{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:34:51Z","timestamp":1783632891476,"version":"3.55.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Endocrinol Invest"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s40618-016-0565-y","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T06:45:49Z","timestamp":1477032349000},"page":"319-322","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Risk of malignant neoplasms in acromegaly: a case\u2013control study"],"prefix":"10.1007","volume":"40","author":[{"given":"K.","family":"Wolinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stangierski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Dyrda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nowicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Car","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lazizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bednarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Czarnywojtek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gurgul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ruchala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"565_CR1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","volume":"25","author":"A Colao","year":"2009","unstructured":"Colao A, Ferone D, Marzullo P, Lombardi G (2009) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocr Rev 25:102\u2013152","journal-title":"Endocr Rev"},{"key":"565_CR2","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","volume":"355","author":"S Melmed","year":"2006","unstructured":"Melmed S (2006) Medical progress: acromegaly. N Engl J Med 355:2558\u20132573","journal-title":"N Engl J Med"},{"key":"565_CR3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1987.tb00805.x","volume":"26","author":"JD Nabarro","year":"1987","unstructured":"Nabarro JD (1987) Acromegaly. Clin Endocrinol 26:481\u2013512","journal-title":"Clin Endocrinol"},{"key":"565_CR4","first-page":"401","volume":"62","author":"A Ba\u0142dys-Walig\u00f3rska","year":"2011","unstructured":"Ba\u0142dys-Walig\u00f3rska A, Krzentowska-Korek A, Go\u0142kowski F, Soko\u0142owski G, Hubalewska-Dydejczyk A (2011) The predictive value of the IGF-1 level in acromegaly patients treated by surgery and a somatostatin analogue. Endokrynol Pol 62:401\u2013408","journal-title":"Endokrynol Pol"},{"key":"565_CR5","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2016.0053","author":"CL Boguszewski","year":"2016","unstructured":"Boguszewski CL, Boguszewski MC, Kopchick JJ (2016) Growth hormone, insulin-like growth factor system and carcinogenesis. Endokrynol Pol. doi: 10.5603\/EP.a2016.0053","journal-title":"Endokrynol Pol"},{"key":"565_CR6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4149\/endo_2011_04_191","volume":"45","author":"F Golkowski","year":"2011","unstructured":"Golkowski F, Krzentowska-Korek A, Baldys-Waligorska A, Hubalewska-Dydejczyk A (2011) Goiter, cardiovascular and metabolic disorders in patients with acromegaly. Endocr Regul 45:191\u2013197","journal-title":"Endocr Regul"},{"key":"565_CR7","first-page":"29","volume":"61","author":"A Ba\u0142dys-Walig\u00f3rska","year":"2010","unstructured":"Ba\u0142dys-Walig\u00f3rska A, Krzentowska A, Go\u0142kowski F, Soko\u0142owski G, Hubalewska-Dydejczyk A (2010) The prevalence of benign and malignant neoplasms in acromegalic patients. Endokrynol Pol 61:29\u201334","journal-title":"Endokrynol Pol"},{"key":"565_CR8","first-page":"111","volume":"16","author":"M Rucha\u0142a","year":"2012","unstructured":"Rucha\u0142a M, Szczepanek-Parulska E, Fularz M, Woli\u0144ski K (2012) Risk of neoplasms in acromegaly. Contemp Oncol 16:111\u2013117","journal-title":"Contemp Oncol"},{"key":"565_CR9","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1210\/jcem.86.7.7634","volume":"86","author":"PJ Jenkins","year":"2001","unstructured":"Jenkins PJ, Besser M (2001) Clinical perspective: acromegaly and cancer: a problem. J Clin Endocrinol Metab 86:2935\u20132941","journal-title":"J Clin Endocrinol Metab"},{"key":"565_CR10","unstructured":"Wen-Ko C, Szu-Tah C, Feng-Hsuan L, Chen-Nen C, Ming-Hsu W, Jen-Der L (2016) The impact of diabetes mellitus on the survival of patients with acromegaly. Endokrynol Pol. 2016 Feb 17 [Epub ahead of print]"},{"key":"565_CR11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/BF03343997","volume":"25","author":"M Gasperi","year":"2002","unstructured":"Gasperi M, Martino E, Manetti L, Arosio M, Porretti S, Faglia G, Mariotti S, Colao AM, Lombardi G, Baldelli R, Camanni F, Liuzzi A, Acromegaly Study Group of the Italian Society of Endocrinology (2002) Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study. J Endocrinol Invest 25:240\u2013245","journal-title":"J Endocrinol Invest"},{"key":"565_CR12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s40618-015-0404-6","volume":"39","author":"MG Baroni","year":"2016","unstructured":"Baroni MG, Giorgino F, Pezzino V, Scaroni C, Avogaro A (2016) Italian Society for the Study of Diabetes (SID)\/Italian Endocrinological Society (SIE) guidelines on the treatment of hyperglycemia in Cushing\u2019s syndrome and acromegaly. J Endocrinol Invest 39:235\u2013255","journal-title":"J Endocrinol Invest"},{"key":"565_CR13","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1210\/jc.2004-0240","volume":"90","author":"M Terzolo","year":"2005","unstructured":"Terzolo M, Reimondo G, Gasperi M, Cozzi R, Pivonello R, Vitale G, Scillitani A, Attanasio R, Cecconi E, Daffara F, Gaia E, Martino E, Lombardi G, Angeli A, Colao A (2005) Colonoscopic screening and follow-up in patients with acromegaly: a multicenter study in Italy. J Clin Endocrinol Metab 90:84\u201390","journal-title":"J Clin Endocrinol Metab"},{"key":"565_CR14","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.3748\/wjg.14.3484","volume":"14","author":"T Rokkas","year":"2008","unstructured":"Rokkas T, Pistiolas D, Sechopoulos P, Margantinis G, Koukoulis G (2008) Risk of colorectal neoplasm in patients with acromegaly: a meta-analysis. World J Gastroenterol 14:3484\u20133489","journal-title":"World J Gastroenterol"},{"key":"565_CR15","doi-asserted-by":"crossref","first-page":"e88787","DOI":"10.1371\/journal.pone.0088787","volume":"9","author":"K Wolinski","year":"2014","unstructured":"Wolinski K, Czarnywojtek A, Ruchala M (2014) Risk of thyroid nodular disease and thyroid cancer in patients with acromegaly\u2014meta-analysis and systematic review. PLoS One 9:e88787","journal-title":"PLoS One"},{"key":"565_CR16","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1210\/jc.2014-2700","volume":"99","author":"L Katznelson","year":"2014","unstructured":"Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, Wass JA, Endocrine Society (2014) Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 99:3933\u20133951","journal-title":"J Clin Endocrinol Metab"},{"key":"565_CR17","first-page":"382","volume":"30","author":"M Ruchala","year":"2009","unstructured":"Ruchala M, Skiba A, Gurgul E, Uruski P, Wasko R, Sowinski J (2009) The occurrence of thyroid focal lesions and a need for fine needle aspiration biopsy in patients with acromegaly due to an increased risk of thyroid cancer. Neuro Endocrinol Lett 30:382\u2013386","journal-title":"Neuro Endocrinol Lett"},{"key":"565_CR18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s11102-010-0224-9","volume":"13","author":"BE Gullu","year":"2010","unstructured":"Gullu BE, Celik O, Gazioglu N, Kadioglu P (2010) Thyroid cancer is the most common cancer associated with acromegaly. Pituitary 13:242\u2013248","journal-title":"Pituitary"},{"key":"565_CR19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1530\/eje.0.1510439","volume":"151","author":"A Mestron","year":"2004","unstructured":"Mestron A, Webb SM, Astorga R, Benito P, Catala M, Gaztambide S, Gomez JM, Halperin