{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:49:27Z","timestamp":1789426167126,"version":"build-2803163510"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1007\/s40618-015-0335-2","type":"journal-article","created":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T12:25:45Z","timestamp":1434975945000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome"],"prefix":"10.1007","volume":"39","author":[{"given":"M. A.","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Duran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Basaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"issue":"1","key":"335_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ecl.2013.10.003","volume":"43","author":"A Nandi","year":"2014","unstructured":"Nandi A, Chen Z, Patel R, Poretsky L (2014) Polycystic ovary syndrome. Endocrinol Metab Clin North Am 43(1):123\u2013147. doi: 10.1016\/j.ecl.2013.10.003","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"1","key":"335_CR2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","volume":"97","author":"BC Fauser","year":"2012","unstructured":"Fauser BC, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, Carmina E, Chang J, Yildiz BO, Laven JS, Boivin J, Petraglia F, Wijeyeratne CN, Norman RJ, Dunaif A, Franks S, Wild RA, Dumesic D, Barnhart K (2012) Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-Sponsored 3rd PCOS Consensus Workshop Group. Fertil Steril 97(1):28\u201338e25. doi: 10.1016\/j.fertnstert.2011.09.024","journal-title":"Fertil Steril"},{"issue":"4","key":"335_CR3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.fertnstert.2014.06.027","volume":"102","author":"L Chen","year":"2014","unstructured":"Chen L, Xu WM, Zhang D (2014) Association of abdominal obesity, insulin resistance, and oxidative stress in adipose tissue in women with polycystic ovary syndrome. Fertil Steril 102(4):1167\u20131174e1164. doi: 10.1016\/j.fertnstert.2014.06.027","journal-title":"Fertil Steril"},{"issue":"2","key":"335_CR4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00404-014-3199-3","volume":"290","author":"R Keskin Kurt","year":"2014","unstructured":"Keskin Kurt R, Okyay AG, Hakverdi AU, Gungoren A, Dolapcioglu KS, Karateke A, Dogan MO (2014) The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study. Arch Gynecol Obstet 290(2):315\u2013319. doi: 10.1007\/s00404-014-3199-3","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"335_CR5","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/jcem.86.6.7580","volume":"86","author":"CC Kelly","year":"2001","unstructured":"Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N (2001) Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab 86(6):2453\u20132455. doi: 10.1210\/jcem.86.6.7580","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"335_CR6","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1210\/jc.2004-0751","volume":"89","author":"I Tarkun","year":"2004","unstructured":"Tarkun I, Arslan BC, Canturk Z, Turemen E, Sahin T, Duman C (2004) Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. J Clin Endocrinol Metab 89(11):5592\u20135596. doi: 10.1210\/jc.2004-0751","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"335_CR7","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000189809","volume":"18","author":"X Ruan","year":"2009","unstructured":"Ruan X, Dai Y (2009) Study on chronic low-grade inflammation and influential factors of polycystic ovary syndrome. Med Princ Pract 18(2):118\u2013122. doi: 10.1159\/000189809","journal-title":"Med Princ Pract"},{"issue":"5","key":"335_CR8","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.2337\/diacare.26.5.1619","volume":"26","author":"ZT Bloomgarden","year":"2003","unstructured":"Bloomgarden ZT (2003) Inflammation and insulin resistance. Diabetes Care 26(5):1619\u20131623","journal-title":"Diabetes