{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:54:51Z","timestamp":1776689691224,"version":"3.51.2"},"reference-count":74,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,3,15]],"date-time":"2015-03-15T00:00:00Z","timestamp":1426377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s40618-015-0243-5","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T04:11:46Z","timestamp":1426306306000},"page":"669-684","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Immunohistochemistry, histopathology, and biomarker studies of swertiamarin, a secoiridoid glycoside, prevents and protects streptozotocin-induced \u03b2-cell damage in Wistar rat pancreas"],"prefix":"10.1007","volume":"38","author":[{"given":"G.","family":"Dhanavathy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,15]]},"reference":[{"key":"243_CR1","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.2337\/dc07-S042","volume":"30","author":"American Diabetes Association","year":"2007","unstructured":"American Diabetes Association (2007) Diagnosis and classification of diabetes mellitus. Diabetes Care 30:S42\u2013S47","journal-title":"Diabetes Care"},{"key":"243_CR2","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4103\/0253-7613.28209","volume":"38","author":"MD Shalam","year":"2006","unstructured":"Shalam MD, Harish MS, Farhana SA (2006) Prevention of dexamethasone- and fructose-induced insulin resistance in rats by SH-01D, a herbal preparation. Indian J Pharmacol 38:419\u2013422","journal-title":"Indian J Pharmacol"},{"key":"243_CR3","unstructured":"World Health Organization (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. In: Report of WHO Consultation. Part 1: diagnosis and classification of diabetes mellitus. World Health Organization, Geneva"},{"key":"243_CR4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jep.2013.08.051","volume":"150","author":"Randhir Singh","year":"2013","unstructured":"Singh Randhir, Kaur Navpreet, Kishore Lalit, Gupta Girish Kumar (2013) Management of diabetic complications: A chemical constituents based approach. J Ethnopharmacol 150:51\u201370","journal-title":"J Ethnopharmacol"},{"key":"243_CR5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1472-6882-13-63","volume":"13","author":"CM Teugwa","year":"2013","unstructured":"Teugwa CM, Boudjeko T, Tchinda BT, Mejiato PC, Zofou D (2013) Anti-hyperglycemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa. BMC Complement Altern Med 13:63","journal-title":"BMC Complement Altern Med"},{"key":"243_CR6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1758-5996-5-75","volume":"5","author":"MT Abdel Aziz","year":"2013","unstructured":"Abdel Aziz MT, El-Asmar MF, Rezq AM, Mahfouz SM, Wassef MA, Fouad HH, Ahmed HH, Taha FM (2013) The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study). Diabetol Metab Syndr 5:75","journal-title":"Diabetol Metab Syndr"},{"key":"243_CR7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00005792-197001000-00003","volume":"49","author":"RI Hamby","year":"1970","unstructured":"Hamby RI (1970) Primary myocardial disease\u2014a prospective clinical and hemodynamic evaluation of 100 patients. Medicine 49:55\u201378","journal-title":"Medicine"},{"key":"243_CR8","first-page":"19","volume":"2","author":"IK Rahman","year":"2000","unstructured":"Rahman IK, Das AK, Gogoi GN (2000) Diabetic autonomic neuropathy and its clinical profile in NIDDM (type 2). Asian J Diabetol 2:19\u201323","journal-title":"Asian J Diabetol"},{"key":"243_CR9","doi-asserted-by":"crossref","unstructured":"Kumar R, Arora V, Ram V, Bhandari A, Vyas P (2011) Hypoglycemic and hypolipidemic effect of Allopolyherbal formulations in streptozotocin induced diabetes mellitus in rats. Int J Diabetes Mellit","DOI":"10.1016\/j.ijdm.2011.01.005"},{"key":"243_CR10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40618-014-0069-6","volume":"37","author":"E