I, Lucas-Morante T, Moreno B, Obiols G, de Pablos P, Paramo C, Pico A, Torres E, Varela C, Vazquez JA, Zamora J, Albareda M, Gilabert M (2004) Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol de Acromegalia, REA). Eur J Endocrinol 151:439\u2013446","journal-title":"Eur J Endocrinol"},{"key":"565_CR20","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1023\/A:1015713732717","volume":"13","author":"D Baris","year":"2002","unstructured":"Baris D, Gridley G, Ron E, Weiderpass E, Mellemkjaer L, Ekbom A, Olsen JH, Baron JA, Fraumeni JF Jr (2002) Acromegaly and cancer risk: a cohort study in Sweden and Denmark. Cancer Causes Control 13:395\u2013400","journal-title":"Cancer Causes Control"},{"key":"565_CR21","first-page":"2730","volume":"83","author":"SM Orme","year":"1998","unstructured":"Orme SM, McNally RJ, Cartwright RA, Belchetz PE (1998) Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group. J Clin Endocrinol Metab 83:2730\u20132734","journal-title":"J Clin Endocrinol Metab"},{"key":"565_CR22","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/1097-0142(19911015)68:8<1673::AID-CNCR2820680802>3.0.CO;2-0","volume":"68","author":"E Ron","year":"1991","unstructured":"Ron E, Gridley G, Hrubec Z, Page W, Arora S, Fraumeni JF Jr (1991) Acromegaly and gastrointestinal cancer. Cancer 68:1673\u20131677","journal-title":"Cancer"},{"key":"565_CR23","doi-asserted-by":"crossref","first-page":"3894","DOI":"10.1210\/jc.2015-2372","volume":"100","author":"D Petroff","year":"2015","unstructured":"Petroff D, T\u00f6njes A, Grussendorf M, Droste M, Dimopoulou C, Stalla G, Jaursch-Hancke C, Mai M, Schopohl J, Sch\u00f6fl C (2015) The incidence of cancer among acromegaly patients: results from the German Acromegaly Registry. J Clin Endocrinol Metab 100:3894\u20133902","journal-title":"J Clin Endocrinol Metab"},{"key":"565_CR24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2265.1998.00536.x","volume":"49","author":"V Popovic","year":"1998","unstructured":"Popovic V, Damjanovic S, Micic D, Nesovic M, Djurovic M, Petakov M, Obradovic S, Zoric S, Simic M, Penezic Z, Marinkovic J (1998) Increased incidence of neoplasia in patients with pituitary adenomas. The Pituitary Study Group. Clin Endocrinol 49:441\u2013445","journal-title":"Clin Endocrinol"},{"key":"565_CR25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.5603\/EP.2014.0045","volume":"65","author":"M Bolanowski","year":"2014","unstructured":"Bolanowski M, Rucha\u0142a M, Zgliczy\u0144ski W, Kos-Kud\u0142a B, Ba\u0142dys-Walig\u00f3rska A, Zieli\u0144ski G, Bednarczuk T, Hubalewska-Dydejczyk A, Kami\u0144ski G, Marek B, Daroszewski J, Wa\u015bko R, Lewi\u0144ski A (2014) Acromegaly\u2014a novel view of the patient. Polish proposals for diagnostic and therapeutic procedures in the light of recent reports. Endokrynol Pol 65:326\u2013331","journal-title":"Endokrynol Pol"},{"key":"565_CR26","doi-asserted-by":"crossref","first-page":"R147","DOI":"10.1530\/EJE-16-0178","volume":"175","author":"CL Boguszewski","year":"2016","unstructured":"Boguszewski CL, Ayuk J (2016) Management of endocrine disease: acromegaly and cancer: an old debate revisited. Eur J Endocrinol 175:R147\u2013R156","journal-title":"Eur J Endocrinol"}],"container-title":["Journal of Endocrinological Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-016-0565-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40618-016-0565-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40618-016-0565-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T21:47:35Z","timestamp":1498340855000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40618-016-0565-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,21]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["565"],"URL":"https:\/\/doi.org\/10.1007\/s40618-016-0565-y","relation":{},"ISSN":["1720-8386"],"issn-type":[{"value":"1720-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,21]]}}}