Care"},{"issue":"6","key":"335_CR9","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1210\/jc.2003-030178","volume":"88","author":"P Dandona","year":"2003","unstructured":"Dandona P, Aljada A, Chaudhuri A, Bandyopadhyay A (2003) The potential influence of inflammation and insulin resistance on the pathogenesis and treatment of atherosclerosis-related complications in type 2 diabetes. J Clin Endocrinol Metab 88(6):2422\u20132429. doi: 10.1210\/jc.2003-030178","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"335_CR10","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1001\/archinte.159.10.1104","volume":"159","author":"PW Wilson","year":"1999","unstructured":"Wilson PW, Kannel WB, Silbershatz H, D\u2019Agostino RB (1999) Clustering of metabolic factors and coronary heart disease. Arch Intern Med 159(10):1104\u20131109","journal-title":"Arch Intern Med"},{"key":"335_CR11","unstructured":"Ravn P (2015) New paradigms in PCOS: Impaired glucose tolerance and cardiovascular risk. Clinical approach. Minerva Ginecologica"},{"issue":"1","key":"335_CR12","first-page":"165","volume":"84","author":"RS Legro","year":"1999","unstructured":"Legro RS, Kunselman AR, Dodson WC, Dunaif A (1999) Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab 84(1):165\u2013169. doi: 10.1210\/jcem.84.1.5393","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"335_CR13","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/cen.12137","volume":"79","author":"H Kahal","year":"2013","unstructured":"Kahal H, Aburima A, Ungvari T, Rigby AS, Dawson AJ, Coady AM, Vince RV, Ajjan RA, Kilpatrick ES, Naseem KM, Atkin SL (2013) Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity. Clin Endocrinol 79(2):252\u2013258. doi: 10.1111\/cen.12137","journal-title":"Clin Endocrinol"},{"issue":"4","key":"335_CR14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3109\/09513590.2011.613967","volume":"28","author":"JW Kim","year":"2012","unstructured":"Kim JW, Han JE, Kim YS, Won HJ, Yoon TK, Lee WS (2012) High sensitivity C-reactive protein and its relationship with impaired glucose regulation in lean patients with polycystic ovary syndrome. Gynecol Endocrinol 28(4):259\u2013263. doi: 10.3109\/09513590.2011.613967","journal-title":"Gynecol Endocrinol"},{"issue":"3","key":"335_CR15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/01443615.2011.553693","volume":"31","author":"AC Herlihy","year":"2011","unstructured":"Herlihy AC, Kelly RE, Hogan JL, O\u2019Connor N, Farah N, Turner MJ (2011) Polycystic ovary syndrome and the peripheral blood white cell count. J Obstet Gynaecol 31(3):242\u2013244. doi: 10.3109\/01443615.2011.553693","journal-title":"J Obstet Gynaecol"},{"issue":"1","key":"335_CR16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2265.2012.04454.x","volume":"78","author":"N Phelan","year":"2013","unstructured":"Phelan N, O\u2019Connor A, Kyaw Tun T, Correia N, Boran G, Roche HM, Gibney J (2013) Leucocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance. Clin Endocrinol 78(1):107\u2013113. doi: 10.1111\/j.1365-2265.2012.04454.x","journal-title":"Clin Endocrinol"},{"issue":"5","key":"335_CR17","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1001\/archinte.165.5.500","volume":"165","author":"KL Margolis","year":"2005","unstructured":"Margolis KL, Manson JE, Greenland P, Rodabough RJ, Bray PF, Safford M, Grimm RH Jr, Howard BV, Assaf AR, Prentice R, Women\u2019s Health Initiative Research G (2005) Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women\u2019s Health Initiative Observational Study. Arch Intern Med 165(5):500\u2013508. doi: 10.1001\/archinte.165.5.500","journal-title":"Arch Intern Med"},{"issue":"1","key":"335_CR18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/jcla.21564","volume":"27","author":"M Celikbilek","year":"2013","unstructured":"Celikbilek M, Dogan S, Ozbakir O, Zararsiz G, Kucuk H, Gursoy S, Yurci A, Guven K, Yucesoy M (2013) Neutrophil-lymphocyte