Mannucci","year":"2014","unstructured":"Mannucci E, Monami M, Dicembrini I, Piselli A, Porta M (2014) Achieving HbA1c targets in clinical trials and in the real world: a systematic review and meta-analysis. J Endocrinol Investig 37:477\u2013495","journal-title":"J Endocrinol Investig"},{"key":"243_CR11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF03346565","volume":"3","author":"A Kutan Fenercioglu","year":"2010","unstructured":"Kutan Fenercioglu A, Saler T, Genc E, Sabuncu H, Altuntas Y (2010) The effect of polyphenol-containing antioxidants on oxidative stress and lipid Peroxidation in Type 2 diabetes mellitus without complications. J Endocrinol Invest 3:118\u2013124","journal-title":"J Endocrinol Invest"},{"key":"243_CR12","unstructured":"Kirtikar KR, Basu BD (1935) Indian medicinal plants, vol. 3, 2nd. Bishen Singh Mahendra Pal Singh, Dehra Dun, pp 1655\u20131656"},{"key":"243_CR13","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-0028-1099580","volume":"22","author":"PN Natarajan","year":"1972","unstructured":"Natarajan PN, Prasad S (1972) Chemical investigation of Enicotemma littorale. Planta Med 22:42\u201346","journal-title":"Planta Med"},{"key":"243_CR14","first-page":"677","volume":"22","author":"KR Retnam","year":"1988","unstructured":"Retnam KR, DeBritto AJ (1988) Preliminary phytochemical screening of three medicinal plants of Tirunelveli hills. J Econ Tax Bot 22:677\u2013681","journal-title":"J Econ Tax Bot"},{"key":"243_CR15","first-page":"148","volume":"35","author":"J Rai","year":"1966","unstructured":"Rai J, Thakar KA (1966) Chemical investigation of Enicotemma littorale Blume. Curr Sci 35:148\u2013149","journal-title":"Curr Sci"},{"key":"243_CR16","first-page":"457","volume":"4","author":"PD Desai","year":"1966","unstructured":"Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, Mohamed PA, Nagle SK, Nayak RH, Saksena AK, Sathe SS, Vishwanathan N (1966) Chemical investigation of some Indian Medicinal Plants: part II Indian. J Chem 4:457\u2013459","journal-title":"J Chem"},{"key":"243_CR17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/13880200490885095","volume":"42","author":"SL Vishwakarma","year":"2004","unstructured":"Vishwakarma SL, Rajani M, Milind S Bagul, Goyal RK (2004) A rapid method for the isolation of swertiamarin from Enicostemma littorale. Pharm Biol 42:400\u2013403","journal-title":"Pharm Biol"},{"key":"243_CR18","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/jps.2600630632","volume":"63","author":"S Ghosal","year":"1974","unstructured":"Ghosal S, Singh AK, Sharma PV, Chaudhuri RK (1974) Chemical constituents of Gentianacceae IX: natural occurrence of erythrocentaurin in Enicostemma hyssopifolium and Swertialawii. J Pharm Sci 63:944\u2013945","journal-title":"J Pharm Sci"},{"key":"243_CR19","first-page":"127","volume":"3","author":"RK Chaudhuri","year":"1974","unstructured":"Chaudhuri RK, Singh AK, Ghosal S (1974) Chemical constituents of Gentianaceae. XVIII. Structure of enicoflavine. Monoterpene alkaloids from Enicostemma hyssopifolium. Chem Ind (London) 3:127\u2013128","journal-title":"Chem Ind (London)"},{"key":"243_CR20","first-page":"781","volume":"38","author":"R Vijayvargia","year":"2000","unstructured":"Vijayvargia R, Kumar M, Gupta S (2000) Hypoglycemic effect of aqueous extract of Enicostemma littorale Blume. (chhotachirayata) on alloxan induced diabetes mellitus in rats. Indian J Exp Biol 38:781\u2013784","journal-title":"Indian J Exp Biol"},{"key":"243_CR21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0378-8741(02)00095-8","volume":"81","author":"J Maroo","year":"2002","unstructured":"Maroo J, Vasu VT, Aalinkeel R, Gupta S (2002) Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action.J. Ethnopharmacol 