue":"3","key":"75_CR26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.immuni.2010.08.017","volume":"33","author":"Y Omatsu","year":"2010","unstructured":"Omatsu Y, Sugiyama T, Kohara H, Kondoh G, Fujii N, Kohno K, et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity. 2010;33(3):387\u201399.","journal-title":"Immunity"},{"issue":"7440","key":"75_CR27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11885","volume":"495","author":"L Ding","year":"2013","unstructured":"Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013;495(7440):231\u20135.","journal-title":"Nature"},{"issue":"7308","key":"75_CR28","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","volume":"466","author":"S Mendez-Ferrer","year":"2010","unstructured":"Mendez-Ferrer S, Michurina TV, Ferraro F, Mazloom AR, Macarthur BD, Lira SA, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829\u201334.","journal-title":"Nature"},{"issue":"7228","key":"75_CR29","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature07547","volume":"457","author":"CK Chan","year":"2009","unstructured":"Chan CK, Chen CC, Luppen CA, Kim JB, DeBoer AT, Wei K, et al. Endochondral ossification is required for haematopoietic stem-cell niche formation. Nature. 2009;457(7228):490\u20134.","journal-title":"Nature"},{"issue":"2","key":"75_CR30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2007.08.025","volume":"131","author":"B Sacchetti","year":"2007","unstructured":"Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131(2):324\u201336.","journal-title":"Cell"},{"issue":"2","key":"75_CR31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/path.1443","volume":"201","author":"Q Li","year":"2003","unstructured":"Li Q, Yu Y, Bischoff J, Mulliken JB, Olsen BR. Differential expression of CD146 in tissues and endothelial cells derived from infantile haemangioma and normal human skin. J Pathol. 2003;201(2):296\u2013302.","journal-title":"J Pathol"},{"issue":"3","key":"75_CR32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","volume":"3","author":"M Crisan","year":"2008","unstructured":"Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 2008;3(3):301\u201313.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"75_CR33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.stemcr.2016.05.011","volume":"6","author":"B Sacchetti","year":"2016","unstructured":"\u2022 Sacchetti B, Funari A, Remoli C, Giannicola G, Kogler G, Liedtke S, et al. No identical \u201cmesenchymal stem cells\u201d at different times and sites: human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels. Stem Cell Reports. 2016;6(6):897\u2013913. Evidence that there is not a single kind of perivascular stem cell; rather, perivascular mesenchymal populations from different tissues have different lineage potentials","journal-title":"Stem Cell Reports"},{"issue":"4","key":"75_CR34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(90)90662-X","volume":"60","author":"U Lendahl","year":"1990","unstructured":"Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell. 1990;60(4):585\u201395.","journal-title":"Cell"},{"issue":"1\u20132","key":"75_CR35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cell.2014.11.042","volume":"160","author":"DL Worthley","year":"2015","unstructured":"\u2022 Worthley DL, Churchill M, Compton JT, Tailor Y, Rao M, Si Y, et al. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. Cell. 2015;160(1\u20132):269\u201384. Use of Gremlin 1 as a marker for osteochodroreticular cells of bone metaphysis","journal-title":"Cell"},{"issue":"3","key":"75_CR36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.devcel.2014.03.014","volume":"29","author":"N Ono","year":"2014","unstructured":"\u2022\u2022 Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM. Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Dev Cell. 2014;29(3):330\u20139. Demonstration that nestin-GFP is a marker for SSCs that are first identified in the perichondrium during bone development","journal-title":"Dev Cell"},{"issue":"2","key":"75_CR37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.stem.2014.07.001","volume":"15","author":"Y Matsuzaki","year":"2014","unstructured":"Matsuzaki Y, Mabuchi Y, Okano H. Leptin receptor makes its mark on MSCs. Cell Stem Cell. 2014;15(2):112\u20134.","journal-title":"Cell Stem Cell"},{"issue":"6","key":"75_CR38","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/002215549704500613","volume":"45","author":"N Takakura","year":"1997","unstructured":"Takakura N, Yoshida H, Ogura Y, Kataoka H, Nishikawa S, Nishikawa S. PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5. J Histochem Cytochem. 