ratio as a predictor of disease severity in ulcerative colitis. J Clin Lab Anal 27(1):72\u201376. doi: 10.1002\/jcla.21564","journal-title":"J Clin Lab Anal"},{"issue":"4","key":"335_CR19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ymgme.2011.06.019","volume":"104","author":"F Imtiaz","year":"2011","unstructured":"Imtiaz F, Rashed MS, Al-Mubarak B, Allam R, El-Karaksy H, Al-Hassnan Z, Al-Owain M, Al-Zaidan H, Rahbeeni Z, Qari A, Meyer BF, Al-Sayed M (2011) Identification of mutations causing hereditary tyrosinemia type I in patients of Middle Eastern origin. Mol Genet Metab 104(4):688\u2013690. doi: 10.1016\/j.ymgme.2011.06.019","journal-title":"Mol Genet Metab"},{"issue":"5","key":"335_CR20","doi-asserted-by":"crossref","first-page":"323","DOI":"10.6061\/clinics\/2014(05)05","volume":"69","author":"M Demir","year":"2014","unstructured":"Demir M, Cosar S, Melek M (2014) Evaluation of plasma eosinophil count and mean platelet volume in patients with coronary slow flow. Clinics 69(5):323\u2013326","journal-title":"Clinics"},{"issue":"4","key":"335_CR21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/1076029612468941","volume":"20","author":"DY Sahin","year":"2014","unstructured":"Sahin DY, Gur M, Elbasan Z, Yildirim A, Akilli RE, Koyunsever NY, Ozaltun B, Gozubuyuk G, Kivrak A, Cayli M (2014) Mean platelet volume associated with aortic distensibility, chronic inflammation, and diabetes in patients with stable coronary artery disease. Clin Appl Thromb Hemost 20(4):416\u2013421. doi: 10.1177\/1076029612468941","journal-title":"Clin Appl Thromb Hemost"},{"issue":"7","key":"335_CR22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/09537100500163572","volume":"16","author":"E Coban","year":"2005","unstructured":"Coban E, Yazicioglu G, Berkant Avci A, Akcit F (2005) The mean platelet volume in patients with essential and white coat hypertension. Platelets 16(7):435\u2013438. doi: 10.1080\/09537100500163572","journal-title":"Platelets"},{"issue":"1","key":"335_CR23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138161211795049804","volume":"17","author":"AY Gasparyan","year":"2011","unstructured":"Gasparyan AY, Ayvazyan L, Mikhailidis DP, Kitas GD (2011) Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des 17(1):47\u201358","journal-title":"Curr Pharm Des"},{"issue":"1","key":"335_CR24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2174\/157016108783331295","volume":"6","author":"A Schafer","year":"2008","unstructured":"Schafer A, Bauersachs J (2008) Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis. Curr Vasc Pharmacol 6(1):52\u201360","journal-title":"Curr Vasc Pharmacol"},{"issue":"5","key":"335_CR25","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3109\/09537101003628421","volume":"21","author":"Y Tavil","year":"2010","unstructured":"Tavil Y, Sen N, Yazici H, Turfan M, Hizal F, Cengel A, Abaci A (2010) Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients. Platelets 21(5):368\u2013372. doi: 10.3109\/09537101003628421","journal-title":"Platelets"},{"issue":"7","key":"335_CR26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/09537100600901590","volume":"17","author":"A Gursoy","year":"2006","unstructured":"Gursoy A, Ertugrul DT, Pamuk B, Sahin M, Asik M, Yilmaz H, Haydardedeoglu F, Tutuncu NB, Demirag NG (2006) Mean platelet volume in patients with polycystic ovary disease. Platelets 17(7):505\u2013506. doi: 10.1080\/09537100600901590","journal-title":"Platelets"},{"key":"335_CR27","author":"S Kabil Kucur","year":"2014","unstructured":"Kabil Kucur S, Gozukara I, Aksoy A, Uludag EU, Keskin H, Kamalak Z, Carlioglu A (2014) How medical treatment affects mean platelet volume as a cardiovascular risk marker in polycystic ovary syndrome? Blood Coagul Fibrinolysis. doi: 10.1097\/MBC.0000000000000229","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"2","key":"335_CR28","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00404-008-0884-0","volume":"280","author":"L