81:317\u2013320","journal-title":"Ethnopharmacol"},{"key":"243_CR22","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1076\/phbi.41.5.388.15943","volume":"41","author":"J Maroo","year":"2003","unstructured":"Maroo J, Ghosh A, Mathur R, Vasu VT, Gupta S (2003) Anti-diabetic efficacy of Enicostemma littorale methanol extract in alloxan induced diabetic rats. Pharm Biol 41:388\u2013391","journal-title":"Pharm Biol"},{"key":"243_CR23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1078\/094471103321659933","volume":"10","author":"J Maroo","year":"2003","unstructured":"Maroo J, Vasu VT, Gupta S (2003) Dose dependent hypoglycemic effect of Enicostemma littorale Blume in alloxan induced diabetic rats. Phytomed 10:196\u2013199","journal-title":"Phytomed"},{"key":"243_CR24","doi-asserted-by":"crossref","unstructured":"Vasu VT, Ashwinikumar C, Maroo J, Gupta S, Gupta S (2003) Antidiabetic effect of Enicostemman littorale Blume aqueous extract in newly diagnosed non-insulin dependent diabetes mellitus patients (NIDDM): a preliminary investigation OPEM 3:84\u201389","DOI":"10.3742\/OPEM.2003.3.2.084"},{"key":"243_CR25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.jep.2005.05.007","volume":"101","author":"VT Vasu","year":"2005","unstructured":"Vasu VT, Modi H, Thaikoottathil JV (2005) Hypolipidemic and antioxidant effect of Enicostemma littorale Blume aqueous extract in cholesterol fed rats. J Ethnopharmacol 101:277\u2013282","journal-title":"J Ethnopharmacol"},{"key":"243_CR26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-010-0393-x","volume":"340","author":"RD Sonawane","year":"2010","unstructured":"Sonawane RD, Vishwakarma SL, Lakshmi S, Rajani M, Padh H, Goyal RK (2010) Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol Cell Biochem 340:1\u20136","journal-title":"Mol Cell Biochem"},{"key":"243_CR27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11418-009-0350-8","volume":"63","author":"Hitesh Vaidya","year":"2009","unstructured":"Vaidya Hitesh, Rajani Mandapati, Sudarsanam Vasudevan, Padh Harish, Goyal Ramesh (2009) Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats. J Nat Med 63:437\u2013442","journal-title":"J Nat Med"},{"key":"243_CR28","first-page":"120","volume":"4","author":"SL Vishwakarma","year":"2004","unstructured":"Vishwakarma SL, Goyal RK (2004) Hepatoprotective activity of Enicostemma littorale in CCl4-induced liver damage. J Nat Rem 4:120\u2013126","journal-title":"J Nat Rem"},{"key":"243_CR29","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/13880200490885095","volume":"42","author":"SL Vishwakarma","year":"2004","unstructured":"Vishwakarma SL, Rajani M, Bagul Milind S, Goyal RK (2004) A rapid method for isolation of swertiamarin from Enicostemma littorale. Pharm Biol 42:400\u2013403","journal-title":"Pharm Biol"},{"issue":"1","key":"243_CR30","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4103\/0253-7613.40484","volume":"40","author":"R Barik","year":"2008","unstructured":"Barik R, Jain S, Qwatra D, Joshi A, Tripathi GS, Goyal R (2008) Antidiabetic activity of aqueous root extract of Ichnocarpus frutescens in streptozotocin\u2013nicotinamide induced type-II diabetes in rats. Indian J Pharmacol 40(1):19\u201322","journal-title":"Indian J Pharmacol"},{"key":"243_CR31","doi-asserted-by":"crossref","first-page":"F1068","DOI":"10.1152\/ajprenal.00434.2002","volume":"285","author":"R Nasrallah","year":"2003","unstructured":"Nasrallah R, Landry A, Singh S, Sklepowicz M, Hebert RL (2003) Increased expression of cyclooxygenase-1 and -2 in the diabetic rat renal medulla. Am J Physiol Renal Physiol 285:F1068\u2013F1077","journal-title":"Am J Physiol Renal Physiol"},{"key":"243_CR32","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0021-9258(18)76122-X","volume":"98","author":"DL Drabkin","year":"1932","unstructured":"Drabkin DL, Austin JM (1932) Spectrophotometric constants for common hemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 98:719\u2013733","journal-title":"J Biol Chem"},{"key":"243_CR33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OH Lowry","year":"1951","unstructured":"Lowry OH, Rosenbrough NJ, Farr AL (1951) Protein measurement with Folinphenol reagent. J Biol Chem 193:265\u2013275","journal-title":"J Biol Chem"},{"key":"243_CR34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","volume":"28","author":"S Reitman","year":"1957","unstructured":"Reitman S, Frankel SA (1957) Colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28:56\u201363","journal-title":"Am J Clin Pathol"},{"key":"243_CR35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/ajcp\/30.3.234","volume":"30","author":"PC Cabaud","year":"1958","unstructured":"Cabaud PC (1958) Wroblewski\u00a0F.\u00a0Calorimetric measurement of lactate dehydrogenase activity of body fluids.J. Clin Pathol 30:234\u2013236","journal-title":"Clin Pathol"},{"key":"243_CR36","first-page":"801","volume":"80B","author":"GB Principato","year":"1985","unstructured":"Principato GB, Asia MC, Talesa V, Rosin G, Giovannini E (1985) Characterization of the soluble alkaline phosphatase from hepatopancreas of Squilla mantis\u00a0L. Comp Biochem Physiol 80B:801\u2013804","journal-title":"Comp Biochem Physiol"},{"key":"243_CR37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/geronj\/12.2.166","volume":"12","author":"N Brandstrup","year":"1957","unstructured":"Brandstrup N, Kirk JE, Bruni C (1957) Determination of hexokinase in tissues. J. Gerontol 12:166\u2013171","journal-title":"J. Gerontol"},{"key":"243_CR38","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0009-8981(59)90165-2","volume":"4","author":"H Koide","year":"1959","unstructured":"Koide H, Oda T (1959) Pathological occurrence of glucose-6-phosphatase in serum in liver diseases. Clin Chim Acta 4:554\u2013561","journal-title":"Clin Chim Acta"},{"key":"243_CR39","first-page":"132","volume":"76","author":"JM Gancedo","year":"1971","unstructured":"Gancedo JM, Gancedo C (1971) Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts. Arch Microbiol 76:132\u2013138","journal-title":"Arch Microbiol"},{"key":"243_CR40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0003-2697(65)90013-8","volume":"11","author":"E Van-Handle","year":"1965","unstructured":"Van-Handle E (1965) Estimation of glycogen in small amounts of tissue. Anal Biochem 11:256\u2013262","journal-title":"Anal Biochem"},{"key":"243_CR41","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1542\/pir.29-11-374","volume":"29","author":"DW Cooke","year":"2008","unstructured":"Cooke DW, Plotnick L (2008) Type 1 diabetes mellitus in pediatrics. Pediatr Rev 29:374\u2013384","journal-title":"Pediatr Rev"},{"issue":"6","key":"243_CR42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0367-326X(00)00227-6","volume":"71","author":"JK Grover","year":"2000","unstructured":"Grover JK, Rathi SS, Vats V (2000) Preliminary study of Fresh juice of Benincasahispidaon morphine addiction in mice. Fitoterapia 71(6):707\u2013709","journal-title":"Fitoterapia"},{"key":"243_CR43","doi-asserted-by":"crossref","unstructured":"Patel TP, Soni S, Parikh P, Gosai J, Chruvattil R, Gupt S (2013) Swertiamarin: an active lead from Enicostemma littorale regulates hepatic and adipose tissue gene expression by targeting PPAR- and improves insulin sensitivity in experimental NIDDM rat model. Evidence-based complementary and alternative medicine. pp 11","DOI":"10.1155\/2013\/358673"},{"key":"243_CR44","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.peptides.2010.05.016","volume":"31","author":"H Yin","year":"2010","unstructured":"Yin H, Miao J, Zhang Y (2010) Protective effect of \u03b2-casomorphin-7 on type 1 diabetes rats induced with streptozotocin. Peptides 