1997;45(6):883\u201393.","journal-title":"J Histochem Cytochem"},{"issue":"11","key":"75_CR39","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1084\/jem.20091046","volume":"206","author":"S Morikawa","year":"2009","unstructured":"Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med. 2009;206(11):2483\u201396.","journal-title":"J Exp Med"},{"issue":"2","key":"75_CR40","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.stem.2014.06.008","volume":"15","author":"BO Zhou","year":"2014","unstructured":"\u2022\u2022 Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014;15(2):154\u201368. Identification of Leptin receptor as a marker for pluripotent SCCs in adult mice","journal-title":"Cell Stem Cell"},{"issue":"7","key":"75_CR41","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1084\/jem.20122252","volume":"210","author":"S Pinho","year":"2013","unstructured":"Pinho S, Lacombe J, Hanoun M, Mizoguchi T, Bruns I, Kunisaki Y, et al. PDGFRalpha and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med. 2013;210(7):1351\u201367.","journal-title":"J Exp Med"},{"key":"75_CR42","doi-asserted-by":"crossref","first-page":"362753","DOI":"10.1155\/2015\/362753","volume":"2015","author":"RM Farahani","year":"2015","unstructured":"\u2022 Farahani RM, Xaymardan M. Platelet-derived growth factor receptor alpha as a marker of mesenchymal stem cells in development and stem cell biology. Stem Cells Int. 2015;2015:362753. Review of studies using PDGFR\u03b1 as a mesenchymal stem cell marker","journal-title":"Stem Cells Int"},{"key":"75_CR43","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Yue R, Zhou BO, Shimada IS, Zhao Z, Morrison SJ. Leptin receptor promotes Adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow. Cell Stem Cell. 2016;18(6):782\u2013796. Demonstration of a functional role for leptin signaling in control of SCC lineage in the marrow of adult mice.","DOI":"10.1016\/j.stem.2016.02.015"},{"issue":"3","key":"75_CR44","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.stem.2012.02.003","volume":"10","author":"D Park","year":"2012","unstructured":"Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, et al. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012;10(3):259\u201372.","journal-title":"Cell Stem Cell"},{"issue":"3","key":"75_CR45","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.devcel.2014.03.013","volume":"29","author":"T Mizoguchi","year":"2014","unstructured":"\u2022 Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, et al. Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014;29(3):340\u20139. During development, the expression profile of osterix is shown to include BM stroma and osteolineage cells while adult expression is restricted to the osteoblast lineage.","journal-title":"Dev Cell"},{"issue":"7382","key":"75_CR46","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","volume":"481","author":"L Ding","year":"2012","unstructured":"Ding L, Saunders TL, Enikolopov G, Morrison SJ. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012;481(7382):457\u201362.","journal-title":"Nature"},{"issue":"2","key":"75_CR47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","volume":"19","author":"C Maes","year":"2010","unstructured":"Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, et al. Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. 2010;19(2):329\u201344.","journal-title":"Dev Cell"},{"issue":"8","key":"75_CR48","doi-asserted-by":"crossref","first-page":"e71318","DOI":"10.1371\/journal.pone.0071318","volume":"8","author":"Y Liu","year":"2013","unstructured":"\u2022 Liu Y, Strecker S, Wang L, Kronenberg MS, Wang W, Rowe DW, et al. Osterix-cre labeled progenitor cells contribute to the formation and maintenance of the bone marrow stroma. PLoS One. 2013;8(8):e71318. Evidence that osterix-positive cells contribute to different lineages at different developmental stages","journal-title":"PLoS One"},{"issue":"4","key":"75_CR49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<225::AID-GENE10>3.0.CO;2-F","volume":"26","author":"JF Martin","year":"2000","unstructured":"Martin JF, Olson EN. Identification of a prx1 limb enhancer. Genesis. 