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SPF has a research contract from Pfizer|BioNTech as a site for clinical trials of their SARS-CoV-2 RNA vaccine, which is unrelated to the work reported in this paper. JSF has consulted for Shionogi Inc. LT and SD have received research funding on an unrelated topic from GlaxoSmithKline and SD has received funding from Jazz Pharmaceuticals for unrelated work. Non-financial Interests: none.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The funders had no role in selecting health systems, study design, data collection, data analysis, data interpretation, or writing up of the results.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}