31:1725\u20131729","journal-title":"Peptides"},{"key":"243_CR45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/1472-6882-14-243","volume":"14","author":"D Ahmed","year":"2014","unstructured":"Ahmed D, Kumar V, Verma A, Gupta PS, Kumar H, Dhingra V, Mishra V, Sharma M (2014) Antidiabetic, renal\/hepatic\/pancreas\/cardiac protective and antioxidant potential of methanol\/dichloromethane extract of Albizzia Lebbeck Benth. stem bark (ALEx) on Streptozotocin induced diabetic rats. BMC Complement Altern Med 14:243","journal-title":"BMC Complement Altern Med"},{"key":"243_CR46","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.phymed.2010.07.005","volume":"18","author":"C Wua","year":"2011","unstructured":"Wua C, Li Y, Chena Y, Laoa X, Shenga L, Daia R, Menga W, Denga Y (2011) Hypoglycemic effect of Belamcandachinensis leaf extract in normal and STZ-induced 617 diabetic rats and its potential active faction. Phytomedicine 18:292\u2013297","journal-title":"Phytomedicine"},{"issue":"2","key":"243_CR47","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0944-7113(11)80059-0","volume":"2","author":"RJ Marles","year":"1995","unstructured":"Marles RJ, Farnsworth NR (1995) Antidiabetic plants and their active constituents. Phytomedicine 2(2):137\u2013189","journal-title":"Phytomedicine"},{"key":"243_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.54.1.1","volume":"54","author":"A Ceriello","year":"2005","unstructured":"Ceriello A (2005) Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54:1\u20137","journal-title":"Diabetes"},{"key":"243_CR49","doi-asserted-by":"crossref","unstructured":"Gray AM, Abdel-Wahab YHA, Flatt PR (2000) The traditional plant treatment, Sabucusnigra (Elder), exhibits insulin-like and insulin releasing actions in vitro. J Nutr:15\u201320","DOI":"10.1093\/jn\/130.1.15"},{"key":"243_CR50","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2337\/diabetes.47.11.1722","volume":"47","author":"YM Tian","year":"1998","unstructured":"Tian YM, Johnson G, Ashcroft JH (1998) Sulfonylureas enhance exocytosis from pancreatic \u03b2-cells by a mechanism that does not involve direct activation of protein kinase C. Diabetes 47:1722\u20131726","journal-title":"Diabetes"},{"issue":"2","key":"243_CR51","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1210\/jcem-61-2-247","volume":"61","author":"A Pernet","year":"1985","unstructured":"Pernet A, Trimble ER, Kuntschen F, Assal JP, Hahn C, Renold AE (1985) Sulfonylureas in insulin-dependent (type I) diabetes: evidence for an extrapancreatic effect in vivo. J Clin Endocrinol Metab 61(2):247\u2013251","journal-title":"J Clin Endocrinol Metab"},{"key":"243_CR52","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1210\/me.2003-0357","volume":"18","author":"JJ Collier","year":"2000","unstructured":"Collier JJ, Scott DK (2000) 4) \u201cSweet changes: glucose homeostasis can be altered by manipulating genes controlling hepatic glucose metabolism\u201d. Mol Endocrinol 18:1051\u20131063","journal-title":"Mol Endocrinol"},{"key":"243_CR53","volume-title":"Text book of medical biochemistry","author":"MN Chatterja","year":"2002","unstructured":"Chatterja MN, Shinde R (2002) Text book of medical biochemistry, 5th edn. Medical Publishers, New Delhi 54","edition":"5"},{"key":"243_CR54","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.fct.2010.02.023","volume":"48","author":"VK Kondeti","year":"2010","unstructured":"Kondeti VK, Badri KR, Maddirala DR, Thur SKM, Fatima SS, Kasetti RB (2010) Effect of Pterocarpus santalinus bark, on blood glucose, serum lipids, plasma insulin and hepatic carbohydrate metabolic enzymes in streptozotocin insulin and hepatic carbohydrate metabolic enzymes in streptozotocin induced diabetic rats. Food Chem Toxicol 48:1281\u20131285","journal-title":"Food Chem