Kebapcilar","year":"2009","unstructured":"Kebapcilar L, Taner CE, Kebapcilar AG, Sari I (2009) High mean platelet volume, low-grade systemic coagulation and fibrinolytic activation are associated with androgen and insulin levels in polycystic ovary syndrome. Arch Gynecol Obstet 280(2):187\u2013193. doi: 10.1007\/s00404-008-0884-0","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"335_CR29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","volume":"81","author":"EA-SPCWG Rotterdam","year":"2004","unstructured":"Rotterdam EA-SPCWG (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81(1):19\u201325","journal-title":"Fertil Steril"},{"issue":"10","key":"335_CR30","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1365-2362.2006.01712.x","volume":"36","author":"E Diamanti-Kandarakis","year":"2006","unstructured":"Diamanti-Kandarakis E, Alexandraki K, Piperi C, Protogerou A, Katsikis I, Paterakis T, Lekakis J, Panidis D (2006) Inflammatory and endothelial markers in women with polycystic ovary syndrome. Eur J Clin Invest 36(10):691\u2013697. doi: 10.1111\/j.1365-2362.2006.01712.x","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"335_CR31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3329\/jhpn.v31i1.14749","volume":"31","author":"MA Farhangi","year":"2013","unstructured":"Farhangi MA, Keshavarz SA, Eshraghian M, Ostadrahimi A, Saboor-Yaraghi AA (2013) White blood cell count in women: relation to inflammatory biomarkers, haematological profiles, visceral adiposity, and other cardiovascular risk factors. J Health Popul Nutr 31(1):58\u201364","journal-title":"J Health Popul Nutr"},{"issue":"3","key":"335_CR32","first-page":"589","volume":"30","author":"DB Silfeler","year":"2014","unstructured":"Silfeler DB, Kurt RK, Yengil E, Un B, Arica S, Baloglu A (2014) Evaluation of Mean Platelet Volume values in lean women with polycystic ovary syndrome. Pak J Med Sci 30(3):589\u2013592. doi: 10.12669\/pjms.303.4475","journal-title":"Pak J Med Sci"},{"issue":"4","key":"335_CR33","first-page":"e18642","volume":"12","author":"BA Dogan","year":"2014","unstructured":"Dogan BA, Arduc A, Tuna MM, Karakilic E, Dagdelen I, Tutuncu Y, Berker D, Guler S (2014) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome. Int J Endocrinol Metab 12(4):e18642. doi: 10.5812\/ijem.18642","journal-title":"Int J Endocrinol Metab"},{"issue":"8","key":"335_CR34","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1742-1241.2005.00500.x","volume":"59","author":"E Coban","year":"2005","unstructured":"Coban E, Ozdogan M, Yazicioglu G, Akcit F (2005) The mean platelet volume in patients with obesity. Int J Clin Pract 59(8):981\u2013982. doi: 10.1111\/j.1742-1241.2005.00500.x","journal-title":"Int J Clin Pract"},{"issue":"1","key":"335_CR35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.14310\/horm.2002.1563","volume":"14","author":"O Papalou","year":"2015","unstructured":"Papalou O, Livadas S, Karachalios A, Tolia N, Kokkoris P, Tripolitakis K, Diamanti-Kandarakis E (2015) White blood cells levels and PCOS: direct and indirect relationship with obesity and insulin resistance, but not with hyperandrogenemia. Hormones 14(1):91\u201399. doi: 10.14310\/horm.2002.1563","journal-title":"Hormones"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-015-0335-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-015-0335-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-015-0335-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T19:55:57Z","timestamp":1748462157000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-015-0335-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,23]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["335"],"URL":"https:\/\/doi.org\/10.1007\/s40618-015-0335-2","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,23]]}}}