2000;26(4):225\u20139.","journal-title":"Genesis"},{"issue":"3","key":"75_CR50","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1242\/dev.126.3.495","volume":"126","author":"MF Lu","year":"1999","unstructured":"Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, et al. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development. 1999;126(3):495\u2013504.","journal-title":"Development"},{"issue":"4","key":"75_CR51","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.stemcr.2017.03.002","volume":"8","author":"K Wilk","year":"2017","unstructured":"\u2022\u2022 Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, et al. Postnatal calvarial skeletal stem cells expressing PRX1 reside exclusively in the calvarial sutures and are required for bone regeneration. Stem Cell Reports. 2017;8(4):933\u201346. Demonstration of the importance of Prx1-positive cells to craniofacial development","journal-title":"Stem Cell Reports"},{"issue":"7440","key":"75_CR52","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","volume":"495","author":"A Greenbaum","year":"2013","unstructured":"Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227\u201330.","journal-title":"Nature"},{"issue":"6","key":"75_CR53","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.devcel.2016.11.008","volume":"39","author":"DR Rux","year":"2016","unstructured":"\u2022\u2022 Rux DR, Song JY, Swinehart IT, Pineault KM, Schlientz AJ, Trulik KG, et al. Regionally restricted Hox function in adult bone marrow multipotent mesenchymal stem\/stromal cells. Dev Cell. 2016;39(6):653\u201366. Very novel demonstration of skeletal element-restricted expression of the Hox genes in SSCs of adult mice. Also, Hox activity is necessary for fracture repair","journal-title":"Dev Cell"},{"issue":"11","key":"75_CR54","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1002\/dvdy.21756","volume":"237","author":"LT Nelson","year":"2008","unstructured":"Nelson LT, Rakshit S, Sun H, Wellik DM. Generation and expression of a Hoxa11eGFP targeted allele in mice. Dev Dyn. 2008;237(11):3410\u20136.","journal-title":"Dev Dyn"},{"issue":"22","key":"75_CR55","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1242\/dev.096693","volume":"140","author":"IT Swinehart","year":"2013","unstructured":"Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM. Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Development. 2013;140(22):4574\u201382.","journal-title":"Development"},{"issue":"12","key":"75_CR56","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/ncb3067","volume":"16","author":"N Ono","year":"2014","unstructured":"\u2022\u2022 Ono N, Ono W, Nagasawa T, Kronenberg HM. A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones. Nat Cell Biol. 2014;16(12):1157\u201367. Demonstration that Col2+ chondrogenic cells can also form osteoblasts","journal-title":"Nat Cell Biol"},{"issue":"4","key":"75_CR57","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/1097-0177(2000)9999:9999<::AID-DVDY1073>3.0.CO;2-F","volume":"219","author":"LA Opperman","year":"2000","unstructured":"Opperman LA. Cranial sutures as intramembranous bone growth sites. Dev Dyn. 2000;219(4):472\u201385.","journal-title":"Dev Dyn"},{"issue":"4","key":"75_CR58","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ncb3139","volume":"17","author":"H Zhao","year":"2015","unstructured":"\u2022\u2022 Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015;17(4):386\u201396. Identification of Gli1+ cells as cranial suture stem cells","journal-title":"Nat Cell Biol"},{"issue":"2","key":"75_CR59","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.ydbio.2007.08.028","volume":"311","author":"E Lana-Elola","year":"2007","unstructured":"Lana-Elola E, Rice R, Grigoriadis AE, Rice DP. Cell fate specification during calvarial bone and suture development. Dev Biol. 2007;311(2):335\u201346.","journal-title":"Dev Biol"},{"key":"75_CR60","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1038\/ncomms10526","volume":"7","author":"T Maruyama","year":"2016","unstructured":"Maruyama T, Jeong J, Sheu TJ, Hsu W. Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration. Nat Commun. 2016;7:10526.","journal-title":"Nat Commun"},{"key":"75_CR61","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.biomaterials.2015.05.030","volume":"61","author":"G Abagnale","year":"2015","unstructured":"\u2022 Abagnale G, Steger M, Nguyen VH, Hersch N, Sechi A, Joussen S, et al. Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages. Biomaterials. 2015;61:316\u201326. Cell culture surfaces are shown to affect differentiation of SSCs","journal-title":"Biomaterials"},{"issue":"4","key":"75_CR62","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","volume":"126","author":"AJ Engler","year":"2006","unstructured":"Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 2006;126(4):677\u201389.","journal-title":"Cell"},{"issue":"11","key":"75_CR63","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.0903269107","volume":"107","author":"KA Kilian","year":"2010","unstructured":"Kilian KA, Bugarija B, Lahn BT, Mrksich M. Geometric cues for directing the differentiation of mesenchymal stem cells. Proc Natl Acad Sci U S A. 2010;107(11):4872\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"75_CR64","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1534-5807(04)00075-9","volume":"6","author":"R McBeath","year":"2004","unstructured":"McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004;6(4):483\u201395.","journal-title":"Dev Cell"},{"key":"75_CR65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2015.04.008","volume":"20","author":"J Hao","year":"2015","unstructured":"\u2022\u2022 Hao J, Zhang Y, Jing D, Shen Y, Tang G, Huang S, et al. Mechanobiology of mesenchymal stem cells: perspective into mechanical induction of MSC fate. Acta Biomater. 2015;20:1\u20139. Review of biomechanical influence on SSC behavior","journal-title":"Acta Biomater"},{"issue":"5","key":"75_CR66","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1210\/en.2006-1704","volume":"148","author":"V David","year":"2007","unstructured":"David V, Martin A, Lafage-Proust MH, Malaval L, Peyroche S, Jones DB, et al. Mechanical loading down-regulates peroxisome proliferator-activated receptor gamma in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. 2007;148(5):2553\u201362.","journal-title":"Endocrinology"},{"issue":"Pt 16","key":"75_CR67","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1242\/jcs.01207","volume":"117","author":"Y Tanabe","year":"2004","unstructured":"Tanabe Y, Koga M, Saito M, Matsunaga Y, Nakayama K. Inhibition of adipocyte differentiation by mechanical stretching through ERK-mediated downregulation of PPARgamma2. J Cell Sci. 2004;117(Pt 16):3605\u201314.","journal-title":"J Cell Sci"},{"issue":"3","key":"75_CR68","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/jcp.25102","volume":"231","author":"C Ge","year":"2016","unstructured":"\u2022\u2022 Ge C, Cawthorn WP, Li Y, Zhao G, Macdougald OA, Franceschi RT. Reciprocal control of osteogenic and Adipogenic differentiation by ERK\/MAP kinase phosphorylation of Runx2 and PPARgamma transcription factors. J Cell Physiol. 2016;231(3):587\u201396. A MAP kinase-mediated lineage switching mechanism is described in SSCs involving phosphorylation of RUNX2 and PPAR\u03b3 transcription factors leading to increased osteoblastogenesis and inhibition of adipocytes","journal-title":"J Cell Physiol"},{"issue":"2","key":"75_CR69","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cellsig.2013.11.006","volume":"26","author":"J Hao","year":"2014","unstructured":"\u2022 Hao J, Zhang Y, Wang Y, Ye R, Qiu J, Zhao Z, et al. Role of extracellular matrix and YAP\/TAZ in cell fate determination. Cell Signal. 2014;26(2):186\u201391. Review of the role of mechanotransduction in control of SC fate","journal-title":"Cell Signal"},{"key":"75_CR70","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Tang Y, Feinberg T, Keller, Li XY, Weiss SJ. Snail\/Slug binding interactions with YAP\/TAZ control skeletal stem cell self-renewal and differentiation. Nat Cell Biol. 2016;18(9):917\u201329. Cooperative interactions between Snail\/Slug-YAP\/TAZ signaling are shown to control SSC fate.","DOI":"10.1038\/ncb3394"},{"issue":"5","key":"75_CR71","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/15384101.2017.1280643","volume":"16","author":"Y Tang","year":"2017","unstructured":"Tang Y, Weiss SJ. Snail\/Slug-YAP\/TAZ complexes cooperatively regulate mesenchymal stem cell function and bone formation. Cell Cycle. 2017;16(5):399\u2013405.","journal-title":"Cell Cycle"},{"issue":"6","key":"75_CR72","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.stemcr.2015.05.004","volume":"4","author":"NP Talele","year":"2015","unstructured":"Talele NP, Fradette J, Davies JE, Kapus A, Hinz B. Expression of alpha-smooth muscle actin determines the fate of mesenchymal stromal cells. Stem Cell Reports. 