Toxicol"},{"key":"243_CR55","volume-title":"Hemoglobin within the Red Cell","author":"DW Allen","year":"1964","unstructured":"Allen DW (1964) Hemoglobin within the Red Cell. Academic Press, NewYork\/London"},{"key":"243_CR56","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.cbi.2010.11.005","volume":"189","author":"RCR Latha","year":"2011","unstructured":"Latha RCR, Daisy P (2011) Insulin secretagogue, antihyperlipidemic and other protective effects of gallic acid isolated from Terminaliabellerica Roxb. in streptozotocin induced diabetic rats. Chem Biol Interact 189:112\u2013118","journal-title":"Chem Biol Interact"},{"key":"243_CR57","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ejphar.2011.09.159","volume":"670","author":"GR Gandhi","year":"2011","unstructured":"Gandhi GR, Ignacimuthu S, Paulraj MG, Sasikumar P (2011) Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanumtorvum Swartz. fruit in streptozotocin induced diabetic rats. Eur J Pharmacol 670:623\u2013631","journal-title":"Eur J Pharmacol"},{"key":"243_CR58","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cbi.2008.10.017","volume":"179","author":"J Eliza","year":"2009","unstructured":"Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V (2009) Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats. Chem Biol Interact 179:329\u2013334","journal-title":"Chem Biol Interact"},{"key":"243_CR59","first-page":"13","volume":"46","author":"H Vestergard","year":"1999","unstructured":"Vestergard H (1999) Studies of gene expression and activity of hexokinase, phosphofructokinase and glycogen synthase in human skeletal muscle in states of altered insulin-stimulated glucose metabolism. Dan Med Bull 46:13\u201334","journal-title":"Dan Med Bull"},{"key":"243_CR60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0168-8227(98)00080-1","volume":"41","author":"Y Ishikawa","year":"1998","unstructured":"Ishikawa Y, Saito MN, Ikemoto T, Takeno H, Watanabe K, Tani T (1998) Actions of the novel oral antidiabetic agent HQL-975 in insulin-resistant non-insulin dependent diabetes mellitus model animals. Diabetes Res Clin Pract 41:101\u2013111","journal-title":"Diabetes Res Clin Pract"},{"key":"243_CR61","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-5793(03)00565-9","volume":"546","author":"JC Ferrer","year":"2003","unstructured":"Ferrer JC, Favre C, Gomis RR, Fern\u00e1ndez-Novell JM, Garcia-Rocha M, De LaIglesia N (2003) Control of glycogen deposition. FEBS Lett 546:127\u2013132","journal-title":"FEBS Lett"},{"key":"243_CR62","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1010425932561","volume":"21","author":"OC Ohaeri","year":"2001","unstructured":"Ohaeri OC (2001) Effect of garlic oil on the levels of various enzyme in the serum and tissue of streptozotocin diabetic rats. Biosci Rep 21:19\u201324","journal-title":"Biosci Rep"},{"key":"243_CR63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.fct.2004.08.012","volume":"43","author":"FM El-Demerdash","year":"2005","unstructured":"El-Demerdash FM, Yousef MI, Abou El-Naga NI (2005) Biochemical study on the hypoglycemic effects of onion andgarlic in alloxan-induced diabetic rats. Food Chem Toxicol 43:57\u201363","journal-title":"Food Chem Toxicol"},{"issue":"9","key":"243_CR64","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/j.fct.2009.06.023","volume":"47","author":"HA Hassan","year":"2009","unstructured":"Hassan HA, Yousef MI (2009) Mitigating effects of antioxidant properties of black berry juice on sodium fluoride induced-hepatotoxicity and oxidative stress in rats. Food Chem Toxicol 47(9):2332\u20132337","journal-title":"Food Chem Toxicol"},{"key":"243_CR65","doi-asserted-by":"crossref","unstructured":"Sonawane RD, Vishwakarma SL, Lakshmi S, Rajani M, Padh H, Goyal RK (2010) Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats. Mol Cell Biochem 340:1\u20136","DOI":"10.1007\/s11010-010-0393-x"},{"key":"243_CR66","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jep.2006.03.012","volume":"107","author":"A Shirwaikar","year":"2006","unstructured":"Shirwaikar A, Rajendran K, Barik R (2006) Effect of aqueous bark extract of Garugapinnata Roxb. In streptozotocin-nicotinamide induced type-II diabetes mellitus. J Ethnopharmacol 107:285\u2013290","journal-title":"J Ethnopharmacol"},{"key":"243_CR67","first-page":"41","volume":"2","author":"F Ahmed","year":"2008","unstructured":"Ahmed F, Urooj A (2008) Antihyperglycemic activity of Ficusglomerata stem bark instreptozotocin-induced diabetic rats. Global J Pharmacol 2:41\u201345","journal-title":"Global J Pharmacol"},{"key":"243_CR68","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1995-7645(11)60101-6","volume":"4","author":"S Kumar","year":"2011","unstructured":"Kumar S, Kumar V, Prakash O (2011) Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats. Asian Pac J Trop Med 4:347\u2013352","journal-title":"Asian Pac J Trop Med"},{"key":"243_CR69","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1254\/jphs.11184FP","volume":"119","author":"AK Sharma","year":"2012","unstructured":"Sharma AK, Bharti S, Kumar R, Krishnamurthy B, Bhatia J, Kumari S, Arya DS (2012) Syzygium cumini ameliorates insulin resistance and \u03b2-Cell dysfunction via modulation of PPAR, dyslipidemia, oxidative stress, and TNF-\u03b1 in type 2 diabetic rats. J Pharmacol Sci 119:205\u2013213","journal-title":"J Pharmacol Sci"},{"key":"243_CR70","first-page":"123","volume":"60","author":"M Suparna","year":"1998","unstructured":"Suparna M, Ranjana J, Sibabrata M (1998) Indian J. Pharm. Sci. 60:123","journal-title":"Indian J. Pharm. Sci."},{"key":"243_CR71","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2337\/diab.31.1.S71","volume":"31","author":"DM Brown","year":"1982","unstructured":"Brown DM, Andres GA, Hostetter TH, Mauer SM, Price R, Venkatachalam MA (1982) Kidney complications. Diabetes 31:71\u201382","journal-title":"Diabetes"},{"key":"243_CR72","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Galicia MC, Burgueno-Tapia E, Romero-Rojas A, Garc\u00eda-Zebad\u00faa JC, Cornejo-Garrido J, Ordaz-Pichardo C (2014) Anti-hyperglycemic effect, inhibition of inflammatory cytokines expression, and histopathology profile in streptozotocin-induced diabetic rats treated with Arracacia tolucensis aerial-parts extracts. J Ethnopharmacol 152:91\u201398","DOI":"10.1016\/j.jep.2013.12.031"},{"key":"243_CR73","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0168-8227(02)00103-1","volume":"58","author":"MV Risbud","year":"2002","unstructured":"Risbud MV, Bhonde RR (2002) Models of pancreatic regeneration in diabetes. Diabetes Res Clin Pract 58:155\u2013165","journal-title":"Diabetes Res Clin Pract"},{"key":"243_CR74","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.biopha.2005.05.006","volume":"59","author":"JD M\u00e9ndez","year":"2005","unstructured":"M\u00e9ndez JD, De Haro Hern\u00e1ndez R (2005) l-arginine and polyamine administration protect \u03b2-cells against alloxan diabetogenic effect in Sprague-Dawley rats. Biomed Pharmacother 59:283\u2013289","journal-title":"Biomed Pharmacother"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-015-0243-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-015-0243-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-015-0243-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T18:35:25Z","timestamp":1651516525000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-015-0243-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,15]]},"references-count":74,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["243"],"URL":"https:\/\/doi.org\/10.1007\/s40618-015-0243-5","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,15]]}}}