2015;4(6):1016\u201330.","journal-title":"Stem Cell Reports"},{"issue":"1","key":"75_CR73","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1097-2765(00)80003-9","volume":"1","author":"W Vogel","year":"1997","unstructured":"Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997;1(1):13\u201323.","journal-title":"Mol Cell"},{"key":"75_CR74","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2350-15-42","volume":"15","author":"A Al-Kindi","year":"2014","unstructured":"Al-Kindi A, Kizhakkedath P, Xu H, John A, Sayegh AA, Ganesh A, et al. A novel mutation in DDR2 causing spondylo-meta-epiphyseal dysplasia with short limbs and abnormal calcifications (SMED-SL) results in defective intra-cellular trafficking. BMC Med Genet. 2014;15:42.","journal-title":"BMC Med Genet"},{"key":"75_CR75","doi-asserted-by":"crossref","unstructured":"\u2022\u2022 Ge C, Wang Z, Zhao G, Li B, Liao J, Sun H, et al. Discoidin receptor 2 controls bone formation and marrow adipogenesis. J Bone Miner Res. 2016. Demonstration that the collagen-activated receptor tyrosine kinase, DDR2, controls SSC fate to stimulate bone formation.","DOI":"10.1002\/jbmr.2893"},{"issue":"4","key":"75_CR76","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.devcel.2013.04.011","volume":"25","author":"Y Tang","year":"2013","unstructured":"\u2022\u2022 Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, et al. MT1-MMP-dependent control of skeletal stem cell commitment via a beta1-integrin\/YAP\/TAZ signaling axis. Dev Cell. 2013;25(4):402\u201316. MT1-mediated matrix remodeling is shown to alter ECM stiffness and SSC lineage commitment","journal-title":"Dev Cell"},{"issue":"4","key":"75_CR77","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1210\/endo.140.4.6637","volume":"140","author":"T Thomas","year":"1999","unstructured":"Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL. Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology. 1999;140(4):1630\u20138.","journal-title":"Endocrinology"},{"issue":"3","key":"75_CR78","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cmet.2017.01.001","volume":"25","author":"Y Fan","year":"2017","unstructured":"\u2022\u2022 Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, et al. Parathyroid hormone directs bone marrow mesenchymal cell fate. Cell Metab. 2017;25(3):661\u201372. PTH is shown to control SSC fate","journal-title":"Cell Metab"},{"issue":"6704","key":"75_CR79","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","volume":"395","author":"JM Friedman","year":"1998","unstructured":"Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature. 1998;395(6704):763\u201370.","journal-title":"Nature"},{"issue":"3","key":"75_CR80","first-page":"99","volume":"4","author":"MW Hamrick","year":"2007","unstructured":"Hamrick MW. Leptin and bone: a consensus emerging? Int Bone Min Soc. 2007;4(3):99\u2013107.","journal-title":"Int Bone Min Soc"},{"issue":"10","key":"75_CR81","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/jbmr.1665","volume":"27","author":"SW Kim","year":"2012","unstructured":"Kim SW, Pajevic PD, Selig M, Barry KJ, Yang JY, Shin CS, et al. Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts. J Bone Miner Res. 2012;27(10):2075\u201384.","journal-title":"J Bone Miner Res"},{"issue":"9","key":"75_CR82","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jbmr.1663","volume":"27","author":"B Yu","year":"2012","unstructured":"Yu B, Zhao X, Yang C, Crane J, Xian L, Lu W, et al. Parathyroid hormone induces differentiation of mesenchymal stromal\/stem cells by enhancing bone morphogenetic protein signaling. J Bone Miner Res. 2012;27(9):2001\u201314.","journal-title":"J Bone Miner Res"}],"container-title":["Current Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40610-017-0075-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40610-017-0075-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40610-017-0075-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T21:19:06Z","timestamp":1659647946000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40610-017-0075-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["75"],"URL":"https:\/\/doi.org\/10.1007\/s40610-017-0075-5","relation":{},"ISSN":["2198-6428"],"issn-type":[{"value":"2198-6428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}